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Research Article

Supplementation with food-derived oligopeptides promotes lipid metabolism in young male cyclists: a randomized controlled crossover trial

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Article: 2254741 | Received 07 Feb 2023, Accepted 29 Aug 2023, Published online: 06 Sep 2023

References

  • Lin, X, Li, H. Obesity: epidemiology, pathophysiology, and therapeutics. Front Endocrinol. 2021;12:706978. doi: 10.3389/fendo.2021.706978
  • Kim, JH, Park, Y. Combined effects of phytochemicals and exercise on fatty acid oxidation. J Exerc Nutr Biochem. 2016;20(4):20–773. doi: 10.20463/jenb.2016.0053
  • Hetlelid, KJ, Plews, DJ, Herold, E, et al. Rethinking the role of fat oxidation: substrate utilisation during high-intensity interval training in well-trained and recreationally trained runners. BMJ Open Sport Exerc Med. 2015;1(1):e000047. doi: 10.1136/bmjsem-2015-000047
  • Aslankeser, Z, Balci, SS. Re-examination of the contribution of substrates to energy expenditure during high-intensity intermittent exercise in endurance athletes. PeerJ. 2017;5:e3769. doi: 10.7717/peerj.3769
  • Muscella, A, Stefàno, E, Lunetti, P. The regulation of fat metabolism during aerobic exercise. Biomolecules. 2020;10(12):1699. doi: 10.3390/biom10121699
  • Horowitz, JF, Klein, S. Lipid metabolism during endurance exercise. Am J Clin Nutr. 2000;72(S2):558S–563S. doi: 10.1093/ajcn/72.2.558S
  • Kainulainen, H, Hulmi, JJ, Kujala, UM. Potential role of branched-chain amino acid catabolism in regulating fat oxidation. Exerc Sport Sci Rev. 2013;41(4):194–200. doi: 10.1097/JES.0b013e3182a4e6b6
  • Chen, CN, Hsu, KJ, Chien, KY, et al. Effects of combined high-protein diet and exercise intervention on cardiometabolic health in middle-aged obese adults: A randomized controlled trial. Front Cardiovasc Med. 2018;8:705282. doi: 10.3389/fcvm.2021.705282
  • Oliveira, C, Boulé, NG, Berg, A, et al. Consumption of a high-protein meal replacement leads to higher fat oxidation, suppression of hunger, and improved metabolic profile after an exercise session. Nutrients. 2021;13(1):155. doi: 10.3390/nu13010155
  • Kim, DH, Kim, SH, Jeong, WS, et al. Effect of BCAA intake during endurance exercises on fatigue substances, muscle damage substances, and energy metabolism substances. J Exerc Nutr Biochem. 2013;17(4):169–180. doi: 10.5717/jenb.2013.17.4.169
  • Ueda, K, Nakamura, Y, Yamaguchi, M, et al. Amino acid mixture enriched with arginine, alanine, and phenylalanine stimulates fat metabolism during exercise. Int J Sport Nutr Exerc Metab. 2016;26(1):46–54. doi: 10.1123/ijsnem.2015-0137
  • Kujala, UM, Peltonen, M, Laine, MK, et al. Branched-chain amino acid levels are related with surrogates of disturbed lipid metabolism among older men. Front Med. 2016;3:57. doi: 10.3389/fmed.2016.00057
  • Karvinen, S, Fachada, V, Sahinaho, UM, et al. Branched-chain amino acid deprivation decreases lipid oxidation and lipogenesis in C2C12 myotubes. Metabolites. 2022;12(4):328. doi: 10.3390/metabo12040328
  • Duan, Y, Zhang, L, Li, F, et al. β-Hydroxy-β-methylbutyrate modulates lipid metabolism in adipose tissues of growing pigs. Food Funct. 2018;9(9):4836–4846. doi: 10.1039/C8FO00898A
  • Kamei, Y, Hatazawa, Y, Uchitomi, R, et al. Regulation of skeletal muscle function by amino acids. Nutrients. 2020;12(1):261. doi: 10.3390/nu12010261
  • Tam, CS, Johnson, WD, Rood, J, et al. Increased human growth hormone after oral consumption of an amino acid supplement: results of a randomized, placebo-controlled, double-blind, crossover study in healthy subjects. Am J Ther. 2020;27(4):e333–e337. doi: 10.1097/MJT.0000000000000893
  • Ruiz Ruiz, JC, Betancur Ancona, DA, Segura Campos, MR. Bioactive vegetable proteins and peptides in lipid-lowering; nutraceutical potential. Nutrición Hospitalaria. 2014;29(4):776–784. doi: 10.3305/nh.2014.29.4.7208
  • Chatterjee, C, Gleddie, S, Xiao, CW. Soybean bioactive peptides and their functional properties. Nutrients. 2018;10(9):1211. doi: 10.3390/nu10091211
  • Mizushige, T. Neuromodulatory peptides: orally active anxiolytic-like and antidepressant-like peptides derived from dietary plant proteins. Peptides. 2021;142:170569. doi: 10.1016/j.peptides.2021.170569
  • Peighambardoust, SH, Karami, Z, Pateiro, M, et al. A review on health-promoting, biological, and functional aspects of bioactive peptides in food applications. Biomolecules. 2021;11(5):631. doi: 10.3390/biom11050631
  • Yuan, H, Luo, Z, Ban, Z, et al. Bioactive peptides of plant origin: distribution, functionality, and evidence of benefits in food and health. Food Funct. 2022;13(6):3133–3158. doi: 10.1039/D1FO04077D
  • Ejima, A, Nakamura, M, Suzuki YA, et al. Identification of food-derived peptides in human blood after ingestion of corn and wheat gluten hydrolysates. J Food Bioact. 2018;2:104–111. doi: 10.31665/JFB.2018.2145
  • Udenigwe, CC, Rouvinen-Watt, K. The role of food peptides in lipid metabolism during dyslipidemia and associated health conditions. Int J Mol Sci. 2015;16(5):9303–9313. doi: 10.3390/ijms16059303
  • Sidorova, YS, Mazo, VK, Kochetkova, AA. Experimental evaluation of hypolipidemic properties of soy and rice proteins and their enzyme hydrolysates. A brief review. Vopr Pitan. 2018;87(2):77–84. doi: 10.24411/0042-8833-2018-10021
  • Nagaoka, S. Structure-function properties of hypolipidemic peptides. J Food Biochem. 2019;43(1):e12539. doi: 10.1111/jfbc.12539
  • Nagaoka, S, Takeuchi, A, Banno, A. Plant-derived peptides improving lipid and glucose metabolism. Peptides. 2021;142:170577. doi: 10.1016/j.peptides.2021.170577
  • Pan, X, Hu, Y, Gu, R, et al. Preventive effect of wheat peptides supplementation on the occurrence of overtraining in Sanda athletes (in Chinese). Chin J Sports Med. 2015;34(2):170–174.
  • Li, M, Yin, M, Ling, K, et al. Experimental study on the antifatigue function of soybean peptide and wheat peptide (in Chinese). Food Sci Technol. 2019;44(9):303–307.
  • Li, H, Li, Y, Wang, W. Effects of food-derived oligopeptides with different levels of purine on hyperuricemia (in Chinese). Chin J Convalescent Med. 2023;32(3):225–230.
  • Huang, M, Xu, S. Research progress on digestion and absorption mechanism and nutritional function of food derived oligopeptides (in Chinese). Food And Nutr In China. 2021;27(10):55–58.
  • Jäger, R, Kerksick, CM, Campbell, BI, et al. International society of sports nutrition position stand: protein and exercise. J Int Soc Sport Nutr. 2017;14:20. doi: 10.1186/s12970-017-0177-8
  • Han, X, Luo, R, Wang, L, et al. Potential predictive value of serum targeted metabolites and concurrently mutated genes for EGFR-TKI therapeutic efficacy in lung adenocarcinoma patients with EGFR sensitizing mutations. Am J Cancer Res. 2020;10(12):4266–4286.
  • Zhang, P, Zhang, X, Huang, Y, et al. Atorvastatin alleviates microglia-mediated neuroinflammation via modulating the microbial composition and the intestinal barrier function in ischemic stroke mice. Free Radic Biol Med. 2021;162:104–117. doi: 10.1016/j.freeradbiomed.2020.11.032
  • Ueda, K, Sanbongi, C, Yamaguchi, M, et al. The effects of phenylalanine on exercise-induced fat oxidation: a preliminary, double-blind, placebo-controlled, crossover trial. J Int Soc Sports Nutr. 2017;14(1):34. doi: 10.1186/s12970-017-0191-x
  • Caponio, GR, Wang, DQ, Di Ciaula, A, et al. Regulation of cholesterol metabolism by bioactive components of soy proteins: novel translational evidence. Int J Mol Sci. 2020;22(1):227. doi: 10.3390/ijms22010227
  • Rutherfurd-Markwick, KJ. Food proteins as a source of bioactive peptides with diverse functions. Br J Nutr. 2012;108(S2):S149–S157. doi: 10.1017/S000711451200253X
  • Chakrabarti, S, Guha, S, Majumder, K. Food-derived bioactive peptides in human health: challenges and opportunities. Nutrients. 2018;10(11):1738. doi: 10.3390/nu10111738
  • Nakayama, K, Sanbongi, C, Ikegami, S. Effects of whey protein hydrolysate ingestion on postprandial aminoacidemia compared with a free amino acid mixture in young men. Nutrients. 2018;10(4):507. doi: 10.3390/nu10040507
  • Jeukendrup, A, Gleeson, M. Sports nutrition: an introduction to energy production and performance. 2nd ed. Champaign, IL: Human Kinetics; 2010. p. 82-91&p170–193.
  • Morris, C, Grada, CO, Ryan, M, et al. The relationship between aerobic fitness level and metabolic profiles in healthy adults. Mol Nutr Food Res. 2013;57(7):1246–1254. doi: 10.1002/mnfr.201200629
  • Moore, DR, Camera, DM, Areta, JL. Beyond muscle hypertrophy: why dietary protein is important for endurance athletes. Appl Physiol Nutr Metab. 2014;39(9):987–997. doi: 10.1139/apnm-2013-0591
  • Gumus Balikcioglu, P, Ramaker, ME, Mason, KA, et al. Branched-chain amino acid catabolism and cardiopulmonary function following acute maximal exercise testing in adolescents. Front Cardiovasc Med. 2021;8:721354. doi: 10.3389/fcvm.2021.721354
  • Mikulski, T, Dabrowski, J, Hilgier, W. Effects of supplementation with branched chain amino acids and ornithine aspartate on plasma ammonia and central fatigue during exercise in healthy men. Folia Neuropathol. 2015;53(4):377–386. doi: 10.5114/fn.2015.56552
  • Contrepois, K, Wu, S, Moneghetti, KJ, et al. Molecular choreography of acute exercise. Cell. 2020;181(5):1112–1130.e16. doi: 10.1016/j.cell.2020.04.043
  • Schranner, D, Kastenmüller, G, Schönfelder, M, et al. Metabolite concentration changes in humans after a bout of exercise: a systematic review of exercise metabolomics studies. Sports Med - Open. 2020;6(1):11. doi: 10.1186/s40798-020-0238-4
  • Cermak, NM, van Loon, LJ. The use of carbohydrates during exercise as an ergogenic aid. Sports Med. 2013;43(11):1139–1155. doi: 10.1007/s40279-013-0079-0
  • Melanson, EL, Maclean, PS, Hill, JO. Exercise improves fat metabolism in muscle but does not increase 24-h fat oxidation. Exerc Sport Sci Rev. 2009;37(2):93–101. doi: 10.1097/JES.0b013e31819c2f0b
  • Jonvik, KL, Paulussen, KJM, Danen, SL, et al. Protein supplementation does not augment adaptations to endurance exercise training. Med Sci Sports Exercise. 2019;51(10):2041–2049. doi: 10.1249/MSS.0000000000002028
  • Naclerio, F, Larumbe-Zabala, E, Cooper, R, et al. Effect of a carbohydrate-protein multi-ingredient supplement on intermittent sprint performance and muscle damage in recreational athletes. Appl Physiol Nutr Metab. 2014;39(10):1151–1158. doi: 10.1139/apnm-2013-0556
  • Greer, BK, Price, A, Jones, B. Timing influence of carbohydrate-protein ingestion on muscle soreness and next-day running performance. J Diet Suppl. 2014;11(2):166–174. doi: 10.3109/19390211.2013.859215
  • Coletta, A, Thompson, DL, Raynor, HA. The influence of commercially-available carbohydrate and carbohydrate-protein supplements on endurance running performance in recreational athletes during a field trial. J Int Soc Sports Nutr. 2013;10(1):17–24. doi: 10.1186/1550-2783-10-17
  • McLellan, TM, Pasiakos, SM, Lieberman, HR. Effects of protein in combination with carbohydrate supplements on acute or repeat endurance exercise performance: a systematic review. Sports Med. 2014;44(4):535–550. doi: 10.1007/s40279-013-0133-y