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Research Article

In Vitro Pro-inflammatory Regulatory role of Substance P in Alveolar Macrophages and Type II Pneumocytes after JP-8 Exposure

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Pages 61-67 | Received 31 Aug 2006, Accepted 22 Nov 2006, Published online: 09 Oct 2008

REFERENCES

  • ATSDR (Agency for Toxic Substances and Disease Registry). Toxicological Profile for Jet Fuels (JP-5 and JP-8). U S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry, Atlanta, GA 1998
  • Boulares A. H., Contreras F. J., Espinoza L. A., Smulson M. E. Roles of oxidative stress and glutathione depletion in JP-8 jet fuel-induced apoptosis in rat lung epithelial cells. Toxicol. Appl. Pharmacol. 2002; 180: 92–99
  • Crapo J., Barry B., Foscue H., Shelburne J. Structural and biochemical changes in rat lungs occurring during exposures to lethal and adaptive doses of oxygen. Am. Rev. Resp. Dis. 1980; 122: 123–145
  • Crapo J., Barry B., Gehr P., Bachofen M., Weibel E. Cell number and cell characteristic of the normal human lung. Am. Rev. Resp. Dis. 1982; 125: 332–337
  • Crestani B., Aubier M. Inflammatory role of alveolar epithelial cells. Kidney Int. 1998; 53(S65)S88–S93
  • Gibson R., Pleil J., Smith S., Toschlog D. Assessment of JP* in blood. JP8 Final Risk Assessment. The Institute of Environmental and Human Health (TIEHH), Lubbock, TX 2001; 29–31
  • Hahon N., Castranova V. Interferon production in rat type II pneumocytes and alveolar macrophages. Exp. Lung Res. 1989; 15: 429–445
  • Haies D., Gil J., Weibel E. Morphometric study of rat cell. Am. Rev. Resp. Dis. 1981; 123: 533–541
  • Hays A. M., Lantz R. C., Witten M. L. Correlation between in vivo in vitro pulmonary responses to jet propulsion fuel-8 using precision-cut lung slices and a dynamic organ culture system. Toxicol. Pathol. 2003; 31: 200–207
  • Henz K. Survey of Jet Fuels Procured by the Defense Energy Support Center, 1990–1996. Defense Logistics Agencies, Ft. Belvior, VA 1998
  • Janssen Y. M., Driscoll K. E., Timblin C. R., Hassenbein D., Mossman B. T. Modulation of mitochondrial gene expression in pulmonary epithelial cells exposed to oxidants. Environ. Health Perspect. 1998; 106(S5)1191–1195
  • Kabbur M. B., Rogers J. V., Gunasekar P. G., Garrett C. M., Geiss K. T., Brinkley W. W., McDougal J. N. Effect of JP-8 jet fuel on molecular and histological parameters related to acute skin irritation. Toxicol. Appl. Pharmacol. 2001; 175: 83–88
  • Mattie D. R., Alden C. L., Newell T. K., Gaworski C. L., Flemming C. D. A 90-day continuous vapor inhalation toxicity study of JP-8 jet fuel followed by 20 or 21 months of recovery in Fischer 344 rats and C57BL/6 mice. Toxicol. Pathol. 1991; 19: 77–87
  • Monteiro-Riviere N. A., Inman A. O., Riviere J. E. Skin toxicity of jet fuels: Ultrastructural studies and the effects of substance P. Toxicol. Appl. Pharmacol. 2004; 195: 339–347
  • Parra S. C., Burnette R., Price H. P., Takaro T. Zonal distribution of alveolar macrophages, type II pneumocytes, and alveolar septal connective tissue gaps in adult human lungs. Am. Rev. Resp. Dis. 1986; 133: 908–912
  • Pfaff J., Parton K., Lantz R. C., Chen H., Hays A., Witten M. L. Inhalation exposure to JP-8 jet fuel alters pulmonary function and substance P levels in Fischer 344 rats. J. Appl. Toxicol. 1995; 15: 249–256
  • Pfaff J., Tollinger B. J., Lantz R. C., Chen H., Hays A., Witten M. L. Neutral endopeptidase (NEP) and its role in pathological pulmonary change with inhalation exposure to JP-8 jet fuel. Toxicol. Ind. Health. 1996; 12: 93–103
  • Robledo R. F., Witten M. L. NK1-receptor activation prevents hydrocarbon-induced lung injury in mice. Am. J. Physiol. 1999a; 276: L229–L238
  • Robledo R. F., Witten M. L. Acute pulmonary response to inhaled JP-8 jet fuel aerosol in mice. Inhal. Toxicol. 1998; 10: 531–553
  • Robledo R. F., Young R. S., Lantz R. C., Witten M. L. Short-term pulmonary response to inhaled JP-8 jet fuel aerosol in mice. Toxicol. Pathol. 2000; 228: 656–663
  • Robledo R. F., Barber D. S., Witten M. L. Modulation of bronchial epithelial cell barrier function by in vitro jet-propulsion fuel 8 exposure. Toxicol. Sci. 1999b; 51: 119–125
  • Wang S. J., Young S., Sun N. N., Witten M. L. In vitro cytokine releases from rat type II pneumocytes and alveolar macrophages following exposure to JP-8 jet fuel in co-culture. Toxicology 2002; 173: 211–219
  • Wang S. J., Young R. S., Witten M. L. Age-related differences in pulmonary inflammatory responses to JP-8 jet fuel aerosol inhalation. Toxicol. Ind. Health 2001; 17: 23–29
  • Witzmann F. A., Bauer M. D., Fieno A. M., Grant R. A., Keough T. W., Kornguth S. E., Lacey M. P., Siegel F. L., Sun Y., Wright L. S., Young R. S., Witten M. L. Proteomic analysis of simulated occupational jet fuel exposure in the lung. Electrophoresis 1999; 20: 3659–3669
  • Wong S. S., Hyde J., Sun N. N., Lantz R. C., Witten M. L. Inflammatory responses in mice sequentially exposed to JP-8 jet fuel and influenza virus. Toxicology 2004; 197: 139–147

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