The effects of nano-sized PbO on biomarkers of membrane disruption and DNA damage in a sub-chronic inhalation study on mice

References

• AzoNano. 2013. “Lead Oxide (PbO) Nanoparticles – Properties, Applications.” http://www.azonano.com/article.aspx?ArticleID=3339
   Google Scholar
• Bláhová, L., J. Kohoutek, J. Lebedová, L. Bláha, Z. Večeřa, M. Buchtová, I. Míšek, and K. Hilscherová. 2014. “Simultaneous Determination of Reduced and Oxidized Glutathione in Tissues by a Novel Liquid Chromatography-Mass Spectrometry Method: Application in an Inhalation Study of Cd Nanoparticles.” Analytical and Bioanalytical Chemistry 406(24): 5867–5876. doi:10.1007/s00216-014-8033-z.
   PubMed Web of Science ®Google Scholar
• Blum, J.L., J.Q. Xiong, C. Hoffman, and J.T. Zelikoff. 2012. “Cadmium Associated with Inhaled Cadmium Oxide Nanoparticles Impacts Fetal and Neonatal Development and Growth.” Toxicological Sciences 126(2): 478–486. doi:10.1093/toxsci/kfs008.
   PubMed Web of Science ®Google Scholar
• Blum, J.L., L.K. Rosenblum, G. Grunig, M.B. Beasley, J.Q. Xiong, and J.T. Zelikoff. 2014. “Short-Term Inhalation of Cadmium Oxide Nanoparticles Alters Pulmonary Dynamics Associated with Lung Injury, Inflammation, and Repair in a Mouse Model.” Inhalation Toxicology 26(1): 48–58. doi:10.3109/08958378.2013.851746.
   PubMed Web of Science ®Google Scholar
• Brose, S. a., B.T. Thuen, and M.Y. Golovko. 2011. “LC/MS/MS Method for Analysis of E2 Series Prostaglandins and Isoprostanes.” Journal of Lipid Research 52(4): 850–859. doi:10.1194/jlr.D013441.
   PubMed Web of Science ®Google Scholar
• Cho, W.S., R. Duffin, C.A. Poland, A. Duschl, G.J. Oostingh, W. MacNee, M. Bradley, I.L. Megson, and K. Donaldson. 2012. “Differential Pro-Inflammatory Effects of Metal Oxide Nanoparticles and Their Soluble Ions In Vitro and In Vivo; Zinc and Copper Nanoparticles, But Not Their Ions, Recruit Eosinophils to the Lungs.” Nanotoxicology 6(1): 22–35. doi:10.3109/17435390.2011.552810.
   PubMed Web of Science ®Google Scholar
• Cho, W-S., R. Duffin, C.A. Poland, S.E.M. Howie, W. MacNee, M. Bradley, I.L. Megson, and K. Donaldson. 2010. “Metal Oxide Nanoparticles Induce Unique Inflammatory Footprints in the Lung: Important Implications for Nanoparticle Testing.” Environmental Health Perspectives 118(12): 1699–1706. doi:10.1289/ehp.1002201.
   PubMed Web of Science ®Google Scholar
• Chuang, H.C., H.T. Juan, C.N. Chang, Y.H. Yan, T.H. Yuan, J.S. Wang, H.C. Chen, Y.H. Hwang, C.H. Lee, and T.J. Cheng. 2014. “Cardiopulmonary Toxicity of Pulmonary Exposure to Occupationally Relevant Zinc Oxide Nanoparticles.” Nanotoxicology 8(6): 593–604. doi:10.3109/17435390.2013.809809.
   PubMed Web of Science ®Google Scholar
• Chuang, H.C., K.J. Chuang, J.K. Chen, H.E. Hua, Y.L. Shen, W.N. Liao, C.H. Lee, C.H. Pan, K.Y. Chen, K.Y. Lee., et al. 2017. “Pulmonary Pathobiology Induced by zinc oxide nanoparticles in mice: A 24-hour and 28-day follow-up study.” Toxicology and Applied Pharmacology 327: 13–22. doi:10.1016/j.taap.2017.04.018.
   PubMed Web of Science ®Google Scholar
• Chuang, H.C., T.C. Hsiao, C.K. Wu, H.H. Chang, C.H. Lee, C.C. Chang, and T.J. Cheng. 2013. “Allergenicity and Toxicology of Inhaled Silver Nanoparticles in Allergen-Provocation Mice Models.” International Journal of Nanomedicine 8: 4495–4506. doi:10.2147/IJN.S52239.
   PubMed Web of Science ®Google Scholar
• Coccini, T., E. Roda, S. Barni, C. Signorini, and L. Manzo. 2012. “Long-Lasting Oxidative Pulmonary Insult in Rat After Intratracheal Instillation of Silica Nanoparticles Doped with Cadmium.” Toxicology 302(2-3): 203–211. doi:10.1016/j.tox.2012.07.019.
   PubMed Web of Science ®Google Scholar
• Dumkova, J., L. Vrlikova, Z. Vecera, B. Putnova, B. Docekal, P. Mikuska, P. Fictum, A. Hampl, and M. Buchtova. 2016. “Inhaled Cadmium Oxide Nanoparticles: Their in Vivo Fate and Effect on Target Organs.” International Journal of Molecular Sciences 17: pii: E874. doi:10.3390/ijms17060874.
   Web of Science ®Google Scholar
• Dumková, J., T. Smutná, L. Vrlíková, P. Le Coustumer, Z. Večeřa, B. Dočekal, P. Mikuška, L. Čapka, P. Fictum, A. Hampl., et al. 2017. “Sub-Chronic Inhalation of Lead Oxide Nanoparticles Revealed Their Broad Distribution and Tissue-Specific Subcellular Localization in Target Organs.” Particale and Fibre Toxicology 14: 1–19. doi:10.1186/s12989-017-0236-y.
   PubMed Web of Science ®Google Scholar
• Fu, P.P., Q. Xia, H.M. Hwang, P.C. Ray, and H. Yu. 2014. “Mechanisms of nanotoxicity: Generation of reactive oxygen species.” Journal of Food and Drug Analysis 22(1): 64–75. doi:10.1016/j.jfda.2014.01.005.
   PubMed Web of Science ®Google Scholar
• Garza, A., R. Vega, and E. Soto. 2006. “Cellular Mechanisms of Lead Neurotoxicity.” Medical Science Monitoring : International Medical Journal of Experimantal and Clinical Research 12(3): RA57–RA65.
   Google Scholar
• Hardisty, J.F., and A.E. Brix. 2005. “Comparative Hepatic Toxicity: PrechroniC/Chronic Liver Toxicity in Rodents.” Toxicologic Pathology 33(1): 35–40. doi:10.1080/01926230590522077.
   PubMed Web of Science ®Google Scholar
• Hardy, K.D., B.E. Cox, G.L. Milne, H. Yin, and L.J. Roberts. 2011. “Nonenzymatic Free Radical-Catalyzed Generation of 15-Deoxy-Δ(12,14)-Prostaglandin J2-Like Compounds (Deoxy-J2-Isoprostanes) in Vivo.” Journal of Lipid Research 52(1): 113–124. doi:10.1194/jlr.M010264.
   PubMed Web of Science ®Google Scholar
• Horie, M., Y. Yoshiura, H. Izumi, T. Oyabu, T. Tomonaga, T. Okada, B.-W. Lee, T. Myojo, M. Kubo, M. Shimada., et al. 2016. “Comparison of the Pulmonary Oxidative Stress Caused by Intratracheal Instillation and Inhalation of NiO Nanoparticles when Equivalent Amounts of NiO are Retained in the Lung.” Antioxidants 5(1): 4. doi:10.3390/antiox5010004.
   Web of Science ®Google Scholar
• Hou, X., L. J. Roberts, D. F. Taber, J. D. Morrow, K. Kanai, F. Gobeil, M. H. Beauchamp, S. G. Bernier, G. Lepage, D. R. Varma., et al. 2001. “2,3-Dinor-5,6-Dihydro-15-F2t-isoprostane: A Bioactive Prostanoid Metabolite.” American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 281(2): R391–R400. doi:10.1152/ajpregu.2001.281.2.R391.
   PubMed Web of Science ®Google Scholar
• Inoue, M., T. Osaki, M. Noguchi, S. Hirohashi, K. Yasumoto, and H. Kasai. 1998. “Lung Cancer Patients Have Increased 8-Hydroxydeoxyguanosine Levels in Peripheral Lung Tissue DNA.” Japanese Journal of Cancer Research 89(7): 691–695. doi:10.1111/j.1349-7006.1998.tb03272.x.
   PubMedGoogle Scholar
• Khalil, W.K.B., E. Girgis, A.N. Emam, M.B. Mohamed, and K. V. Rao. 2011. “Genotoxicity Evaluation of Nanomaterials: DNA Damage, Micronuclei, and 8-Hydroxy-2-Deoxyguanosine Induced by Magnetic Doped CdSe Quantum Dots in Male Mice.” Chemical Research in Toxicology 24(5): 640–650. doi:10.1021/tx2000015.
   PubMed Web of Science ®Google Scholar
• Kim, Y.S., C.H. Lim, S.H. Shin, and J.C. Kim. 2017. “Twenty-Eight-Day Repeated Inhalation Toxicity Study of Nano-Sized Neodymium Oxide in Male Sprague–Dawley Rats.” Toxicological Research 33(3): 239–253. doi:10.5487/TR.2017.33.3.239.
   PubMed Web of Science ®Google Scholar
• Lebedová, J., L. Bláhová, Z. Večeřa, P. Mikuška, B. Dočekal, M. Buchtová, I. Míšek, J. Dumková, A. Hampl, and K. Hilscherová. 2016. “Impact of Acute and Chronic Inhalation Exposure to CdO Nanoparticles on Mice.” Environmental Science and Pollution Research 23(23): 24047–24060. doi:10.1007/s11356-016-7600-6.
   PubMed Web of Science ®Google Scholar
• Lebedová, J., Z. Nováková, Z. Večeřa, M. Buchtová, J. Dumková, B. Dočekal, L. Bláhová, P. Mikuška, I. Míšek, A. Hampl., et al. 2018. “Impact of acute and subchronic inhalation exposure to PbO Nanoparticles on Mice.” Nanotoxicology 12(4): 290–304., doi:10.1080/17435390.2018.1438679.
   PubMed Web of Science ®Google Scholar
• Li, Q., X. Hu, Y. Bai, M. Alattar, D. Ma, Y. Cao, Y. Hao, L. Wang, and C. Jiang. 2013. “The Oxidative Damage and Inflammatory Response Induced by Lead Sulfide Nanoparticles in Rat Lung.” Food and Chemical Toxicology 60: 213–217. doi:10.1016/j.fct.2013.07.046.
   PubMed Web of Science ®Google Scholar
• Lowry, O.H., N.J. Rosebrough, A.L. Farr, and R.J. Randall. 1951. “Protein Measurement With the Folin Phenol Reagent.” The Journal of Biological Chemistry 193(1): 265–275. doi:10.1016/0304-3894(92)87011-4.
   PubMed Web of Science ®Google Scholar
• Máté, Z., E. Horváth, G. Kozma, T. Simon, Z. Kónya, E. Paulik, A. Papp, and A. Szabó. 2016. “Size-Dependent Toxicity Differences of Intratracheally Instilled Manganese Oxide Nanoparticles: Conclusions of a Subacute Animal Experiment.” Biological Trace Element Research 171(1): 156–166. doi:10.1007/s12011-015-0508-z.
   PubMed Web of Science ®Google Scholar
• Noël, A., K. Maghni, Y. Cloutier, C. Dion, K.J. Wilkinson, S. Hallé, R. Tardif, and G. Truchon. 2012. “Effects of Inhaled Nano-TiO2 Aerosols Showing Two Distinct Agglomeration States on Rat Lungs.” Toxicology Letters 214(2): 109–119. doi:10.1016/j.toxlet.2012.08.019.
   PubMed Web of Science ®Google Scholar
• Noël, A., M. Charbonneau, Y. Cloutier, R. Tardif, and G. Truchon. 2013. “Rat Pulmonary Responses to Inhaled Nano-TiO2: Effect of Primary Particle Size and Agglomeration State.” Particle and Fibre Toxicology 10(1): 48. doi:10.1186/1743-8977-10-48.
   PubMedGoogle Scholar
• Oszlánczi, G., T. Vezér, L. Sárközi, E. Horváth, A. Szabó, E. Horváth, Z. Kónya, and A. Papp. 2010. “Metal Deposition and Functional Neurotoxicity in Rats After 3-6 Weeks Nasal Exposure by two Physicochemical Forms of Manganese.” Environmental Toxicology and Pharmacology 30(2): 121–126. doi:10.1016/j.etap.2010.04.006.
   PubMed Web of Science ®Google Scholar
• Oszlánczi, G., A. Papp, A. Szabó, L. Nagymajtényi, A. Sápi, Z. Kónya, E. Paulik, and T. Vezér. 2011. “Nervous System Effects in Rats on Subacute Exposure by Lead-Containing Nanoparticles via the Airways.” Inhalation Toxicology 23(4): 173–181. doi:10.3109/08958378.2011.553248.
   PubMed Web of Science ®Google Scholar
• Pelclova, D., V. Zdimal, Z. Fenclova, S. Vlckova, F. Turci, I. Corazzari, P. Kacer, J. Schwarz, N. Zikova, O. Makes., et al. 2016. “Markers of Oxidative Damage of Nucleic Acids and Proteins Among Workers Exposed to TiO2 (Nano) Particles.” Occupational and Environmental Medicine 73(2): 110–118. doi:10.1136/oemed-2015-103161.
   PubMed Web of Science ®Google Scholar
• Pietroiusti, A., H. Stockmann-Juvala, F. Lucaroni, and K. Savolainen. 2018. “Nanomaterial Exposure, Toxicity, and Impact on Human Health.” Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology 10: 1–21. doi:10.1002/wnan.1513.
   Web of Science ®Google Scholar
• Pujalté, I., D. Dieme, S. Haddad, A.M. Serventi, and M. Bouchard. 2017. “Toxicokinetics of Titanium Dioxide (TiO2) Nanoparticles After Inhalation in Rats.” Toxicology Letters 265: 77–85. doi:10.1016/j.toxlet.2016.11.014.
   PubMed Web of Science ®Google Scholar
• Roberts, L.J., and D.J. Morrow. 2000. “Forum: Oxidative Stress Status.” Science (80) 30: 1137–1140.
   Google Scholar
• Sharifi, S., S. Behzadi, S. Laurent, M.L. Forrest, P. Stroeve, and M. Mahmoudi. 2012. “Toxicity of Nanomaterials.” Chemical Society Reviews 41(6): 2323–2343. doi:10.1016/B978-0-12-385926-6.00024-7.
   PubMed Web of Science ®Google Scholar
• Sheng, L., X. Wang, X. Sang, Y. Ze, X. Zhao, D. Liu, S. Gui, Q. Sun, J. Cheng, Z. Cheng., et al. 2013. “Cardiac Oxidative Damage in mice following exposure to nanoparticulate titanium dioxide.” Journal of Biomedical Materials Research Part A 101: 3238–3246. doi:10.1002/jbm.a.34634.
   PubMed Web of Science ®Google Scholar
• Shvedova, A.A., E. Kisin, A.R. Murray, V.J. Johnson, O. Gorelik, S. Arepalli, A.F. Hubbs, R.R. Mercer, P. Keohavong, N. Sussman., et al. 2008. “Inhalation vs. Aspiration of Single-Walled Carbon Nanotubes in C57BL/6 Mice: Inflammation, Fibrosis, Oxidative Stress, and Mutagenesis.” American Journal of Physiology. Lung Cellular and Molecular Physiology 26505: 552–565. doi:10.1152/ajplung.90287.2008.
   Google Scholar
• Sicilia, T., A. Mally, U. Schauer, A. Pähler, and W. Völkel. 2008. “LC-MS/MS Methods for the Detection of Isoprostanes (iPF2α-III and 8,12-iso-iPF2α-VI) as Biomarkers of CCl4-Induced Oxidative Damage to Hepatic Tissue.” Journal of Chromatography B 861(1): 48–55. doi:10.1016/j.jchromb.2007.11.021.
   PubMed Web of Science ®Google Scholar
• Solberg, R., M. Longini, F. Proietti, P. Vezzosi, O.D. Saugstad, and G. Buonocore. 2012. “Resuscitation with Supplementary Oxygen Induces Oxidative Injury in the Cerebral Cortex.” Free Radical Biology and Medicine 53(5): 1061–1067. doi:10.1016/j.freeradbiomed.2012.07.022.
   PubMed Web of Science ®Google Scholar
• Spickett, C.M., I. Wiswedel, W. Siems, K. Zarkovic, and N. Zarkovic. 2010. “Advances in Methods for the Determination of Biologically Relevant Lipid Peroxidation Products.” Free Radical Research 44(10): 1172–1202. doi:10.3109/10715762.2010.498476.
   PubMed Web of Science ®Google Scholar
• Takenaka, S., E. Karg, W.G. Kreyling, B. Lentner, H. Schulz, A. Ziesenis, P. Schramel, and J. Heyder. 2004. “Fate and Toxic Effects of Inhaled Ultrafine Cadmium Oxide Particles in the Rat Lung.” Inhalation Toxicology 16(sup1): 83–92. doi:10.1080/08958370490443141.
   PubMed Web of Science ®Google Scholar
• Tanaka, M., H. Takano, Y. Fujitani, S. Hirano, T. Ichinose, A. Shimada, and K.I. Inoue. 2013. “Effects of Exposure to Nanoparticle-Rich Diesel Exhaust on 8-OHdG Synthesis in the Mouse Asthmatic Lung.” Experimental and Therapeutic Medicine 6(3): 703–706. doi:10.3892/etm.2013.1198.
   PubMed Web of Science ®Google Scholar
• Thoolen, B., R.R. Maronpot, T. Harada, A. Nyska, C. Rousseaux, T. Nolte, D.E. Malarkey, W. Kaufmann, K. Küttler, U. Deschl., et al. 2010. “Proliferative and Nonproliferative Lesions of the Rat and Mouse Hepatobiliary System.” Toxicologic Pathology 38: 5–81. doi:10.1177/0192623310386499.
   PubMed Web of Science ®Google Scholar
• Valavanidis, A., T. Vlachogianni, and C. Fiotakis. 2009. “8-hydroxy-2'-deoxyguanosine (8-OHdG): A critical biomarker of oxidative stress and carcinogenesis.” Journal of Environmental Science and Health. Part C. Environmental Carcinogens & Ecotoxicology Reviews 27(2): 120–139. doi:10.1080/10590500902885684.
   Google Scholar
• Večeřa, Z., P. Mikuška, P. Moravec, and J. Smolík. 2011. Unique exposure system for the whole body inhalation experiments with small animals. Proceedings from NANOCON 2011, Sep 21–23, Brno, Czech Republic. p. 652–654.
   Google Scholar
• Wang, J., C. Chen, Y. Liu, F. Jiao, W. Li, F. Lao, Y. Li, B. Li, C. Ge, G. Zhou., et al. 2008. “Potential Neurological Lesion After Nasal Instillation of TiO2 Nanoparticles in the Anatase and Rutile Crystal Phases.” Toxicology Letters 183(1-3): 72–80. doi:10.1016/j.toxlet.2008.10.001.
   PubMed Web of Science ®Google Scholar
• Wu, T., and M. Tang. 2018. “Review of the Effects of Manufactured Nanoparticles on Mammalian Target Organs.” Journal of Applied Toxicology 38(1): 25–40. doi:10.1002/jat.3499.
   PubMed Web of Science ®Google Scholar
• Zarakowska, E., D. Gackowski, M. Foksinski, and R. Olinski. 2014. “Are 8-Oxoguanine (8-oxoGua) and 5-Hydroxymethyluracil (5-hmUra) Oxidatively Damaged DNA Bases or Transcription (Epigenetic) Marks?” Mutation Research/Genetic Toxicology and Environmental Mutagenesis 764–765: 58–63. doi:10.1016/j.mrgentox.2013.09.002.
   PubMed Web of Science ®Google Scholar
• Ze, Y., L. Zheng, X. Zhao, S. Gui, X. Sang, J. Su, N. Guan, L. Zhu, L. Sheng, R. Hu., et al. 2013. “Molecular Mechanism of Titanium Dioxide Nanoparticles-Induced Oxidative Injury in the Brain of Mice.” Chemosphere 92(9): 1183–1189. doi:10.1016/j.c.
   PubMed Web of Science ®Google Scholar