129
Views
7
CrossRef citations to date
0
Altmetric
Research Article

Metabolomic approach to understand the acute and chronic hepatotoxicity of Veratrum nigrum extract in mice based on ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry

, , , , , & show all
Pages 687-696 | Received 05 May 2017, Accepted 02 Jul 2017, Published online: 28 Jul 2017

References

  • Best J, Dolle L, Manka P, Coombes J, van Grunsven LA, Syn W-K 2013. Role of liver progenitors in acute liver injury. Front Physiol. 4:258.
  • Bijlsma S, Bobeldijk I, Verheij ER, Ramaker R, Kochhar S, Macdonald IA, Smilde AK. 2006. Large-scale human metabolomics studies: a strategy for data (pre-) processing and validation. Anal Chem. 78:567–574.
  • Cai Y, Gao Y, Tan G, Wu S, Dong X, Lou Z, Chai Y. 2013. Myocardial lipidomics profiling delineate the toxicity of traditional Chinese medicine Aconiti Lateralis radix praeparata. J Ethnopharmacol. 147:349–356.
  • Chen J, Wang W, Lv S, Yin P, Zhao X, Lu X, Xu G. 2009. Metabonomics study of liver cancer based on ultra performance liquid chromatography coupled to mass spectrometry with HILIC and RPLC separations. Anal Chim Acta. 650:3–9.
  • Choi YJ, Yoon Y, Choi HS, Park S, Oh S, Jeong SM, Lee BH. 2011. Effects of medicinal herb extracts and their components on steatogenic hepatotoxicity in Sk-hep1 cells. Toxicol Res. 27:211–216.
  • Cong Y, Guo J-G, Tang Z, Zhang Q-C, Cai Z-W. 2014. Identification of in vitro and in vivo metabolites of 12 beta-hydroxylveratroylzygadenine associated with neurotoxicity by using HPLC-MS/MS. Chinese Chemical Letters. 25:1107–1111.
  • Cong Y, Guo J, Tang Z, Lin S, Zhang Q, Li J, Cai Z. 2015. Metabolism study of veratramine associated with neurotoxicity by using HPLC-MSn. J Chromatogr Sci. 53:1092–1099.
  • Gika HG, Theodoridis GA, Wingate JE, Wilson ID. 2007. Within-day reproducibility of an HPLC-MS-based method for metabonomic analysis: application to human urine. J Proteome Res. 6:3291–3303.
  • Hernandez-Corbacho MJ, Salama MF, Canals D, Senkal CE, Obeid LM. 2017. Sphingolipids in mitochondria. Biochim Biophys Acta Lipids. 1862:56–68.
  • Kang C, Han J-H, Oh J, Kulkarni R, Zhou W, Ferreira D, Na M. 2015. Steroidal alkaloids from Veratrum nigrum enhance glucose uptake in skeletal muscle cells. J Nat Prod. 78:803–810.
  • Lee KJ, Choi JH, Kim HG, Han EH, Hwang YP, Lee YC, Jeong HG. 2008. Protective effect of saponins derived from the roots of Platycodon grandiflorum against carbon tetrachloride induced hepatotoxicity in mice. Food Chem Toxicol. 46:1778–1785.
  • Leung AY. 2006. Traditional toxicity documentation of Chinese Materia Medica--an overview. Toxicol Pathol. 34:319–326.
  • Li H-l, Tang J, Liu R-h, Lin M, Wang B, Lv Y-f, Zhang W-d. 2007. Characterization and identification of steroidal alkaloids in the Chinese herb Veratrum nigrum L. by high-performance liquid chromatography/electrospray ionization with multi-stage mass spectrometry. Rapid Commun Mass Spectrom. 21:869–879.
  • Li Q, Yang K-X, Zhao Y-L, Qin X-J, Yang X-W, Liu L, Luo X-D. 2016. Potent anti-inflammatory and analgesic steroidal alkaloids from Veratrum taliense. J Ethnopharmacol. 179:274–279.
  • Liu W, Guo X, Li Q, Xu G, Feng M, Guan T, Lv H. 2015. Mass spectrometry based molecular profile dissects the complexity of traditional Chinese medicine. Anal Methods. 7:2902–2912.
  • Morgan MY, Marshall AW, Milsom JP, Sherlock S. 1982. Plasma amino-acid patterns in liver disease. Gut. 23:362–370.
  • Mutomba MC, Yuan H, Konyavko M, Adachi S, Yokoyama CB, Esser V, Gottlieb RA. 2000. Regulation of the activity of caspases by L-carnitine and palmitoylcarnitine. FEBS Lett. 478:19–25.
  • Nicholson JK, Lindon JC, Holmes E. 1999. ‘Metabonomics’: understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica. 29:1181–1189.
  • Park J, Jeon Y-D, Kim H-L, Kim D-S, Han Y-H, Jung Y, Um J-Y. 2016. Veratri Nigri Rhizoma et Radix (Veratrum nigrum L.) and Its constituent jervine prevent adipogenesis via activation of the LKB1-AMPK alpha-ACC axis in vivo and in vitro. Evidence-Based Complementary and Alternative Medicine. DOI: 10.1155/2016/8674397
  • Park J, Jeon Y-D, Kim H-L, Lim H, Jung Y, Youn D-H, Um J-Y. 2013. Interaction of Veratrum nigrum with Panax ginseng against obesity: a sang-ban relationship. Evidence-Based Complementary and Alternative Medicine: eCAM. 2013:732126–732126.
  • Smith CA, Want EJ, O'Maille G, Abagyan R, Siuzdak G. 2006. XCMS: processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification. Anal Chem. 78:779–787.
  • Song Q-l, Wang S-s, Li Y-q, Zhao W-j. 2014. Study on antithrombotic activities and structure-activity relationships of Veratrum nigrum alkaloids. Zhong Yao Cai = Zhongyaocai = Journal of Chinese Medicinal materials. 37:2034–2038.
  • Tan G, Liao W, Dong X, Yang G, Zhu Z, Li W, Lou Z. 2012. Metabonomic profiles delineate the effect of traditional Chinese medicine sini decoction on myocardial infarction in rats. PLoS One. 7. DOI: 10.1371/journal.pone.0034157
  • Teschke R, Eickhoff A. 2015. Herbal hepatotoxicity in traditional and modern medicine: actual key issues and new encouraging steps. Front Pharmacol. 6. DOI: 10.3389/fphar.2015.00072
  • Wang H, Li S-y, Zhao C-k, Zeng X. 2009. A system for screening agonists targeting beta(2)-adrenoceptor from Chinese medicinal herbs. J Zhejiang Univ Sci B. 10:243–250.
  • Wang L, Li W, Liu Y. 2008. Hypotensive effect and toxicology of total alkaloids and veratramine from roots and rhizomes of Veratrum nigrum L. in spontaneously hypertensive rats. J Zhejiang Univ Sci B. 63:606–610.
  • Wang P, Wang Q, Yang B, Zhao S, Kuang H. 2015. The progress of metabolomics study in traditional Chinese medicine research. Am J Chin Med. 43:1281–1310.
  • Xu Y, Ding J, An J-n, Qu Y-k, Li X, Ma X-p, Lin N. 2016. Effect of the interaction of Veratrum nigrum with Panax ginseng on estrogenic activity in vivo and in vitro. Sci Rep. 6. DOI: 10.1038/srep26924
  • Yin P, Wan D, Zhao C, Chen J, Zhao X, Wang W, Xu G. 2009. A metabonomic study of hepatitis B-induced liver cirrhosis and hepatocellular carcinoma by using RP-LC and HILIC coupled with mass spectrometry. Mol BioSyst. 5:868–876.
  • Zagler B, Zelger A, Salvatore C, Pechlaner C, De Giorgi F, Wiedermann CJ. 2005. Dietary poisoning with veratrum album ? a report of two cases. Wien Klin Wochenschr. 117:106–108.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.