Potential impact of inorganic nanoparticles on macronutrient digestion: titanium dioxide nanoparticles slightly reduce lipid digestion under simulated gastrointestinal conditions

References

• Cao, Y., J. Li, F. Liu, X. Li, Q. Jiang, S. Cheng, and Y. Gu. 2016. “Consideration of Interaction between Nanoparticles and Food Components for the Safety Assessment of Nanoparticles Following Oral Exposure: A Review.” Environmental Toxicology and Pharmacology 46: 206–210.
   PubMed Web of Science ®Google Scholar
• Chantrapornchai, W., F. M. Clydesdale, and D. J. McClements. 2000. “Optical Properties of Oil-in-water Emulsions Containing Titanium Dioxide Particles.” Colloids and Surfaces A: Physicochemical and Engineering Aspects 166: 123–131.
   Web of Science ®Google Scholar
• Chen, T., J. Yan, and Y. Li. 2014. “Genotoxicity of Titanium Dioxide Nanoparticles.” Journal of Food and Drug Analysis 22: 95–104.
   PubMed Web of Science ®Google Scholar
• Chen, X. X., B. Cheng, Y. X. Yang, A. Cao, J. H. Liu, L. J. Du, Y. Liu, Y. Zhao, and H. Wang. 2013. “Characterization and Preliminary Toxicity Assay of Nano-titanium Dioxide Additive in Sugar-coated Chewing Gum.” Small (Weinheim an Der Bergstrasse, Germany) 9: 1765–1774.
   PubMed Web of Science ®Google Scholar
• Cohen, J. M., G. M. DeLoid, and P. Demokritou. 2015. “A Critical Review of In Vitro Dosimetry for Engineered Nanomaterials.” Nanomedicine (London, England) 10: 3015–3032.
   PubMed Web of Science ®Google Scholar
• Cohen, J. M., J. G. Teeguarden, and P. Demokritou. 2014. “An Integrated Approach for the In Vitro Dosimetry of Engineered Nanomaterials.” Particle and Fibre Toxicology 11: 20.
   PubMed Web of Science ®Google Scholar
• DeLoid, G., B. Casella, S. Pirela, R. Filoramo, G. Pyrgiotakis, P. Demokritou, and L. Kobzik. 2016. “Effects of Engineered Nanomaterial Exposure on Macrophage Innate Immune Function.” Nano Impact 2: 70–81.
   Google Scholar
• Di Silvio, D., N. Rigby, B. Bajka, A. Mackie, and F. B. Bombelli. 2016. “Effect of Protein Corona Magnetite Nanoparticles Derived from Bread In Vitro Digestion on Caco-2 Cells Morphology and Uptake.” International Journal of Biochemistry & Cell Biology 75: 212–222.
   PubMed Web of Science ®Google Scholar
• Fage, S. W., J. Muris, S. S. Jakobsen, and J. P. Thyssen. 2016. “Titanium: A Review on Exposure, Release, Penetration, Allergy, Epidemiology, and Clinical Reactivity.” Contact Dermatitis 74: 323–345.
   PubMed Web of Science ®Google Scholar
• FAO. 2006. Combined Compendium of Food Additive Specifications. Rome: Joint FAO/WHO Expert Committee on Food Additives, Food and Agriculture Organization of the United Nations.
   Google Scholar
• Gu, Y. S., E. A. Decker, and D. J. McClements. 2007. “Formation of Colloidosomes by Adsorption of Small Charged Oil Droplets onto the Surface of Large Oppositely Charged Oil Droplets.” Food Hydrocolloids 21: 516–526.
   Web of Science ®Google Scholar
• Heringa, M., L. Geraets, J. van Eijkeren, R. Vandebriel, W. de Jong, and A. Oomen. 2016. “Risk Assessment of Titanium Dioxide Nanoparticles via Oral Exposure, Including Toxicokinetic Considerations.” Nanotoxicology 10: 1515–1525.
   PubMed Web of Science ®Google Scholar
• Holmberg, J. P., E. Ahlberg, J. Bergenholtz, M. Hassellov, and Z. Abbas. 2013. “Surface Charge and Interfacial Potential of Titanium Dioxide Nanoparticles: Experimental and Theoretical Investigations.” Journal of Colloid and Interface Science 407: 168–176.
   PubMed Web of Science ®Google Scholar
• Israelachvili, J. N. 2011. Intermolecular and Surface Forces: Revised 3rd ed. Burlington, MA: Academic Press.
   Google Scholar
• Izak-Nau, E., A. Huk, B. Reidy, H. Uggerud, M. Vadset, S. Eiden, M. Voetz, et al. 2015. “Impact of Storage Conditions and Storage Time on Silver Nanoparticles’ Physicochemical Properties and Implications for their Biological Effects.” Rsc Advances 5: 84172–84185.
   Web of Science ®Google Scholar
• Lefebvre, D. E., K. Venema, L. Gombau, L. G. Valerio, J. Raju, G. S. Bondy, H. Bouwmeester, et al. 2015. “Utility of Models of the Gastrointestinal Tract for Assessment of the Digestion and Absorption of Engineered Nanomaterials Released Rom Food Matrices.” Nanotoxicology 9: 523–542.
   PubMed Web of Science ®Google Scholar
• Li, Y., M. Hu, and D. J. McClements. 2011. “Factors Affecting Lipase Digestibility of Emulsified Lipids Using an In Vitro Digestion Model: Proposal for a Standardised pH-stat Method.” Food Chemistry 126: 498–505.
   Web of Science ®Google Scholar
• Lichtenstein, D., J. Ebmeyer, P. Knappe, S. Juling, L. Boehmert, S. Selve, B. Niemann, A. Braeuning, A. Thuenemann, and A. Lampen. 2015a. “The Influence of Food Components during Artificial Digestion on Silver Nanoparticles and the Impact on Their Cytotoxicity and Uptake in Caco-2 Cells.” Toxicology Letters 238: S197–S197.
   Web of Science ®Google Scholar
• Lichtenstein, D., J. Ebmeyer, P. Knappe, S. Juling, L. Boehmert, S. Selve, B. Niemann, A. Braeuning, A. Thuenemann, and A. Lampen. 2015b. “Impact of Food Components during In Vitro Digestion of Silver Nanoparticles on Cellular Uptake and Cytotoxicity in Intestinal Cells.” Biological Chemistry 396: 1255–1264.
   PubMed Web of Science ®Google Scholar
• Lim, J. H., P. Sisco, T. K. Mudalige, G. Sanchez-Pomales, P. C. Howard, and S. W. Linder. 2015. “Detection and Characterization of SiO2 and TiO2 Nanostructures in Dietary Supplements.” Journal of Agricultural and Food Chemistry 63: 3144–3152.
   PubMed Web of Science ®Google Scholar
• Lu, X., I. R. Miousse, S. V. Pirela, S. Melnyk, I. Koturbash, and P. Demokritou. 2016. “Short-term Exposure to Engineered Nanomaterials Affects Cellular Epigenome.” Nanotoxicology 10: 140–150.
   PubMed Web of Science ®Google Scholar
• Mackie, A. R., H. Rafiee, P. Malcolm, L. Salt, and G. van Aken. 2013. “Specific Food Structures Supress Appetite through Reduced Gastric Emptying Rate.” American Journal of Physiology-Gastrointestinal and Liver Physiology 304: G1038–G1043.
   PubMed Web of Science ®Google Scholar
• McClements, D. J., G. DeLoid, G. Pyrgiotakis, J. A. Shatkin, H. Xiao, and P. Demokritou. 2016. “The Role of the Food Matrix and Gastrointestinal Tract in the Assessment of Biological Properties of Ingested Engineered Nanomaterials (iENMs): State of the Science and Knowledge Gaps.” NanoImpact 3: 47–57.
   Web of Science ®Google Scholar
• Peters, R. J., G. van Bemmel, Z. Herrera-Rivera, H. P. Helsper, H. J. Marvin, S. Weigel, P. C. Tromp, A. G. Oomen, A. G. Rietveld, and H. Bouwmeester. 2014. “Characterization of Titanium Dioxide Nanoparticles in Food Products: Analytical Methods to Define Nanoparticles.” Journal of Agricultural and Food Chemistry 62: 6285–6293.
   PubMed Web of Science ®Google Scholar
• Qian, C., E. A. Decker, H. Xiao, and D. J. McClements. 2012. “Nanoemulsion Delivery Systems: Influence of Carrier oil on β-carotene Bioaccessibility.” Food Chemistry 135: 1440–1447.
   PubMed Web of Science ®Google Scholar
• Robichaud, C. O., A. E. Uyar, M. R. Darby, L. G. Zucker, and M. R. Wiesner. 2009. “Estimates of Upper Bounds and Trends in Nano-TiO2 Production As a Basis for Exposure Assessment.” Environmental Science & Technology and Technology 43: 4227–4233.
   PubMed Web of Science ®Google Scholar
• Rompelberg, C., M. Heringa, G. van Donkersgoed, J. Drijvers, A. Roos, S. Westenbrink, R. Peters, G. van Bemmel, and A. Oomen. 2016. “Oral Intake of Added Titanium Dioxide and Its Nanofraction from Food Products, Food Supplements and Toothpaste by the Dutch Population.” Nanotoxicology 10: 1404–1414.
   PubMed Web of Science ®Google Scholar
• Ruiz-Rodriguez, P. E., D. Meshulam, and U. Lesmes. 2014. “Characterization of Pickering O/W Emulsions Stabilized by Silica Nanoparticles and Their Responsiveness to In Vitro Digestion Conditions.” Food Biophysics 9: 406–415.
   Web of Science ®Google Scholar
• Shakeel, M., F. Jabeen, S. Shabbir, M. S. Asghar, M. S. Khan, and A. S. Chaudhry. 2016. “Toxicity of Nano-titanium Dioxide (TiO2-NP) through Various Routes of Exposure: A Review.” Biological Trace Element Research 172: 1–36.
   PubMed Web of Science ®Google Scholar
• Shi, H., R. Magaye, V. Castranova, and J. Zhao. 2013. “Titanium Dioxide Nanoparticles: A Review of Current Toxicological Data.” Particle and Fibre Toxicology 10:15.
   PubMed Web of Science ®Google Scholar
• Singh, H., A. Ye, and D. Horne. 2009. “Structuring Food Emulsions in the Gastrointestinal Tract to Modify Lipid Digestion.” Progress in Lipid Research 48: 92–100.
   PubMed Web of Science ®Google Scholar
• Singh, H., and A. Sarkar. 2011. “Behaviour of Protein-stabilised Emulsions under Various Physiological Conditions.” Advances in Colloid and Interface Science 165: 47–57.
   PubMed Web of Science ®Google Scholar
• Steingoetter, A., T. Radovic, S. Buetikofer, J. Curcic, D. Menne, M. Fried, W. Schwizer, and T. J. Wooster. 2015. “Imaging Gastric Structuring of Lipid Emulsions and its Effect on Gastrointestinal Function: A Randomized Trial in Healthy Subjects.” American Journal of Clinical Nutrition 101: 714–724.
   PubMed Web of Science ®Google Scholar
• van Aken, G. A. 2010. “Relating Food Emulsion Structure and Composition to the Way it is Processed in the Gastrointestinal Tract and Physiological Responses: What are the Opportunities?” Food Biophysics 5: 258–283.
   Web of Science ®Google Scholar
• van den Brule, S., J. Ambroise, H. Lecloux, C. Levard, R. Soulas, P. J. De Temmerman, M. Palmai-Pallag, E. Marbaix, and D. Lison. 2016. “Dietary Silver Nanoparticles can Disturb the Gut Microbiota in Mice.” Particle and Fibre Toxicology 13: 38.
   PubMed Web of Science ®Google Scholar
• Warheit, D. B. 2013. “How to Measure Hazards/risks Following Exposures to Nanoscale or Pigment-grade Titanium Dioxide Particles.” Toxicology Letters 220: 193–204.
   PubMed Web of Science ®Google Scholar
• Weir, A., P. Westerhoff, L. Fabricius, K. Hristovski, and N. von Goetz. 2012. “Titanium Dioxide Nanoparticles in Food and Personal Care Products.” Environmental Science & Technology 46: 2242–2250.
   PubMed Web of Science ®Google Scholar
• Yada, R. Y., N. Buck, R. Canady, C. DeMerlis, T. Duncan, G. Janer, L. Juneja, et al. 2014. “Engineered Nanoscale Food Ingredients: Evaluation of Current Knowledge on Material Characteristics Relevant to Uptake from the Gastrointestinal Tract.” Comprehensive Reviews in Food Science and Food Safety 13: 730–744.
   Web of Science ®Google Scholar
• Yang, Y., K. Doudrick, X. Bi, K. Hristovski, P. Herckes, P. Westerhoff, and R. Kaegi. 2014. “Characterization of Food-grade Titanium Dioxide: The Presence of Nanosized Particles.” Environmental Science & Technology 48: 6391–6400.
   PubMed Web of Science ®Google Scholar
• Yates, P. D., G. V. Franks, S. Biggs, and G. J. Jameson. 2005. “Heteroaggregation with Nanoparticles: Effect of Particle Size Ratio on Optimum Particle Dose.” Colloids and Surfaces A - Physicochemical and Engineering Aspects 255: 85–90.
   Web of Science ®Google Scholar
• Zhang, R., Z. Zhang, H. Zhang, E. A. Decker, and D. J. McClements. 2015. “Influence of Emulsifier Type on Gastrointestinal Fate of Oil-in-water Emulsions Containing Anionic Dietary Fiber (Pectin).” Food Hydrocolloids 45: 175–185.
   Web of Science ®Google Scholar
• Zhang, R., Z. Zhang, L. Zou, H. Xiao, G. Zhang, E. A. Decker, and D. J. McClements. 2015. “Enhancing Nutraceutical Bioavailability from Raw and Cooked Vegetables Using Excipient Emulsions: Influence of Lipid Type on Carotenoid Bioaccessibility from Carrots.” Journal of Agricultural and Food Chemistry 63: 10508–10517.
   PubMed Web of Science ®Google Scholar
• Zhang, R., Z. Zhang, L. Zou, H. Xiao, G. Zhang, E. A. Decker, and D. J. McClements. 2016. “Enhancement of Carotenoid Bioaccessibility from Carrots Using Excipient Emulsions: Influence of Particle Size of Digestible Lipid Droplets.” Food & Function 7: 93–103.
   PubMed Web of Science ®Google Scholar
• Zhang, Y., Y. Chen, P. Westerhoff, and J. Crittenden. 2009. “Impact of Natural Organic Matter and Divalent Cations on the Stability of Aqueous Nanoparticles.” Water Research 43: 4249–4257.
   PubMed Web of Science ®Google Scholar
• Zou, L., W. Liu, C. Liu, H. Xiao, and D. J. McClements. 2015. “Utilizing Food Matrix Effects to Enhance Nutraceutical Bioavailability: Increase of Curcumin Bioaccessibility Using Excipient Emulsions.” Journal of Agricultural and Food Chemistry 63: 2052–2062.
   PubMed Web of Science ®Google Scholar