The PRKAA1/AMPKα1 pathway triggers autophagy during CSF1-induced human monocyte differentiation and is a potential target in CMML

References

• Auffray C, Sieweke MH, Geissmann F. Blood monocytes: development, heterogeneity, and relationship with dendritic cells. Annu Rev Immunol 2009; 27:669–92; PMID:19132917; http://dx.doi.org/10.1146/annurev.immunol.021908.132557
   PubMed Web of Science ®Google Scholar
• Kikuta J, Ishii M. Osteoclast migration, differentiation and function: novel therapeutic targets for rheumatic diseases. Rheumatology 2013; 52:226–34; PMID:23024017; http://dx.doi.org/10.1093/rheumatology/kes259
   PubMed Web of Science ®Google Scholar
• Geissmann F, Manz MG, Jung S, Sieweke MH, Merad M, Ley K. Development of monocytes, macrophages, and dendritic cells. Science 2010; 327:656–61; PMID:20133564; http://dx.doi.org/10.1126/science.1178331
   PubMed Web of Science ®Google Scholar
• Hamilton JA, Achuthan A. Colony stimulating factors and myeloid cell biology in health and disease. Trends Immunol 2013; 34:81–9; PMID:23000011; http://dx.doi.org/10.1016/j.it.2012.08.006
   PubMed Web of Science ®Google Scholar
• Jacquel A, Benikhlef N, Paggetti J, Lalaoui N, Guery L, Dufour EK, Ciudad M, Racoeur C, Micheau O, Delva L, et al. Colony-stimulating factor-1-induced oscillations in phosphatidylinositol-3 kinase/AKT are required for caspase activation in monocytes undergoing differentiation into macrophages. Blood 2009; 114:3633–41; PMID:19721010; http://dx.doi.org/10.1182/blood-2009-03-208843
   PubMed Web of Science ®Google Scholar
• Rebe C, Cathelin S, Launay S, Filomenko R, Prevotat L, L'Ollivier C, Gyan E, Micheau O, Grant S, Dubart-Kupperschmitt A, et al. Caspase-8 prevents sustained activation of NF-kappaB in monocytes undergoing macrophagic differentiation. Blood 2007; 109:1442–50; PMID:17047155; http://dx.doi.org/10.1182/blood-2006-03-011585
   PubMed Web of Science ®Google Scholar
• Jacquel A, Obba S, Boyer L, Dufies M, Robert G, Gounon P, Lemichez E, Luciano F, Solary E, Auberger P. Autophagy is required for CSF-1-induced macrophagic differentiation and acquisition of phagocytic functions. Blood 2012; 119:4527–31; PMID:22452982; http://dx.doi.org/10.1182/blood-2011-11-392167
   PubMed Web of Science ®Google Scholar
• Jacquel A, Obba S, Solary E, Auberger P. Proper macrophagic differentiation requires both autophagy and caspase activation. Autophagy 2012; 8:1141–3; PMID:22751215; http://dx.doi.org/10.4161/auto.20367
   PubMed Web of Science ®Google Scholar
• Boya P, Reggiori F, Codogno P. Emerging regulation and functions of autophagy. Nat Cell Biol 2013; 15:713–20; PMID:23817233; http://dx.doi.org/10.1038/ncb2788
   PubMed Web of Science ®Google Scholar
• Yang Z, Klionsky DJ. Eaten alive: a history of macroautophagy. Nat Cell Biol 2010; 12:814–22; PMID:20811353; http://dx.doi.org/10.1038/ncb0910-814
   PubMed Web of Science ®Google Scholar
• Colosetti P, Puissant A, Robert G, Luciano F, Jacquel A, Gounon P, Cassuto JP, Auberger P. Autophagy is an important event for megakaryocytic differentiation of the chronic myelogenous leukemia K562 cell line. Autophagy 2009; 5:1092–8; PMID:19786835; http://dx.doi.org/10.4161/auto.5.8.9889
   PubMed Web of Science ®Google Scholar
• Mizushima N, Levine B. Autophagy in mammalian development and differentiation. Nat Cell Biol 2010; 12:823–30; PMID:20811354; http://dx.doi.org/10.1038/ncb0910-823
   PubMed Web of Science ®Google Scholar
• Mortensen M, Ferguson DJ, Edelmann M, Kessler B, Morten KJ, Komatsu M, Simon AK. Loss of autophagy in erythroid cells leads to defective removal of mitochondria and severe anemia in vivo. Proc Natl Acad Sci U S A 2010; 107:832–7; PMID:20080761; http://dx.doi.org/10.1073/pnas.0913170107
   PubMed Web of Science ®Google Scholar
• Wong PM, Puente C, Ganley IG, Jiang X. The ULK1 complex: sensing nutrient signals for autophagy activation. Autophagy 2013; 9:124–37; PMID:23295650; http://dx.doi.org/10.4161/auto.23323
   PubMed Web of Science ®Google Scholar
• Russell RC, Tian Y, Yuan H, Park HW, Chang YY, Kim J, Kim H, Neufeld TP, Dillin A, Guan KL. ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase. Nat Cell Biol 2013; 15:741–50; PMID:23685627; http://dx.doi.org/10.1038/ncb2757
   PubMed Web of Science ®Google Scholar
• Itzkson R, Fenaux P, Solary E. Chronic myelomonocytic leukemia: Myelodysplastic or myeloproliferative? Best Pract Res Clin Haematol 2013; 26:387–400; PMID:24507815; http://dx.doi.org/10.1016/j.beha.2013.09.006
   PubMed Web of Science ®Google Scholar
• Droin N, Jacquel A, Hendra JB, Racoeur C, Truntzer C, Pecqueur D, Benikhlef N, Ciudad M, Guery L, Jooste V, et al. Alpha-defensins secreted by dysplastic granulocytes inhibit the differentiation of monocytes in chronic myelomonocytic leukemia. Blood 2009; 115:78–88; PMID:19864642; http://dx.doi.org/10.1182/blood-2009-05-224352
   PubMed Web of Science ®Google Scholar
• Hawley SA, Pan DA, Mustard KJ, Ross L, Bain J, Edelman AM, Frenguelli BG, Hardie DG. Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase. Cell Metab 2005; 2:9–19; PMID:16054095; http://dx.doi.org/10.1016/j.cmet.2005.05.009
   PubMed Web of Science ®Google Scholar
• Woods A, Johnstone SR, Dickerson K, Leiper FC, Fryer LG, Neumann D, Schlattner U, Wallimann T, Carlson M, Carling D. LKB1 is the upstream kinase in the AMP-activated protein kinase cascade. Curr Biol 2003; 13:2004–8; PMID:14614828; http://dx.doi.org/10.1016/j.cub.2003.10.031
   PubMed Web of Science ®Google Scholar
• Foretz M, Hebrard S, Guihard S, Leclerc J, Do Cruzeiro M, Hamard G, Niedergang F, Gaudry M, Viollet B. The AMPKgamma1 subunit plays an essential role in erythrocyte membrane elasticity, and its genetic inactivation induces splenomegaly and anemia. FASEB J 2011; 25:337–47; PMID:20881209; http://dx.doi.org/10.1096/fj.10-169383
   PubMed Web of Science ®Google Scholar
• Tokumitsu H, Soderling TR. Requirements for calcium and calmodulin in the calmodulin kinase activation cascade. J Biol Chem 1996; 271:5617–22; PMID:8621423; http://dx.doi.org/10.1074/jbc.271.10.5617
   PubMed Web of Science ®Google Scholar
• Bourgin-Hierle C, Gobert-Gosse S, Therier J, Grasset MF, Mouchiroud G. Src-family kinases play an essential role in differentiation signaling downstream of macrophage colony-stimulating factor receptors mediating persistent phosphorylation of phospholipase C-gamma2 and MAP kinases ERK1 and ERK2. Leukemia 2008; 22:161–9; PMID:17972959; http://dx.doi.org/10.1038/sj.leu.2404986
   PubMed Web of Science ®Google Scholar
• Roach TI, Rebres RA, Fraser ID, Decamp DL, Lin KM, Sternweis PC, Simon MI, Seaman WE. Signaling and cross-talk by C5a and UDP in macrophages selectively use PLCbeta3 to regulate intracellular free calcium. J Biol Chem 2008; 283:17351–61; PMID:18411281; http://dx.doi.org/10.1074/jbc.M800907200
   PubMed Web of Science ®Google Scholar
• Yu W, Hill WG. Lack of specificity shown by P2Y6 receptor antibodies. Naunyn Schmiedebergs Arch Pharmacol 2013; 386:885–91; PMID:23793102; http://dx.doi.org/10.1007/s00210-013-0894-8
   PubMed Web of Science ®Google Scholar
• Zhao M, Klionsky DJ. AMPK-dependent phosphorylation of ULK1 induces autophagy. Cell Metab 2011; 13:119–20; PMID:21284977; http://dx.doi.org/10.1016/j.cmet.2011.01.009
   PubMed Web of Science ®Google Scholar
• Feng Y, He D, Yao Z, Klionsky DJ. The machinery of macroautophagy. Cell Res 2014; 24:24–41; PMID:24366339; http://dx.doi.org/10.1038/cr.2013.168
   PubMed Web of Science ®Google Scholar
• Chen P, Cescon M, Bonaldo P. Autophagy-mediated regulation of macrophages and its applications for cancer. Autophagy 2014; 10:192–200; PMID:24300480; http://dx.doi.org/10.4161/auto.26927
   PubMed Web of Science ®Google Scholar
• Ma Y, Galluzzi L, Zitvogel L, Kroemer G. Autophagy and cellular immune responses. Immunity 2013; 39:211–27; PMID:23973220; http://dx.doi.org/10.1016/j.immuni.2013.07.017
   PubMed Web of Science ®Google Scholar
• Mortensen M, Ferguson DJ, Simon AK. Mitochondrial clearance by autophagy in developing erythrocytes: clearly important, but just how much so? Cell Cycle 2010; 9:1901–6; PMID:20495377; http://dx.doi.org/10.4161/cc.9.10.11603
   PubMed Web of Science ®Google Scholar
• Singh R, Xiang Y, Wang Y, Baikati K, Cuervo AM, Luu YK, Tang Y, Pessin JE, Schwartz GJ, Czaja MJ. Autophagy regulates adipose mass and differentiation in mice. J Clin Invest 2009; 119:3329–39; PMID:19855132; http://dx.doi.org/10.1172/JCI35541
   PubMed Web of Science ®Google Scholar
• Guery L, Benikhlef N, Gautier T, Paul C, Jego G, Dufour E, Jacquel A, Cally R, Manoury B, Vanden Berghe T, et al. Fine-tuning nucleophosmin in macrophage differentiation and activation. Blood 2011; 118:4694–704; PMID:21876121; http://dx.doi.org/10.1182/blood-2011-03-341255
   PubMed Web of Science ®Google Scholar
• Zhang Y, Morgan MJ, Chen K, Choksi S, Liu ZG. Induction of autophagy is essential for monocyte-macrophage differentiation. Blood 2012; 119:2895–905; PMID:22223827; http://dx.doi.org/10.1182/blood-2011-08-372383
   PubMed Web of Science ®Google Scholar
• Noronha-Matos JB, Costa MA, Magalhaes-Cardoso MT, Ferreirinha F, Pelletier J, Freitas R, Neves JM, Sévigny J, Correia-de-Sá P. Role of ecto-NTPDases on UDP-sensitive P2Y(6) receptor activation during osteogenic differentiation of primary bone marrow stromal cells from postmenopausal women. J Cell Physiol 2012; 227:2694–709; PMID:21898410; http://dx.doi.org/10.1002/jcp.23014
   PubMed Web of Science ®Google Scholar
• Milosevic J, Brandt A, Roemuss U, Arnold A, Wegner F, Schwarz SC, Storch A, Zimmermann H, Schwarz J. Uracil nucleotides stimulate human neural precursor cell proliferation and dopaminergic differentiation: involvement of MEK/ERK signalling. J Neurochem 2006; 99:913–23; PMID:17076658; http://dx.doi.org/10.1111/j.1471-4159.2006.04132.x
   PubMed Web of Science ®Google Scholar
• Orriss IR, Wang N, Burnstock G, Arnett TR, Gartland A, Robaye B, Boeynaems JM. The P2Y(6) receptor stimulates bone resorption by osteoclasts. Endocrinology 2011; 152:3706–16; PMID:21828185; http://dx.doi.org/10.1210/en.2011-1073
   PubMed Web of Science ®Google Scholar
• Chatterjee C, Sparks DL. Extracellular nucleotides inhibit insulin receptor signaling, stimulate autophagy and control lipoprotein secretion. PloS One 2012; 7:e36916; PMID:22590634; http://dx.doi.org/10.1371/journal.pone.0036916
   PubMedGoogle Scholar
• de The H, Chen Z. Acute promyelocytic leukaemia: novel insights into the mechanisms of cure. Nat Rev Cancer 2010; 10:775–83; PMID:20966922; http://dx.doi.org/10.1038/nrc2943
   PubMed Web of Science ®Google Scholar
• Wang Z, Cao L, Kang R, Yang M, Liu L, Zhao Y, Yu Y, Xie M, Yin X, Livesey KM, et al. Autophagy regulates myeloid cell differentiation by p62/SQSTM1-mediated degradation of PML-RARalpha oncoprotein. Autophagy 2011; 7:401–11; PMID:21187718; http://dx.doi.org/10.4161/auto.7.4.14397
   PubMed Web of Science ®Google Scholar
• Auberger P. BCR-ABL/p62/SQSTM1: a cannibal embrace. Blood 2012; 120:3389–90; PMID:23100300; http://dx.doi.org/10.1182/blood-2012-08-451492
   PubMed Web of Science ®Google Scholar
• Ablain J, Nasr R, Bazarbachi A, de The H. The drug-induced degradation of oncoproteins: an unexpected Achilles' heel of cancer cells? Cancer Dis 2011; 1:117–27; PMID:22586354; http://dx.doi.org/10.1158/2159-8290.CD-11-0087
   PubMed Web of Science ®Google Scholar
• Lalic H, Dembitz V, Lukinovic-Skudar V, Banfic H, Visnjic D. 5-Aminoimidazole-4-carboxamide ribonucleoside induces differentiation of acute myeloid leukemia cells. Leuk Lymphoma 2014; 55:2375–83; PMID:24359245; http://dx.doi.org/10.3109/10428194.2013.876633
   PubMed Web of Science ®Google Scholar
• Braun T, Itzykson R, Renneville A, de Renzis B, Dreyfus F, Laribi K, Bouabdallah K, Vey N, Toma A, Recher C, et al. Molecular predictors of response to decitabine in advanced chronic myelomonocytic leukemia: a phase 2 trial. Blood 2011; 118:3824–31; PMID:21828134; http://dx.doi.org/10.1182/blood-2011-05-352039
   PubMed Web of Science ®Google Scholar
• Fenaux P, Mufti GJ, Hellstrom-Lindberg E, Santini V, Finelli C, Giagounidis A, Gattermann N, Sanz G, List A, Gore SD, et al. Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study. Lancet Oncol 2009; 10:223–32; PMID:19230772; http://dx.doi.org/10.1016/S1470-2045(09)70003-8
   PubMed Web of Science ®Google Scholar
• Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 2012; 8:445–544; PMID:22966490; http://dx.doi.org/10.4161/auto.19496
   PubMed Web of Science ®Google Scholar