Biochemical, physiological, and performance response of a functional watermelon juice enriched in L-citrulline during a half-marathon race

References

• Bescós R, Sureda A, Tur JA, et al. The effect of nitric-oxide-related supplements on human performance. Sports Med. 2012;42:99–12. DOI: 10.2165/11596860-000000000-00000
   PubMed Web of Science ®Google Scholar
• Curis E, Nicolis I, Moinard C, et al. Almost all about citrulline in mammals. Amino Acids. 2005;29:177–205. DOI:10.1007/s00726-005-0235-4
   PubMed Web of Science ®Google Scholar
• Suzuki T, Morita M, Kobayashi Y, et al. Oral l-citrulline supplementation enhances cycling time trial performance in healthy trained men: double-blind randomized PLA-controlled 2-way crossover study. J Int Soc Sports Nutr. 2016;13:1–8.
   Web of Science ®Google Scholar
• Glenn JM, Gray M, Wethington LN, et al. Acute citrulline malate supplementation improves upper- and lower-body submaximal weightlifting exercise performance in resistance-trained females. Eur J Nutr. 2015;11:1–10.
   Google Scholar
• Petrovic V, Buzadzic B, Korac A, et al. Antioxidative defence alterations in skeletal muscle during prolonged acclimation to cold: role of l-arginine/NO-producing pathway. J Exp Biol. 2008;211:114–120.
   PubMed Web of Science ®Google Scholar
• Meneguello MO, Mendoca JR, Lancha AH, et al. Effect of arginine, ornithine and citrulline supplementation upon performance and metabolism of trained rats. Cell Biochem Funct. 2003;21:85–91.
   PubMed Web of Science ®Google Scholar
• Mutch BJ, Banister EW. Ammonia metabolism in exercise and fatigue: a review. Med Sci Sports Exerc. 1983;15:41–50.
   PubMed Web of Science ®Google Scholar
• Takeda K, Machida M, Kohara A, et al. Effects of citrulline supplementation on fatigue and exercise performance in mice. J Nutr Sci Vitaminol. 2011;57:246–250.
   PubMed Web of Science ®Google Scholar
• Urdampilleta A, Armentia I, Gómez-Zorita S, et al. La fatiga muscular en los deportistas: métodos físicos, nutricionales y farmacológicos para combatirla. Arch Med Deport. 2015;32:36–43.
   Google Scholar
• Areces F, Salinero JJ, Abian-Vicen J, et al. A 7-day oral supplementation with branched-chain amino acids was ineffective to prevent muscle damage during a marathon. Amino Acids. 2014;46:1169–1176. DOI:10.1007/s00726-014-1677-3
   Web of Science ®Google Scholar
• Brancaccio P, Maffulli N, Buonauro R, et al. Serum enzyme monitoring in sports medicine. Clin Sport Med. 2008;27:1–18. DOI:10.1016/j.csm.2007.09.005
   PubMed Web of Science ®Google Scholar
• Yan B, Lai X, Yi L, et al. Effects of five-week resistance training in hypoxia on hormones and muscle strength. J Strength Cond Res. 2016;30:184–193. DOI:10.1519/JSC.0000000000001056
   PubMed Web of Science ®Google Scholar
• Cribb PJ, Hayes A. Effects of supplement timing and resistance exercise on skeletal muscle hypertrophy. Med Sci Sports Exerc. 2006;38:1918–1925.
   PubMed Web of Science ®Google Scholar
• Bendahan D, Mattei JP, Ghattas B, et al. Citrulline malate promotes aerobic energy production in human exercising muscle. Br J Sport Med. 2002;36:282–289.
   PubMed Web of Science ®Google Scholar
• Sureda A, Córdova A, Ferrer MD, et al. l-Citrullinemalate influence over branched chain amino acid utilization during exercise. Eur J Appl Physiol. 2010;110:341–351.
   PubMed Web of Science ®Google Scholar
• Pérez-Guisado J, Jakeman PM. Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness. J Strength Cond Res. 2010;24:1215–1222.
   PubMed Web of Science ®Google Scholar
• Wax B, Kavazis AN, Luckett W. Effects of supplemental citrulline-malate ingestion on blood lactate, cardiovascular dynamics, and resistance exercise performance in trained males. J Diet Suppl. 2016;13:269–282.
   PubMedGoogle Scholar
• Wax B, Kavazis AN, Weldon K, et al. Effects of supplemental citrulline malate ingestion during repeated bouts of lower-body exercise in advanced weightlifters. J Strength Cond Res. 2015;29:786–792.
   PubMed Web of Science ®Google Scholar
• Tarazona-Díaz MP, Alacid F, Carrasco M, et al. Watermelon juice: potential functional drink for sore muscle relief in athletes. J Agric Food Chem. 2013;61:7522–7528.
   PubMed Web of Science ®Google Scholar
• Cutrufello PT, Gadomski SJ, Zavorsky GS. The effect of l-citrulline and watermelon juice supplementation on anaerobic and aerobic exercise performance. J Sports Sci. 2015;33(14):1459–1466.
   PubMed Web of Science ®Google Scholar
• Bailey SJ, Blackwell JR, Williams E, et al. Two weeks of watermelon juice supplementation improves nitric oxide bioavailability but not endurance exercise performance in humans. Nitric Oxide. 2016;59:10–20. DOI:10.1016/j.niox.2016.06.008
   PubMed Web of Science ®Google Scholar
• Hickner RC, Tanner CJ, Evans CA, et al. l-Citrulline reduces time to exhaustion and insulin response to a graded exercise test. Med Sci Sport Exerc. 2006;38:660–666.
   PubMed Web of Science ®Google Scholar
• Bailey SJ, Blackwell JR, Lord T, et al. l-Citrulline supplementation improves O2 uptake kinetics and high-intensity exercise performance in humans. J Appl Physiol. 2015;119:385–395. DOI:10.1152/japplphysiol.00192.2014
   PubMed Web of Science ®Google Scholar
• Borg G. Perceived exertion as an indicator of somatic stress. Scand J Rehabil Med. 1970;2:92–98.
   PubMedGoogle Scholar
• Collins JK, Wu G, Perkins-Veazie P, et al. Watermelon consumption increases plasma arginine concentrations in adults. Nutr. 2007;23:261–266. DOI:10.1016/j.nut.2007.01.005
   PubMed Web of Science ®Google Scholar
• Hill DW, Cureton KJ, Grisham SC, et al. Effect of training on the rating of perceived exertion at the ventilatory threshold. Eur J Appl Physiol. 1987;56(2):206–211.
   Web of Science ®Google Scholar
• Steed J, Gaesser GA, Weltman A. Rating of perceived exertion and blood lactate concentration during submaximal running. Med Sci Sport Exerc. 1994;26:797–803.
   PubMed Web of Science ®Google Scholar
• Armstrong RB. Muscle damage and endurance events. Sports Med. 1986;3:370–381.
   PubMed Web of Science ®Google Scholar
• Kirby TJ, Triplett NT, Haines TL, et al. Effect of leucine supplementation on indices of muscle damage following drop jumps and resistance exercise. Amino Acids. 2012;42:1987–1996.
   Web of Science ®Google Scholar
• Del Coso J, Gonzalez-Millan C, Salinero JJ, et al. Muscle damage and its relationship with muscle fatigue during a half-iron triathlon. Plos One. 2012;7:e43280.
   PubMed Web of Science ®Google Scholar
• Ramos-Campo DJ, Ávila-Gandía V, Alacid F, et al. Muscle damage, physiological changes, and energy balance in ultra-endurance mountain-event athletes. Appl Physiol Nutr Metab. 2016;41:872–878.
   PubMed Web of Science ®Google Scholar
• Del Coso J, González C, Abián-Vicen J, et al. Relationship between physiological parameters and performance during a half-ironman triathlon in the heat. J Sports Sci. 2014;32(18):1680–1687.
   PubMed Web of Science ®Google Scholar
• Del Coso JD, Salinero JJ, Abián-Vicen J, et al. Influence of body mass loss and myoglobinuria on the development of muscle fatigue after a marathon in a warm environment. Appl Physiol Nutr Metab. 2013a;38(3):286–291.
   Web of Science ®Google Scholar
• Del Coso JD, Fernández D, Abián-Vicen J, et al. Running pace decrease during a marathon is positively related to blood markers of muscle damage. PLoS One. 2013b;8(2):e57602.
   PubMed Web of Science ®Google Scholar
• Mandel H, Levy N, Izkovitch S, et al. Elevated plasma citrulline and arginine due to consumption of Citrullus vulgaris (watermelon). J Inherit Metab Dis. 2005;28(4):467–472. DOI:10.1007/s10545-005-0467-1
   PubMed Web of Science ®Google Scholar
• Wu G, Collins JK, Perkins-Venzie P, et al. Dietary supplementation with watermelon pomace juice enhances arginine availability and ameliorates the metabolic syndrome in Zucker diabetic fatty rats. J Nutr. 2007;137:2680–2685.
   PubMed Web of Science ®Google Scholar
• Schwedhelm E, Maas E, Freese R, et al. Pharmacokinetic and pharmacodynamics properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism. Br J Clin Pharmacol. 2008;65:51–59. DOI:10.1111/j.1365-2125.2007.02990.x
   PubMed Web of Science ®Google Scholar
• Sureda A, Córdova A, Ferrer MD, et al. Effects of l-citrulline oral supplementation on polymorphonuclear neutrophils oxidative burst and nitric oxide production after exercise. Free Rad Res. 2009;43:828–835.
   PubMed Web of Science ®Google Scholar
• Callis A, Magnan De Bornier B, Serrano JJ, et al. Activity of citrulline malate on acid-base balance and blood ammonia and amino acid levels. Study in the animal and in man. Arzneim-Forsch. 1991;41:660–663.
   PubMed Web of Science ®Google Scholar
• Calbet JA, De Paz JA, Garatachea N, et al. Anaerobic energy provision does not limit Wingate exercise performance in endurance-trained cyclists. J Appl Physiol. 2003;94:668–676.
   PubMed Web of Science ®Google Scholar
• Williams MH. Human energy. In: Nutrition for health, fitness and sport. 8th ed. New York (NY): McGraw-Hill; 2007. p. 81–110.
   Google Scholar
• Leers MPG, Schepers R, Baumgarten R. Effects of a long-distance run on cardiac markers in healthy athletes. Clin Chem Lab Med. 2006;44:999–1003.
   PubMed Web of Science ®Google Scholar
• Murray RK. Muscle and the cytoskeleton. In: Murray RK, Bender DA, Botham KM, et al., editors. Harper´s illustrated biochemistry. 29th ed. New York (NY): MCGraw-Hill; 2012. p. 608–628.
   Google Scholar
• Mastaloudis A, Leonard SW, Traber MG. Oxidative stress in athletes during extreme endurance exercise. Free Radic Biol Med. 2001;31:911–922.
   PubMed Web of Science ®Google Scholar
• Urdampilleta A, Martínez-Sanz JM, López-Grueso R. Valoración bioquímica del entrenamiento: herramienta para el dietista-nutricionista deportivo. Rev Española Nutr Humana Y Dietética. 2013;17:73–83.
   Google Scholar
• Hellsten Y. The role of xanthine oxidase in exercise. In: Sen C, Packer L, Hanninen O, editors. Handbook of oxidants and antioxidants in exercise. Amsterdam: Elsevier; 2000. p. 153–276.
   Google Scholar
• Pettersson J, Hindorf U, Persson P, et al. Muscular exercise can cause highly pathological liver function tests in healthy men. Br J Clin Pharmacol. 2007;65:253–259.
   Web of Science ®Google Scholar
• Machado M, Antunes WD, Tamy AL, et al. Effect of a single dose of caffeine supplementation and intermittent-interval exercise on muscle damage markers in soccer players. J Exerc Sci Fit. 2009;7:91–97.
   Web of Science ®Google Scholar
• Munjal DD, McFadden JA, Matix PA, et al. Changes in serum myoglobin, total creatine kinase, lactate dehydrogenase and creatine kinase MB levels in runners. Clin Biochem. 1983;16:195–199.
   PubMed Web of Science ®Google Scholar
• Lippi G, Schena F, Salvagno GL, et al. Acute variation of biochemical markers of muscle damage following a 21-km, half-marathon run. Scand J Clin Lab Invest. 2008;68(7):667–672.
   PubMed Web of Science ®Google Scholar
• Lappalainen H, Tiula E, Uotila L, et al. Elimination kinetics of myoglobin and creatine kinase in rhabdomyolysis: implications for follow-up. Crit Care Med. 2002;30:2212–2215.
   PubMed Web of Science ®Google Scholar