267
Views
27
CrossRef citations to date
0
Altmetric
Original Investigation

Reactivity to addictive drugs in the methylazoxymethanol (MAM) model of schizophrenia in male and female rats

, , , , , & show all
Pages 129-142 | Received 10 Dec 2015, Accepted 09 May 2016, Published online: 21 Jun 2016

References

  • Abel KM, Drake R, Goldstein JM. 2010. Sex differences in schizophrenia. Int Rev Psychiatry. 22:417–428.
  • Amchova P, Kucerova J, Giugliano V, Babinska Z, Zanda MT, Scherma M, Dusek L, Fadda P, Micale V, Sulcova A, Fratta W, Fattore L. 2014. Enhanced self-administration of the CB1 receptor agonist WIN55,212-2 in olfactory bulbectomized rats: evaluation of possible serotonergic and dopaminergic underlying mechanisms. Front Pharmacol. 5:44.
  • Anderson ML, Nokia MS, Govindaraju KP, Shors TJ. 2012. Moderate drinking? Alcohol consumption significantly decreases neurogenesis in the adult hippocampus. Neuroscience. 224:202–209.
  • Bahorik AL, Newhill CE, Eack SM. 2013. Characterizing the longitudinal patterns of substance use among individuals diagnosed with serious mental illness after psychiatric hospitalization. Addiction. 108:1259–1269.
  • Becker JB, Perry AN, Westenbroek C. 2012. Sex differences in the neural mechanisms mediating addiction: a new synthesis and hypothesis. Biol Sex Differ. 3:14.
  • Berg SA, Czachowski CL, Chambers RA. 2011. Alcohol seeking and consumption in the NVHL neurodevelopmental rat model of schizophrenia. Behav Brain Res. 218:346–349.
  • Brady AM, McCallum SE, Glick SD, O'Donnell P. 2008. Enhanced methamphetamine self-administration in a neurodevelopmental rat model of schizophrenia. Psychopharmacology (Berl). 200:205–215.
  • Brisch R, Saniotis A, Wolf R, Bielau H, Bernstein HG, Steiner J, Bogerts B, Braun K, Jankowski Z, Kumaratilake J, Henneberg M, Gos T. 2014. The role of dopamine in schizophrenia from a neurobiological and evolutionary perspective: old fashioned, but still in vogue. Front Psychiatry. 5:47.
  • Caspi A, Moffitt TE, Cannon M, McClay J, Murray R, Harrington H, Taylor A, Arseneault L, Williams B, Braithwaite A, Poulton R, Craig IW. 2005. Moderation of the effect of adolescent-onset cannabis use on adult psychosis by a functional polymorphism in the catechol-O-methyltransferase gene: longitudinal evidence of a gene X environment interaction. Biol Psychiatry. 57:1117–1127.
  • Chambers RA, Krystal JH, Self DW. 2001. A neurobiological basis for substance abuse comorbidity in schizophrenia. Biol Psychiatry. 50:71–83.
  • Chambers RA, Self DW. 2002. Motivational responses to natural and drug rewards in rats with neonatal ventral hippocampal lesions: an animal model of dual diagnosis schizophrenia. Neuropsychopharmacology. 27:889–905.
  • Chambers RA, Taylor JR. 2004. Animal modeling dual diagnosis schizophrenia: sensitization to cocaine in rats with neonatal ventral hippocampal lesions. Biol Psychiatry. 56:308–316.
  • Conroy SK, Rodd Z, Chambers RA. 2007. Ethanol sensitization in a neurodevelopmental lesion model of schizophrenia in rats. Pharmacol Biochem Behav. 86:386–394.
  • Cox BM, Young AB, See RE, Reichel CM. 2013. Sex differences in methamphetamine seeking in rats: impact of oxytocin. Psychoneuroendocrinology. 38:2343–2353.
  • Czachowski CL. 2005. Manipulations of serotonin function in the nucleus accumbens core produce differential effects on ethanol and sucrose seeking and intake. Alcohol Clin Exp Res. 29:1146–1155.
  • Di Chiara G, Bassareo V, Fenu S, De Luca MA, Spina L, Cadoni C, Acquas E, Carboni E, Valentini V, Lecca D. 2004. Dopamine and drug addiction: the nucleus accumbens shell connection. Neuropharmacology. 47:227–241.
  • Du Y, Grace AA. 2013. Peripubertal diazepam administration prevents the emergence of dopamine system hyperresponsivity in the MAM developmental disruption model of schizophrenia. Neuropsychopharmacology. 38:1881–1888.
  • Featherstone RE, Burton CL, Coppa-Hopman R, Rizos Z, Sinyard J, Kapur S, Fletcher PJ. 2009. Gestational treatment with methylazoxymethanol (MAM) that disrupts hippocampal-dependent memory does not alter behavioural response to cocaine. Pharmacol Biochem Behav. 93:382–390.
  • Ford MM, Eldridge JC, Samson HH. 2002. Ethanol consumption in the female Long-Evans rat: a modulatory role of estradiol. Alcohol. 26:103–113.
  • Fuchs RA, Branham RK, See RE. 2006. Different neural substrates mediate cocaine seeking after abstinence versus extinction training: a critical role for the dorsolateral caudate-putamen. J Neurosci. 26:3584–3588.
  • Gomez JL, Luine VN. 2014. Female rats exposed to stress and alcohol show impaired memory and increased depressive-like behaviors. Physiol Behav. 123:47–54.
  • Grant KM, LeVan TD, Wells SM, Li M, Stoltenberg SF, Gendelman HE, Carlo G, Bevins RA. 2012. Methamphetamine-associated psychosis. J Neuroimmune Pharmacol. 7:113–139.
  • Gururajan A, Manning EE, Klug M, van den Buuse M. 2012. Drugs of abuse and increased risk of psychosis development. Aust N Z J Psychiatry. 46:1120–1135.
  • Hahn B, Harvey AN, Concheiro-Guisan M, Huestis MA, Holcomb HH, Gold JM. 2013. A test of the cognitive self-medication hypothesis of tobacco smoking in schizophrenia. Biol Psychiatry. 74:436–443.
  • Hall W, Degenhardt L. 2015. High potency cannabis: a risk factor for dependence, poor psychosocial outcomes, and psychosis. BMJ. 350:h1205.
  • Harrod SB, Booze RM, Welch M, Browning CE, Mactutus CF. 2005. Acute and repeated intravenous cocaine-induced locomotor activity is altered as a function of sex and gonadectomy. Pharmacol Biochem Behav. 82:170–181.
  • Hartz SM, Pato CN, Medeiros H, Cavazos-Rehg P, Sobell JL, Knowles JA, Bierut LJ, Pato MT. 2014. Comorbidity of severe psychotic disorders with measures of substance use. JAMA Psychiatry. 71:248–254.
  • Hazane F, Krebs MO, Jay TM, Le Pen G. 2009. Behavioral perturbations after prenatal neurogenesis disturbance in female rat. Neurotox Res. 15:311–320.
  • Holtz NA, Lozama A, Prisinzano TE, Carroll ME. 2012. Reinstatement of methamphetamine seeking in male and female rats treated with modafinil and allopregnanolone. Drug Alcohol Depend. 120:233–237.
  • Jeanblanc J, Balguerie K, Coune F, Legastelois R, Jeanblanc V, Naassila M. 2014. Light alcohol intake during adolescence induces alcohol addiction in a neurodevelopmental model of schizophrenia. Addict Biol. 20:490–499.
  • Johnson JL, Ratner PA, Malchy LA, Okoli CT, Procyshyn RM, Bottorff JL, Groening M, Schultz A, Osborne M. 2010. Gender-specific profiles of tobacco use among non-institutionalized people with serious mental illness. BMC Psychiatry. 10:101.
  • Juarez J, Barrios de Tomasi E. 1999. Sex differences in alcohol drinking patterns during forced and voluntary consumption in rats. Alcohol. 19:15–22.
  • Kalejaiye O, Bhatti BH, Taylor RE, Tizabi Y. 2013. Nicotine blocks the depressogenic effects of alcohol: implications for drinking-smoking co-morbidity. J Drug Alcohol Res. 2:235709.
  • Kalyoncu A, Mirsal H, Pektas O, Unsalan N, Tan D, Beyazyurek M. 2005. Use of lamotrigine to augment clozapine in patients with resistant schizophrenia and comorbid alcohol dependence: a potent anti-craving effect? J Psychopharmacol. 19:301–305.
  • Karlsson RM, Kircher DM, Shaham Y, O'Donnell P. 2013. Exaggerated cue-induced reinstatement of cocaine seeking but not incubation of cocaine craving in a developmental rat model of schizophrenia. Psychopharmacology (Berl). 226:45–51.
  • Kern AM, Akerman SC, Nordstrom BR. 2014. Opiate dependence in schizophrenia: case presentation and literature review. J Dual Diagn. 10:52–57.
  • Kerner B. 2015. Comorbid substance use disorders in schizophrenia: a latent class approach. Psychiatry Res. 225:395–401.
  • Khantzian EJ. 1985. The self-medication hypothesis of addictive disorders: focus on heroin and cocaine dependence. Am J Psychiatry. 142:1259–1264.
  • Koskinen J, Lohonen J, Koponen H, Isohanni M, Miettunen J. 2009. Prevalence of alcohol use disorders in schizophrenia–a systematic review and meta-analysis. Acta Psychiatr Scand. 120:85–96.
  • Krystal JH, D'Souza DC, Gallinat J, Driesen N, Abi-Dargham A, Petrakis I, Heinz A, Pearlson G. 2006. The vulnerability to alcohol and substance abuse in individuals diagnosed with schizophrenia. Neurotox Res. 10:235–252.
  • Kucerova J, Pistovcakova J, Vrskova D, Dusek L, Sulcova A. 2012. The effects of methamphetamine self-administration on behavioural sensitization in the olfactory bulbectomy rat model of depression. Int. J. Neuropsychopharmacol. 15:1503–1511.
  • Kucerova J, Tabiova K, Drago F, Micale V. 2014. Therapeutic potential of cannabinoids in schizophrenia. Recent Pat CNS Drug Discov. 9:13–25.
  • Kucerova J, Vrskova D, Sulcova A. 2009. Impact of repeated methamphetamine pretreatment on intravenous self-administration of the drug in males and estrogenized or non- estrogenized ovariectomized female rats. Neuro Endocrinol Lett. 30:663–670.
  • Liu X, Lee JG, Yee SK, Bresee CJ, Poland RE, Pechnick RN. 2004. Endotoxin exposure in utero increases ethanol consumption in adult male offspring. Neuroreport. 15:203–206.
  • Lodge DJ, Grace AA. 2009. Gestational methylazoxymethanol acetate administration: a developmental disruption model of schizophrenia. Behav Brain Res. 204:306–312.
  • Lodge DJ, Grace AA. 2012. Divergent activation of ventromedial and ventrolateral dopamine systems in animal models of amphetamine sensitization and schizophrenia. Int J Neuropsychopharmacol. 15:69–76.
  • Lybrand J, Caroff S. 2009. Management of schizophrenia with substance use disorders. Psychiatr Clin North Am. 32:821–833.
  • Lynch WJ, Carroll ME. 2000. Reinstatement of cocaine self-administration in rats: sex differences. Psychopharmacology (Berl). 148:196–200.
  • Lynch WJ, Taylor JR. 2004. Sex differences in the behavioral effects of 24-h/day access to cocaine under a discrete trial procedure. Neuropsychopharmacology. 29:943–951.
  • Mackowick KM, Barr MS, Wing VC, Rabin RA, Ouellet-Plamondon C, George TP. 2014. Neurocognitive endophenotypes in schizophrenia: modulation by nicotinic receptor systems. Prog Neuropsychopharmacol Biol Psychiatry. 52:79–85.
  • Malave LB, Broderick PA. 2014. Caffeine's Attenuation of Cocaine-Induced Dopamine Release by Inhibition of Adenosine. J Caffeine Res. 4:35–40.
  • McLean D, Gladman B, Mowry B. 2011. Significant relationship between lifetime alcohol use disorders and suicide attempts in an Australian schizophrenia sample. Aust N Z J Psychiatry. 46:132–140.
  • McLoughlin BC, Pushpa-Rajah JA, Gillies D, Rathbone J, Variend H, Kalakouti E, Kyprianou K. 2014. Cannabis and schizophrenia. Cochrane Database Syst Rev. 10:CD004837.
  • Melle I, Johannessen JO, Friis S, Haahr U, Joa I, Larsen TK, Opjordsmoen S, Rund BR, Simonsen E, Vaglum P, McGlashan T. 2010. Course and predictors of suicidality over the first two years of treatment in first-episode schizophrenia spectrum psychosis. Arch Suicide Res. 14:158–170.
  • Mendrek A. 2015. Is It Important to Consider Sex and Gender in Neurocognitive Studies? Front Psychiatry. 6:83.
  • Mesholam-Gately RI, Gibson LE, Seidman LJ, Green AI. 2014. Schizophrenia and co-occurring substance use disorder: reward, olfaction and clozapine. Schizophr Res. 155:45–51.
  • Micale V, Kucerova J, Sulcova A. 2013. Leading compounds for the validation of animal models of psychopathology. Cell Tissue Res 354:309–330.
  • Moore H, Jentsch JD, Ghajarnia M, Geyer MA, Grace AA. 2006. A neurobehavioral systems analysis of adult rats exposed to methylazoxymethanol acetate on E17: implications for the neuropathology of schizophrenia. Biol Psychiatry. 60:253–64.
  • Murawski NJ, Stanton ME. 2011. Effects of dose and period of neonatal alcohol exposure on the context preexposure facilitation effect. Alcohol Clin Exp Res. 35:1160–1170.
  • Ng E, McGirr A, Wong AH, Roder JC. 2013. Using rodents to model schizophrenia and substance use comorbidity. Neurosci Biobehav Rev. 37:896–910.
  • O'Connor EC, Chapman K, Butler P, Mead AN. 2011. The predictive validity of the rat self-administration model for abuse liability. Neurosci Biobehav Rev. 35:912–38.
  • Perez SM, Carreno FR, Frazer A, Lodge DJ. 2014. Vagal nerve stimulation reverses aberrant dopamine system function in the methylazoxymethanol acetate rodent model of schizophrenia. J Neurosci. 34:9261–9267.
  • Perez SM, Shah A, Asher A, Lodge DJ. 2013. Hippocampal deep brain stimulation reverses physiological and behavioural deficits in a rodent model of schizophrenia. Int J Neuropsychopharmacol. 16:1331–1339.
  • Piano MR, Carrigan TM, Schwertz DW. 2005. Sex differences in ethanol liquid diet consumption in Sprague-Dawley rats. Alcohol. 35:113–118.
  • Piano MR, Geenen DL, Schwertz DW, Chowdhury SA, Yuzhakova M. 2007. Long-term effects of alcohol consumption in male and female rats. Cardiovasc Toxicol. 7:247–54.
  • Pistovcakova J, Dostalek M, Sulcova A, Jezova D. 2008. Tiagabine treatment is associated with neurochemical, immune and behavioural alterations in the olfactory bulbectomized rat model of depression. Pharmacopsychiatry. 41:54–59.
  • Regier DA, Farmer ME, Rae DS, Locke BZ, Keith SJ, Judd LL, Goodwin FK. 1990. Comorbidity of mental disorders with alcohol and other drug abuse. Results from the Epidemiologic Catchment Area (ECA) Study. JAMA. 264:2511–2518.
  • Reichel CM, Bevins RA. 2009. Forced abstinence model of relapse to study pharmacological treatments of substance use disorder. Curr Drug Abuse Rev. 2:184–194.
  • Reichel CM, Chan CH, Ghee SM, See RE. 2012. Sex differences in escalation of methamphetamine self-administration: cognitive and motivational consequences in rats. Psychopharmacology (Berl). 223:371–380.
  • Richtand NM, Ahlbrand R, Horn PS, Chambers B, Davis J, Benoit S. 2012. Effects of prenatal immune activation and peri-adolescent stress on amphetamine-induced conditioned place preference in the rat. Psychopharmacology (Berl). 222:313–324.
  • Robinson TE. 1984. Behavioral sensitization: characterization of enduring changes in rotational behavior produced by intermittent injections of amphetamine in male and female rats. Psychopharmacology (Berl). 84:466–475.
  • Robinson TE, Becker JB, Presty SK. 1982. Long-term facilitation of amphetamine-induced rotational behavior and striatal dopamine release produced by a single exposure to amphetamine: sex differences. Brain Res. 253:231–241.
  • Roth ME, Carroll ME. 2004. Sex differences in the acquisition of IV methamphetamine self-administration and subsequent maintenance under a progressive ratio schedule in rats. Psychopharmacology. 172:443–449.
  • Ruda-Kucerova J, Amchova P, Babinska Z, Dusek L, Micale V, Sulcova A. 2015a. Sex differences in the reinstatement of methamphetamine seeking after forced abstinence in Sprague-Dawley rats. Front Psychiatry. 6:8.
  • Ruda-Kucerova J, Amchova P, Halickova T, Jerabek P, Babinska Z, Kacer P, Syslova K, Sulcova A, Sustkova-Fiserova M. 2015b. Reward related neurotransmitter changes in a model of depression: an in vivo microdialysis study. World J Biol Psychiatry. 16:521-535.
  • Samaha AN. 2014. Can antipsychotic treatment contribute to drug addiction in schizophrenia? Prog Neuropsychopharmacol Biol Psychiatry. 52:9–16.
  • Samson HH, Pfeffer AO, Tolliver GA. 1988. Oral ethanol self-administration in rats: models of alcohol-seeking behavior. Alcohol Clin Exp Res. 12:591–598.
  • Semple DM, McIntosh AM, Lawrie SM. 2005. Cannabis as a risk factor for psychosis: systematic review. J Psychopharmacol. 19:187–194.
  • Schindler CW, Bross JG, Thorndike EB. 2002. Gender differences in the behavioral effects of methamphetamine. Eur J Pharmacol. 442:231–235.
  • Schmidt LM, Hesse M, Lykke J. 2011. The impact of substance use disorders on the course of schizophrenia–a 15-year follow-up study: dual diagnosis over 15 years. Schizophr Res. 130:228–233.
  • Stohr T, Schulte Wermeling D, Weiner I, Feldon J. 1998. Rat strain differences in open-field behavior and the locomotor stimulating and rewarding effects of amphetamine. Pharmacol Biochem Behav. 59:813–818.
  • Tseng KY, Chambers RA, Lipska BK. 2009. The neonatal ventral hippocampal lesion as a heuristic neurodevelopmental model of schizophrenia. Behav Brain Res. 204:295–305.
  • van Haaren F, Meyer ME. 1991. Sex differences in locomotor activity after acute and chronic cocaine administration. Pharmacol Biochem Behav. 39:923–927.
  • van Hest A, van Haaren F, van de Poll NE. 1987. Behavioral differences between male and female Wistar rats in food rewarded lever holding. Physiol Behav. 39:263–267.
  • Volkow ND. 2004. The reality of comorbidity: depression and drug abuse. Biol Psychiatry. 56:714–717.
  • Volkow ND. 2009. Substance use disorders in schizophrenia–clinical implications of comorbidity. Schizophr Bull. 35:469–472.
  • Wedekind D, Jacobs S, Karg I, Luedecke C, Schneider U, Cimander K, Baumann P, Ruether E, Poser W, Havemann-Reinecke U. 2010. Psychiatric comorbidity and additional abuse of drugs in maintenance treatment with L- and D,L-methadone. World J Biol Psychiatry. 11:390–399.
  • Wing VC, Wass CE, Soh DW, George TP. 2012. A review of neurobiological vulnerability factors and treatment implications for comorbid tobacco dependence in schizophrenia. Ann N Y Acad Sci. 1248:89–106.
  • Yahyavi-Firouz-Abadi N, See RE. 2009. Anti-relapse medications: preclinical models for drug addiction treatment. Pharmacol Ther. 124:235–247.
  • Yui K, Ikemoto S, Ishiguro T, Goto K. 2000. Studies of amphetamine or methamphetamine psychosis in Japan: relation of methamphetamine psychosis to schizophrenia. Ann N Y Acad Sci. 914:1–12.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.