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Research Article

Identification and semi-quantification of protein allergens in complex mixtures using proteomic and AllerCatPro 2.0 bioinformatic analyses: a proof-of-concept investigation

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Article: 2305452 | Received 12 Sep 2023, Accepted 09 Jan 2024, Published online: 31 Jan 2024

References

  • Bredehorst R, David K. 2001. What establishes a protein as an allergen? J Chromatogr B Biomed Sci Appl. 756(1–2):33–40. doi:10.1016/s0378-4347(01)00069-x.
  • Cabanillas B, Jappe U, Novak N. 2018. Allergy to peanut, soybean, and other legumes: recent advances in allergen characterization, stability to processing and IgE cross-reactivity. Mol Nutr Food Res. 62(1):1700446. doi:10.1002/mnfr.201700446.
  • Castro AJ, Lima-Cabello E, Alché JDD. 2020. Identification of seed storage proteins as the major constituents of the extra virgin olive oil proteome. Food Chem X. 7:100099. doi:10.1016/j.fochx.2020.100099.
  • Craig R, Cortens J, Beavis R. 2004. Open source system for analyzing, validating, and storing protein identification data. J Proteome Res. 3(6):1234–1242. doi:10.1021/pr049882h.
  • Eigenmann P, Burks A, Bannon G, Sampson H. 1996. Identification of unique peanut and soy allergens in sera adsorbed with cross-reacting antibodies. J Allergy Clin Immunol. 98(5):969–978. doi:10.1016/s0091-6749(96)80014-5.
  • Hoopmann M, Winget J, Mendoza L, Moritz R. 2018. StPeter: seamless label-free quanti-fication with the trans-proteomic pipeline. J Proteome Res. 17(3):1314–1320. doi:10.1021/acs.jproteome.7b00786.
  • Huby R, Dearman R, Kimber I. 2000. Why are some proteins allergens? Toxicol Sci. 55(2):235–246. doi:10.1093/toxsci/55.2.235.
  • Johnson P, Sayers R, Gethings L, Balasundaram A, Marsh J, Langridge J, Mills E. 2016. Quantitative proteomic profiling of peanut allergens in food ingredients used for oral food challenges. Anal Chem. 88(11):5689–5695. doi:10.1021/acs.analchem.5b04466.
  • Kim M, Lee K, Hong J, Kim K, Kim K, Sohn M, Park J. 2016. IgE cross-reactivity of peanut with walnut and soybean in children with food allergy. Allergol Immunopathol (Madr). 44(6):524–530. doi:10.1016/j.aller.2016.04.012.
  • Kimber I, Dearman R. 2002. Factors affecting the development of food allergy. Proc Nutr Soc. 61(4):435–439. doi:10.1079/pns2002184.
  • Kobayashi T, Iijima K, Dent AL, Kita H. 2017. Follicular helper T cells mediate IgE antibody response to airborne allergens. J Allergy Clin Immunol. 139(1):300–313 e307. doi:10.1016/j.jaci.2016.04.021.
  • Koppelman S, Vlooswijk R, Knippels L, Hessing M, Knol E, van Reijsen F, Bruijnzeel-Koomen C. 2001. Quantification of major peanut allergens Ara h 1 and Ara h 2 in the peanut varieties Runner, Spanish, Virginia, and Valencia, bred in different parts of the world. Allergy. 56(2):132–137. doi:10.1034/j.1398-9995.2001.056002132.x.
  • Krutz N, Kimber I, Maurer-Stroh S, Gerberick G. 2020. Determination of the relative allergenic potency of proteins: hurdles and opportunities. Crit Rev Toxicol. 50(6):521–530. doi:10.1080/10408444.2020.1793895.
  • Krutz N, Kimber I, Winget J, Nguyen M, Limviphuvadh V, Maurer-Stroh S, Mahony C, Gerberick G. 2023. Application of AllerCatPro 2.0 for protein safety assessments of consumer products. Front Allergy. 4:1209495. doi:10.3389/falgy.2023.1209495.
  • Krutz N, Winget J, Ryan C, Wimalasena R, Maurer-Stroh S, Dearman R, Kimber I, Gerberick G. 2019. Proteomic and bioinformatic analyses for the identification of proteins with low allergenic potential for hazard assessment. Toxicol Sci. 170(1):210–222. doi:10.1093/toxsci/kfz078.
  • Maleki S, Teuber S, Cheng H, Chen D, Comstock S, Ruan S, Schein C. 2011. Computa-tionally-predicted IgE epitopes of walnut allergens contribute to cross-reactivity with peanuts. Allergy. 66(12):1522–1529. doi:10.1111/j.1398-9995.2011.02692.x.
  • Maurer-Stroh S, Krutz N, Kern P, Gunalan V, Nguyen M, Limviphuvadh V, Eisenhaber F, Gerberick G. 2019. AllerCatPro-prediction of protein allergenicity potential from the protein sequence. Bioinformatics. 35(17):3020–3027. doi:10.1093/bioinformatics/btz029.
  • Nguyen M, Krutz N, Limviphuvadh V, Lopata A, Gerberick G, Maurer-Stroh S. 2022. AllerCatPro 2.0: a web server for predicting protein allergenicity potential. Nucleic Acids Res. 50(W1):W36–W43. doi:10.1093/nar/gkac446.
  • Sahiner UM, Layhadi JA, Golebski K, István Komlósi Z, Peng Y, Sekerel B, Durham SR, Brough H, Morita H, Akdis M, et al. 2021. Innate lymphoid cells: the missing part of a puzzle in food allergy. Allergy. 76(7):2002–2016. doi:10.1111/all.14776.
  • San Segundo-Acosta P, Oeo-Santos C, Benedé S, de Los Ríos V, Navas A, Ruiz-Leon B, Moreno C, Pastor-Vargas C, Jurado A, Villalba M, et al. 2019. Delineation of the olive pollen proteome and its allergenome unmasks cyclophilin as a relevant cross-reactive allergen. J Proteome Res. 18(8):3052–3066. doi:10.1021/acs.jproteome.9b00167.
  • Sardiu M, Washburn M. 2010. Enriching quantitative proteomics with SI(N). Nat Biotechnol. 28(1):40–42. doi:10.1038/nbt0110-40.
  • Scheurer S, Toda M, Vieths S. 2015. What makes an allergen? Clin Exp Allergy. 45(7):1150–1161. doi:10.1111/cea.12571.
  • Schocker F, Scharf A, Kull S, Jappe U. 2017. Detection of the peanut allergens Ara h 2 and Ara h 6 in human breast milk: development of two sensitive and specific Sandwich ELISA assays. Int Arch Allergy Immunol. 174(1):17–25. doi:10.1159/000479388.
  • Sudharson S, Kalic T, Hafner C, Breiteneder H. 2021. Newly defined allergens in the WHO/IUIS allergen nomenclature database during 01/2019-03/2021. Allergy. 76(11):3359–3373. doi:10.1111/all.15021.
  • Suzek B, Wang Y, Huang H, McGarvey P, Wu C, UniProt Consortium. 2015. UniRef clusters: a comprehensive and scalable alternative for improving sequence similarity searches. Bioinformatics. 31(6):926–932. doi:10.1093/bioinformatics/btu739.
  • Wang W, Tai F, Hu X. 2010. Chapter 3. Current initiatives in proteomics of the olive tree. In: Preedy V and Watson R, Editors. Olives and olive oil in health and disease prevention. San Diego (CA): Academic Press; p. 25–32.
  • Zhang Y, Du W, Fan Y, Yi J, Lyu S, Nadeau K, Thomas A, McHugh T. 2017. Purification and characterization of a black walnut (Juglans nigra) Allergen, Jug n 4. J Agric Food Chem. 65(2):454–462. doi:10.1021/acs.jafc.6b04387.