The hepatoprotective effects of curcumin against drugs and toxic agents: an updated review

References

• Abdel-Daim MM, Abdou RH. (2015). Protective effects of diallyl sulfide and curcumin separately against thallium-induced toxicity in rats. Cell J 17:379–88.
   PubMed Web of Science ®Google Scholar
• Abdel-Wahhab MA, Salman AS, Ibrahim MI, et al. (2016). Curcumin nanoparticles loaded hydrogels protects against aflatoxin B1-induced genotoxicity in rat liver. Food Chem Toxicol 94:159–71.
   PubMed Web of Science ®Google Scholar
• Abu-Rizq HA, Mansour MH, Afzal M. (2015). Curcuma longa attenuates carbon tetrachloride-induced oxidative stress in T-lymphocyte subpopulations. Methods Mol Biol 1208:159–70.
   PubMedGoogle Scholar
• Aggarwal BB, Kumar A, Aggarwal MS, Shishodia S. (2005). Curcumin derived from turmeric (Curcuma longa): a spice for all seasons. Phytopharm Cancer Chemopre 23:351–87.
   Google Scholar
• Aggarwal BB, Kumar A, Bharti AC. (2003). Anticancer potential of curcumin: preclinical and clinical studies. Anticancer Res 23:363–98.
   PubMed Web of Science ®Google Scholar
• Agrawal ND, Nirala SK, Shukla S, Mathur R. (2015). Co-administration of adjuvants along with Moringa oleifera attenuates beryllium-induced oxidative stress and histopathological alterations in rats. Pharm Biol 53:1465–73.
   PubMed Web of Science ®Google Scholar
• Akram M, Uddin S, Ahmed A, et al. (2010). Curcuma longa and curcumin: a review article. Rom J Biol-Plant Biol 55:65–70.
   Google Scholar
• Ali SO, Darwish HA, Ismail NA. (2014). Modulatory effects of curcumin, silybin-phytosome and alpha-R-lipoic acid against thioacetamide-induced liver cirrhosis in rats. Chem Biol Interact 5:26–33.
   Web of Science ®Google Scholar
• Ali SO, Darwish HA, Ismail NA. (2016). Curcumin, silybin-phytosome® and α-R-lipoic acid mitigate chronic hepatitis in rat by inhibiting oxidative stress and inflammatory cytokines production. Basic Clin Pharmacol Toxicol 118:369–80.
   PubMed Web of Science ®Google Scholar
• Alm-Eldeen AA, Mona MH, Shati AA, El-Mekkawy HI. (2015). Synergistic effect of black tea and curcumin in improving the hepatotoxicity induced by aflatoxin B1 in rats. Toxicol Ind Health 31:1269–80.
   PubMed Web of Science ®Google Scholar
• Awad AS, El-Sharif AA. (2011). Curcumin immune-mediated and anti-apoptotic mechanisms protect against renal ischemia/reperfusion and distant organ induced injuries. Int Immunopharmacol 11:992–6.
   PubMed Web of Science ®Google Scholar
• Badria FA, Ibrahim AS, Badria AF, Elmarakby AA. (2015). Curcumin attenuates iron accumulation and oxidative stress in the liver and spleen of chronic iron-overloaded rats. PLoS One 31:0134156.
   Google Scholar
• Bahmani M, Farkhondeh T, Sadighar P. (2012). The anti-parasitic effects of nicotina tabacum on leeches. Comp Clin Path 21:357–9.
   Google Scholar
• Bangphumi K, Kittiviriyakul C, Towiwat P, et al. (2015). Pharmacokinetics of curcumin diethyl disuccinate, a prodrug of curcumin, in Wistar rats. Eur J Drug Metab Pharmacokinet. [Epub ahead of print]. doi: 10.1007/s13318-015-0308-z.
   PubMedGoogle Scholar
• Chattopadhyay I, Biswas K, Bandyopadhyay U, Banerjee RK. (2004). Turmeric and curcumin: biological actions and medicinal applications. Curr Sci (Bangalore) 87:44–53.
   Web of Science ®Google Scholar
• Chen C, Fang H. (1997). Chemical analysis of the active principles of curcuma species. Mod Treat Chin Herb Med 3:95–105.
   Google Scholar
• Cheng A-L, Hsu C-H, Lin J-K, et al. (2001). Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. Anticancer Res 21:2895–900.
   PubMed Web of Science ®Google Scholar
• Chin D, Huebbe P, Frank J, et al. (2014). Curcumin may impair iron status when fed to mice for six months. Redox Biol 2:563–9.
   PubMed Web of Science ®Google Scholar
• Choudhury ST, Das N, Ghosh S, et al. (2016). Vesicular (liposomal and nanoparticulated) delivery of curcumin: a comparative study on carbon tetrachloride-mediated oxidative hepatocellular damage in rat model. Int J Nanomedicine 11:2179–93.
   PubMed Web of Science ®Google Scholar
• Cutrin JC, Crich SG, Burghelea D, et al. (2013). Curcumin/Gd loaded apoferritin: a novel “theranostic” agent to prevent hepatocellular damage in toxic induced acute hepatitis. Mol Pharm 10:2079–85.
   PubMed Web of Science ®Google Scholar
• Dcodhar S, Sethi R, Srimal R. (2013). Preliminary study on antirheumatic activity of curcumin (diferuloyl methane). Ind J Med Res 71:632–4..
   Google Scholar
• Eigner D, Scholz D. (1999). Ferula asa-foetida and Curcuma longa in traditional medical treatment and diet in Nepal. J Ethnopharmacol 67:1–6.
   PubMed Web of Science ®Google Scholar
• El-Bahr SM. (2015). Effect of curcumin on hepatic antioxidant enzymes activities and gene expressions in rats intoxicated with aflatoxin B1. Phytother Res 29:134–40.
   PubMed Web of Science ®Google Scholar
• Farahmand SK, Samini F, Samini M, Samarghandian S. (2013). Safranal ameliorates antioxidant enzymes and suppresses lipid peroxidation and nitric oxide formation in aged male rat liver. Biogerontology 14:63–71.
   PubMed Web of Science ®Google Scholar
• Farkhondeh T, Samarghandian S, Azimin-Nezhad M, Samini F. (2015). Effect of chrysin on nociception in formalin test and serum levels of noradrenalin and corticosterone in rats. Int J Clin Exp Med 8:2465–70.
   PubMed Web of Science ®Google Scholar
• Fazal Y, Fatima SN, Shahid SM, Mahboob T. (2015). Effects of curcumin on angiotensin-converting enzyme gene expression, oxidative stress and anti-oxidant status in thioacetamide-induced hepatotoxicity. J Renin Angiotensin Aldosterone Syst 16:1046–51.
   PubMed Web of Science ®Google Scholar
• Fu J, Shi Q, Song X, et al. (2016). Tetrachlorobenzoquinone exhibits neurotoxicity by inducing inflammatory responses through ROS-mediated IKK/IκB/NF-κB signaling. Environ Toxicol Pharmacol 41:241–50.
   PubMed Web of Science ®Google Scholar
• Galaly SR, Ahmed OM, Mahmoud AM. (2014). Thymoquinone and curcumin prevent gentamicin-induced liver injury by attenuating oxidative stress, inflammation and apoptosis. J Physiol Pharmacol 65:823–32.
   PubMed Web of Science ®Google Scholar
• Garcea G, Berry DP, Jones DJ, et al. (2005). Consumption of the putative chemopreventive agent curcumin by cancer patients: assessment of curcumin levels in the colorectum and their pharmacodynamic consequences. Cancer Epidemiol Biomarkers Prev 14:120–5.
   PubMed Web of Science ®Google Scholar
• Goo YK, Yamagishi J, Ueno A, et al. (2015). Characterization of toxoplasma gondii glyoxalase 1 and evaluation of inhibitory effects of curcumin on the enzyme and parasite cultures. Parasit Vectors 8:654.
   PubMed Web of Science ®Google Scholar
• Han W, Wu D, Liu H, et al. (2014). Curcumin alleviated liver oxidative stress injury of rat induced by paraquat. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 32:352–6.
   PubMedGoogle Scholar
• Hatcher H, Planalp R, Cho J, et al. (2008). Curcumin: from ancient medicine to current clinical trials. Cell Mol Life Sci 65:1631–52.
   PubMed Web of Science ®Google Scholar
• Holt PR, Katz S, Kirshoff R. (2005). Curcumin therapy in inflammatory bowel disease: a pilot study. Dig Dis Sci 50:2191–3.
   PubMed Web of Science ®Google Scholar
• Iqbal M, Sharma SD, Okazaki Y, et al. (2003). Dietary supplementation of curcumin enhances antioxidant and phase II metabolizing enzymes in ddY male mice: possible role in protection against chemical carcinogenesis and toxicity. Pharmacol Toxicol 92:33–8.
   PubMedGoogle Scholar
• Jain A, Samykutty A, Jackson C, et al. (2015). Curcumin inhibits PhIP induced cytotoxicity in breast epithelial cells through multiple molecular targets. Cancer Lett 365:122–31.
   PubMed Web of Science ®Google Scholar
• Lao CD, Ruffin MT, Normolle D, et al. (2006). Dose escalation of a curcuminoid formulation. BMC Complement Altern Med 6:10.
   PubMedGoogle Scholar
• Lu C, Zhang F, Xu W, et al. (2015). Curcumin attenuates ethanol-induced hepatic steatosis through modulating Nrf2/FXR signaling in hepatocytes. IUBMB Life 67:645–58.
   PubMed Web of Science ®Google Scholar
• Luthra PM, Lal N. (2016). Prospective of curcumin, a pleiotropic signalling molecule from Curcuma longa in the treatment of Glioblastoma. Eur J Med Chem 109:23–35.
   PubMed Web of Science ®Google Scholar
• Mahfouz ME. (2015). Ameliorative effect of curcumin on aflatoxin B1-induced changes in liver gene expression of Oreochromis niloticus. Mol Biol (Mosk) 49:313–24.
   PubMed Web of Science ®Google Scholar
• Man S, Li J, Liu J, et al. (2015). Curcumin alleviated the toxic reaction of Rhizoma Paridis saponins in a 45-day sub-chronic toxicological assessment of rats. Environ Toxicol.. [Epub ahead of print]. doi: 10.1002/tox.22194.
   Google Scholar
• Mendonça LM, Machado Cda S, Teixeira CC, et al. (2015). Comparative study of curcumin and curcumin formulated in a solid dispersion: evaluation of their antigenotoxic effects. Genet Mol Biol 38:490–8.
   PubMed Web of Science ®Google Scholar
• Mustafa HN. (2016). The role of curcumin in streptozotocin-induced hepatic damage and the trans-differentiation of hepatic stellate cells. Tissue Cell 48:81–8.
   PubMed Web of Science ®Google Scholar
• Palipoch S, Punsawad C, Koomhin P, Suwannalert P. (2014). Hepatoprotective effect of curcumin and alpha-tocopherol against cisplatin-induced oxidative stress. BMC Complement Altern Med 14:111.
   PubMed Web of Science ®Google Scholar
• Pandeya N. (2005). Old wives’ tales: modern miracles—turmeric as traditional medicine in India. Trees Life J 1:3..
   Google Scholar
• Parmar MS, Syed I, Gray JP, Ray SD. (2015). Curcumin, hesperidin, and rutin selectively interfere with apoptosis signaling and attenuate streptozotocin-induced oxidative stress-mediated hyperglycemia. Curr Neurovasc Res 12:363–74.
   PubMed Web of Science ®Google Scholar
• Patumraj S, Yoysungneon P. (2007). Curcumin as a therapeutic agent against cancer. Asian Biomed 1:239.
   Web of Science ®Google Scholar
• Pulikkotil SJ, Nath S. (2015). Effects of curcumin on crevicular levels of IL-1β and CCL28 in experimental gingivitis. Aust Dent J 60:317–27.
   PubMed Web of Science ®Google Scholar
• Sahu PK, Sahu PK, Sahu PL, Agarwal DD. (2015). Structure activity relationship, cytotoxicity and evaluation of antioxidant activity of curcumin derivatives. Bioorg Med Chem Lett 26:1342–7.
   PubMed Web of Science ®Google Scholar
• Samarghandian S, Afshari JT, Davoodi S. (2011a). Chrysin reduces proliferation and induces apoptosis in the human prostate cancer cell line pc-3. Clinics (Sao Paulo) 66:1073–9.
   PubMed Web of Science ®Google Scholar
• Samarghandian S, Afshari JT, Davoodi S. (2011b). Honey induces apoptosis in renal cell carcinoma. Pharmacogn Mag 7:46–52.
   PubMed Web of Science ®Google Scholar
• Samarghandian S, Asadi-Samani M, Farkhondeh T, Bahmani M. (2016a). Assessment the effect of saffron ethanolic extract (Crocus sativus L.) on oxidative damages in aged male rat. Der Pharmacia Lettre 8:283–90.
   Google Scholar
• Samarghandian S, Azimi-Nezhad M, Mehrad-Majd H, Mirhafez SR. (2015). Thymoquinone ameliorates acute renal failure in gentamicin-treated adult male rats. Pharmacology 96:112–17.
   PubMed Web of Science ®Google Scholar
• Samarghandian S, Azimi-Nezhad M, Samini F, Farkhondeh T. (2016b). Chrysin treatment improves diabetes and its complications in liver, brain, and pancreas in streptozotocin-induced diabetic rats. Can J Physiol Pharmacol 94:388–93.
   PubMed Web of Science ®Google Scholar
• Samarghandian S, Borji A, Delkhosh MB, Samini F. (2013a). Safranal treatment improves hyperglycemia, hyperlipidemia and oxidative stress in streptozotocin-induced diabetic rats. J Pharm Sci 16:352–62.
   Web of Science ®Google Scholar
• Samarghandian S, Borji A, Farahmand SK, et al. (2013b). Crocus sativus L. (saffron) stigma aqueous extract induces apoptosis in alveolar human lung cancer cells through caspase-dependent pathways activation. Biomed Res Int 2013:417928.
   PubMed Web of Science ®Google Scholar
• Samarghandian S, Boskabady MH, Davoodi S. (2010). Use of in vitro assays to assess the potential antiproliferative and cytotoxic effects of saffron (Crocus sativus L.) in human lung cancer cell line. Pharmacogn Mag 6:309–14.
   PubMed Web of Science ®Google Scholar
• Samarghandian S, Farkhondeh T, Samini F, Borji A. (2016c). Protective effects of carvacrol against oxidative stress induced by chronic stress in rat's brain, liver, and kidney. Biochem Res Int 2016:2645237.
   PubMed Web of Science ®Google Scholar
• Samarghandian S, Hadjzadeh MA, Amin Nya F, Davoodi S. (2012). Antihyperglycemic and antihyperlipidemic effects of guar gum on streptozotocin-induced diabetes in male rats. Pharmacogn Mag 8:65–72.
   PubMed Web of Science ®Google Scholar
• Samarghandian S, Shabestari MM. (2013). DNA fragmentation and apoptosis induced by safranal in human prostate cancer cell line. Indian J Urol 29:177–83.
   PubMedGoogle Scholar
• Samarghandian S, Tavakkol Afshari J, Davoodi S. (2011c). Suppression of pulmonary tumor promotion and induction of apoptosis by Crocus sativus L. extraction. Appl Biochem Biotechnol 164:238–47.
   PubMed Web of Science ®Google Scholar
• Samini F, Samarghandian S, Borji A, et al. (2013). Curcumin pretreatment attenuates brain lesion size and improves neurological function following traumatic brain injury in the rat. Pharmacol Biochem Behav 110:238–44.
   PubMed Web of Science ®Google Scholar
• Sarlak N, Sadighara P. (2015). Nutritional-qualitative factors changes during ripening of canned olives at different temperatures storage. Carpath J Food Sci Technol 7:19–27.
   Google Scholar
• Sharma RA, McLelland HR, Hill KA, et al. (2001). Pharmacodynamic and pharmacokinetic study of oral Curcuma extract in patients with colorectal cancer. Clin Cancer Res 7:1894–900.
   PubMed Web of Science ®Google Scholar
• Thayyullathil F, Chathoth S, Hago A, et al. (2008). Rapid reactive oxygen species (ROS) generation induced by curcumin leads to caspase-dependent and -independent apoptosis in L929 cells. Free Radic Biol Med 45:1403–12.
   PubMed Web of Science ®Google Scholar
• Tilak JC, Banerjee M, Mohan H, Devasagayam T. (2004). Antioxidant availability of turmeric in relation to its medicinal and culinary uses. Phytother Res 18:798–804.
   PubMed Web of Science ®Google Scholar
• Varatharajalu R, Garige M, Leckey LC, et al. (2016). Protective role of dietary curcumin in the prevention of the oxidative stress induced by chronic alcohol with respect to hepatic injury and antiatherogenic markers. Oxid Med Cell Longev 2016:5017460.
   PubMed Web of Science ®Google Scholar
• Waseem M, Pandey P, Tomar B, et al. (2014). Ameliorative action of curcumin in cisplatin-mediated hepatotoxicity: an in vivo study in Wistar rats. Arch Med Res 45:462–8.
   PubMed Web of Science ®Google Scholar
• Wu GQ, Chai KQ, Zhu XM, et al. (2016). Anti-cancer effects of curcumin on lung cancer through the inhibition of EZH2 and NOTCH. Oncotarget. [Epub ahead of print]. doi: 10.18632/oncotarget.8532.
   Web of Science ®Google Scholar
• Xiong ZE, Dong WG, Wang BY, et al. (2015). Curcumin attenuates chronic ethanol-induced liver injury by inhibition of oxidative stress via mitogen-activated protein kinase/nuclear factor E2-related factor 2 pathway in mice. Pharmacogn Mag 11:707–15.
   PubMed Web of Science ®Google Scholar
• Xu D, Hu L, Su C, et al. (2014). Tetrachloro-p-benzoquinone induces hepatic oxidative damage and inflammatory response, but not apoptosis in mouse: the prevention of curcumin. Toxicol Appl Pharmacol 15:305–13.
   Web of Science ®Google Scholar
• Xu Y, Lin D, Li S, et al. (2009). Curcumin reverses impaired cognition and neuronal plasticity induced by chronic stress. Neuropharmacology 57:463–71.
   PubMed Web of Science ®Google Scholar
• Yu W, Wu J, Cai F, et al. (2013). Curcumin alleviates diabetic cardiomyopathy in experimental diabetic rats. PLoS One 7:52013.
   Web of Science ®Google Scholar
• Yun DG, Lee DG. (2016). Antibacterial activity of curcumin via apoptosis-like response in Escherichia coli. Appl Microbiol Biotechnol 100:5505–14.
   PubMed Web of Science ®Google Scholar
• Zhang W, Chen C, Shi H, et al. (2016). Curcumin is a biologically active copper chelator with antitumor activity. Phytomedicine 23:1–8.
   PubMed Web of Science ®Google Scholar