Diethylene glycol poisoning

References

• Cavender FL, Sowinski EJ. Glycols. In: Clayton GDClayton FE eds. Patty's Industrial Hygiene and Toxicology. New York:John Wiley & Sons Inc, 1994:4645–4719.
   Google Scholar
• O'Neil M The Merck Index. 14th ed. Whitehouse Station, NJ:Merck & Co, 2006.
   Google Scholar
• Winek CL, Shingleton DP, Shanor SP. Ethylene and diethylene glycol toxicity. Clin Toxicol 1978; 13:297–324.
   PubMed Web of Science ®Google Scholar
• Calvery HO, Klumpp TG. The toxicity for human beings of diethylene glycol with sulfanilamide. South Med J 1939; 32:1105–1109.
   Google Scholar
• Danby MY, Danby EB, Loranz CP. Deaths following elixir sulfanilamide massengill: report of the Secretary of Agriculture. South Med J 1937; 30:1231–1232.
   Google Scholar
• Leech PN. (AMA Chemical Laboratory). Elixir of sulfanilamide-Massengill. JAMA 1937; 109:1531–1539.
   Google Scholar
• Lynch KM. Diethylene glycol poisoning in the human. South Med J 1938; 32:134–137.
   Google Scholar
• Wax PM. Elixirs, diluents, and the passage of the 1938 Federal Food, Drug and Cosmetic Act. Ann Intern Med 1995; 122:456–461.
   PubMed Web of Science ®Google Scholar
• Wax PM. Controversies in toxicology – elixir sulfanilamide-Massengill revisited (Reprinted From Mithridata, Vol 4, 1994). Vet Hum Toxicol 1994; 36:561–562.
   PubMedGoogle Scholar
• Deaths following elixir of sulfanilamide-Massengill [Editorial] JAMA 1938; 111:1567–1568.
   Google Scholar
• Bowie MD, McKenzie D. Diethylene glycol poisoning in children. S Afr Med J 1972; 46:931–934.
   PubMed Web of Science ®Google Scholar
• Cantarell MC, Fort J, Camps J, Sans M, Piera L. Acute intoxication due to topical application of diethylene glycol [letter]. Ann Intern Med 1987; 106:478–479.
   PubMed Web of Science ®Google Scholar
• Pandya SK. Letter from Bombay. An unmitigated tragedy [letter]. BMJ 1988; 297:117–119.
   PubMed Web of Science ®Google Scholar
• Okuonghae HO, Ighogboja IS, Lawson JO, Nwana EJC. Diethylene glycol poisoning in Nigerian children. Ann Trop Paediatr 1992; 12:235–238.
   PubMed Web of Science ®Google Scholar
• Hanif M, Mobarak MR, Ronan A, Rahman D, Donovan JJ, Bennish ML. Fatal renal-failure caused by diethylene glycol in paracetamol elixir – the Bangladesh epidemic. BMJ 1995; 311:88–891.
   PubMed Web of Science ®Google Scholar
• O'Brien KL, Selanikio JD, Hecdivert C, Placide MF, Louis M, Barr DB, Barr JR, Hospedales CJ, Lewis MJ, Schwartz B, Philen RM, St Victor S, Espindola J, Needham LL, Denerville K. Epidemic of pediatric deaths from acute renal failure caused by diethylene glycol poisoning. Acute Renal Failure Investigation Team. JAMA 1998; 279:1175–1180.
   Google Scholar
• Malebranche R, Hecdivert C, Lassegue A, Victor S, Derosena R, Denerville K, Amand CH, Severe D, Compas E, Cleophat P, Buteau JH, Fabien D, Colimon J, Verdier RI, Cayemitte MI, Placide MF, Hospedales J, Lewis M, Diouf MA, Garcia S, Parekh R, Bunchman T, Racusen L. Fatalities associated with ingestion of diethylene glycol-contaminated glycerin used to manufacture acetaminophen syrup–Haiti, November 1995–June 1996. MMWR Morb Mortal Wkly Rep 1996; 45:649–650.
   PubMedGoogle Scholar
• Scalzo AJ. Diethylene glycol toxicity revisited: the 1996 Haitian epidemic. J Toxicol Clin Toxicol 1996; 34:513–516.
   PubMed Web of Science ®Google Scholar
• Woolf AD. The Haitian diethylene glycol poisoning tragedy: a dark wood revisited [Editorial]. JAMA 1998; 279:1215–1216.
   PubMed Web of Science ®Google Scholar
• Junod SW. Diethylene glycol deaths in Haiti. Public Health Rep 2000; 115:78–86.
   PubMed Web of Science ®Google Scholar
• Anonymous Diethylene glycol poisoning associated with paracetamol liquid formulations. Adverse Drug React Toxicol Rev 1998; 17:207–208.
   PubMedGoogle Scholar
• Wax PM. It's happening again – another diethylene glycol mass poisoning. J Toxicol Clin Toxicol 1996; 34:517–520.
   PubMed Web of Science ®Google Scholar
• Litovitz TL, Smilkstein M, Felberg L, Klein-Schwartz W, Berlin R, Morgan JL. 1996 Annual report of the American Association of Poison Control Centers Toxic Exposure Surveillance System. Am J Emerg Med 1997; 15:447–500.
   PubMed Web of Science ®Google Scholar
• Drut R, Quijano G, Jones MC, Scanferla P. Pathologic findings in diethylene glycol poisoning [Spanish]. Medicina (B Aires) 1994; 54:1–5.
   PubMed Web of Science ®Google Scholar
• Ferrari LA, Giannuzzi L. Clinical parameters, postmortem analysis and estimation of lethal dose in victims of a massive intoxication with diethylene glycol. Forensic Sci Int 2005; 153:45–51.
   PubMed Web of Science ®Google Scholar
• Singh J, Dutta AK, Khare S, Dubey NK, Harit AK, Jain NK, Wadhwa TC, Gupta SR, Dhariwal AC, Jain DC, Bhatia R, Sokhey J. Diethylene glycol poisoning in Gurgaon, India, 1998. Bull World Health Organ 2001; 79:88–95.
   PubMed Web of Science ®Google Scholar
• Kumar A. Diethylene glycol poisoning in Gurgaon, Haryana, India, 1998. Bull World Health Organ 2001; 79:686–686.
   PubMed Web of Science ®Google Scholar
• Hari P, Jain Y, Kabra SK. Fatal encephalopathy and renal failure caused by diethylene glycol poisoning. J Trop Pediatr 2006; 52:442–444.
   PubMed Web of Science ®Google Scholar
• Rentz ED, Lewis L, Mujica OJ, Barr DB, Schier JG, Weerasekera G, Kuklenyik P, McGeehin M, Osterloh J, Wamsley J, Lum W, Alleyne C, Sosa N, Motta J, Rubin C. Outbreak of acute renal failure in Panama in 2006: a case-control study. Bull World Health Organ 2008; 86:749–756.
   PubMed Web of Science ®Google Scholar
• Bogdanich W, Hooker J. From China to Panama, a Trail of Poisoned Medicine. New York: New York Times; 2007. http://www.nytimes.com/2007/05/06/world/americas/06poison. html. Accessed 21 March 2009.
   Google Scholar
• Barr DB, Barr JR, Weerasekera G, Wamsley J, Kalb SR, Sjodin A, Schier JG, Rentz ED, Lewis L, Rubin C, Needham LL, Jones RL, Sampson EJ. Identification and quantification of diethylene glycol in pharmaceuticals implicated in poisoning epidemics: an historical laboratory perspective. J Anal Toxicol 2007; 31:295–303.
   PubMed Web of Science ®Google Scholar
• Schier JG, Conklin L, Sabogal R, Dell'aglio D, Sanchez C, Sejvar J. Medical toxicology and public health – update on research and activities at the centers for disease control and prevention and the agency for toxic substances and disease registry (Panama Follow-Up Investigation Workgroup). J Med Toxicol 2008; 4:40–42.
   PubMedGoogle Scholar
• Lin BL, Zhao ZX, Chong YT, Li JG, Zuo X, Tao Y, Lou TQ, Gao ZL. Venous diethylene glycol poisoning in patients with preexisting severe liver disease in China. World J Gastroenterol 2008; 14:3236–3241.
   PubMed Web of Science ®Google Scholar
• Peng XM, Huang MX, Gu L, Lin BL, Chen GH. Characteristics of patients with liver disease intravenously exposed to diethylene glycol in China 2006. Clin Toxicol (Phila) 2009; 47:124–131.
   PubMed Web of Science ®Google Scholar
• BBC. Arrests in Nigeria Baby Poisoning. London: BBC; 2009. http://news.bbc.co.uk/2/hi/africa/7884202.stm. Accessed 21 March 2009.
   Google Scholar
• Polgreen L. 84 Children Are Killed by Medicine in Nigeria. New York: New York Times; 2009. http://www.nytimes.com/2009/02/07/world/africa/07nigeria.html. Accessed 29 March 2009.
   Google Scholar
• Riska O Children are killed by poisoned drugs in Nigeria [Norweigan]. Tidsskr Nor Laegeforen, 2009;129:546.
   Google Scholar
• Some Wine to Break the Ice [Editorial] Lancet 1985; 2:254–254.
   PubMed Web of Science ®Google Scholar
• van der Linden-Cremers PM, Sangster B. Medical sequelae of the contamination of wine with diethylene glycol [Dutch]. Ned Tijdschr Geneeskd 1985; 129:1890–1891.
   PubMedGoogle Scholar
• Sangster B. Diethylene glycol in wine [Dutch]. Ned Tijdschr Geneeskd 1985; 129:1457–1459.
   PubMedGoogle Scholar
• van Leusen R, Uges DR. A patient with acute tubular necrosis as a consequence of drinking diethylene glycol-treated wine [Dutch]. Ned Tijdschr Geneeskd 1987; 131:768–771.
   PubMedGoogle Scholar
• Fake toothpaste found Br Dent J 2007; 203:68.
   PubMedGoogle Scholar
• Pérez E, Limeres J, Tomas I, Diz P. Letter to the editor: toothpastes with diethylene glycol. Med Oral Patol Oral Cir Bucal 2008; 13:E222–E223.
   PubMed Web of Science ®Google Scholar
• Haller C. Made in China. J Med Toxicol 2008; 4:141–142.
   PubMedGoogle Scholar
• FDA. US Food and Drug Administration. Imported Toothpaste. Washington; 2007. http://www.fda.gov/oc/opacom/hottopics/toothpaste.html. Accessed 21 March 2009.
   Google Scholar
• Doyle CR, Win N, Hodgman M, Krenzelok EP. Diethylene glycol abuse with resultant multiple fatalities [abstract]. J Toxicol Clin Toxicol 1998; 36:516–517.
   Google Scholar
• Rollins YD, Filley CM, McNutt JT, Chahal S, Kleinschmidt-DeMasters BK. Fulminant ascending paralysis as a delayed sequela of diethylene glycol (Sterno) ingestion. Neurology 2002; 59:1460–463.
   PubMed Web of Science ®Google Scholar
• Alfred S, Coleman P, Harris D, Wigmore T, Stachowski E, Graudins A. Delayed neurologic sequelae resulting from epidemic diethylene glycol poisoning. Clin Toxicol (Phila) 2005; 43:155–159.
   PubMed Web of Science ®Google Scholar
• Marraffa JM, Holland MG, Stork CM, Hoy CD, Hodgman MJ. Diethylene glycol: widely used solvent presents serious poisoning potential. J Emerg Med 2008; 35:401–406.
   PubMed Web of Science ®Google Scholar
• Wordley E. Diethylene glycol poisoning – report on 2 cases. J Clin Pathol 1947; 1:44–46.
   PubMed Web of Science ®Google Scholar
• Borron SW, Baud FJ, Garnier R. Intravenous 4-methylpyrazole as an antidote for diethylene glycol and triethylene glycol poisoning: a case report. Vet Hum Toxicol 1997; 39:26–28.
   PubMedGoogle Scholar
• Bronstein AC, Spyker DA, Cantilena LJ, Green J, Rumack BH, Heard SE. 2006 Annual Report of the American Association of Poison Control Centers’ National Poison Data System (NPDS). Clin Toxicol 2007; 45:815–917.
   PubMed Web of Science ®Google Scholar
• Hasbani MJ, Sansing LH, Perrone J, Asbury AK, Bird SJ. Encephalopathy and peripheral neuropathy following diethylene glycol ingestion. Neurology 2005; 64:1273–1275.
   PubMed Web of Science ®Google Scholar
• Brophy PD, Tenenbein M, Gardner J, Bunchman TE, Smoyer WE. Childhood diethylene glycol poisoning treated with alcohol dehydrogenase inhibitor fomepizole and hemodialysis. Am J Kidney Dis 2000; 35:958–962.
   PubMed Web of Science ®Google Scholar
• Kruger M, Regenthal R, Bohm R, Lindner D, Trauer H, Caffier P. Fatal diethylene glycol intoxication after misuse of Goldgeist (R) forte – a case report [German]. Anasthesiol Intensivmed 2002; 43:21–26.
   Web of Science ®Google Scholar
• Geiling EM, Cannon PR. Pathologic effects of elixir of sulfanilamide (diethylene glycol) poisoning. JAMA 1938; 111:919–926.
   Google Scholar
• Heilmair R, Lenk W, Lohr D. Toxicokinetics of diethylene glycol (DEG) in the rat. Arch Toxicol 1993; 67:655–666.
   PubMed Web of Science ®Google Scholar
• Mathews JM, Parker MK, Matthews HB. Metabolism and disposition of diethylene glycol in rat and dog. Drug Metab Dispos 1991; 19:1066–1070.
   PubMed Web of Science ®Google Scholar
• Lenk W, Lohr D, Sonnenbichler J. Pharmacokinetics and biotransformation of diethylene glycol and ethylene glycol in the rat. Xenobiotica 1989; 19:961–979.
   PubMed Web of Science ®Google Scholar
• Wiener HL, Richardson KE. Metabolism of diethylene glycol in male rats. Biochem Pharmacol 1989; 38:539–541.
   PubMed Web of Science ®Google Scholar
• Haag HB, Ambrose AM. Studies of the physiological effect of diethylene glycol: II toxicity and fate. J Pharmacol Exp Ther 1937; 59:93–100.
   Google Scholar
• Durand A, Auzepy P, Hebert JL, Trieu TC. A study of mortality and urinary excretion of oxalate in male rats following acute experimental intoxication with diethylene-glycol. Preliminary report. Eur J Intensive Care Med 1976; 2:143–146.
   PubMedGoogle Scholar
• Hébert JL, Fabre M, Auzépy P, Paillas J. Acute experimental poisoning by diethylene glycol: acid base balance and histological data in male rats. Toxicol Eur Res 1978; 1:2890–2894.
   PubMedGoogle Scholar
• Morris HJ, Nelson AA, Calvery HO. Observations on the chronic toxicities of propylene glycol, ethylene glycol, diethylene glycol, ethylene glycol mono-ethyl-ether, and diethylene glycol mono-ethyl-ether. J Pharmacol Exp Ther 1942; 74:266–273.
   Google Scholar
• Hébert JL, Auzepy P, Durand A. Acute human and experimental poisoning with diethylene glycol [French]. Sem Hop 1983; 59:344–349.
   PubMedGoogle Scholar
• Wiley FH, Hueper WC, Bergen DS. The formation of oxalic acid from ethylene glycol and related solvents. J Ind Hyg Toxicol 1938; 20:267–277.
   Google Scholar
• Vale JA, Buckley BM. Metabolic acidosis in diethylene glycol poisoning. Lancet 1985; 2:394.
   PubMed Web of Science ®Google Scholar
• Besenhofer LM, Cain MC, Latimer B, McMartin K. Metabolites of diethylene glycol (DEG) are responsible for the renal toxicity associated with acute DEG poisoning. March 15–19. 2009. Toxicologist 2009; 108:103–104.
   Google Scholar
• Vale A. Ethylene and diethylene glycol. Medicine 2007; 35:617–618.
   Google Scholar
• Schep LJ, Slaughter RJ. Comments on diethylene glycol concentrations [letter]. Forensic Sci Int 2005; 155:233.
   PubMed Web of Science ®Google Scholar
• Woolf A, Pearson K. Presence of diethylene glycol in commercial polyethylene glycol (PEG) solutions. J Toxicol Clin Toxicol 1995; 33:490.
   Google Scholar
• Raymond RW. Glycol ethers and diethylene glycol. In: Ford MDDelaney KALing LJErickson T eds. Clinical Toxicology. Philadelphia, PA:Saunders Company, 2001:774–781.
   Google Scholar
• Oliver J, Macdowell M, Tracy A. The pathogenesis of acute renal failure associated with traumatic and toxic injury; renal ischemia, nephrotoxic damage and the ischemic episode. J Clin Invest 1951; 12:1307–439.
   Google Scholar
• Wilkinson DP. Diethylene glycol poisoning. Med J Aust 1967; 2:403–404.
   Google Scholar
• Maurer H, Kessler C. Identification and quantification of ethylene glycol and diethylene glycol in plasma using gas chromatography-mass spectrometry. Arch Toxicol 1988; 62:66–69.
   PubMed Web of Science ®Google Scholar
• Maurer HH, Peters FT, Paul LD, Kraemer T. Validated gas chromatographic-mass spectrometric assay for determination of the antifreezes ethylene glycol and diethylene glycol in human plasma after microwave-assisted pivalylation. J Chromatogr B Biomed Sci Appl 2001; 754:401–409.
   PubMedGoogle Scholar
• Shin JM, Sachs G, Kraut JA. Simple diagnostic tests to detect toxic alcohol intoxications. Transl Res 2008; 152:194–201.
   PubMed Web of Science ®Google Scholar
• Smithline N, Gardner KDJ. Gaps – anionic and osmolal. JAMA 1976; 236:1594–1597.
   PubMed Web of Science ®Google Scholar
• Hoffman RS, Smilkstein MJ, Howland MA, Goldfrank LR. Osmol gaps revisited: normal values and limitations. J Toxicol Clin Toxicol 1993; 31:81–93.
   PubMed Web of Science ®Google Scholar
• Kraut JA, Kurtz I. Toxic alcohol ingestions: clinical features, diagnosis, and management. Clin J Am Soc Nephrol 2008; 3:208–225.
   PubMed Web of Science ®Google Scholar
• Winter SD, Pearson JR, Gabow PA, Schultz AL, Lepoff RB. The fall of the serum anion gap. Arch Intern Med 1990; 150:311–313.
   PubMed Web of Science ®Google Scholar
• Brent J. Fomepizole for ethylene glycol and methanol poisoning. N Engl J Med 2009; 360:2216–2223.
   PubMed Web of Science ®Google Scholar
• Jacobsen D, McMartin KE. Methanol and ethylene-glycol poisonings mechanism of toxicity, clinical course, diagnosis and treatment. Med Toxicol Adverse Drug Exp 1986; 1:309–334.
   Google Scholar
• Wallace KL. Toxin induced seizures. In: Brent JWallace KLBurkhart KKPhillips SDDonovan JW eds. Critical Care Toxicology: Diagnosis and Management of the Critically Poisoned Patient. Philadelphia, PA:Elsevier Mosby, 2005:225–239.
   Google Scholar
• Vale JA, Kulig K. American Academy of Clinical Toxicology; European Association of Poisons Centres and Clinical Toxicologists. Position paper: gastric lavage. J Toxicol Clin Toxicol 2004; 42:933–943.
   PubMed Web of Science ®Google Scholar
• Neuvonen PJ, Olkkola KT. Oral activated charcoal in the treatment of intoxications. Role of single and repeated doses. Med Toxicol Adverse Drug Exp 1988; 3:33–58.
   PubMedGoogle Scholar
• Seger D, Muelenbelt J. Position paper: Ipecac syrup. J Toxicol Clin Toxicol 2004; 42:133–143.
   PubMedGoogle Scholar
• Daubert GP, Katiyar A, Wilson J, Baltarowich L. Encephalopathy and peripheral neuropathy following diethylene glycol ingestion. Neurology 2006; 66:782–783.
   PubMed Web of Science ®Google Scholar
• Auzépy P, Taktak H, Toubas PL, Deparis M. Acute ethylene glycol and diethylene glycol poisoning in adults. 2 cases with recovery [French]. Sem Hop 1973; 49:1371–1374.
   PubMedGoogle Scholar
• Pietruszko R. Human liver alcohol-dehydrogenase – inhibition of methanol activity by pyrazole, 4-methylpyrazole, 4-hydroxymethylpyrazole and 4-carboxypyrazole. Biochem Pharmacol 1975; 24:1603–1607.
   PubMed Web of Science ®Google Scholar
• Brent J, McMartin K, Phillips S, Burkhart KK, Donovan JW, Wells M, Kulig K. Fomepizole for the treatment of ethylene glycol poisoning. N Engl J Med 1999; 340:832–838.
   PubMed Web of Science ®Google Scholar
• Antizol Medicines Datasheet, USA: Paladin Labs (USA) Inc. Dover, DL: Paladin Labs (USA) Inc; 2006. http://www.antizol.com. Accessed 22 March 2009.
   Google Scholar
• Brent J, McMartin K, Phillips S, Aaron C, Kulig K. Fomepizole for the treatment of methanol poisoning. N Engl J Med 2001; 344:424–429.
   PubMed Web of Science ®Google Scholar
• Jacobsen D, Sebastian CS, Blomstrand R, McMartin KE. 4-Methylpyrazole – a controlled-study of safety in healthy-human subjects after single, ascending doses. Alcohol Clin Exp Res 1988; 12:516–522.
   PubMed Web of Science ®Google Scholar
• Wacker WE, Haynes H, Druyan R, Fisher W, Coleman JE. Treatment of ethylene glycol poisoning with ethyl alcohol. JAMA 1965; 194:1231–1233.
   PubMed Web of Science ®Google Scholar
• Barceloux DG, Krenzelok EP, Olson K, Watson W. American academy of clinical toxicology practice guidelines on the treatment of ethylene glycol poisoning. Ad Hoc Committee. J Toxicol Clin Toxicol 1999; 37:537–560.
   PubMed Web of Science ®Google Scholar
• Sidell FR, Pless JE. Ethyl alcohol: blood levels and performance decrements after oral administration to man. Psychopharmacologia 1971; 19:246–261.
   PubMedGoogle Scholar
• Leung AK. Ethyl alcohol ingestion in children. A 15-year review. Clin Pediatr (Phila) 1986; 25:617–619.
   PubMed Web of Science ®Google Scholar
• Davis DP, Bramwell KJ, Hamilton RS, Williams SR. Ethylene glycol poisoning: case report of a record-high level and a review. J Emerg Med 1997; 15:653–667.
   PubMedGoogle Scholar
• Brent J. Current management of ethylene glycol poisoning. Durgs 2009; 61:979–988.
   Google Scholar