3,492
Views
77
CrossRef citations to date
0
Altmetric
Review

Mesenchymal stem cells: potential for therapy and treatment of chronic non-healing skin wounds

, , , , , , , , , , , , & show all
Pages 183-206 | Received 05 Oct 2015, Accepted 23 Nov 2015, Published online: 18 Feb 2016

Bibliography

  • Atiyeh BS, Ioannovich J, Al-Amm CA, El-Musa KA. Management of acute and chronic open wounds: the importance of moist environment in optimal wound healing. Curr Pharm Biotechnol 2002; 3:179-95; PMID:12164477; http://dx.doi.org/10.2174/1389201023378283
  • Branski LK, Gauglitz GG, Herndon DN, Jeschke MG. A review of gene and stem cell therapy in cutaneous wound healing. Burns 2009; 35:171-80; PMID:18603379; http://dx.doi.org/10.1016/j.burns.2008.03.009
  • Boulton AJ, Vileikyte L, Ragnarson-Tennvall G, Apelqvist J. The global burden of diabetic foot disease. Lancet 2005; 366:1719-24; PMID:16291066; http://dx.doi.org/10.1016/S0140-6736(05)67698-2
  • Reddy M, Gill SS, Rochon PA. Preventing pressure ulcers: a systematic review. Jama 2006; 296:974-84; PMID:16926357; http://dx.doi.org/10.1001/jama.296.8.974
  • Abbade LP, Lastoria S. Venous ulcer: epidemiology, physiopathology, diagnosis and treatment. Int J Dermatol 2005; 44:449-56; PMID:15941430; http://dx.doi.org/10.1111/j.1365-4632.2004.02456.x
  • Gibran NS, Heimbach DM. Current status of burn wound pathophysiology. Clin Plast Surg 2000; 27:11-22; PMID:10665353
  • Singer AJ, Clark RA. Cutaneous wound healing. N Engl J Med 1999; 341:738-46; PMID:10471461; http://dx.doi.org/10.1056/NEJM199909023411006
  • Gualtierotti R, Adorni G, Lubatti C, Zeni S, Meroni PL, Ingegnoli F. Digital ulcer management in patients with systemic sclerosis. OA Arthritis 2014; 2:2
  • Silva I, Almeida J, Vasconcelos C. A PRISMA-driven systematic review for predictive risk factors of digital ulcers in systemic sclerosis patients. Autoimmun Rev 2015; 14:140-52; PMID:25449678; http://dx.doi.org/10.1016/j.autrev.2014.10.009
  • Tingey T, Shu J, Smuczek J, Pope J. Meta-analysis of healing and prevention of digital ulcers in systemic sclerosis. Arthritis Care Res (Hoboken) 2013; 65:1460-71; PMID:23554239; http://dx.doi.org/10.1002/acr.22018
  • Pikuła M, Marek-Trzonkowska N, Wardowska A, Renkielska A, Trzonkowski P. Adipose tissue-derived stem cells in clinical applications. Expert Opin Biol Ther 2013; 13:1357-70; PMID:23919743; http://dx.doi.org/10.1517/14712598.2013.823153
  • Zuk PA, Zhu M, Mizuno H, Huang J, Futrell JW, Katz AJ, Benhaim P, Lorenz HP, Hedrick MH. Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng 2001; 7:211-28; PMID:11304456; http://dx.doi.org/10.1089/107632701300062859
  • Erices A, Conget P, Minguell JJ. Mesenchymal progenitor cells in human umbilical cord blood. Br J Haematol 2000; 109:235-42; PMID:10848804; http://dx.doi.org/10.1046/j.1365-2141.2000.01986.x
  • Roufosse CA, Direkze NC, Otto WR, Wright NA. Circulating mesenchymal stem cells. Int J Biochem Cell Biol 2004; 36:585-97; PMID:15010325
  • Meng X, Ichim TE, Zhong J, Rogers A, Yin Z, Jackson J, Wang H, Ge W, Bogin V, Chan KW, et al. Endometrial regenerative cells: a novel stem cell population. J Transl Med 2007; 5:57; PMID:18005405; http://dx.doi.org/10.1186/1479-5876-5-57
  • Fang RC, Galiano RD. A review of becaplermin gel in the treatment of diabetic neuropathic foot ulcers. Biologics 2008; 2:1-12; PMID:19707423
  • Martí-Carvajal AJ, Gluud C, Nicola S, Simancas-Racines D, Reveiz L, Oliva P, Cedeño-Taborda J. Growth factors for treating diabetic foot ulcers. Cochrane Database Syst Rev 2015; 10:CD008548
  • Gronthos S, Mankani M, Brahim J, Robey PG, Shi S. Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo. Proc Natl Acad Sci U S A 2000; 97:13625-30; PMID:11087820; http://dx.doi.org/10.1073/pnas.240309797
  • Sessarego N, Parodi A, Podesta M, Benvenuto F, Mogni M, Raviolo V, Lituania M, Kunkl A, Ferlazzo G, Bricarelli FD, et al. Multipotent mesenchymal stromal cells from amniotic fluid: solid perspectives for clinical application. Haematologica 2008; 93:339-46; PMID:18268281; http://dx.doi.org/10.3324/haematol.11869
  • Yan XL, Fu CJ, Chen L, Qin JH, Zeng Q, Yuan HF, Nan X, Chen HX, Zhou JN, Lin YL, et al. Mesenchymal stem cells from primary breast cancer tissue promote cancer proliferation and enhance mammosphere formation partially via EGF/EGFR/Akt pathway. Breast Cancer Res Treat 2012; 132:153-64; PMID:21584665; http://dx.doi.org/10.1007/s10549-011-1577-0
  • Murphy MB, Moncivais K, Caplan AI. Mesenchymal stem cells: environmentally responsive therapeutics for regenerative medicine. Exp Mol Med 2013; 45:e54; PMID:24232253; http://dx.doi.org/10.1038/emm.2013.94
  • García-Gómez I, Elvira G, Zapata AG, Lamana ML, Ramírez M, Castro JG, Arranz MG, Vicente A, Bueren J, García-Olmo D. Mesenchymal stem cells: biological properties and clinical applications. Expert Opin Biol Ther 2010; 10:1453-68; http://dx.doi.org/10.1517/14712598.2010.519333
  • Phinney DG, Prockop DJ. Concise review: mesenchymal stem/multipotent stromal cells: the state of transdifferentiation and modes of tissue repair-current views. Stem Cells 2007; 25:2896-902; PMID:17901396; http://dx.doi.org/10.1634/stemcells.2007-0637
  • Meirelles Lda S, Fontes AM, Covas DT, Caplan AI. Mechanisms involved in the therapeutic properties of mesenchymal stem cells. Cytokine Growth Factor Rev 2009; 20:419-27; PMID:19926330; http://dx.doi.org/10.1016/j.cytogfr.2009.10.002
  • Rani S, Ryan AE, Griffin MD, Ritter T. Mesenchymal Stem Cell-derived Extracellular Vesicles: Toward Cell-free Therapeutic Applications. Mol Ther 2015; 23:812-23; PMID:25868399; http://dx.doi.org/10.1038/mt.2015.44
  • Caplan AI. Review: mesenchymal stem cells: cell-based reconstructive therapy in orthopedics. Tissue Eng 2005; 11:1198-211; PMID:16144456; http://dx.doi.org/10.1089/ten.2005.11.1198
  • Petrie Aronin CE, Tuan RS. Therapeutic potential of the immunomodulatory activities of adult mesenchymal stem cells. Birth Defects Res C Embryo Today 2010; 90:67-74; PMID:20301222; http://dx.doi.org/10.1002/bdrc.20174
  • Haynesworth SE, Baber MA and Caplan AI. Cytokine expression by human marrow-derived mesenchymal progenitor cells in vitro: effects of dexamethasone and IL-1 alpha. J Cell Physiol 1996; 166:585-92; PMID:8600162; http://dx.doi.org/10.1002/(SICI)1097-4652(199603)166:3%3c585::AID-JCP13%3e3.0.CO;2-6
  • Blocki A, Wang Y, Koch M, Peh P, Beyer S, Law P, Hui J, Raghunath M. Not all MSCs can act as pericytes: functional in vitro assays to distinguish pericytes from other mesenchymal stem cells in angiogenesis. Stem Cells Dev 2013; 22:2347-55; PMID:23600480; http://dx.doi.org/10.1089/scd.2012.0415
  • Spradling A, Drummond-Barbosa D, Kai T. Stem cells find their niche. Nature 2001; 414:98-104; PMID:11689954; http://dx.doi.org/10.1038/35102160
  • Nuschke A. Activity of mesenchymal stem cells in therapies for chronic skin wound healing. Organogenesis 2014; 10:29-37; PMID:24322872; http://dx.doi.org/10.4161/org.27405
  • Wang Y, Crisostomo PR, Wang M, Markel TA, Novotny NM, Meldrum DR. TGF-alpha increases human mesenchymal stem cell-secreted VEGF by MEK- and PI3-K- but not JNK- or ERK-dependent mechanisms. Am J Physiol Regul Integr Comp Physiol 2008; 295:R1115-23; PMID:18685072; http://dx.doi.org/10.1152/ajpregu.90383.2008
  • Aggarwal S, Pittenger MF. Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood 2005; 105:1815-22; PMID:15494428; http://dx.doi.org/10.1182/blood-2004-04-1559
  • Jiang XX, Zhang Y, Liu B, Zhang SX, Wu Y, Yu XD, Mao N. Human mesenchymal stem cells inhibit differentiation and function of monocyte-derived dendritic cells. Blood 2005; 105:4120-6; PMID:15692068; http://dx.doi.org/10.1182/blood-2004-02-0586
  • Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D, Deans R, Keating A, Prockop DJ, Horwitz E. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 2006; 8:315-7; PMID:16923606; http://dx.doi.org/10.1080/14653240600855905
  • Scherberich A, Di Maggio ND, McNagny KM. A familiar stranger: CD34 expression and putative functions in SVF cells of adipose tissue. World J Stem Cells 2013; 5:1-8; PMID:23362435; http://dx.doi.org/10.4252/wjsc.v5.i1.1
  • Yoshimura K, Shigeura T, Matsumoto D, Sato T, Takaki Y, Aiba-Kojima E, Sato K, Inoue K, Nagase T, Koshima I, Gonda K. Characterization of freshly isolated and cultured cells derived from the fatty and fluid portions of liposuction aspirates. J Cell Physiol 2006; 208:64-76; PMID:16557516; http://dx.doi.org/10.1002/jcp.20636
  • Wu Y, Wang J, Scott PG, Tredget EE. Bone marrow-derived stem cells in wound healing: a review. Wound Repair Regen. 2007; 15:S18-26; PMID:17727462; http://dx.doi.org/10.1111/j.1524-475X.2007.00221.x
  • Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, Moorman MA, Simonetti DW, Craig S, Marshak DR. Multilineage potential of adult human mesenchymal stem cells. Science 1999; 284:143-7; PMID:10102814; http://dx.doi.org/10.1126/science.284.5411.143
  • Rao MS, Mattson MP. Stem cells and aging: expanding the possibilities. Mech Ageing Dev 2001; 122:713-34
  • Broxmeyer HE, Douglas GW, Hangoc G, Cooper S, Bard J, English D, Arny M, Thomas L, Boyse EA. Human umbilical cord blood as a potential source of transplantable hematopoietic stem/progenitor cells. Proc Natl Acad Sci U S A 1989; 86:3828-32; PMID:2566997; http://dx.doi.org/10.1073/pnas.86.10.3828
  • Kim JY, Jeon HB, Yang YS, Oh W, Chang JW. Application of human umbilical cord blood-derived mesenchymal stem cells in disease models. World J Stem Cells 2010; 2:34-8; PMID:21607114; http://dx.doi.org/10.4252/wjsc.v2.i2.34
  • Valbonesi M, Giannini G, Migliori F, Dalla Costa R, Dejana AM. Cord blood (CB) stem cells for wound repair. Preliminary report of 2 cases. Transfusion Apheresis Sei 2004; 30; 153-6; http://dx.doi.org/10.1016/j.transci.2003.11.006
  • Lin J, Xiang D, Zhang JL, Allickson J, Xiang C. Plasticity of human menstrual blood stem cells derived from the endometrium. J Zhejiang Univ Sci B 2011; 12:372-80; PMID:21528491; http://dx.doi.org/10.1631/jzus.B1100015
  • Murphy MP, Wang H, Patel AN, Kambhampati S, Angle N, Chan K, Marleau AM, Pyszniak A, Carrier E, Ichim TE, Riordan NH. Allogeneic endometrial regenerative cells: an "Off the shelf solution" for critical limb ischemia? J Transl Med 2008; 19: 6:45
  • Verdi J, Tan A, Shoae-Hassani A, Seifalian AM. Endometrial stem cells in regenerative medicine. J Biol Eng 2014; 8:20; PMID:25097665; http://dx.doi.org/10.1186/1754-1611-8-20
  • Su K, Edwards SL, Tan KS, White JF, Kandel S, Ramshaw JA, Gargett CE, Werkmeister JA. Induction of endometrial mesenchymal stem cells into tissue-forming cells suitable for fascial repair. Acta Biomater 2014; 10:5012-5020; PMID:25194931; http://dx.doi.org/10.1016/j.actbio.2014.08.031
  • Ulrich D, Edwards SL, White JF, Supit T, Ramshaw JA, Lo C, Rosamilia A, Werkmeister JA, Gargett CE: A preclinical evaluation of alternative synthetic biomaterials for fascial defect repair using a rat abdominal hernia model. PLoS One 2012; 7:e50044; PMID:23185528; http://dx.doi.org/10.1371/journal.pone.0050044
  • Edwards SL, Werkmeister JA, Rosamilia A, Ramshaw JA, White JF, Gargett CE: Characterisation of clinical and newly fabricated meshes for pelvic organ prolapse repair. J Mech Behav Biomed Mater 2013; 23:53-61; PMID:23651550; http://dx.doi.org/10.1016/j.jmbbm.2013.04.002
  • Yamanaka S. Strategies and new developments in the generation of patient-specific pluripotent stem cells. Cell Stem Cell 2007; 1:39-49; PMID:18371333; http://dx.doi.org/10.1016/j.stem.2007.05.012
  • Zhou H, Wu S, Joo JY, Zhu S, Han DW, Lin T, Trauger S, Bien G, Yao S, Zhu Y, et al. Generation of induced pluripotent stem cells using recombinant proteins. Cell Stem Cell. 2009; 4(5):381-4; PMID:19398399; http://dx.doi.org/10.1016/j.stem.2009.04.005
  • Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, Yamanaka S. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007; 131(5):861-72; PMID:18035408; http://dx.doi.org/10.1016/j.cell.2007.11.019
  • Lian Q, Zhang Y, Zhang J, Zhang HK, Wu X, Zhang Y, Lam FF, Kang S, Xia JC, Lai WH, et al. Functional mesenchymal stem cells derived from human induced pluripotent stem cells attenuate limb ischemia in mice. Circulation. 2010; 121(9):1113-23; PMID:20176987; http://dx.doi.org/10.1161/CIRCULATIONAHA.109.898312
  • Himeno T, Kamiya H, Naruse K, Cheng Z, Ito S, Kondo M, Okawa T, Fujiya A, Kato J, Suzuki H, et al. Mesenchymal stem cell-like cells derived from mouse induced pluripotent stem cells ameliorate diabetic polyneuropathy in mice. Biomed Res Int. 2013; 2013:259187; PMID:24319678; http://dx.doi.org/10.1155/2013/259187
  • Sebastiano V, Zhen HH, Haddad B, Bashkirova E, Melo SP, Wang P, Leung TL, Siprashvili Z, Tichy A, Li J, et al. Human COL7A1-corrected induced pluripotent stem cells for the treatment of recessive dystrophic epidermolysis bullosa. Sci Transl Med. 2014; 6(264):264ra163; PMID:25429056
  • Kapur SK, Katz AJ. Review of the adipose derived stem cell secretome. Biochimie 2013; 95:2222-8; PMID:23770442; http://dx.doi.org/10.1016/j.biochi.2013.06.001
  • Salgado AJ, Reis RL, Sousa NJ, Gimble JM. Adipose tissue derived stem cells secretome: soluble factors and their roles in regenerative medicine. Curr Stem Cell Res Ther 2010; 5:103-10; PMID:19941460; http://dx.doi.org/10.2174/157488810791268564
  • Zuk PA, Zhu M, Ashjian P, De Ugarte DA, Huang JI, Mizuno H, Alfonso ZC, Fraser JK, Benhaim P, Hedrick MH. Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell 2002; 13:4279-95; PMID:12475952; http://dx.doi.org/10.1091/mbc.E02-02-0105
  • McIntosh KR, Frazier T, Rowan BG, Gimble JM. Evolution and future prospects of adipose-derived immunomodulatory cell therapeutics. Expert Rev Clin Immunol 2013; 9:175-84; PMID:23390948; http://dx.doi.org/10.1586/eci.12.96
  • Qin JB, Li KA, Li XX, Xie QS, Lin JY, Ye KC, Jiang ME, Zhang GX, Lu XW. Long-term MRI tracking of dual-labeled adipose-derived stem cells homing into mouse carotid artery injury. Int J Nanomedicine 2012; 7:5191-203; PMID:23125528
  • Marfia G, Campanella R, Navone SE, Zucca I, Scotti A, Figini M, Di Vito C, Alessandri G, Riboni L, Parati E. Potential use of human adipose mesenchymal stromal cells for intervertebral disc regeneration: a preliminary study on biglycan-deficient murine model of chronic disc degeneration. Arthritis Res Ther 2014; 16:457; PMID:25293819; http://dx.doi.org/10.1186/s13075-014-0457-5
  • Fraser JK, Wulur I, Alfonso Z, Hedrick MH. Fat tissue: an underappreciated source of stem cells for biotechnology. Trends Biotechnol 2006; 24:150-4; PMID:16488036; http://dx.doi.org/10.1016/j.tibtech.2006.01.010
  • Jurgens, WJ, Oedayrajsingh-Varma MJ, Helder MN, Zandiehdoulabi B, Schouten TE, Kuik DJ, Ritt MJ, van Milligen FJ. Effect of tissue-harvesting site on yield of stem cells derived from adipose tissue: implications for cell-based therapies. Cell Tissue Res 2008; 332:415-26; PMID:18379826; http://dx.doi.org/10.1007/s00441-007-0555-7
  • Schipper, BM, Marra KG, Zhang W, Donnenberg AD, Rubin JP. Regional anatomic and age effects on cell function of human adipose-derived stem cells. Ann Plast Surg 2008; 60:538-44; PMID:18434829; http://dx.doi.org/10.1097/SAP.0b013e3181723bbe
  • Bianchi, F, Maioli M, Leonardi E, Olivi E, Pasquinelli G, Valente S, Mendez AJ, Ricordi C, Raffaini M, Tremolada C, Ventura C. A new nonenzymatic method and device to obtain a fat tissue derivative highly enriched in pericyte-like elements by mild mechanical forces from human lipoaspirates. Cell Transplant 2013; 22:2063-77; PMID:23051701; http://dx.doi.org/10.3727/096368912X657855
  • Giori A, Tremolada C, Vailati R, Navone S E, Marfia G, Caplan AI. Recovery of Function in Anal Incontinence After Micro-Fragmented Fat Graft (Lipogems→) Injection: Two Years Follow Up of the First 5 Cases. CellR4 2015; 3:e1544
  • Eto H, Suga H, Matsumoto D, Inoue K, Aoi N, Kato H, Araki J, Yoshimura K. Characterization of structure and cellular components of aspirated and excised adipose tissue. Plast Reconstr Surg 2009; 124:1087-97; PMID:19935292; http://dx.doi.org/10.1097/PRS.0b013e3181b5a3f1
  • Hager G, Holnthoner W, Wolbank S, Husa AM, Godthardt K, Redl H, Gabriel C. Three specific antigens to isolate endothelial progenitor cells from human liposuction material. Cytotherapy 2013; 15(11):1426-35; PMID:24094492; http://dx.doi.org/10.1016/j.jcyt.2013.06.018
  • Gentile P, Orlandi A, Scioli MG, Di Pasquali C, Bocchini I, Cervelli V. Concise review: adipose-derived stromal vascular fraction cells and platelet-rich plasma: basic and clinical implications for tissue engineering therapies in regenerative surgery. Stem Cells Transl Med 2012; 1(3):230-6; PMID:23197782; http://dx.doi.org/10.5966/sctm.2011-0054
  • Astori G, Vignati F, Bardelli S, Tubio M, Gola M, Albertini V, Bambi F, Scali G, Castelli D, Rasini V, et al. "In vitro" and multicolour phenotypic characterization of cell subpopulations identified in fresh human adipose tissue stromal vascular fraction and in the derived mesenchymal stem cells. J Transl Med 2007; 5:55; PMID:17974012; http://dx.doi.org/10.1186/1479-5876-5-55
  • Zimmerlin L, Donnenberg VS, Rubin JP, Donnenberg AD. Mesenchymal markers on human adipose stem/progenitor cells. Cytometry A. 2013;83:134-40; PMID:23184564; http://dx.doi.org/10.1002/cyto.a.22227
  • Menke NB, Ward KR, Witten TM, Bonchev DG, Diegelmann RF. Impaired wound healing. Clin Dermatol 2007; 25:19-25; PMID:17276197; http://dx.doi.org/10.1016/j.clindermatol.2006.12.005
  • Fahey TJ, 3rd, Sadaty A, Jones WG, 2nd, Barber A, Smoller B, Shires GT. Diabetes impairs the late inflammatory response to wound healing. J Surg Res 1991; 50:308-13; PMID:2020184; http://dx.doi.org/10.1016/0022-4804(91)90196-S
  • Stanley AC, Park HY, Phillips TJ, Russakovsky V, Menzoian JO. Reduced growth of dermal fibroblasts from chronic venous ulcers can be stimulated with growth factors. J Vasc Surg 1997; 26:994-9; PMID:9423715; http://dx.doi.org/10.1016/S0741-5214(97)70012-0
  • Khatami M. Unresolved inflammation: 'immune tsunami' or erosion of integrity in immune- privileged and immune-responsive tissues and acute and chronic inflammatory diseases or cancer. Expert Opin Biol Ther 2011; 11(11):1419-32; PMID:21663532; http://dx.doi.org/10.1517/14712598.2011.592826
  • Moran ME. Scleroderma and evidence based non-pharmaceutical treatment modalities for digital ulcers: a systematic review. J Wound Care. 2014; 23(10):510-6; PMID:25296352; http://dx.doi.org/10.12968/jowc.2014.23.10.510
  • Greer N, Foman NA, MacDonald R, Dorrian J, Fitzgerald P, Rutks I, Wilt TJ. Advanced wound care therapies for nonhealing diabetic, venous, and arterial ulcers: a systematic review. Ann Intern Med 2013; 15; 159(8):532-42; http://dx.doi.org/10.7326/0003-4819-159-8-201310150-00006
  • Jackson WM, Nesti LJ, Tuan RS. A review: mesenchymal stem cell therapy for attenuation of scar formation during wound healing. Stem Cell Res Ther 2012; 3:20; PMID:22668751; http://dx.doi.org/10.1186/scrt111
  • Spaggiari GM, Abdelrazik H, Becchetti F, Moretta L. MSCs inhibit monocyte-derived DC maturation and function by selectively interfering with the generation of immature DCs: central role of MSC-derived prostaglandin E2. Blood 2009; 113(26):6576-83; PMID:19398717; http://dx.doi.org/10.1182/blood-2009-02-203943
  • Duffy MM, Ritter T, Ceredig R, Griffin MD. Mesenchymal stem cell effects on T-cell effector pathways. Stem Cell Res Ther 2011; 2:34; PMID:21861858
  • Gonzalez-Rey E, Gonzalez MA, Varela N, O'Valle F, Hernandez-Cortes P, Rico L, Büscher D, Delgado M. Human adipose-derived mesenchymal stem cells reduce inflammatory and T cell responses and induce regulatory T cells in vitro in rheumatoid arthritis. Ann Rheum Dis 2010; 69:241-8; PMID:19124525; http://dx.doi.org/10.1136/ard.2008.101881
  • Franquesa M, Mensah FK, Huizinga R, Strini T, Boon L, Lombardo E, DelaRosa O, Laman JD, Grinyó JM, Weimar W, et al. Human adipose tissue-derived mesenchymal stem cells abrogate plasmablast formation and induce regulatory B cells independently of T helper cells. Stem Cells 2015; 33:880-91; PMID:25376628; http://dx.doi.org/10.1002/stem.1881
  • González MA, Gonzalez-Rey E, Rico L, Büscher D, Delgado M. Adipose-derived mesenchymal stem cells alleviate experimental colitis by inhibiting inflammatory and autoimmune responses. Gastroenterology 2009; 136:978-89; http://dx.doi.org/10.1053/j.gastro.2008.11.041
  • Nie C, Yang D, Xu J, Si Z, Jin X, Zhang J. Locally administered adipose-derived stem cells accelerate wound healing through differentiation and vasculogenesis. Cell Transplant 2011; 20:205-16; PMID:20719083; http://dx.doi.org/10.3727/096368910X520065
  • Siitonen OI, Niskanen LK, Laasko M, Siitonen JT, Pyörälä K. Lower-extremity amputations in diabetic and nondiabetic patients. Diabetes care 1993; 16:16-20; PMID:8422771; http://dx.doi.org/10.2337/diacare.16.1.16
  • Amos PJ, Kapur SK, Stapor PC, Shang H, Bekiranov S, Khurgel M, Rodeheaver GT, Peirce SM, Katz AJ. Human adipose-derived stromal cells accelerate diabetic wound healing: impact of cell formulation and delivery. Tissue Eng Part A 2010; 16:1595-606; PMID:20038211; http://dx.doi.org/10.1089/ten.tea.2009.0616
  • Kuo YR, Wang CT, Cheng JT, Kao GS, Chiang YC, Wang CJ. Adipose-derived stem cells accelerate diabetic wound healing through the induction of autocrine and paracrine effects. Cell Transplant 2015 Apr 7. [Epub ahead of print]
  • Kim WS, Park BS, Sung JH, Yang JM, Park SB, Kwak SJ, Park JS. Wound healing effect of adipose-derived stem cells: a critical role of secretory factors on human dermal fibroblasts. J Dermatol Sci 2007; 48:15-24; PMID:17643966; http://dx.doi.org/10.1016/j.jdermsci.2007.05.018
  • Navone SE, Pascucci L, Dossena M, Ferri A, Invernici G, Acerbi F, Cristini S, Bedini G, Tosetti V, Ceserani V, et al. Decellularized silk fibroin scaffold primed with adipose mesenchymal stromal cells improves wound healing in diabetic mice. Stem Cell Res Ther 2014; 5:7; PMID:24423450; http://dx.doi.org/10.1186/scrt396
  • Lu D, Chen B, Liang Z, Deng W, Jiang Y, Li S, Xu J, Wu Q, Zhang Z, Xie B, Chen S. Comparison of bone marrow mesenchymal stem cells with bone marrow-derived mononuclear cells for treatment of diabetic critical limb ischemia and foot ulcer: a double-blind, randomized, controlled trial. Diabetes Res Clin Pract 2011; 92(1):26-36; PMID:21216483; http://dx.doi.org/10.1016/j.diabres.2010.12.010
  • Kočí Z, Turnovcová K, Dubský M, Baranovičová L, Holáň V, Chudíčková M, Syková E, Kubinová S. Characterization of human adipose tissue-derived stromal cells isolated from diabetic patient's distal limbs with critical ischemia. Cell Biochem Funct 2014; 32(7):597-604; http://dx.doi.org/10.1002/cbf.3056
  • Dumoitier N, Lofek S, Mouthon L. Pathophysiology of systemic sclerosis: state of the art in 2014. Presse Med 2014; 43:e267-78; PMID:25179277; http://dx.doi.org/10.1016/j.lpm.2014.08.001
  • Cipriani P, Ruscitti P, Di Benedetto P, Carubbi F, Liakouli V, Berardicurti O, Ciccia F, Triolo G, Giacomelli R. Mesenchymal stromal cells and rheumatic diseases: new tools from pathogenesis to regenerative therapies. Cytotherapy 2015; 17:832-49; PMID:25680301; http://dx.doi.org/10.1016/j.jcyt.2014.12.006
  • Larghero J, Farge D, Braccini A, Lecourt S, Scherberich A, Foïs E, Verrecchia F, Daikeler T, Gluckman E, Tyndall A, et al. Phenotypical and functional characteristics of in vitro expanded bone marrow mesenchymal stem cells from patients with systemic sclerosis. Ann Rheum Dis 2008; 67:443-9; PMID:17526552; http://dx.doi.org/10.1136/ard.2007.071233
  • Cipriani P, Marrelli A, Benedetto PD, Liakouli V, Carubbi F, Ruscitti P, Alvaro S, Pantano I, Campese AF, Grazioli P, et al. Scleroderma Mesenchymal Stem Cells display a different phenotype from healthy controls; implications for regenerative medicine. Angiogenesis 2013; 16:595-607; PMID:23413114; http://dx.doi.org/10.1007/s10456-013-9338-9
  • Guiducci S, Manetti M, Romano E, Mazzanti B, Ceccarelli C, Dal Pozzo S, Milia AF, Bellando-Randone S, Fiori G, Conforti ML, et al. Bone marrow-derived mesenchymal stem cells from early diffuse systemic sclerosis exhibit a paracrine machinery and stimulate angiogenesis in vitro. Ann Rheum Dis 2011; 70:2011-21; PMID:21821866; http://dx.doi.org/10.1136/ard.2011.150607
  • Granel B, Daumas A, Jouve E, Harlé JR, Nguyen PS, Chabannon C, Colavolpe N, Reynier JC, Truillet R, Mallet S, et al. Safety, tolerability and potential efficacy of injection of autologous adipose-derived stromal vascular fraction in the fingers of patients with systemic sclerosis: an open-label phase I trial. Ann Rheum Dis 2015; 74:2175-82; PMID:25114060; http://dx.doi.org/10.1136/annrheumdis-2014-205681
  • Del Papa N, Di Luca G, Sambataro D, Zaccara E, Maglione W, Gabrielli A, Fraticelli P, Moroncini G, Beretta L, Santaniello A, et al. Regional implantation of autologous adipose tissue-derived cells induces a prompt healing of long-lasting indolent digital ulcers in patients with Systemic Sclerosis. Cell Transplant 2015; 24:2297-305; PMID:25506730; http://dx.doi.org/10.3727/096368914X685636
  • Guiducci S, Porta F, Saccardi R, Guidi S, Ibba-Manneschi L, Manetti M, Mazzanti B, Dal Pozzo S, Milia AF, Bellando-Randone S, et al. Autologous mesenchymal stem cells foster revascularization of ischemic limbs in systemic sclerosis: a case report. Ann Intern Med 2010; 153:650-4; PMID:21079220; http://dx.doi.org/10.7326/0003-4819-153-10-201011160-00007
  • Guo K Ikehara S, Meng X. Mesenchymal stem cells for inducing tolerance in organ transplantation. Front Cell Dev Biol 2014; 2:8; PMID:25364716; http://dx.doi.org/10.3389/fcell.2014.00008
  • Kebriaei P, Robinson S. Treatment of graft-versus-host-disease with mesenchymal stromal cells. Cytotherapy 2011; 13:262-8; PMID:21231805; http://dx.doi.org/10.3109/14653249.2010.549688
  • Tyndall A. Mesenchymal stem cell treatments in rheumatology: a glass half full? Nat Rev Rheumatol 2014; 10:117-24; PMID:24217581; http://dx.doi.org/10.1038/nrrheum.2013.166
  • Choi EW, Shin IS, Park SY, Park JH, Kim JS, Yoon EJ, Kang SK, Ra JC, Hong SH. Reversal of serologic, immunologic, and histologic dysfunction in mice with systemic lupus erythematosus by long-term serial adipose tissue-derived mesenchymal stem cell transplantation. Arthritis Rheum 2012; 64:243-53; PMID:21904997; http://dx.doi.org/10.1002/art.33313
  • Choi EW, Yun TW, Song JW, Lee M, Yang J, Choi KS. Preventive effects of CTLA4Ig-overexpressing adipose tissue-derived mesenchymal stromal cells in rheumatoid arthritis. Cytotherapy 2015; 17:271-82; PMID:25541299; http://dx.doi.org/10.1016/j.jcyt.2014.10.010
  • Park MJ, Kwok SK, Lee SH, Kim EK, Park SH, Cho ML. Adipose tissue-derived mesenchymal stem cells induce expansion of Interleukin-10 producing regulatory B cells and ameliorate autoimmunity in a murine model of systemic lupus erythematosus. Cell Transplant 2015; 24:2367-77; PMID:25506685; http://dx.doi.org/10.3727/096368914X685645
  • González MA, Gonzalez-Rey E, Rico L, Büscher D, Delgado M. Treatment of experimental arthritis by inducing immune tolerance with human adipose-derived mesenchymal stem cells. Arthritis Rheum 2009; 60:1006-19; http://dx.doi.org/10.1002/art.24405
  • Zhou B, Yuan J, Zhou Y, Ghawji M Jr, Deng YP, Lee AJ, Lee AJ, Nair U, Kang AH, Brand DD, et al. Administering human adipose-derived mesenchymal stem cells to prevent and treat experimental arthritis. Clin Immunol 2011; 141:328-37; PMID:21944669; http://dx.doi.org/10.1016/j.clim.2011.08.014
  • Serratrice N, Bruzzese L, Magalon J, Véran J, Giraudo L, Aboudou H, Ould-Ali D, Nguyen PS, Bausset O, Daumas A, et al. New fat-derived products for treating skin-induced lesions of scleroderma in nude mice. Stem Cell Res Ther 2014; 5:138; PMID:25519759; http://dx.doi.org/10.1186/scrt528
  • González MA, Gonzalez-Rey E, Rico L, Büscher D, Delgado M. Treatment of experimental arthritis by inducing immune tolerance with human adipose-derived mesenchymal stem cells. Arthritis Rheum 2009; 60:1006-19; http://dx.doi.org/10.1002/art.24405
  • Gonzalez-Rey E, Anderson P, González MA, Rico L, Büscher D, Delgado M. Human adult stem cells derived from adipose tissue protect against experimental colitis and sepsis. Gut 2009; 58:929-39; PMID:19136511; http://dx.doi.org/10.1136/gut.2008.168534
  • Gonçalves Fda C, Schneider N, Pinto FO, Meyer FS, Visioli F, Pfaffenseller B, Lopez PL, Passos EP, Cirne-Lima EO, Meurer L, et al. Intravenous vs intraperitoneal mesenchymal stem cells administration: What is the best route for treating experimental colitis? World J Gastroenterol 2014; 20:18228-39; http://dx.doi.org/10.3748/wjg.v20.i48.18228
  • Zhou Y, Yuan J, Zhou B, Lee AJ, Lee AJ, Ghawji M Jr, Yoo TJ. The therapeutic efficacy of human adipose tissue-derived mesenchymal stem cells on experimental autoimmune hearing loss in mice. Immunology 2011; 133:133-40; PMID:21366561; http://dx.doi.org/10.1111/j.1365-2567.2011.03421.x
  • Choi EW, Shin IS, Lee HW, Park SY, Park JH, Nam MH, Kim JS, Woo SK, Yoon EJ, Kang SK, et al. Transplantation of CTLA4Ig gene-transduced adipose tissue-derived mesenchymal stem cells reduces inflammatory immune response and improves Th1/Th2 balance in experimental autoimmune thyroiditis. J Gene Med 2011; 13:3-16; PMID:21259404; http://dx.doi.org/10.1002/jgm.1531
  • Choi EW, Lee JM, Lee HW, Yang J, Youn HY. Therapeutic effects of CTLA4Ig gene-transduced adipose tissue-derived mesenchymal stem cell transplantation on established autoimmune thyroiditis. Cell Transplant 2015; 24:2221-36; PMID:25299180; http://dx.doi.org/10.3727/096368914X685122
  • Constantin G, Marconi S, Rossi B, Angiari S, Calderan L, Anghileri E, Gini B, Bach SD, Martinello M, Bifari F, et al. Adipose-derived mesenchymal stem cells ameliorate chronic experimental autoimmune encephalomyelitis. Stem Cells 2009; 27:2624-35; PMID:19676124; http://dx.doi.org/10.1002/stem.194
  • Payne NL, Sun G, McDonald C, Moussa L, Emerson-Webber A, Loisel-Meyer S, Medin JA, Siatskas C, Bernard CC. Human adipose-derived mesenchymal stem cells engineered to secrete IL-10 inhibit APC function and limit CNS autoimmunity. Brain Behav Immun 2013; 30:103-14; PMID:23369732; http://dx.doi.org/10.1016/j.bbi.2013.01.079
  • Scruggs BA, Semon JA, Zhang X, Zhang S, Bowles AC, Pandey AC, Imhof KM, Kalueff AV, Gimble JM, Bunnell BA. Age of the donor reduces the ability of human adipose-derived stem cells to alleviate symptoms in the experimental autoimmune encephalomyelitis mouse model. Stem Cells Transl Med 2013; 2:797-807; PMID:24018793; http://dx.doi.org/10.5966/sctm.2013-0026
  • Yousefi F, Ebtekar M, Soleimani M, Soudi S, Hashemi SM. Comparison of in vivo immunomodulatory effects of intravenous and intraperitoneal administration of adipose-tissue mesenchymal stem cells in experimental autoimmune encephalomyelitis (EAE). Int Immunopharmacol 2013; 17:608-16; PMID:23973288; http://dx.doi.org/10.1016/j.intimp.2013.07.016
  • Semon JA, Zhang X, Pandey AC, Alandete SM, Maness C, Zhang S, Scruggs BA, Strong AL, Sharkey SA, Beuttler MM, et al. Administration of murine stromal vascular fraction ameliorates chronic experimental autoimmune encephalomyelitis. Stem Cells Transl Med 2013; 2:789-96; PMID:23981726; http://dx.doi.org/10.5966/sctm.2013-0032
  • Zhang X, Bowles AC, Semon JA, Scruggs BA, Zhang S, Strong AL, Gimble JM, Bunnell BA. Transplantation of autologous adipose stem cells lacks therapeutic efficacy in the experimental autoimmune encephalomyelitis model. PLoS One 2014; 9:e85007; PMID:24465465; http://dx.doi.org/10.1371/journal.pone.0085007
  • Tafreshi AP, Payne N, Sun G, Sylvain A, Schulze K, Bernard C. Inactive GSK3beta is disturbed in the spinal cord during experimental autoimmune encephalomyelitis, but rescued by stem cell therapy. Neuroscience 2014; 277:498-505; PMID:25064057; http://dx.doi.org/10.1016/j.neuroscience.2014.07.013
  • Semon JA, Maness C, Zhang X, Sharkey SA, Beuttler MM, Shah FS, Pandey AC, Gimble JM, Zhang S, Scruggs BA, et al. Comparison of human adult stem cells from adipose tissue and bone marrow in the treatment of experimental autoimmune encephalomyelitis. Stem Cell Res Ther 2014; 5:2; PMID:24405805; http://dx.doi.org/10.1186/scrt391
  • Bassi EJ, Moraes-Vieira PM, Moreira-Sa CS, Almeida DC, Vieira LM, Cunha CS, Hiyane MI, Basso AS, Pacheco-Silva A, Câmara NO. Immune regulatory properties of allogeneic adipose-derived mesenchymal stem cells in the treatment of experimental autoimmune diabetes. Diabetes 2012; 61:2534-45; PMID:22688334; http://dx.doi.org/10.2337/db11-0844
  • Xiao J, Zhang C, Zhang Y, Zhao J, Liang J, Zhong X, Chen Y. Transplantation of adipose-derived mesenchymal stem cells into a murine model of passive chronic immune thrombocytopenia. Transfusion 2012; 52:2551-8; PMID:22486546; http://dx.doi.org/10.1111/j.1537-2995.2012.03642.x
  • Cras A, Farge D, Carmoi T, Lataillade JJ, Wang DD, Sun L. Update on mesenchymal stem cell-based therapy in lupus and scleroderma. Arthritis Res Ther. 2015; 17(1):301; PMID:26525582; http://dx.doi.org/10.1186/s13075-015-0819-7
  • Trottier V, Marceau-Fortier G, Germain L, Vincent C, Fradette J.. IFATS collection: Using human adipose-derived stem/stromal cells for the production of new skin substitutes. Stem Cells 2008; 26:2713-23; PMID:18617689; http://dx.doi.org/10.1634/stemcells.2008-0031
  • Altman AM, Yan Y, Matthias N, Bai X, Rios C, Mathur AB, Song YH, Alt EU. IFATS collection: Human adipose-derived stem cells seeded on a silk fibroin-chitosan scaffold enhance wound repair in a murine soft tissue injury model. Stem Cells 2009; 27:250-8; PMID:18818439; http://dx.doi.org/10.1634/stemcells.2008-0178
  • Kato Y, Iwata T, Morikawa S, Yamato M, Okano T, Uchigata Y. Allogeneic Transplantation of an Adipose-Derived Stem Cell Sheet Combined With Artificial Skin Accelerates Wound Healing in a Rat Wound Model of Type 2 Diabetes and Obesity. Diabetes. 2015; 64(8):2723-34; PMID:25795216; http://dx.doi.org/10.2337/db14-1133
  • Hsu SH, Hsieh PS. Self-assembled adult adipose-derived stem cell spheroids combined with biomaterials promote wound healing in a rat skin repair model. Wound Repair Regen. 2015; 23(1):57-64; PMID:25421559; http://dx.doi.org/10.1111/wrr.12239
  • Tan HB, Wang FY, Ding W, Zhang Y, Ding J, Cai DX, Yu KF, Yang J, Yang L, Xu YQ. Fabrication and Evaluation of Porous Keratin/chitosan (KCS) Scaffolds for Effectively Accelerating Wound Healing. Biomed Environ Sci. 2015; 28(3):178-89; PMID:25800442
  • FDA Proposed Approach to Regulation of Cellular and Tissue-Based Products. Available online:http://www.fda.gov/downloads/BiologicasBloodVaccines/GuidanceComplianceRegulatoryInformation/Guidances/Tissue/UCM062601.pdf (Accessed on 14 May 2015).
  • Halme DG, Kessler DA. FDA regulation of stem-cell-based therapies. N Engl J Med 2006; 355:1730-5; PMID:17050899; http://dx.doi.org/10.1056/NEJMhpr063086
  • Pacini S. Deterministic and stochastic approaches in the clinical application of mesenchymal stromal cells (MSCs). Front Cell Dev Biol. 2014; 2:50; PMID:25364757
  • Martin, I, Ireland H, Baldomero H, Passweg J. The survey on cellular and engineered tissue therapies in europe in 2012. Tissue Eng Part A 2015; 21:1-13; PMID:25425342; http://dx.doi.org/10.1089/ten.tea.2014.0515
  • Ra JC, Shin IS, Kim SH, Kang SK, Kang BC, Lee HY, Kim YJ, Jo JY, Yoon EJ, Choi HJ, et al. Safety of intravenous infusion of human adipose tissue-derived mesenchymal stem cells in animals and humans. Stem Cells Dev 2011; 20:1297-308; PMID:21303266; http://dx.doi.org/10.1089/scd.2010.0466
  • Tolar J, Nauta AJ, Osborn MJ, Panoskaltsis Mortari A, McElmurry RT, Bell S, Xia L, Zhou N, Riddle M, Schroeder TM, et al. Sarcoma derived from cultured mesenchymal stem cells. Stem Cells 2007; 25:371-9; PMID:17038675; http://dx.doi.org/10.1634/stemcells.2005-0620
  • Zimmerlin L, Donnenberg AD, Rubin JP, Basse P, Landreneau RJ, Donnenberg VS. Regenerative therapy and cancer: in vitro and in vivo studies of the interaction between adipose-derived stem cells and breast cancer cells from clinical isolates. Tissue Eng Part A 2011; 17:93-106; PMID:20673000; http://dx.doi.org/10.1089/ten.tea.2010.0248
  • Herberts CA, Kwa MS, Hermsen HP. Risk factors in the development of stem cell therapy. J Transl Med. 2011 Mar 22; 9:29; http://dx.doi.org/10.1186/1479-5876-9-29
  • Perrot P, Rousseau J, Bouffaut AL, Rédini F, Cassagnau E, Deschaseaux F, Heymann MF, Heymann D, Duteille F, Trichet V, et al. Safety concern between autologous fat graft, mesenchymal stem cell and osteosarcoma recurrence. PLoS One 2010; 5:e10999; PMID:20544017; http://dx.doi.org/10.1371/journal.pone.0010999
  • Chaput B, Foucras L, Le Guellec S, Grolleau JL, Garrido I. Recurrence of an invasive ductal breast carcinoma 4 months after autologous fat grafting. Plast Reconstr Surg 2013; 131:123e-4e; PMID:23271541; http://dx.doi.org/10.1097/PRS.0b013e318272a1f6

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.