99
Views
0
CrossRef citations to date
0
Altmetric
Meta-analysis

Do the chitosan nanoparticles really augment the drugs’ transdermal fluxes: ending the debate using meta-analysis

, &
Pages 325-335 | Received 08 Nov 2023, Accepted 26 Jan 2024, Published online: 01 Mar 2024

References

  • Jeong WY, Kwon M, Choi HE, et al. Recent advances in transdermal drug delivery systems: a review. Biomater Res. 2021;25(1):24. doi: 10.1186/s40824-021-00226-6tpdel
  • Heaf JG. The origin of the 1·73-m 2 body surface area normalization: problems and implications. Clin Physio Funct Imaging. 2007 May 1;27(3):135–137. doi: 10.1111/j.1475-097X.2006.00718.x
  • Tomoda K, Makino K. Chapter 7 - nanoparticles for transdermal drug delivery system (TDDS). In: Ohshima H Makino K, editors Colloid and interface science in pharmaceutical research and development. Amsterdam: Elsevier; 2014. p. 131–147.
  • Palmer BC, DeLouise LA. Nanoparticle-enabled transdermal drug delivery systems for enhanced dose control and tissue targeting. Molecules. 2016;21(12):1719. doi: 10.3390/molecules21121719
  • Hathout RM, Gad HA, Bdel-Hafez SM, et al. Gelatinized core liposomes: a new Trojan horse for the development of a novel timolol maleate glaucoma medication. Int J Pharm. 2019;556:192–199. doi: 10.1016/j.ijpharm.2018.12.015
  • Abdel-Hafez SM, Hathout RM, Sammour OA. Curcumin-loaded ultradeformable nanovesicles as a potential delivery system for breast cancer therapy. Colloids Surf B Biointerfaces. 2018 Jul 1;167:63–72. doi: 10.1016/j.colsurfb.2018.03.051
  • Parhi R, Mohanta BC, Jena GK, et al. Chapter 14 - recent advancements in lipid-based nanocarriers for transdermal drug delivery. In: Inamuddin NCJ, and Altalhi T, editors Green sustainable process for chemical and environmental engineering and science. Amsterdam, Nertherlands: Elsevier; 2023. p. 347–401.
  • Abdel-Hafez SM, Hathout RM, Sammour OA. Tracking the transdermal penetration pathways of optimized curcumin-loaded chitosan nanoparticles via confocal laser scanning microscopy. Int j biol macromol. 2018;108:753–64. doi: 10.1016/j.ijbiomac.2017.10.170
  • Umair T, uD M, Majeed A, et al. Skin permeation of nanoparticles: mechanisms involved and critical factors governing topical drug delivery. Curr Pharm Des. 2020;26(36):4601–4614. doi: 10.2174/1381612826666200701204010
  • Afzal O, Akhter MH, Ahmad I, et al. A B-Sitosterol encapsulated biocompatible alginate/chitosan polymer nanocomposite for the treatment of breast cancer. Pharmaceutics. 2022;14(8):1711. doi: 10.3390/pharmaceutics14081711
  • Karim S, Akhter MH, Burzangi AS, et al. Phytosterol-loaded surface-tailored bioactive-polymer nanoparticles for cancer treatment: optimization, in vitro cell viability, antioxidant activity, and stability studies. Gels. 2022;8(4):219. doi: 10.3390/gels8040219
  • Ahmad I, Farheen M, Kukreti A, et al. Natural oils enhance the topical delivery of ketoconazole by nanoemulgel for fungal infections. ACS Omega. 2023 Aug 8;8(31):28233–48. doi: 10.1021/acsomega.3c01571
  • Md S, Alhakamy NA, Aldawsari HM, et al. Plumbagin-loaded glycerosome gel as topical delivery system for skin cancer therapy. Polymers. 2021;13(6):923. doi: 10.3390/polym13060923
  • Lim K, Hamid ZAA. 10 - polymer nanoparticle carriers in drug delivery systems: research trend. In: Inamuddin AA, and Mohammad A, editors Applications of nanocomposite materials in drug delivery woodhead publishing series in biomaterials. Cambridge, UK: Woodhead Publishing; 2018. p. 217–37.
  • Hesham H, Rady M, Hathout RM, et al. The skin delivery of tofacitinib citrate using transethosomes and hybridized ethosomes/nanostructured lipid carriers for vitiligo therapy: dermatopharmacokinetics and in vivo assays. Int J Pharmaceut. 2022;629:122387. doi: 10.1016/j.ijpharm.2022.122387
  • Moser K, Kriwet K, Naik A, et al. Passive skin penetration enhancement and its quantification in vitro. Eur J Pharm Biopharm. 2001;52(2):103–112. doi: 10.1016/S0939-6411(01)00166-7
  • Hathout RM. Using principal component analysis in studying the transdermal delivery of a lipophilic drug from soft nano-colloidal carriers to develop a quantitative composition effect permeability relationship. Pharm Dev Technol. 2014 Aug 1;19(5):598–604. doi: 10.3109/10837450.2013.813544
  • Hathout RM, Woodman TJ, Mansour S, et al. Microemulsion formulations for the transdermal delivery of testosterone. Eur J Pharmaceut Sci. 2010;40(3):188–96. doi: 10.1016/j.ejps.2010.03.008
  • Mitragotri S, Anissimov YG, Bunge AL, et al. Mathematical models of skin permeability: an overview. Int J Pharmaceut. 2011;418(1):115–29. doi: 10.1016/j.ijpharm.2011.02.023
  • Naik A, Kalia YN, Guy RH. Transdermal drug delivery: overcoming the skinGÇÖs barrier function. Pharm Sci Technol Today. 2000;3(9):318–326. doi: 10.1016/S1461-5347(00)00295-9
  • Safwat S, Hathout RM, Ishak RA, et al. Elaborated survey in the scope of nanocarriers engineering for boosting chemotherapy cytotoxicity: a meta-analysis study. Int J Pharmaceut. 2021;610:121268. doi: 10.1016/j.ijpharm.2021.121268
  • Hathout RM, Metwally AA. Pharmaceutics informatics: bio/Chemoinformatics in drug delivery. In: Saharan V, editor. Computer aided pharmaceutics and drug delivery: an application guide for students and researchers of pharmaceutical sciences. Singapore: Springer Nature Singapore; 2022. p. 705–724.
  • Nasser N, Hathout RM, Abd-Allah H, et al. Enhancement of oral bioavailability of drugs using lipid-based carriers: a meta-analysis study. Drug Dev Ind Pharm. 2020;46(12):2105–10. doi: 10.1080/03639045.2020.1851245
  • Elmeligy S, Hathout RM, Khalifa SAM, et al. Pharmaceutical manipulation of citrus flavonoids towards improvement of its bioavailability and stability. A mini review and a meta-analysis study. Food Biosci. 2021;44:101428. doi: 10.1016/j.fbio.2021.101428
  • Kassem DH, Kamal MM. Therapeutic efficacy of umbilical cord-derived stem cells for diabetes mellitus: a meta-analysis study. Stem Cell Res Ther. 2020;11(1):484. doi: 10.1186/s13287-020-01996-x
  • Matthew JP, McKenzie JE, Patrick MB, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021 Mar 29;372:n71. doi: 10.1136/bmj.n71
  • Cortegiani A, Ingoglia G, Ippolito M. et al. A systematic review on the efficacy and safety of chloroquine for the treatment of COVID-19. J Crit Care. 2020 Mar 10;57:279–283. doi: 10.1016/j.jcrc.2020.03.005
  • Misra DP, Ravindran V. Systematic reviews: Current perspectives and future directions. J Royal Coll Physicians Of Edinburgh. 2021 Sep 1;51(3):218–20. doi: 10.4997/jrcpe.2021.303
  • Gabr S, Nikles S, Pferschy Wenzig EM.Characterization and optimization of phenolics extracts from Acacia species in relevance to their anti-inflammatory activity. Biochemical Systematics and Ecology. 2018;78:21–30. doi: 10.1016/j.bse.2018.03.001
  • Malinovskaja-Gomez K, Labouta HI, Schneider M, et al. Transdermal iontophoresis of flufenamic acid loaded PLGA nanoparticles. Eur J Pharmaceut Sci. 2016;89:154–62. doi: 10.1016/j.ejps.2016.04.034
  • Dilawar N, Ur-Rehman T, Shah KU, et al. Development and evaluation of PLGA nanoparticle-loaded organogel for the transdermal delivery of Risperidone. Gels. 2022;8(11):709. doi: 10.3390/gels8110709
  • Hafner A, Lovrić J, Pepić I, et al. Lecithin/Chitosan nanoparticles for transdermal delivery of melatonin. J Microencapsul. 2011;28(8):807–815. doi: 10.3109/02652048.2011.622053
  • ElMasry SR, Hathout RM, Bdel-Halim M, et al. In vitro transdermal delivery of sesamol using oleic acid chemically-modified gelatin nanoparticles as a potential breast cancer medication. J Drug Delivery Sci Technol. 2018;48:30–9. doi: 10.1016/j.jddst.2018.08.017
  • Jana S, Manna S, Nayak AK, et al. Carbopol gel containing chitosan-egg albumin nanoparticles for transdermal aceclofenac delivery. Colloids Surf B Biointerfaces. 2014;114:36–44. doi: 10.1016/j.colsurfb.2013.09.045
  • Talib S, Ahmed N, Khan D, et al. Chitosan-chondroitin based artemether loaded nanoparticles for transdermal drug delivery system. J Drug Delivery Sci Technol. 2021;61:102281. doi: 10.1016/j.jddst.2020.102281
  • AO A, Issah S, AT K-M. Ex vivo skin permeation and retention studies on chitosanGÇôibuprofenGÇôgellan ternary nanogel prepared by in situ ionic gelation techniqueGÇöa tool for controlled transdermal delivery of ibuprofen. Int J Pharmaceut. 2015;490(1):112–130. doi: 10.1016/j.ijpharm.2015.05.030
  • Matos BN, Reis TA, Gratieri T, et al. Chitosan nanoparticles for targeting and sustaining minoxidil sulphate delivery to hair follicles. Int j biol macromol. 2015;75:225–9. doi: 10.1016/j.ijbiomac.2015.01.036
  • Zlowodzki M, Poolman RW, Kerkhoffs GM, et al. How to interpret a meta-analysis and judge its value as a guide for clinical practice. Acta Orthop. 2007 Jan 1;78(5):598–609. doi: 10.1080/17453670710014284
  • Uman LS. Systematic reviews and meta-analyses. J Can Acad Child Adolesc Psychiatry. 2011 Feb;20(1):57–9.
  • Snoswell CL. A meta-analysis of pharmacists and pharmacy technicians’ accuracy checking proficiency. Res Social Administrative Pharm. 2020;16(6):760–5. doi: 10.1016/j.sapharm.2019.08.028
  • Hathout RM. Do polymeric nanoparticles really enhance the bioavailability of oral drugs? A quantitative answer using meta-analysis. Gels. 2022;8(2):119. doi: 10.3390/gels8020119
  • Hathout RM. Particulate systems in the enhancement of the antiglaucomatous drug pharmacodynamics: a meta-analysis study. ACS Omega. 2019 Dec 16;4(26):21909–13. doi: 10.1021/acsomega.9b02895
  • El Zaafarany GM, Hathout RM, Ibrahim SS. Nanocarriers significantly augment the absorption of ocular-delivered drugs: a comparative meta-analysis study. Int J Pharmaceut. 2023;642:123204. doi: 10.1016/j.ijpharm.2023.123204
  • Mills EJ, Bansback N, Ghement I, et al. Multiple treatment comparison meta-analyses: a step forward into complexity. Clin Epidemiol. 2011;3:193–202. doi: 10.2147/CLEP.S16526
  • Rao G, Lopez-Jimenez F, Boyd J, et al. Methodological standards for meta-analyses and qualitative systematic reviews of cardiac prevention and treatment studies: a scientific statement from the American heart association. Circulation. 2017 Sep 5;136(10):e172–e194. doi: 10.1161/CIR.0000000000000523
  • Greenland S, Senn SJ, Rothman KJ, et al. Statistical tests, P values, confidence intervals, and power: a guide to misinterpretations. Eur J Epidemiol. 2016 Apr 2016 May 21;(4):337–350. doi: 10.1007/s10654-016-0149-3
  • Ta Q, Ting J, Harwood S, et al. Chitosan nanoparticles for enhancing drugs and cosmetic components penetration through the skin. Eur J Pharmaceut Sci. 2021;160:105765. doi: 10.1016/j.ejps.2021.105765
  • Hathout RM, Metwally AA. Gelatin Nanoparticles. Methods Mol Biol. 2019;2000:71–78.
  • Hathout RM, Metwally AA, Woodman TJ, et al. Prediction of drug loading in the gelatin matrix using computational methods. ACS Omega. 2020 Jan 28;5(3):1549–56. doi: 10.1021/acsomega.9b03487
  • Fong SY, Brandl M, Bauer-Brandl A. Phospholipid-based solid drug formulations for oral bioavailability enhancement: a meta-analysis. Eur J Pharm Sci. 2015 Dec 1;80:89–110. doi: 10.1016/j.ejps.2015.08.005
  • Hassan EA, Hathout RM, Gad HA, et al. Multi-purpose zein nanoparticles for battling hepatocellular carcinoma: A Green approach. Eur Polym J. 2022;176:111396. doi: 10.1016/j.eurpolymj.2022.111396
  • Abdel-Hafez SM, Hathout RM, Sammour OA. Attempts to enhance the anti-cancer activity of curcumin as a magical oncological agent using transdermal delivery. ADV TRADIT MED (ADTM). 2021;21(1):15–29. doi: 10.1007/s13596-020-00439-5
  • Alvarez-Roman R, Naik A, Kalia YN, et al. Skin penetration and distribution of polymeric nanoparticles. JControlled Release. 2004;99(1):53–62. doi: 10.1016/j.jconrel.2004.06.015
  • Mohammed MA, Syeda JTM, Wasan KM, et al. An overview of Chitosan Nanoparticles and its application in non-parenteral drug delivery. Pharmaceutics. 2017;9(4):53. doi: 10.3390/pharmaceutics9040053
  • Praveen A, Aqil M. Transdermal delivery of chitosan-based systems. In: Jana S Jana S, editors Functional chitosan: drug delivery and biomedical applications. Singapore: Springer Singapore; 2019. p. 75–106.
  • Agnihotri SA, Mallikarjuna NN, Aminabhavi TM. Recent advances on chitosan-based micro- and nanoparticles in drug delivery. J Controlled Release. 2004;100(1):5–28. doi: 10.1016/j.jconrel.2004.08.010
  • Chander S, Piplani M, Waghule T, et al. Chapter 4 - role of chitosan in transdermal drug delivery. In: Hasnain M, Beg S, and Nayak A, editors Chitosan in drug delivery. Cambridge, Massachusetts: Academic Press; 2022. p. 83–105.
  • Sterne JAC, Harbord RM. Funnel Plots in Meta-analysis. Stata J. 2004 Jun 1;4(2):127–41. doi: 10.1177/1536867X0400400204
  • Hathout RM, EM E-M. Meta-analysis: a convenient tool for the choice of Nose-to-Brain Nanocarriers. Bioengineering. 2022;9(11):647. doi: 10.3390/bioengineering9110647
  • Hasan SS, Kairuz T, Thiruchelvam K, et al. Systematic reviews and meta-analysis in pharmacy practice. In: Babar Z-D, editor. Pharmacy practice research methods. Singapore: Springer Singapore; 2020. p. 237–250.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.