Pulmonary toxicity of inhaled nano-sized cerium oxide aerosols in Sprague–Dawley rats

References

• Aalapati, S., S. Ganapathy, S. Manapuram, G. Anumolu, and B. M. Prakya. 2014. “Toxicity and Bio-accumulation of Inhaled Cerium Oxide Nanoparticles in CD1 Mice.” Nanotoxicology 8 (7): 786–798.
   PubMed Web of Science ®Google Scholar
• Asgharian, B., O. Price, F. Miller, R. Subramaniam, F. R. Cassee, J. Freijer, L. Van Bree, and R. De Winter-Sorkina. 2009. MPPD, Multiple-Path Dosimetry Model v2.11. Applied Research Associates (ARA), The Hamner Institutes for Health Sciences, the National Institute of Public Health and the Environment (RIVM), the Netherlands, and the Ministry of Housing, Spatial Planning and the Environment, the Netherlands.
   Google Scholar
• Auffan, M., J. Rose, T. Orsiere, M. De Meo, A. Thill, O. Zeyons, O. Proux, et al. 2009. “CeO2 Nanoparticles Induce DNA Damage towards Human Dermal Fibroblasts in Vitro.” Nanotoxicology 3 (2): 161–171. doi:10.1080/17435390902788086.
   Web of Science ®Google Scholar
• Braakhuis, H. M., F. R. Cassee, P. H. Fokkens, L. J. De La Fonteyne, A. G. Oomen, P. Krystek, W. H. De Jong, H. Van Loveren, and M. V. Park. 2016. “Identification of the Appropriate Dose Metric for Pulmonary Inflammation of Silver Nanoparticles in an Inhalation Toxicity Study.” Nanotoxicology 10:63–73. doi:10.3109/17435390.2015.1012184.
   PubMed Web of Science ®Google Scholar
• Cassee, F. R., A. Campbell, A. J. Boere, S. G. Mclean, R. Duffin, P. Krystek, I. Gosens, and M. R. Miller. 2012. “The Biological Effects of Subacute Inhalation of Diesel Exhaust following Addition of Cerium Oxide Nanoparticles in Atherosclerosis-prone Mice.” Environmental Research 115: 1–10. doi:10.1016/j.envres.2012.03.004.
   PubMed Web of Science ®Google Scholar
• Cassee, F. R., E. C. Van Balen, C. Singh, D. Green, H. Muijser, J. Weinstein, and K. Dreher. 2011. “Exposure, health and Ecological Effects Review of Engineered Nanoscale Cerium and Cerium Oxide Associated with Its Use as a Fuel Additive.” Critical Reviews in Toxicology 41 (3): 213–229. doi:10.3109/10408444.2010.529105.
   PubMed Web of Science ®Google Scholar
• Chen, H.-S., J. Mazzolini, J. Ayers, J. Rappoport, J. Lead, and J. Preece. 2013. Synthesis and characterization of nano ceria for biological applications. Nano-Bio Sensing, Imaging and Spectroscopy SPIE, 7.
   Google Scholar
• Cheng, G., W. Guo, L. Han, E. Chen, L. Kong, L. Wang, W. Ai, N. Song, H. Li, and H. Chen. 2013. “Cerium Oxide Nanoparticles Induce Cytotoxicity in Human Hepatoma SMMC-7721 Cells via Oxidative Stress and the Activation of MAPK Signaling Pathways.” Toxicology in Vitro 27 (3): 1082–1088. doi:10.1016/j.tiv.2013.02.005
   PubMed Web of Science ®Google Scholar
• Cormet-Boyaka, E., K. Jolivette, A. Bonnegarde-Bernard, J. Rennolds, F. Hassan, P. Mehta, S. Tridandapani, J. Webster-Marketon, and P. N. Boyaka. 2012. “An NF-kappaB-independent and Erk1/2-dependent Mechanism Controls CXCL8/IL-8 Responses of Airway Epithelial Cells to Cadmium.” Toxicological Sciences 125 (2): 418–429. doi:10.1093/toxsci/kfr310.
   PubMed Web of Science ®Google Scholar
• Dale, J., S. Cox, M. Vance, L. Marr, and M. Hochella. 2017. “Transformation of Cerium Oxide Nanoparticles from a Diesel Fuel Additive during Combustion in a Diesel Engine.” Environmental Science & Technology 51: 1973–1980.
   PubMed Web of Science ®Google Scholar
• Damoiseaux, R., S. George, M. Li, S. Pokhrel, Z. Ji, B. France, T. Xia, et al. 2011. “No Time to Lose – High Throughput Screening to Assess Nanomaterial Safety.” Nanoscale 3 (4): 1345–1360. doi:10.1039/c0nr00618a.
   PubMed Web of Science ®Google Scholar
• Dekkers, S., M. R. Miller, R. P. F. Schins, I. Romer, M. Russ, R. J. Vandebriel, I. Lynch, et al. 2017. “The Effect of Zirconium Doping of Cerium Dioxide Nanoparticles on Pulmonary and Cardiovascular Toxicity and Biodistribution in Mice after Inhalation.” Nanotoxicology 11, 794–808. doi:10.1080/17435390.2017.1357214.
   PubMed Web of Science ®Google Scholar
• Dekkers, S., T. D. Williams, J. Zhang, J. Zhou, R. J. Vandebriel, L. J. J. De La Fonteyne, E. R. Gremmer, et al. 2018. “Multi-omics Approaches Confirm Metal Ions Mediate the Main Toxicological Pathways of Metal-bearing Nanoparticles in Lung Epithelial A549 Cells.” Environmental Science: Nano 5: 1506–1517. doi:10.1039/C8EN00071A
   Web of Science ®Google Scholar
• Demokritou, P., S. Gass, G. Pyrgiotakis, J. M. Cohen, W. Goldsmith, W. Mckinney, D. Frazer, et al. 2013. “An in Vivo and in Vitro Toxicological Characterisation of Realistic Nanoscale CeO(2) inhalation Exposures.” Nanotoxicology 7 (8): 1338–1350. doi:10.3109/17435390.2012.739665.
   PubMed Web of Science ®Google Scholar
• Deshpande, S., S. Patil, S. V. N. T. Kuchibhatla, and S. Seal. 2005. “Size Dependency Variation in Lattice Parameter and Valency States in Nanocrystalline Cerium Oxide.” Applied Physics Letters 87 (13): 133113. doi:10.1063/1.2061873.
   Web of Science ®Google Scholar
• Eom, H. J., and J. Choi. 2009. “Oxidative Stress of CeO2 Nanoparticles via p38-Nrf-2 Signaling Pathway in Human Bronchial Epithelial Cell, Beas-2B.” Toxicology Letters 187 (2): 77–83.
   PubMed Web of Science ®Google Scholar
• Erdakos, G. B., P. V. Bhave, G. A. Pouliot, H. Simon, and R. Mathur. 2014. “Predicting the Effects of Nanoscale Cerium Additives in Diesel Fuel on Regional-scale Air Quality.” Environmental Science & Technology 48 (21): 12775–12782. doi:10.1021/es504050g.
   PubMed Web of Science ®Google Scholar
• Fu, P. P., Q. Xia, H.-M. Hwang, P. C. Ray, and H. Yu. 2014. “Mechanisms of Nanotoxicity: Generation of Reactive Oxygen Species.” Journal of Food and Drug Analysis 22 (1): 64–75. doi:10.1016/j.jfda.2014.01.005.
   PubMed Web of Science ®Google Scholar
• Gantt, B., S. Hoque, K. M. Fahey, R. D. Willis, J. M. Delgado-Saborit, R. M. Harrison, K. M. Zhang, et al. 2015. “Factors Affecting the Ambient Physicochemical Properties of Cerium-Containing Particles Generated by Nanoparticle Diesel Fuel Additive Use.” Aerosol Science and Technology 49 (6): 371–380. doi:10.1080/02786826.2015.1027809.
   Web of Science ®Google Scholar
• Gantt, B., S. Hoque, R. D. Willis, K. M. Fahey, J. M. Delgado-Saborit, R. M. Harrison, G. B. Erdakos, et al. 2014. “Near-road Modeling and Measurement of Cerium-containing Particles Generated by Nanoparticle Diesel Fuel Additive Use.” Environmental Science & Technology 48 (18): 10607–10613. doi:10.1021/es502169p.
   PubMed Web of Science ®Google Scholar
• Geraets, L., A. G. Oomen, J. D. Schroeter, V. A. Coleman, and F. R. Cassee. 2012. “Tissue Distribution of Inhaled Micro- and Nano-sized Cerium Oxide Particles in Rats: Results from a 28-day Exposure Study.” Toxicological Sciences 127 (2): 463–473. doi:10.1093/toxsci/kfs113.
   PubMed Web of Science ®Google Scholar
• Gosens, I., L. E. Mathijssen, B. G. Bokkers, H. Muijser, and F. R. Cassee. 2014. “Comparative Hazard Identification of Nano- and Micro-sized Cerium Oxide Particles Based on 28-day Inhalation Studies in Rats.” Nanotoxicology 8 (6): 643–653. doi:10.3109/17435390.2013.815814.
   PubMed Web of Science ®Google Scholar
• Griese, M., H. G. Kirmeier, G. Liebisch, D. Rauch, F. Stückler, G. Schmitz, R. Zarbock, and I.-B. W. G. O. T. Kids-Lung-Register. 2015. “Surfactant Lipidomics in Healthy Children and Childhood Interstitial Lung Disease.” PLoS One 10 (2): e0117985. doi:10.1371/journal.pone.0117985.
   PubMed Web of Science ®Google Scholar
• HEI 2001. Evaluation of Human Health Risk from Cerium Added to Diesel Fuel. Communication 9. Boston, MA: Health Effects Institute (HEI).
   Google Scholar
• Keller, J., W. Wohlleben, L. Ma-Hock, V. Strauss, S. Groters, K. Kuttler, K. Wiench, et al. 2014. “Time Course of Lung Retention and Toxicity of Inhaled Particles: Short-term Exposure to nano-Ceria.” Archives of Toxicology 88 (11): 2033–2059. doi:10.1007/s00204-014-1349-9.
   PubMed Web of Science ®Google Scholar
• Landsiedel, R., L. Ma-Hock, T. Hofmann, M. Wiemann, V. Strauss, S. Treumann, W. Wohlleben, S. Gröters, K. Wiench, and B. van Ravenzwaay. 2014. “Application of Short-term Inhalation Studies to Assess the Inhalation Toxicity of Nanomaterials.” Particle and Fibre Toxicology 11: 16.
   PubMed Web of Science ®Google Scholar
• Larsen, S. T., P. Jackson, S. S. Poulsen, M. Levin, K. A. Jensen, H. Wallin, G. D. Nielsen, and I. K. Koponen. 2016. “Airway Irritation, inflammation, and Toxicity in Mice following Inhalation of Metal Oxide Nanoparticles.” Nanotoxicology 10 (9): 1254–1262. doi:10.1080/17435390.2016.1202350.
   PubMed Web of Science ®Google Scholar
• Lee, S.-H., T.-Y. Wang, J.-H. Hong, T.-J. Cheng, and C.-Y. Lin. 2016. “NMR-based Metabolomics to Determine Acute Inhalation Effects of Nano- and Fine-sized ZnO Particles in the Rat Lung.” Nanotoxicology 10 (7): 924–934. doi:10.3109/17435390.2016.1144825.
   PubMed Web of Science ®Google Scholar
• Lee, S. H., C. H. Tang, W. Y. Lin, K. H. Chen, H. J. Liang, T. J. Cheng, and C. Y. Lin. 2018. “LC-MS-based Lipidomics to Examine Acute Rat Pulmonary Responses after Nano- and Fine-sized ZnO Particle Inhalation Exposure.” Nanotoxicology 114: 439–452.
   Google Scholar
• Li, D., M. Morishita, J. G. Wagner, M. Fatouraie, M. Wooldridge, W. E. Eagle, J. Barres, U. Carlander, C. Emond, and O. Jolliet. 2016. “In Vivo Biodistribution and Physiologically Based Pharmacokinetic Modeling of Inhaled Fresh and Aged Cerium Oxide Nanoparticles in Rats.” Particle and Fibre Toxicology 13 (1): 45.
   PubMedGoogle Scholar
• Lin, W., Y. W. Huang, X. D. Zhou, and Y. Ma. 2006. “Toxicity of Cerium Oxide Nanoparticles in Human Lung Cancer cells.” International Journal of Toxicology 25 (6): 451–457.
   PubMed Web of Science ®Google Scholar
• Lopez-Ibanez, J., F. Pazos, and M. Chagoyen. 2016. “MBROLE 2.0-functional Enrichment of Chemical Compounds.” Nucleic Acids Research 44: W201–W204. doi:10.1093/nar/gkw253.
   PubMed Web of Science ®Google Scholar
• Ma, J. Y., R. R. Mercer, M. Barger, D. Schwegler-Berry, J. Scabilloni, J. K. Ma, and V. Castranova. 2012. “Induction of Pulmonary Fibrosis by Cerium Oxide Nanoparticles.” Toxicology and Applied Pharmacology 262 (3): 255–264. doi:10.1016/j.taap.2012.05.005.
   PubMed Web of Science ®Google Scholar
• Ma, J. Y., H. Zhao, R. R. Mercer, M. Barger, M. Rao, T. Meighan, D. Schwegler-Berry, V. Castranova, and J. K. Ma. 2011. “Cerium Oxide Nanoparticle-induced Pulmonary Inflammation and Alveolar Macrophage Functional Change in Rats.” Nanotoxicology 5 (3): 312–325. doi:10.3109/17435390.2010.519835.
   PubMed Web of Science ®Google Scholar
• Majestic, B. J., G. B. Erdakos, M. Lewandowski, K. D. Oliver, R. D. Willis, T. E. Kleindienst, and P. V. Bhave. 2010. “A Review of Selected Engineered Nanoparticles in the Atmosphere: Sources, transformations, and Techniques for Sampling and Analysis.” International Journal of Occupational and Environmental Health 16 (4): 488–507. doi:10.1179/oeh.2010.16.4.488.
   PubMed Web of Science ®Google Scholar
• Morimoto, Y., H. Izumi, Y. Yoshiura, T. Tomonaga, T. Oyabu, T. Myojo, K. Kawai, et al. 2015. “Pulmonary Toxicity of Well-dispersed Cerium Oxide Nanoparticles following Intratracheal Instillation and Inhalation.” Journal of Nanoparticle Research 17: 442.
   PubMed Web of Science ®Google Scholar
• Nemmar, A., P. Yuvaraju, S. Beegam, M. A. Fahim, and B. H. Ali. 2017. “Cerium Oxide Nanoparticles in Lung Acutely Induce Oxidative Stress, Inflammation, and DNA Damage in Various Organs of Mice.” Oxidative Medicine and Cellular Longevity 2017:12. doi:10.1155/2017/9639035.
   Google Scholar
• Oberdörster, G., J. Ferin, and B. E. Lehnert. 1994. “Correlation between Particle Size, in Vivo Particle Persistence, and Lung Injury.” Environmental Health Perspectives 102 (Suppl 5): 173–179. doi:10.1289/ehp.94102s5173.
   PubMed Web of Science ®Google Scholar
• Oberdörster, G., A. Maynard, K. Donaldson, V. Castranova, J. Fitzpatrick, K. Ausman, J. Carter, et al. 2005. “Principles for Characterizing the Potential Human Health Effects from Exposure to Nanomaterials: Elements of a Screening Strategy.” Particle and Fibre Toxicology 2 (1): 8. doi:10.1186/1743-8977-2-8.
   PubMed Web of Science ®Google Scholar
• Park, B., K. Donaldson, R. Duffin, L. Tran, F. Kelly, I. Mudway, J. P. Morin, et al. 2008a. “Hazard and Risk Assessment of a Nanoparticulate Cerium Oxide-based Diesel Fuel Additive – a Case Study.” Inhalation Toxicology 20 (6): 547–566. doi:10.1080/08958370801915309.
   PubMed Web of Science ®Google Scholar
• Park, E. J., J. Choi, Y. K. Park, and K. Park. 2008b. “Oxidative Stress Induced by Cerium Oxide Nanoparticles in Cultured BEAS-2B Cells.” Toxicology 245 (1–2): 90–100. doi:10.1016/j.tox.2007.12.022.
   PubMed Web of Science ®Google Scholar
• Park, E. J., J. Yi, K. H. Chung, D. Y. Ryu, J. Choi, and K. Park. 2008c. “Oxidative Stress and Apoptosis Induced by Titanium Dioxide Nanoparticles in Cultured BEAS-2B Cells.” Toxicology Letters 180 (3): 222–229. doi:10.1016/j.toxlet.2008.06.869.
   PubMed Web of Science ®Google Scholar
• Peng, L., X. He, P. Zhang, J. Zhang, Y. Li, J. Zhang, Y. Ma, et al. 2014. “Comparative Pulmonary Toxicity of Two Ceria Nanoparticles with the Same Primary Size.” International Journal of Molecular Sciences 15 (4): 6072–6085. doi:10.3390/ijms15046072.
   PubMed Web of Science ®Google Scholar
• Reed, K., A. Cormack, A. Kulkarni, M. Mayton, D. Sayle, F. Klaessig, and B. Stadler. 2014. “Exploring the Properties and Applications of Nanoceria: Is There Still Plenty of Room at the Bottom?” Environmental Science: Nano 1: 390–405. doi:10.1039/C4EN00079J.
   Web of Science ®Google Scholar
• Rice, K. M., S. K. Nalabotu, N. D. Manne, M. B. Kolli, G. Nandyala, R. Arvapalli, J. Y. Ma, and E. R. Blough. 2015. “Exposure to Cerium Oxide Nanoparticles Is Associated with Activation of Mitogen-activated Protein Kinases Signaling and Apoptosis in Rat Lungs.” Journal of Preventive Medicine and Public Health 48 (3): 132–141. doi:10.3961/jpmph.15.006.
   PubMedGoogle Scholar
• Schwotzer, D., H. Ernst, D. Schaudien, H. Kock, G. Pohlmann, C. Dasenbrock, and O. Creutzenberg. 2017. “Effects from a 90-day Inhalation Toxicity Study with Cerium Oxide and Barium Sulfate Nanoparticles in Rats.” Particle and Fibre Toxicology 14: 23.
   PubMed Web of Science ®Google Scholar
• Schwotzer, D., M. Niehof, D. Schaudien, H. Kock, T. Hansen, C. Dasenbrock, and O. Creutzenberg. 2018. “Cerium Oxide and Barium Sulfate Nanoparticle Inhalation Affects Gene Expression in Alveolar Epithelial Cells Type II.” Journal of Nanobiotechnology 16: 16.
   PubMed Web of Science ®Google Scholar
• Singh, S., T. Dosani, A. S. Karakoti, A. Kumar, S. Seal, and W. T. Self. 2011. “A Phosphate-dependent Shift in Redox State of Cerium Oxide Nanoparticles and Its Effects on Catalytic Properties.” Biomaterials 32 (28): 6745–6753. doi:10.1016/j.biomaterials.2011.05.073.
   PubMed Web of Science ®Google Scholar
• Skillas, G., Qian, Z., Baltensperger, U., Matter, U. & Burtscher, H., 2000. The Influence of Additives on the Size Distribution and Composition of Particles Produced by Diesel Engines. Combustion Science and Technology, 154, 259–273.
   Web of Science ®Google Scholar
• Snow, S. J., J. Mcgee, D. B. Miller, V. Bass, M. C. Schladweiler, R. F. Thomas, T. Krantz, et al. 2014. “Inhaled Diesel Emissions Generated with Cerium Oxide Nanoparticle Fuel Additive Induce Adverse Pulmonary and Systemic Effects.” Toxicological Sciences 142 (2): 403–417. doi:10.1093/toxsci/kfu187.
   PubMed Web of Science ®Google Scholar
• Southam, A. D., R. J. Weber, J. Engel, M. R. Jones, and M. R. Viant. 2017. “A Complete Workflow for High-resolution Spectral-stitching Nanoelectrospray Direct-infusion Mass-spectrometry-based Metabolomics and Lipidomics.” Nature Protocols 12: 310–328.
   Web of Science ®Google Scholar
• Srinivas, A., P. J. Rao, G. Selvam, P. B. Murthy, and P. N. Reddy. 2011. “Acute Inhalation Toxicity of Cerium Oxide Nanoparticles in Rats.” Toxicology Letters 205 (2): 105–115.
   PubMed Web of Science ®Google Scholar
• Stoeger, T., C. Reinhard, S. Takenaka, A. Schroeppel, E. Karg, B. Ritter, J. Heyder, and H. Schulz. 2006. “Instillation of Six Different Ultrafine Carbon Particles Indicates a Surface Area Threshold Dose for Acute Lung Inflammation in Mice.” Environmental Health Perspectives 114 (3): 328–333. doi:10.1289/ehp.8266.
   PubMed Web of Science ®Google Scholar
• Szymanski, C. J., P. Munusamy, C. Mihai, Y. Xie, D. Hu, M. K. Gilles, T. Tyliszczak, S. Thevuthasan, D. R. Baer, and G. Orr. 2015. “Shifts in Oxidation States of Cerium Oxide Nanoparticles Detected inside Intact Hydrated Cells and Organelles.” Biomaterials 62: 147–154. doi:10.1016/j.biomaterials.2015.05.042.
   PubMed Web of Science ®Google Scholar
• Taylor, N. S., R. Merrifield, T. D. Williams, J. K. Chipman, J. R. Lead, and M. R. Viant. 2016. “Molecular Toxicity of Cerium Oxide Nanoparticles to the Freshwater Alga Chlamydomonas reinhardtii Is Associated with Supra-environmental Exposure Concentrations.” Nanotoxicology 10: 32–41. doi:10.3109/17435390.2014.1002868
   PubMed Web of Science ®Google Scholar
• Titz, B., S. Boue, B. Phillips, M. Talikka, T. Vihervaara, T. Schneider, C. Nury, et al. 2016. “Effects of Cigarette Smoke, Cessation, and Switching to Two Heat-Not-Burn Tobacco Products on Lung Lipid Metabolism in C57BL/6 and Apoe−/− Mice-An Integrative Systems Toxicology Analysis.” Toxicological Sciences 149 (2): 441–457. doi:10.1093/toxsci/kfv244.
   PubMed Web of Science ®Google Scholar
• Tyurina, Y. Y., E. R. Kisin, A. Murray, V. A. Tyurin, V. I. Kapralova, L. J. Sparvero, A. A. Amoscato, et al. 2011. “Global Phospholipidomics Analysis Reveals Selective Pulmonary Peroxidation Profiles upon Inhalation of Single-Walled Carbon Nanotubes.” ACS Nano 5 (9): 7342–7353. doi:10.1021/nn202201j.
   PubMed Web of Science ®Google Scholar
• Wu, H., A. D. Southam, A. Hines, and M. R. Viant. 2008. “High-throughput Tissue Extraction Protocol for NMR- and MS-based Metabolomics.” Analytical Biochemistry 372 (2): 204–212.
   PubMed Web of Science ®Google Scholar
• Yu, L. E., L.-Y. Lanry Yung, C.-N. Ong, Y.-L. Tan, K. Suresh Balasubramaniam, D. Hartono, G. Shui, M. R. Wenk, and W.-Y. Ong. 2007. “Translocation and Effects of Gold Nanoparticles after Inhalation Exposure in Rats.” Nanotoxicology 1 (3): 235–242. doi:10.1080/17435390701763108.
   Web of Science ®Google Scholar
• Zemski Berry, K. A., R. C. Murphy, B. Kosmider, and R. J. Mason. 2017. “Lipidomic Characterization and Localization of Phospholipids in the Human Lung.” Journal of Lipid Research 58 (5): 926–933. doi:10.1194/jlr.M074955.
   PubMed Web of Science ®Google Scholar
• Zhang, J., Y. Nazarenko, L. Zhang, L. Calderon, K. B. Lee, E. Garfunkel, S. Schwander, et al. 2013. “Impacts of a Nanosized Ceria Additive on Diesel Engine Emissions of Particulate and Gaseous Pollutants.” Environmental Science & Technology 47 (22): 13077–13085. doi:10.1021/es402140u.
   PubMed Web of Science ®Google Scholar