9
Views
0
CrossRef citations to date
0
Altmetric
Research Article

Evaluation of toxicity of thymoquinone, as a bioactive compound of nigella sativa using isolated mitochondria from different organs

ORCID Icon, , , , &
Received 07 Feb 2023, Accepted 13 Apr 2024, Published online: 22 Apr 2024

References

  • Aghvami, M., et al., 2018. Matrine induction of ROS mediated apoptosis in human ALL B-lymphocytes via mitochondrial targeting. Asian Pacific journal of cancer prevention, 19, 555–560.
  • Akbar, M., et al., 2016. Mitochondrial dysfunction and cell death in neurodegenerative diseases through nitroxidative stress. Brain research, 1637, 34–55.
  • Al-Gabri, N.A., et al., 2021. Therapeutic potential of thymoquinone and its nanoformulations in pulmonary injury: a comprehensive review. International journal of nanomedicine, 16, 5117–5131.
  • Al-Hayali, M., et al., 2021. Concurrent reactive oxygen species generation and aneuploidy induction contribute to thymoquinone anticancer activity. Molecules (Basel, Switzerland), 26 (17), 5136.
  • Ali, T., et al., 2022. Nanotechnology approach for exploring the enhanced bioactivities and biochemical characterization of freshly prepared Nigella sativa L. nanosuspensions and their phytochemical profile. Frontiers in bioengineering and biotechnology, 10, 888177.
  • Alkharfy, K.M., et al., 2015. Pharmacokinetic plasma behaviors of intravenous and oral bioavailability of thymoquinone in a rabbit model. European journal of drug metabolism and pharmacokinetics, 40 (3), 319–323.
  • Amigo, I., Traba, J., and Rueda, C.B., 2016. Isolating liver mitochondria by differential centrifugation. Bio-protocol, 6 (10), e1809–e1809.
  • Avadhani, N.G., et al., 2011. Bimodal targeting of cytochrome P450s to endoplasmic reticulum and mitochondria: the concept of chimeric signals. The FEBS journal, 278 (22), 4218–4229.
  • Begriche, K., et al., 2011. Drug-induced toxicity on mitochondria and lipid metabolism: Mechanistic diversity and deleterious consequences for the liver. Journal of hepatology, 54 (4), 773–794.
  • Behzadfar, L., et al., 2017. Potentiating role of copper on spatial memory deficit induced by beta amyloid and evaluation of mitochondrial function markers in the hippocampus of rats. Metallomics: integrated biometal science, 9 (7), 969–980.
  • Bernardi, P., et al., 2015. The mitochondrial permeability transition pore: channel formation by F-ATP synthase, integration in signal transduction, and role in pathophysiology. Physiological reviews, 95 (4), 1111–1155.
  • Bolton, J.L., and Dunlap, T., 2017. Formation and biological targets of quinones: cytotoxic versus cytoprotective effects. Chemical research in toxicology, 30 (1), 13–37.
  • Darakhshan, S., et al., 2015. Thymoquinone and its therapeutic potentials. Pharmacological research, 95-96, 138–158.
  • Ding, Q., Qi, Y., and Tsang, S.Y., 2021. Mitochondrial biogenesis, mitochondrial dynamics, and mitophagy in the maturation of cardiomyocytes. Cells, 10 (9), 2463.
  • Dykens, J.A., and Will, Y., 2007. The significance of mitochondrial toxicity testing in drug development. drug discovery today, 12 (17-18), 777–785.
  • Gostimskaya, I., and Galkin, A., 2010. Preparation of highly coupled rat heart mitochondria. Journal of visualized experiments: JOVE, (43).
  • Goyal, S.N., et al., 2017. Therapeutic potential and pharmaceutical development of thymoquinone: a multitargeted molecule of natural origin. Frontiers in pharmacology, 8, 656.
  • Hadrava Vanova, K., et al., 2020. Mitochondrial complex II and reactive oxygen species in disease and therapy. Redox report: communications in free radical research, 25 (1), 26–32.
  • Hajjawi, O.S., 2011. Succinate dehydrogenase: assembly, regulation and role in human disease. European journal of scientific research, 51, 133–142.
  • Khader, M., Bresgen, N., and Eckl, P.M., 2009. In vitro toxicological properties of thymoquinone. Food and chemical toxicology: an international journal published for the British Industrial Biological Research Association, 47 (1), 129–133.
  • Khader, M., and Eckl, P.M., 2014. Thymoquinone: an emerging natural drug with a wide range of medical applications. Iranian journal of basic medical sciences, 17 (12), 950–957.
  • Khezri, S., et al., 2020. Chrysin ameliorates aluminum p hosphide-induced oxidative stress and mitochondrial damages in rat cardiomyocytes and isolated mitochondria. Environmental toxicology, 35 (10), 1114–1124.
  • Kristian, T., 2010. Isolation of mitochondria from the CNS. Current protocols in neuroscience, Chapter 7 (1), Unit 7.22.
  • Lavrich, K.S., et al., 2018. Investigating mitochondrial dysfunction in human lung cells exposed to redox-active PM components. Toxicology and applied pharmacology, 342, 99–107.
  • Li, C., et al., 2019. Recent progress in drug delivery. Acta pharmaceutica sinica. B, 9 (6), 1145–1162.
  • Lin, Y.T., et al., 2021. MitoTox: a comprehensive mitochondrial toxicity database. BMC bioinformatics, 22 (Suppl 10), 369.
  • Luo, Y., Ma, J., and Lu, W., 2020. The significance of mitochondrial dysfunction in cancer. International journal of molecular sciences, 21 (16), 5598.
  • Madeo, J., Zubair, A., and Marianne, F., 2013. A review on the role of quinones in renal disorders. Springerplus, 2 (1), 139.
  • Mahmoud, Y.K., and Abdelrazek, H.M.A., 2019. Cancer: thymoquinone antioxidant/pro-oxidant effect as potential anticancer remedy. Biomedicine & pharmacotherapy = biomedecine & pharmacotherapie, 115, 108783.
  • Mashayekhi-Sardoo, H., Rezaee, R., and Karimi, G., 2018. An overview of in vivo toxicological profile of thymoquinone. Toxin reviews, 39 (2), 115–122.
  • Micakovic, T., et al., 2019. Isolation of pure mitochondria from rat kidneys and western blot of mitochondrial respiratory chain complexes. Bio-protocol, 9 (19), e3379.
  • Mohammadabadi, M., and Mozafari, M., 2018. Enhanced efficacy and bioavailability of thymoquinone using nanoliposomal dosage form. Journal of drug delivery science and technology, 47, 445–453.
  • Ramachandran, A., et al., 2018. Mitochondrial dysfunction as a mechanism of drug-induced hepatotoxicity: current understanding and future perspectives. Journal of clinical and translational research, 4 (1), 75–100.
  • Rana, P., et al., 2018. Evaluation of in vitro mitochondrial toxicity assays and physicochemical properties for prediction of organ toxicity using 228 pharmaceutical drugs. Chemical research in toxicology, 32 (1), 156–167.
  • Reddam, A., Mclarnan, S., and Kupsco, A., 2022. Environmental chemical exposures and mitochondrial dysfunction: a review of recent literature. Current environmental health reports, 9 (4), 631–649.
  • Sabet, N.S., et al., 2020. Curcumin attenuates bevacizumab-induced toxicity via suppressing oxidative stress and preventing mitochondrial dysfunction in heart mitochondria. Naunyn-Schmiedeberg’s archives of pharmacology, 393 (8), 1447–1457.
  • Sesso, A., et al., 2012. Mitochondrial swelling and incipient outer membrane rupture in preapoptotic and apoptotic cells. Anatomical record (Hoboken, N.J. : 2007)), 295 (10), 1647–1659.
  • Shields, H.J., Traa, A., and Van Raamsdonk, J.M., 2021. Beneficial and detrimental effects of reactive oxygen species on lifespan: a comprehensive review of comparative and experimental studies. Frontiers in cell and developmental biology, 9, 628157.
  • Stelmashook, E.V., et al., 2020. Thymoquinone induces mitochondrial damage and death of cerebellar granule neurons. Biochemistry. biokhimiia, 85 (2), 205–212.
  • Vis, M.A., Ito, K., and Hofmann, S., 2020. Impact of culture medium on cellular interactions in in vitro co-culture systems. Frontiers in bioengineering and biotechnology, 8, 911.
  • Wani, M.R., and Shadab, G., 2021. Antioxidant thymoquinone and eugenol alleviate TiO(2) nanoparticle-induced toxicity in human blood cells in vitro. Toxicology mechanisms and methods, 31 (8), 619–629.
  • Will, Y., Shields, J.E., and Wallace, K.B., 2019. Drug-induced mitochondrial toxicity in the geriatric population: challenges and future directions. Biology, 8 (2), 1–14.
  • Wu, D., Wang, X., and Sun, H., 2018. The role of mitochondria in cellular toxicity as a potential drug target. Cell biology and toxicology, 34 (2), 87–91.
  • Yu, S.M., and Kim, S.J., 2013. Thymoquinone-induced reactive oxygen species causes apoptosis of chondrocytes via PI3K/Akt and p38kinase pathway. Experimental biology and medicine (Maywood, N.J.), 238 (7), 811–820.
  • Zakarial Ansar, F.H., et al., 2020. Pharmacokinetics and biodistribution of thymoquinone-loaded nanostructured lipid carrier after oral and intravenous administration into rats. International journal of nanomedicine, 15, 7703–7717.
  • Zolkipli-Cunningham, Z., and Falk, M.J., 2017. Clinical effects of chemical exposures on mitochondrial function. Toxicology, 391, 90–99.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.