Comparison of rates of opioid withdrawal symptoms and reversal of opioid toxicity in patients treated with two naloxone dosing regimens: a retrospective cohort study

References

• United Nations Office on Drugs and Crime: World Drug Report. 2018. (United Nations publication, Sales No. E.18.XI.9)
   Google Scholar
• Scholl L, Seth P, Kariisa M, et al. Drug and opioid-involved overdose deaths – United States, 2013–2017. Morb Mortal Wkly Rep. 2019;67:1419–1427.
   Web of Science ®Google Scholar
• National report: Apparent opioid-related deaths in Canada. September 2019. [cited 2019 Oct 8]. https://health-infobase.canada.ca/datalab/national-surveillance-opioid-mortality.html
   Google Scholar
• McDonald R, Strang J. Are take-home naloxone programmes effective? Systematic review utilizing application of the Bradford Hill criteria. Addiction. 2016;111(7):1177–1187.
   PubMed Web of Science ®Google Scholar
• Coffin PO, Sullivan SD. Cost-effectiveness of distributing naloxone to heroin users for lay overdose reversal. Ann Intern Med. 2013;158(1):1–9.
   PubMed Web of Science ®Google Scholar
• Dettmer K, Sauders B, Strang J. Take home naloxone and the prevention of deaths form opiate overdose: two pilot schemes. Brit Med J. 2001;322(7291):895–896.
   PubMed Web of Science ®Google Scholar
• Irvine MA, Kuo M, Buxton JA, et al. Modelling the combined impact of interventions in averting deaths during a synthetic-opioid overdose epidemic. Addiction. 2019;114(9):1602–1613.
   PubMed Web of Science ®Google Scholar
• Johnson C, Mayer P, Grosz D. Pulmonary edema following naloxone administration in a healthy orthopedic patient. J Clin Anesth. 1995;7(4):356–357.
   PubMed Web of Science ®Google Scholar
• Nath SS, Tripathi M, Pandey C, et al. Naloxone-induced pulmonary edema: a potential cause of postoperative morbidity in laparoscopic donor nephrectomy. Indian J Med Sci. 2009;63(2):72–75.
   PubMedGoogle Scholar
• Partridge BL, Ward CF. Pulmonary edema following low-dose naloxone administration. Anesthesiology. 1986;65(6):709–710.
   PubMed Web of Science ®Google Scholar
• Flacke JW, Flacke WE, Williams GD. Acute pulmonary in healthy teenagers following naloxone reversal of high-dose morphine anesthesia. Anesthesiology. 1977;47:376–378.
   PubMed Web of Science ®Google Scholar
• Prough DS, Roy R, Bumgarner J, et al. Acute pulmonary edema in healthy teenagers following conservative doses of intravenous naloxone. Anesthesiology. 1984;60(5):485–486.
   PubMed Web of Science ®Google Scholar
• Taff RH. Pulmonary edema following naloxone administration in a patient without heart disease. Anesthesiology. 1983;59:576–577.
   PubMed Web of Science ®Google Scholar
• Schwartz JA, Koenigsberg MD. Naloxone-induced pulmonary edema. Ann Emerg Med. 1987;16(11):1294–1296.
   PubMed Web of Science ®Google Scholar
• Tanaka GY. Hypertensive reaction to naloxone. JAMA. 1974;228(1):25–26.
   PubMed Web of Science ®Google Scholar
• Estilo AE, Cottrell JE. Naloxone, hypertension and ruptured cerebral aneurysm. Anesthesiology. 1981;74:627–633.
   Google Scholar
• Azar I, Turndorf H. Severe hypertension and multiple atrial premature contractions following naloxone administration. Anesth Analg. 1979;58(6):524–525.
   PubMed Web of Science ®Google Scholar
• Michaelis LL, Hickey PR, Clark TA, et al. Ventricular irritability associated with the use of naloxone hydrochloride. Two case reports and laboratory assessment of the effects of the drug on cardiac excitability. Ann Thorac Surg. 1974;18:608–614.
   PubMedGoogle Scholar
• Kim HK, Nelson LS. Reducing the harm of opioid overdose with safe use of naloxone: a pharmacologic review. Expert Opin Drug Saf. 2015;14(7):1137–1146.
   PubMed Web of Science ®Google Scholar
• Popper C, Kelen GD, Cunningham G. Naloxone hazard in drug abuser. Lancet. 1989;334(8660):446.
   Google Scholar
• Gaddis GM, Watson WA. Naloxone-associated patient violence: an overlooked toxicity?. Ann Pharmacother. 1992;26:196–198.
   PubMed Web of Science ®Google Scholar
• Cuss FM, Colaco CB, Baron JH. Cardiac arrest after reversal of effects of opiates with naloxone. Brit Med J. 1984;288(6414):363–364.
   PubMed Web of Science ®Google Scholar
• Andree RA. Sudden death following naloxone administration. Anesth Analg. 1980;59(10):782–784.
   PubMed Web of Science ®Google Scholar
• Cook S, Moeschler O, Katarzyna M, Yersin B. Acute opiate overdose: characteristics of 190 consecutive cases. Addiction. 1998;93(10):1559–1565.
   PubMed Web of Science ®Google Scholar
• Seidler D, Stühlinger GH, Fischer G, et al. After antagonization of acute opiate overdose: a survey of hospitals in Vienna. Addiction. 1996;91:1479–1487.
   PubMed Web of Science ®Google Scholar
• Caudarella A, Dong H, Milloy MJ, et al. Non-fatal overdose as a risk factor for subsequent fatal overdose among people who inject drugs. Drug Alcohol Depend. 2016;162:51–55.
   PubMed Web of Science ®Google Scholar
• Nelson LS, Howland MA, et al. Opioid Antagonists. In: Nelson LS, editor. Goldfrank’s toxicologic emergencies, 11th edn. New York: McGraw-Hil; 2019.
   Google Scholar
• Longnecker DE. Anesthesiology. 3rd edn. New York: McGraw-Hill Professional; 2017.
   Google Scholar
• Connors NJ, Nelson LS. The evolution of recommended naloxone dosing for opioid overdose by medical specialty. J Med Tox. 2016;12:1–6.
   PubMed Web of Science ®Google Scholar
• Boyer EW. Management of opioid analgesic overdose. N Engl J Med. 2012;367(2):146–155.
   PubMed Web of Science ®Google Scholar
• Khosravi N, Zamani N, Hassanian-Moghaddam H, et al. Comparison of two naloxone regimens in opioid-dependent methadone overdosed patients: a clinical trial study. CCP. 2018;12(4):259–265.
   Web of Science ®Google Scholar
• Wong F, Edwards CJ, Jarrell DH, et al. Comparison of lower-dose versus higher-dose intravenous naloxone on time to recurrence of opioid toxicity in the emergency department. Clin Toxicol. 2019;57(1):19–24.
   PubMed Web of Science ®Google Scholar
• Hoffman JR, Schriger DL, Luo JS. The empiric use of naloxone in patients with altered mental status: a reappraisal. Ann Emerg Med. 1991;20(3):246–252.
   PubMed Web of Science ®Google Scholar
• Thanacoody R, Winter W, Kelley A, et al. Opioid overdose. BMJ Best Practice. 2015; BMJ Publishing Group Ltd. Available from: https://bestpractice.bmj.com/topics/en-us/339
   Google Scholar
• Wesson DR, Ling W. The Clinical Opiate Withdrawal Scale (COWS). J Psychoactive Drugs. 2003;35(2):253–259.
   PubMed Web of Science ®Google Scholar
• Grafstein E, Bullard MJ, Warren D, et al. Revision of the Canadian Emergency Department Information System (CEDIS) presenting complaint list version 1.1. CJEM. 2008;10(02):151–161.
   PubMedGoogle Scholar
• Buajordet I, Næss A, Jacobsen D, et al. Adverse events after naloxone treatment of episodes of suspected acute opioid overdose. Eur J Emerg Med. 2004;11:19–23.
   PubMed Web of Science ®Google Scholar
• Banjo O, Tzemis D, Al-Qutub D, et al. A quantitative and qualitative evaluation of the British Columbia Take Home Naloxone program. Can Med Assoc J Open. 2014;2(3):E153–E161.
   Google Scholar
• Doe-Simkins M, Walley AY, Epstein A, et al. Saved by the nose: bystander-administrated intranasal naloxone hydrochloride for opioid overdose. Am J Public Health. 2009;99(5):788–791.
   PubMed Web of Science ®Google Scholar
• Enteen L, Bauer J, McLean R, et al. Overdose prevention and naloxone prescription for opioid users in San Francisco. J Urban Health. 2010;87(6):931–941.
   PubMed Web of Science ®Google Scholar
• Watson WA, Steele MT, Muelleman RL, et al. Opioid toxicity recurrence after an initial response to naloxone. J Toxicol Clin Toxicol. 1998;36(1-2):11–17.
   PubMed Web of Science ®Google Scholar
• Dietz P, Cantwell K, Burgess S. Bystander resuscitation attempts at heroin overdose: does it improve outcomes? Drug Alcohol Depend. 2002;67(2):213–218.
   PubMed Web of Science ®Google Scholar
• Green TC, Gilbert M. Counterfeit medications and fentanyl. JAMA Intern Med. 2016;176(10):1555–1557.
   PubMed Web of Science ®Google Scholar
• Yassen A, Olofsen E, Romberg R, et al. Mechanism-based PK/PD modeling of the respiratory depressant effect of buprenophine and fentanyl in healthy volunteers. Clin Pharmacol Ther. 2007;81(1):50–58.
   PubMed Web of Science ®Google Scholar
• Moss RB, Carlo DJ. Higher doses of naloxone are needed in the synthetic opiod era. Subst Abuse Treat Prev Policy. 2019;14(1):6–6.
   PubMed Web of Science ®Google Scholar
• Rzasa Lynn R, Galinkin JL. Naloxone dosage for opioid reversal: current evidence and clinical implications. Ther Adv Drug Saf. 2018;9(1):63–88.
   PubMed Web of Science ®Google Scholar
• Sivilotti M. Flumazenil, naloxone and the ‘coma cocktail’. Br J Clin Pharmacol. 2016;81(3):428–436.
   PubMed Web of Science ®Google Scholar
• Hamel MG. Revisiting naloxone. a different take on overdose guidelines from Lee County, Fla. J Emerg Med Service. 2016;41:46–48.
   PubMedGoogle Scholar
• BC Coroners Service Fentanyl-Detected Illicit Drug Overdose Deaths. [cited 2019 Oct]. Available from: https://www2.gov.bc.ca/assets/gov/public-safety-and-emergency-services/death-investigation/statistical/fentanyl-detected-overdose
   Google Scholar