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Clinical Toxicology Volume 57, 2019 - Issue 6
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Clinical Research

Trending gabapentin exposures in Kentucky after legislation requiring use of the state prescription drug monitoring program for all opioid prescriptionsFootnote#

Kiran A. FaryarDepartment of Emergency Medicine, University of Cincinnati, Cincinnati, OH, USA; Correspondence[email protected]
,
Ashley N. WebbKentucky Poison Control Center, Norton Children’s Hospital, Louisville, KY, USA;
,
Bikash BhandariThe Statistical Consulting Center, Department of Public Health and Information Science, University of Louisville, Louisville, KY, USA
,
Timothy G. PriceThe Statistical Consulting Center, Department of Public Health and Information Science, University of Louisville, Louisville, KY, USA
&
George M. BosseThe Statistical Consulting Center, Department of Public Health and Information Science, University of Louisville, Louisville, KY, USA
Pages 398-403 | Received 15 Jun 2018, Accepted 16 Oct 2018, Published online: 24 Jan 2019

References

  • Verma A, St Clair EW, Radtke RA. A case of sustained massive gabapentin overdose without serious side effects. Ther Drug Monit. 1999;21:615–617.
  • Bryans JS, Davies N, Gee NS, et al. Identification of novel ligands for the gabapentin binding site on the alpha2delta subunit of a calcium channel and their evaluation as anticonvulsant agents. J Med Chem. 1998;41:1838–1845.
  • Belliotti TR, Capiris T, Ekhato IV, et al. Structure-activity relationships of pregabalin and analogues that target the alpha(2)-delta protein. J Med Chem. 2005;48:2294–2307.
  • Middleton O. Suicide by gabapentin overdose. J Forensic Sci. 2011;56:1373–1375.
  • Chen C. Meta-analyses of dose-exposure relationships for gabapentin following oral administration of gabapentin and gabapentin enacarbil. Eur J Clin Pharmacol. 2013;69:1809–1817.
  • Klein-Schwartz W, Shepherd JG, Gorman S, et al. Characterization of gabapentin overdose using a poison center case series. J Toxicol Clin Toxicol. 2003;41:11–15.
  • Moore A, Derry S, Wiffen P. Gabapentin for chronic neuropathic pain. JAMA. 2018;319:818–819.
  • Miller A, Price G. Gabapentin toxicity in renal failure: the importance of dose adjustment. Pain Med. 2009;10:190–192.
  • Sirven JI. New uses for older drugs: the tales of aspirin, thalidomide, and gabapentin. Mayo Clin Proc. 2010;85:508–511.
  • Shanthanna H, Gilron I, Rajarathinam M, et al. Benefits and safety of gabapentinoids in chronic low back pain: a systematic review and meta-analysis of randomized controlled trials. PLoS Med. 2017;14:e1002369.
  • Mowry JB, Spyker DA, Cantilena LR, Jr, et al. Annual report of the American Association of Poison Control Centers’ National Poison Data System (NPDS): 30th annual report. Clin Toxicol. 2013;51:949–1229.
  • Director of the Kentucky Poison Control Center (Dr. Ashley Webb). Personal Communication. Kentucky Poison Control Center of Norton Children’s Hospital; 2017.
  • Kentucky Board of Medical Licensure. Summary of HB 1. Kentucky Board of Medical Licensure; 2012. p. 1–6. Available from: http://www.kbml.ky.gov.
  • Freeman PR, Goodin A, Troske S, et al. Kentucky House Bill 1 Impact Evaluation: Executive Summary. College of Pharmacy, University of Kentucky: Institute for Pharmaceutical Outcomes and Policy; 2015. p.1–6.
  • Schifano F. Misuse and abuse of pregabalin and gabapentin: cause for concern? CNS Drugs. 2014;28:491–496.
  • Johansen ME. Gabapentinoid use in the United States 2002 through 2015. JAMA Internal Medicine. Published online January 2, 2018. DOI:10.1001/jamainternmed.2017.7856.
  • Chiappini S, Schifano F. A decade of gabapentinoid misuse: an analysis of the European Medicines Agency’s ‘Suspected Adverse Drug Reactions’ Database. CNS Drugs. 2016;30:647–654.
  • Knoppert D. The worldwide opioid epidemic: implications for treatment and research in pregnancy and the newborn. Paediatr Drugs. 2011;13:277–279.
  • World Health Organization. Opiates World Health Organization. 2018 [cited 2018 July 20]. Available from: http://www.who.int/substance_abuse/facts/opiates/en/
  • Gummin DD, Mowry JB, Spyker DA, et al. 2016 Annual report of the American Association of Poison Control Centers’ National Poison Data System (NPDS): 34th annual report. Clin Toxicol. 2017;55:1072–1252.
  • Schauer SG, Varney SM. Gabapentin overdose in a military beneficiary. Mil Med. 2013;178:133–135.
  • Shea YF, Mok MM, Chang RS. Gabapentin-induced myoclonus in an elderly with end-stage renal failure. J Formos Med Assoc. 2014;113:660–661.
  • Rasimas JJ, Burkhart KK. Cardiac conduction disturbances after an overdose of nefazodone and gabapentin. Am J Emerg Med. 2006;24:886–888.
  • Hedegaard HWM, Miniño AM. Drug overdose deaths in the United States, 1999–2016. NCHS Data Brief, no 294. Hyattsville (MD): National Center for Health Statistics. 2017/CDC. Wide-ranging online data for epidemiologic research (WONDER). Atlanta (GA): CDC, National Center for Health Statistics; 2016. Available at http://wonder.cdc.gov
  • Kentucky Office of Drug Control Policy. 2016. Overdose Fatality Report. Kentucky Office of Drug Control Policy: Commonwealth of Kentucky, Justice and Public Safety Cabinet. p. 1–27.

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