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Review

Controlled local drug delivery strategies from chitosan hydrogels for wound healing

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Pages 897-908 | Received 24 May 2016, Accepted 06 Oct 2016, Published online: 27 Oct 2016

References

  • Farrar D. Advanced wound repair therapies. Woodhead Publishing Limited, 80 High Street, SAwston, Cambridge CB22 3HJ, UK, ISBN 978-1-84569-700-6; 2011.
  • Sen CK, Gordillo GM, Roy S, et al. Human skin wounds: a major and snowballing threat to public health and the economy. Wound Repair Regen. 2010;17:763–771.
  • Misic AM, Gardner SE, Grice EA. The wound microbiome: modern approaches to examining the role of microorganisms in impaired chronic wound healing. Adv Wound Care. 2012;3:502–510.
  • Lazarus GS, Cooper DM, Knighton DR, et al. Definitions and guidelines for assessment of wounds and evaluation of healing. Wound Repair Regen. 1994;2:165–170.
  • Pachuau L. Recent developments in novel drug delivery systems for wound healing. Expert Opin Drug Deliv. 2015;12:1895–1909.
  • Jones V, Grey JE, Harding KG. ABC of wound healing – wound dressings. Bmj. 2006;332:777–780.
  • Boateng J, Catanzano O. Advanced therapeutic dressings for effective wound healing – a review. Journ Pharm Sci. 2015;104:3653–3680.
  • Ahmadi F, Oveisi Z, Mohammadi Samani S, et al. Chitosan based hydrogels: characteristics and pharmaceutical applications. Res Pharm Sci. 2015;10:1–16.
  • Butcher M, White R. Factors affecting cost-effectiveness in wound care decision making. Nursing Standard. 2014;28:51–58.
  • Kean T, Thanou M. Biodegradation, biodistribution and toxicity of chitosan. Adv Drug Deliv Rev. 2010;62:3–11.
  • Galli C, Parisi L, Elviri L, et al. Chitosan scaffold modified with D-(+) raffinose and enriched with thiol-modified gelatin for improved osteoblast adhesion. Biomed Mat. 2016;11:015004.
  • Kumirska J, Weinhold MX, Czerwicka M. Influence of the chemical structure and physicochemical properties of chitin- and chitosan-based materials on their biomedical activity. Biomedical Engineering, Trends in Materials Science. Laskovski AN ed. InTech; 2011. ISBN: 978-953-307-513-6
  • Lim CK, Halim AS. Biomedical-grade chitosan in wound management and its biocompatibility in vitro. Biopolymers, Elnashar M (ed.), Scyo 2010.
  • Malaise S, Rami L, Montembault A, et al. Bioresorption mechanisms of chitosan physical hydrogels: a scanning electron microscopy study. Mater Sci Eng C. 2014;42:374–384.
  • Gainza G, Villullas S, Pedraz JL, et al. Advances in drug delivery systems (DDSs) to release growth factors for wound healing and skin regeneration nanomed. Nanotech Biol Med. 2015;111:1551–1573.
  • Baldrick P. The safety of chitosan as a pharmaceutical excipient. Regul Toxicol Pharm. 2010;56:290–299.
  • Minagawa T, Okamura Y, Shigemasa Y, et al. Effects of molecular weight and deacetylation degree of chitin/chitosan on wound healing. Carbohy Polym. 2007;67:640–644.
  • Bernkop-Schnurch A, Dunnhaupt S. Chitosan-based drug delivery systems. Eur J Pharm Biopharm. 2012;81:463–469.
  • Schipper NG, Olsson S, Hoogstraate JA, et al. Chitosans as absorption enhancers for poorly absorbable drug 2: mechanism of absorption enhancement. Pharm Res. 1997;14:923–929.
  • Muzzarelli RAA. Chitin and chitosans for the repair of wound skin, nerve, cartilage and bone. Carbohy Polym. 2009;76:167–182.
  • Anitha A, Sowmya S, Sudheesh Kumar PT, et al. Chitin and chitosan in selected biomedical applications. Prog Polym Sci. 2014;39:1644–1667.
  • Kong M, Chen XG, Xing K, et al. Antimicrobial properties of chitosan and mode of action: a state of the art review. Int J Food Microbiol. 2010;144:51–63.
  • Mellegard H, Strand SP, Christensen BE, et al. Antibacterial activity of chemically defined chitosans: influence of molecular weight, degree of acetylation and test organism. Int Journ Food Microbiol. 2011;148:48–54.
  • Mati-Baouche N, Elchinger PH, De Baynast H, et al. Chitosan as an adhesive. Eur Polym J. 2014;60:198–212.
  • Bhattarai N, Gunn J, Zhang M. Chitosan-based hydrogels for controlled localized drug delivery. Adv Drug Deliv Rev. 2010;62:83–99.
  • Granville-Chapman J, Jacobs N, Midwinter MJ. Pre-hospital haemostatic dressings: a systematic review injury. Int J Care Injured. 2011;42:447–459.
  • Ueno H, Mori T, Fujinaga T. Topical formulations and wound healing applications of chitosan. Adv Drug Deliv Rev. 2001;52:105–115.
  • Ahmed S, Ahmad M, Jayachandran M, et al. Chitosan based dressings for wound care. Immunochem Immunopathol. 2015;1:106–111.
  • Jayakumar R, Prabaharan M, Sudheesh KPT, et al. Biomaterials based on chitin and chitosan in wound dressing applications. Biotechnol Adv. 2011;29:322–337.
  • Azuma K, Izumi R, Osaki T, et al. Chitin, chitosan, and its derivatives for wound healing: old and new materials. J Funct Biomater. 2015;6:104–142.
  • Barton MJ, Morle JW, Mahns DA, et al. Tissue repair strength using chitosan adhesives with different physical-chemical characteristics. J Biophotonics. 2014;7:948–955.
  • Bianchera A, Salomi E, Pezzanera M, et al. Chitosan hydrogels for chondroitin sulphate controlled release: an analytical characterization. J Anal Methods Chem. 2014;2014:1–8. DOI:10.1155/2014/808703.
  • Luo Y, Wang Q. Recent development of chitosan-based polyelectrolyte complexes with natural polysaccharides for drug delivery. Int J Biol Macromol. 2014;64:353–367.
  • Patrulea V, Ostafe V, Borhard G, et al. Chitosan as a starting material for wound healing applications. Eur J Pharm Biopharm. 2015;97:417–426.
  • Francesko A, Chitin TT. chitosan and derivatives for wound healing and tissue engineering. Adv Biochem Eng Biotechnol. 2011;125:1–27.
  • Harkins AL, Duri S, Kltoh L, et al. Chitosan–cellulose composite for wound dressing material. part 2. Antimicrobial activity blood absorption ability, and biocompatibility. J Biomed Mater Res B Appl Biomater. 2014;102:1199–1206.
  • Lin WC, Lien CC, Yeh HJ, et al. Bacterial cellulose and bacterial cellulose-chitosan membranes for wound dressing applications. Carbohy Polym. 2013;94:603–611.
  • Dantas MDM, Cavalcante DRR, Araujo FEN, et al. Improvement of dermal burn healing by combining sodium alginate/chitosan-based films and low level laser therapy. J Photoch Photobio B. 2011;105:51–59.
  • Murakami K, Aoki H, Nakamura S, et al. Hydrogel blends of chitin/chitosan, fucoidan and alginate as healing-impaired wound dressings. Biomaterials. 2010;31:83–90.
  • Pandima Devi M, Sekar M, Chamundeswari M, et al. A novel wound dressing material — fibrin–chitosan–sodium alginate composite sheet. Bull Mater Sci. 2012;35:1157–1163.
  • Tseng HJ, Tsou TL, Wang HJ, et al. Characterization of chitosan-gelatin scaffolds for dermal tissue engineering. J Tissue Eng Regen Med. 2013;7:20–31.
  • Kangjian W, Nianhua D, Shiwei X, et al. Preparation and characterization of collagen-chitosan-chondroitin sulfate composite membranes. J Membrane Biol. 2012;245:707–716.
  • Judith R, Nithya M, Rose C, et al. Biopolymer gel matrix as acellular scaffold for enhanced dermal tissue. Biologicals. 2012;40:231–239.
  • Lan G, Lu B, Wang T, et al. Chitosan/gelatin composite sponge is an absorbable surgical hemostatic agent. Colloid Surface B. 2015;136:1026-1034).
  • Feng W, Mingbo W, Zhending S, et al. Collagen/chitosan based two-compartment and bi-functional dermal scaffolds for skin regeneration. Mater Sci Eng C. 2015;52:155-62).
  • Nieto-suarez M, Lopez-Quintela MA, Lazzari M. Preparation and characterization of crosslinked chitosan/gelatin scaffolds by ice segregation induced self-assembly. Carbohy Polym. 2016;141:175–183.
  • Parvez S, Mizanur Rahman M, Khan MA, et al. Preparation and characterization of artificial skin using chitosan and gelatin composites for potential biomedical application. Polym Bull. 2012;69:715–731.
  • Anisha BS, Sankar D, Mohandas A, et al. Chitosan-hyaluronan/nano chondroitin sulphate ternary composite sponges for medical use. Carbohy Polym. 2013;92:1470–1476.
  • Zhao R, Li X, Sun B, et al. Electrospun chitosan/sericin composite nanofibers with antibacterial property as potential wound dressings. Int Journ Biol Macromol. 2014;68:92–97.
  • Cai Z, Mo X, Zhang K, et al. Fabrication of chitosan/silk fibroin composite nanofibers for wound-dressing applications. Int J Mol Sci. 2010;11:3529–3539.
  • Gu Z, Xie HX, Huang C, et al. Preparation of chitosan/silk fibroin blending membrane fixed with alginate dialdehyde for wound dressing. Int J Biol Macromol. 2013;58:121–126.
  • Lu G, Ling K, Zhao P, et al. A novel in situ-formed hydrogel wound dressing by the photocross-linking of a chitosan derivative. Wound Rep Reg. 2010;18:70–79.
  • Morsi NM, Addelbary GA, Ahmed MA. Silver sulfadiazine based cubosome hydrogels for topical treatment of burns: development and in vitro/in vivo characterization. Eur J Pharm Biopharm. 2014;86:178–189.
  • Croisier F, Jérôme C. Chitosan-based biomaterials for tissue engineering. Europ Polym Journ. 2013;49:780–792.
  • Xia G, Lang X, Kong M, et al. Surface fluid-swellable chitosan fiber as the wound dressing material. Carbohy Polym. 2016;136:860–866.
  • Tenenhaus M, Rennekampff HO. Current concepts in tissue engineering: skin and wound. Plast Reconstr Surg. 2016;138:42S–52S.
  • Noel SP, Courtney H, Bumgardner JD, et al. Chitosan films – A potential local drug delivery system for antibiotics. Clin Orthop Relat Res. 2008;466:1377–1382.
  • Smith JK, Mosherf AR, Jennings JA, et al. Chitosan sponges for local synergistic infection therapy: a pilot study. Clin Orthop Relat Res. 2013;471:3158–3164.
  • Tonda-Turo C, Ruini F, Argentati M, et al. Porous CS based membranes with improved antimicrobial properties for the treatment of infected wound in veterinary applications. Material Sci Eng C-Mater Biol App. 2016;60:416–426.
  • Siafaka PI, Zisi AP, Exindari MK, et al. Porous dressings of modified chitosan with poly(2-hydroxyethyl acrylate) for topical wound delivery of levofloxacin. Carbohydr Polym. 2016;143:90–99.
  • Sung JH, Hwang MR, Kim JO, et al. Gel characterization and in vivo evaluation of minocycline-loaded wound dressing with enhanced wound healing using polyvinyl alcohol and chitosan. Int J Pharm. 2010;392:232–240.
  • Zhang D, Zhou W, Wei B, et al. Carboxyl-modified poly(vinyl alcohol)-crosslinked chitosan hydrogel films for potential wound dressing. Carbohydr Polym. 2015;125:189–199.
  • Sinha M, Banik RM, Haldar C, et al. Development of ciprofloxacin hydrochloride loaded poly(ethylene glycol)/chitosan scaffolds as wound dressing. J Porous Mat. 2013;20:799–807.
  • Radhakumary C, Antony M, Sreenivasan K. drug loaded thermoresponsive and cytocompatible chitosan based hydrogel as a potential wound dressing. Carbohydr Polym. 2011;83:705–713.
  • Mahmoud AA, Salama AH. Norfloxacin-loaded collagen/chitosan scaffolds for skin reconstruction: preparation, evaluation and in-vivo wound healing assessment. Eur J Pharm Sci. 2016;83:155–165.
  • Pawar HV, Tetteh J, Boateng JS. Preparation, optimization and characterization of novel wound healing film dressing with streptomycin and diclofenac. Colloids Surf B Biointerfaces. 2013;102:102–110.
  • Amin MA, Abdel-Raheem IT. Accelerated wound healing and anti-inflammatory effects of physically cross linked polyvinyl alcohol-chitosan hydrogel containing honey bee venom in diabetic rats. Arch Pharm Res. 2014;37:1016–1031.
  • Hashemikia S, Hemmatinejad N, Ahmadi E, et al. Antibacterial and anti-inflammatory drug delivery properties on cotton fabric using betamethasone-loaded mesoporous silica particles stabilized with chitosan and silicone softener. Drug Deliv. 2016;29:1–10.
  • Abioye AO, Isssah S, Kola-Mustapha AT. Ex vivo skin permeation and retention studies on chitosan-ibuprofen-gellan ternary nanogel prepared by in situ ionic gelation technique–a tool for controlled transdermal delivery of ibuprofen. Int J Pharm. 2015;490:112–130.
  • Wang F, Wang M, She Z, et al. Collagen/chitosan based two-compartment and bi-functional dermal scaffolds for skin regeneration. Mater Sci Eng C Mater Biol Appl. 2015;52:155–162.
  • Mohandas A, Anisha BS, Chennazi KP, et al. Chitosan–hyaluronic acid/VEGF loaded fibrin nanoparticles composite sponges for enhancing angiogenesis in wounds. Colloid Surface B. 2015;127:105–113.
  • Ribeiro MP, Morgado PI, Miguel SP, et al. Dextran-based hydrogel containing chitosan microparticles loaded with growth factors to be used in wound healing. Mater Sci Eng C. 2013;33:2958–2966.
  • Zhou W, Zhao M, Zhao Y, et al. A fibrin gel loaded with chitosan nanoparticles for local delivery of rhEGF- preparation and in vitro release studies. J Mater Sci Mater Med. 2011;22:1221–1230.
  • Tran NQ, Joung YK, Lih E, et al. In situ forming and rutin-releasing chitosan hydrogels as injectable dressings for dermal wound healing. Biomacromol. 2011;12:2872–2880.
  • Li X, Chen S, Zhang B, et al. In situ injectable nano-composite hydrogel composed of curcumin, N, O-carobxymethyl chitosan and oxidized alginate for wound healing applications. Int Journ Pharm. 2012;437:110–119.
  • Perkyonok VT, Reher V, Zhang S, et al. Chitosan:vitaminc containing hydrogels as a prototype functional prolonged pain management restorative material in-vitro studies. Open J Stomat. 2014;4:389–401.
  • Antunes BP, Moreira AF, Gaspar VM, et al. Chitosan/arginine-chitosan polymer blends for assembly of nanofibrous membranes for wound regeneration. Carbohy Polym. 2015;130:104–112.
  • Kilic C, Peker EGGP, Acarturk F, et al. Investigation of the effects of local glutathione and chitosan administration on incisional oral mucosal wound healing in rabbits. Colloids Surfaces B. 2013;112:499–507.
  • Silva SS, Popa EG, Gomes ME, et al. An investigation of the potential application of chitosan/aloe-based membranes for regenerative medicine. Acta Biomater. 2013;9:6790–6797.
  • Altiok D, Altiok E, Tihmilioglu F. Physical, antibacterial and antioxidant properties of chitosan films incorporated with thyme oil for potential wound healing applications. J Mater Sci Mater Med. 2010;21:2227–2236.
  • Kim JO, Noh JK, Thapa RK, et al. Nitric oxide-releasing chitosan film for enhanced antibacterial and in vivo wound-healing efficacy. Int J Biol Macromol. 2015;79:217–225.
  • Santos TC, Horing B, Reise K, et al. In vivo performance of chitosan/soy-based membranes as wound-dressing devices for acute skin wounds. Tissue Eng A. 2013;19:860–869.
  • Elviri L, Asadzadeh M, Cucinelli R, et al. Macroporous chitosan hydrogels: effects of sulfur on the loading and release behaviour of aminoacid-based compounds. Carbohydr Polym. 2015;132:50–58.
  • De Robertis S, Bonferoni MC, Elviri L, et al. Advances in oral controlled drug delivery: the role of drug-polymer and interpolymer non-covalent interactions. Exp Opin Drug Deliv. 2015;12:441–453.
  • Jayasinghe S, Auguste J, Scotton CJ. Platform technologies for directly reconstructing 3D living biomaterials. Adv Mat. 2015;27:7794–7799.
  • Jayasinghe S. Tissue therapeutics and regenerative medicine. Drug Discov Today. 2014;19:711–713.
  • Hodgkinson T, Bayat A. Dermal substitute-assited healing: enhancing stem cell therapy with novel biomaterial design. Arch Dermatol Res. 2011;303:301–315.

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