L-Arginine in the treatment of valproate overdose – five clinical cases

References

• Chan YC , Tse ML , Lau FL. Two cases of valproic acid poisoning treated with L-carnitine. Hum Exp Toxicol. 2007;26:967–969.
   PubMed Web of Science ®Google Scholar
• Silva MFB , Aires CCP , Luis PBM , et al . Valproic acid metabolism and its effects on mitochondrial fatty acid oxidation: a review. J Inherit Metab Dis. 2008;31:205–216.
   PubMed Web of Science ®Google Scholar
• Crudup III . Recognizing and treating valproic acid toxicity: a case report [Internet]. J Med Cases. 2011. [cited 2014 Aug 16]. Available from: http://www.journalmc.org/index.php/JMC/article/view/234
   Google Scholar
• Eyer F , Felgenhauer N , Gempel K , et al . Acute valproate poisoning: pharmacokinetics, alteration in fatty acid metabolism, and changes during therapy. J Clin Psychopharmacol. 2005;25:376–380.
   PubMed Web of Science ®Google Scholar
• Lheureux PER , Penaloza A , Zahir S , et al . Science review: carnitine in the treatment of valproic acid-induced toxicity – what is the evidence? Crit Care. 2005;9:431–440.
   PubMed Web of Science ®Google Scholar
• Barrueto F , Hack JB. Hyperammonemia and coma without hepatic dysfunction induced by valproate therapy. Acad Emerg Med. 2001;8:999–1001.
   PubMed Web of Science ®Google Scholar
• McCall M , Bourgeois JA. Valproic acid-induced hyperammonemia: a case report. J Clin Psychopharmacol. 2004;24:521–526.
   PubMed Web of Science ®Google Scholar
• Hwu W-L , Chien Y-H , Tang NLS , et al . Deficiency of the carnitine transporter (OCTN2) with partial N-acetylglutamate synthase (NAGS) deficiency. J Inherit Metab Dis. 2007;30:816.
   PubMed Web of Science ®Google Scholar
• Laish I , Ben Ari Z. Noncirrhotic hyperammonaemic encephalopathy. Liver Int off J Int Assoc Study Liver. 2011;31:1259–1270.
   PubMed Web of Science ®Google Scholar
• Schwarz ES , Thoelke M. Altered mental status and hyperammonemia after overdose of valproic acid with therapeutic valproic acid concentrations. IJCM. 2014;5:546–549.
   Google Scholar
• Warter JM , Brandt C , Marescaux C , et al . The renal origin of sodium valproate-induced hyperammonemia in fasting humans. Neurology. 1983;33:1136–1140.
   PubMed Web of Science ®Google Scholar
• Manoguerra AS , Erdman AR , Woolf AD , et al . Valproic acid poisoning: An evidence-based consensus guideline for out-of-hospital management*. Clin Toxicol. 2008;46:661–676.
   PubMed Web of Science ®Google Scholar
• Lheureux PER , Hantson P. Carnitine in the treatment of valproic acid-induced toxicity. Clin Toxicol. 2009;47:101–111.
   PubMed Web of Science ®Google Scholar
• Mock CM , Schwetschenau KH. Levocarnitine for valproic-acid-induced hyperammonemic encephalopathy. Am J Health Syst Pharm. 2012;69:35–39.
   PubMed Web of Science ®Google Scholar
• Sztajnkrycer MD. Valproic acid toxicity: overview and management. J Toxicol Clin Toxicol. 2002;40:789–801.
   PubMed Web of Science ®Google Scholar
• Thanacoody RHK. Extracorporeal elimination in acute valproic acid poisoning. Clin Toxicol. 2009;47:609–616.
   PubMed Web of Science ®Google Scholar
• Aires CCP , van Cruchten A , Ijlst L , et al . New insights on the mechanisms of valproate-induced hyperammonemia: inhibition of hepatic N-acetylglutamate synthase activity by valproyl-CoA. J Hepatol. 2011;55:426–434.
   PubMed Web of Science ®Google Scholar
• Shores NJ , Keeffe EB. Is oral L-acyl-carnitine an effective therapy for hepatic encephalopathy? Review of the literature. Dig Dis Sci. 2008;53:2330–2333.
   PubMed Web of Science ®Google Scholar
• Häberle J , Boddaert N , Burlina A , et al . Suggested guidelines for the diagnosis and management of urea cycle disorders. Orphanet J Rare Dis. 2012;7:32.
   PubMed Web of Science ®Google Scholar
• Heble DE , Oschman A , Sandritter TL. Comparison of arginine hydrochloride and acetazolamide for the correction of metabolic alkalosis in pediatric patients. Am J Ther. 2016;23:e1469–e1473.
   PubMed Web of Science ®Google Scholar
• Perrott J , Murphy NG , Zed PJ. L-Carnitine for acute valproic acid overdose: a systematic review of published cases. Ann Pharmacother. 2010;44:1287–1293.
   PubMed Web of Science ®Google Scholar
• Arbeiter AK , Kranz B , Wingen AM , et al . Continuous venovenous haemodialysis (CVVHD) and continuous peritoneal dialysis (CPD) in the acute management of 21 children with inborn errors of metabolism. Nephrol Dial Transplant. 2010;25:1257–1265.
   PubMed Web of Science ®Google Scholar
• Schaefer F , Straube E , Oh J , et al . Dialysis in neonates with inborn errors of metabolism. Nephrol Dial Transplant. 1999;14:910–918.
   PubMed Web of Science ®Google Scholar
• Spiller HA , Krenzelok EP , Klein-Schwartz W , et al . Multicenter case series of valproic acid ingestion: serum concentrations and toxicity. J Toxicol Clin Toxicol. 2000;38:755–760.
   PubMed Web of Science ®Google Scholar
• Singh SM , McCormick BB , Mustata S , et al . Extracorporeal management of valproic acid overdose: a large regional experience. J Nephrol. 2004;17:43–49.
   PubMed Web of Science ®Google Scholar
• Franssen EJ , van Essen GG , Portman AT , et al . Valproic acid toxicokinetics: serial hemodialysis and hemoperfusion. Ther Drug Monit. 1999;21:289–292.
   PubMed Web of Science ®Google Scholar
• Johnson LZ , Martinez I , Fernández MC , et al . Successful treatment of valproic acid overdose with hemodialysis. Am J Kidney Dis. 1999;33:786–789.
   PubMed Web of Science ®Google Scholar
• Silva MFB , Ruiter JPN , Overmars H , et al . Complete beta-oxidation of valproate: cleavage of 3-oxovalproyl-CoA by a mitochondrial 3-oxoacyl-CoA thiolase. Biochem J. 2002;362:755–760.
   PubMed Web of Science ®Google Scholar
• Shigesada K , Tatibana M. N-Acetylglutamate synthetase from rat-liver mitochondria. Partial purification and catalytic properties. Eur J Biochem. 1978;84:285–291.
   PubMedGoogle Scholar
• Coude FX , Rabier D , Cathelineau L , et al . A mechanism for valproate-induced hyperammonemia. Pediatr Res. 1981;15:974–975.
   PubMed Web of Science ®Google Scholar
• Brusilow SW. Arginine, an indispensable amino acid for patients with inborn errors of urea synthesis. J Clin Invest. 1984;74:2144–2148.
   PubMed Web of Science ®Google Scholar
• Winter SS , Rose E , Katz R. Hyperammonemia after chemotherapy in an adolescent with hepatocellular carcinoma. J Pediatr Gastroenterol Nutr. 1997;25:537–540.
   PubMed Web of Science ®Google Scholar
• Wang M , You Q , Lor K , et al . Chronic alcohol ingestion modulates hepatic macrophage populations and functions in mice. J Leukoc Biol. 2014;96:657–665.
   PubMed Web of Science ®Google Scholar
• Scaglia F , Lee B. Clinical, biochemical, and molecular spectrum of hyperargininemia due to arginase I deficiency. Am J Med Genet C Semin Med Genet. 2006;142C:113–120.
   PubMed Web of Science ®Google Scholar
• Cederbaum SD , Yu H , Grody WW , et al . Arginases I and II: do their functions overlap? Mol Genet Metab. 2004;81(Suppl 1):S38–S44.
   PubMed Web of Science ®Google Scholar