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Review Article

Developmental neurotoxicity of silver nanoparticles: the current state of knowledge and future directions

ORCID Icon, &
Pages 500-525 | Received 09 May 2022, Accepted 20 Jul 2022, Published online: 03 Aug 2022

References

  • Ali, E. H, and L. A. Salih. 2018. “Effect of Maternal Exposure of Silver Nanoparticles on the Histogenesis of Cerebellum in Post-Implantation of Albino Rats Embryos.” Iraqi Journal of Science 59 (1B): 271–277. doi:10.24996/ijs.2018.59.1B.4.
  • Ansorge, M. S., M. Zhou, A. Lira, R. Hen, and J. A. Gingrich. 2004. “Early-Life Blockade of the 5-HT Transporter Alters Emotional Behavior in Adult Mice.” Science (New York, NY) 306 (5697): 879–881. doi:10.1126/science.1101678.
  • Aoyama, K., S. W. Suh, A. M. Hamby, J. Liu, W. Y. Chan, Y. Chen, and R. A. Swanson. 2006. “Neuronal Glutathione Deficiency and Age-Dependent Neurodegeneration in the EAAC1 Deficient Mouse.” Nature Neuroscience 9 (1): 119–126. doi:10.1038/nn1609.
  • Armulik, A., G. Genové, M. Mäe, M. H. Nisancioglu, E. Wallgard, C. Niaudet, L. He, et al. 2010. “Pericytes Regulate the Blood-Brain Barrier.” Nature 468 (7323): 557–561. doi:10.1038/nature09522.
  • Asharani, P. V., Y. Lian Wu, Z. Gong, and S. Valiyaveettil. 2008. “Toxicity of Silver Nanoparticles in Zebrafish Models.” Nanotechnology 19 (25): 255102. doi:10.1088/0957-4484/19/25/255102.
  • Ašmonaitė, G., S. Boyer, K. B. de Souza, B. Wassmur, and J. Sturve. 2016. “Behavioural Toxicity Assessment of Silver Ions and Nanoparticles on Zebrafish Using a Locomotion Profiling Approach.” Aquatic Toxicology (Amsterdam, Netherlands) 173: 143–153. doi:10.1016/j.aquatox.2016.01.013.
  • Bachler, G., N. von Goetz, and K. Hungerbuhler. 2013. “A Physiologically Based Pharmacokinetic Model for Ionic Silver and Silver Nanoparticles.” International Journal of Nanomedicine 8: 3365–3382. doi:10.2147/IJN.S46624.
  • Ballabh, P., A. Braun, and M. Nedergaard. 2004. “The Blood-Brain Barrier: an Overview: Structure, Regulation, and Clinical Implications.” Neurobiology of Disease 16 (1): 1–13. doi:10.1016/j.nbd.2003.12.016.
  • Bearer, C. F. 1995. “How Are Children Different from Adults?” Environmental Health Perspectives. 103 (6): 7–12. doi:10.1289/ehp.95103s67.
  • Bell, R. D., E. A. Winkler, A. P. Sagare, I. Singh, B. LaRue, R. Deane, and B. V. Zlokovic. 2010. “Pericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain Aging.” Neuron 68 (3): 409–427. doi:10.1016/j.neuron.2010.09.043.
  • Ben-Ari, Y., I. Khalilov, K. T. Kahle, and E. Cherubini. 2012. “The GABA Excitatory/Inhibitory Shift in Brain Maturation and Neurological Disorders.” The Neuroscientist: A Review Journal Bringing Neurobiology, Neurology and Psychiatry 18 (5): 467–486. doi:10.1177/1073858412438697.
  • Benn, T., B. Cavanagh, K. Hristovski, J. D. Posner, and P. Westerhoff. 2010. “The Release of Nanosilver from Consumer Products Used in the Home.” Journal of Environmental Quality 39 (6): 1875–1882. doi:10.2134/jeq2009.0363.
  • Bianchi, M. G., D. Bardelli, M. Chiu, and O. Bussolati. 2014. “Changes in the Expression of the Glutamate Transporter EAAT3/EAAC1 in Health and Disease.” Cellular and Molecular Life Sciences 71 (11): 2001–2015. doi:10.1007/s00018-013-1484-0.
  • Bonnin, A., N. Goeden, K. Chen, M. L. Wilson, J. King, J. C. Shih, R. D. Blakely, E. S. Deneris, and P. Levitt. 2011. “A Transient Placental Source of Serotonin for the Fetal Forebrain.” Nature 472 (7343): 347–350. doi:10.1038/nature09972.
  • Bonkowski, D., V. Katyshev, R. D. Balabanov, A. Borisov, and P. Dore-Duffy. 2011. “The CNS Microvascular Pericyte: Pericyte-Astrocyte Crosstalk in the Regulation of Tissue Survival.” Fluids and Barriers of the CNS 8 (1): 8. doi:10.1186/2045-8118-8-8.
  • Brindle, N. P. J., P. Saharinen, and K. Alitalo. 2006. “Signaling and Functions of Angiopoietin-1 in Vascular Protection.” Circulation Research 98 (8): 1014–1023. doi:10.1161/01.RES.0000218275.54089.12.
  • Calderón-Jiménez, B., M. E. Johnson, A. R. Montoro Bustos, K. E. Murphy, M. R. Winchester, and J. R. Vega Baudrit. 2017. “Silver Nanoparticles: Technological Advances, Societal Impacts, and Metrological Challenges.” Frontiers in Chemistry 5: 6. doi:10.3389/fchem.2017.00006.
  • Cameron, S. J., F. Hosseinian, and W. G. Willmor. 2018. “A Current Overview of the Biological and Cellular Effects of Nanosilver.” International Journal of Molecular Sciences 19 (7): 2030. doi:10.3390/ijms19072030.
  • Carlson, C., S. M. Hussain, A. M. Schrand, L. K. Braydich-Stolle, K. L. Hess, R. L. Jones, and J. J. Schlager. 2008. “Unique Cellular Interaction of Silver Nanoparticles: Size-Dependent Generation of Reactive Oxygen Species.” The Journal of Physical Chemistry. B 112 (43): 13608–13619. doi:10.1021/jp712087m.
  • Charehsaz, M., K. S. Hougaard, H. Sipahi, A. I. D. Ekici, Ç. Kaspar, M. Culha, Ü. Ü. Bucurgat, and A. Aydin. 2016. “Effects of Developmental Exposure to Silver in Ionic and Nanoparticle Form: A Study in Rats.” Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences 24 (1): 24. doi:10.1186/s40199-016-0162-9.
  • Chen, I. C., I. L. Hsiao, H. C. Lin, C. H. Wu, C. Y. Chuang, and Y. J. Huang. 2016. “Influence of Silver and Titanium Dioxide Nanoparticles on in Vitro Blood-Brain Barrier Permeability.” Environmental Toxicology and Pharmacology 47: 108–118. doi:10.1016/j.etap.2016.09.009.
  • Choi, J. I., S. J. Chae, J. M. Kim, J. C. Choi, S. J. Park, H. J. Choi, H. Bae, and H. J. Park. 2018. “Potential Silver Nanoparticles Migration from Commercially Available Polymeric Baby Products into Food Simulants.” Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment 35 (5): 996–1005. doi:10.1080/19440049.2017.1411611.
  • Cohen Hubal, E. A., L. S. Sheldon, J. M. Burke, T. R. McCurdy, M. R. Berry, M. L. Rigas, V. G. Zartarian, and N. C. Freeman. 2000. “Children’s Exposure Assessment: A Review of Factors Influencing Children’s Exposure, and the Data Available to Characterize and Assess That Exposure.” Environmental Health Perspectives 108 (6): 475–486. doi:10.1289/ehp.108-1638158.
  • Cull-Candy, S., S. Brickley, and M. Farrant. 2001. “NMDA Receptor Subunits: Diversity, Development and Disease.” Current Opinion in Neurobiology 11 (3): 327–335. doi:10.1016/s0959-4388(00)00215-4.
  • Cunningham, S, and L. Joshi. 2015. “Assessment of Exposure of Marine and Freshwater Model Organisms to Metallic Nanoparticles.” EPA Research Report 150.
  • Daneman, R., L. Zhou, D. Agalliu, J. D. Cahoy, A. Kaushal, and B. A. Barres. 2010. “The Mouse Blood–Brain Barrier Transcriptome: A New Resource for Understanding the Development and Function of Brain Endothelial Cells.” PLoS One 5 (10): e13741. doi:10.1371/journal.pone.0013741.
  • Dănilă, O.-O., A. Sevastre Berghian, V. Dionisie, D. Gheban, D. Olteanu, F. Tabaran, I. Baldea, et al. 2017. “The Effects of Silver Nanoparticles on Behavior, Apoptosis and Nitro-Oxidative Stress in Offspring Wistar Rats.” Nanomedicine (London, England) 12 (12): 1455–1473. doi:10.2217/nnm-2017-0029.
  • Das, P., J. A. McDonald, E. O. Petrof, E. Allen-Vercoe, and V. K. Walker. 2014. “Nanosilver-Mediated Change in Human Intestinal Microbiota.” Journal of Nanomedicine & Nanotechnology 5 (5). doi:10.4172/2157-7439.1000235.
  • Davenport L. L., H. Hsieh , B. L. Eppert, V. S. Carreira, M. Krishan, T. Ingle, P. C. Howard, M. T. Williams, C. V. Vorhees and M. B. Genter. 2015. “Systemic and behavioral effects of intranasal administration of silver nanoparticles.” Neurotoxicology and Teratology 51: 68-76. doi:10.1016/j.ntt.2015.08.006.
  • Dąbrowska-Bouta, B., G. Sulkowski, M. Frontczak-Baniewicz, J. Skalska, M. Sałek, J. Orzelska-Górka, and L. Strużyńska. 2018. “Ultrastructural and Biochemical Features of Cerebral Microvessels of Adult Rat Subjected to a Low Dose of Silver Nanoparticles.” Toxicology 408: 31–38. doi:10.1007/s12640-018-9977-0.
  • Dąbrowska-Bouta, B., G. Sulkowski, J. Orzelska-Górka, L. Strużyńska, E. Kędzierska, and G. Biała. 2021a. “Response of Immature Rats to a Low Dose of Nanoparticulate Silver: Alterations in Behavior, Cerebral Vasculature-Related Transcriptome and Permeability.” Ecotoxicology and Environmental Safety 208: 111416. doi:10.1016/j.ecoenv.2020.111416.
  • Dąbrowska-Bouta, B., G. Sulkowski, M. Sałek, M. Frontczak-Baniewicz, and L. Strużyńska. 2021b. “Early and Delayed Impact of Nanosilver on the Glutamatergic NMDA Receptor Complex in Immature Rat Brain.” International Journal of Molecular Sciences 22 (6): 3067. doi:10.3390/ijms22063067.
  • Dąbrowska-Bouta, B., G. Sulkowski, M. Sałek, M. Gewartowska, M. Sidoryk-Węgrzynowicz, and L. Strużyńska. 2020. “Early Postnatal Exposure to a Low Dose of Nanoparticulate Silver Induces Alterations in Glutamate Transporters in Brain of Immature Rats.” International Journal of Molecular Sciences 21 (23): 8977. doi:10.3390/ijms21238977.
  • Dąbrowska-Bouta, B., G. Sulkowski, W. Strużyński, and L. Strużyńska. 2019. “Prolonged Exposure to Silver Nanoparticles Results in Oxidative Stress in Cerebral Myelin.” Neurotoxicity Research 35 (3): 495–504. doi:10.1007/s12640-018-9977-0.
  • Ding, R., P. Yang, Y. Yang, Z. Yang, L. Luo, H. Li, and Q. Wang. 2018. “Characterisation of Silver Release from Nanoparticle-Treated Baby Products.” Food Additives & Contaminants Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment 35 (10): 2052–2061. doi:10.1080/19440049.2018.1480064.
  • Dong, X.-X., Y. Wang, and Z.-H. Qin. 2009. “Molecular Mechanisms of Excitotoxicity and Their Relevance to Pathogenesis of Neurodegenerative Diseases.” Acta Pharmacologica Sinica 30 (4): 379–387. doi:10.1038/aps.2009.24.
  • Durán, N., C. P. Silveira, M. Durán, and D. S. T. Martinez. 2015. “Silver Nanoparticle Protein Coronaand Toxicity: A Mini-Review.” Journal of Nanobiotechnology 13: 55. 10.1186/s12951-015-0114-4.
  • Edwards-Jones, V. 2009. “The Benefits of Silver in Hygiene, Personal Care and Healthcare.” Letters in Applied Microbiology 49 (2): 147–152. doi:10.1111/j.1472-765X.2009.02648.x.
  • Ek, C. J., K. M. Dziegielewska, M. D. Habgood, and N. R. Saunders. 2012. “Barriers in the Developing Brain and Neurotoxicology.” Neurotoxicology 33 (3): 586–604. doi:10.1016/j.neuro.2011.12.009.
  • Ema, M., M. Gamo, and K. Honda. 2016. “Developmental Toxicity of Engineered Nanomaterials in Rodents.” Toxicology and Applied Pharmacology 299: 47–52. doi:10.1016/j.taap.2015.12.015.
  • Ema, M., H. Okuda, M. Gamo, and K. Honda. 2017. “A Review of Reproductive and Developmental Toxicity of Silver Nanoparticles in Laboratory Animals.” Reproductive Toxicology (Elmsford, NY) 67: 149–164. doi:10.1016/j.reprotox.2017.01.005.
  • Engelhardt, B, and R. M. Ransohoff. 2012. “Capture, Crawl, Cross: The T Cell Code to Breach the Blood-Brain Barriers.” Trends in Immunology 33 (12): 579–589. doi:10.1016/j.it.2012.07.004.
  • Fabrega, J., S. N. Luoma, C. R. Tyler, T. S. Galloway, and J. R. Lead. 2011. “Silver Nanoparticles: Behaviour and Effects in the Aquatic Environment.” Environment International 37 (2): 517–531. doi:10.1016/j.envint.2010.10.012.
  • Fatemi, M., N. H. Roodbari, K. Ghaedi, and G. Naderi. 2013. “The Effects of Prenatal Exposure to Silver Nanoparticles on the Developing Brain in Neonatal Rats.” Journal of Biological Research-Thessaloniki 20: 233–242.
  • Fatemi Tabatabaie, S. R., B. Mehdiabadi, N. Moori Bakhtiari, and M. R. Tabandeh. 2017. “Silver Nanoparticle Exposure in Pregnant Rats Increases Gene Expression of Tyrosine Hydroxylase and Monoamine Oxidase in Offspring Brain.” Drug and Chemical Toxicology 40 (4): 440–447. doi:10.1080/01480545.2016.1255952.
  • Farkas, J., H. Peter, P. Christian, J. A. Gallego Urrea, M. Hassellöv, J. Tuoriniemi, S. Gustafsson, E. Olsson, K. Hylland, and K. V. Thomas. 2011. “Characterization of the Effluent from a Nanosilver Producing Washing Machine.” Environment International 37 (6): 1057–1062. doi:10.1016/j.envint.2011.03.006.
  • Fennell, T. R., N. P. Mortensen, S. R. Black, R. W. Snyder, K. E. Levine, E. Poitras, J. M. Harrington, et al. 2017. “Disposition of Intravenously or Orally Administered Silver Nanoparticles in Pregnant Rats and the Effect on the Biochemical Profile in Urine.” Journal of Applied Toxicology 37 (5): 530–544. doi:10.1002/jat.3387.
  • Flint, A. C., U. S. Maisch, J. H. Weishaupt, A. R. Kriegstein, and H. Monyer. 1997. “NR2A Subunit Expression Shortens NMDA Receptor Synaptic Currents in Developing Neocortex.” The Journal of Neuroscience: The Official Journal of the Society for Neuroscience 17 (7): 2469–2476. doi:10.1523/JNEUROSCI.17-07-02469.1997.
  • Forrest, D., M. Yuzaki, H. D. Soares, L. Ng, D. C. Luk, M. Sheng, C. L. Stewart, J. I. Morgan, J. A. Connor, and T. Curran. 1994. “Targeted Disruption of NMDAR 1 Gene Abolishes NMDA Response and Results in Neonatal Death.” Neuron 13 (2): 325–338. doi:10.1016/0896-6273(94)90350-6.
  • Friedman, J. 2011. “Why is the Nervous System Vulnerable to Oxidative Stress?.” In Oxidative Stress and Free Radical Damage in Neurology. Handbook of Oxidative Stress in Applied Basic Research and Clinical Practice, edited by N. Gadoth and H. H. Gobel, 19–27. Totowa: Humana Press.
  • Ganjuri, M., J. Moshtaghian, and K. Ghaedi. 2015. “Effect of Nanosilver Particles on Procaspase-3 Expression in Newborn Rat Brain.” Cell Journal 17 (3): 489–493. doi:10.22074/cellj.2015.23.
  • Ge, L., Q. Li, M. Wang, J. Ouyang, X. Li, and M. M. Xing. 2014. “Nanosilver Particles in Medical Applications: Synthesis, Performance, and Toxicity.” International Journal of Nanomedicine 9: 2399–2407. doi:10.2147/IJN.S55015.
  • Genter, M. B., N. C. Newman, H. G. Shertzer, S. F. Ali, and B. Bolon. 2012. “Distribution and Systemic Effects of Intranasally Administered 25 nm Silver Nanoparticles in Adult Mice.” Toxicologic Pathology 40 (7): 1004–1013. doi:10.1177/0192623312444470.
  • Ghaderi, S., S. R. F. Tabatabaei, H. N. Varzi, and M. Rashno. 2015. “Induced Adverse Effects of Prenatal Exposure to Silver Nanoparticles on Neurobehavioral Development of Offspring of Mice.” The Journal of Toxicological Sciences 40 (2): 263–275. doi:10.2131/jts.40.263.
  • Giese, B., F. Klaessig, B. Park, R. Kaegi, M. Steinfeldt, H. Wigger, A. von Gleich, and F. Gottschalk. 2018. “Risks, Release and Concentrations of Engineered Nanomaterial in the Environment.” Scientific Reports 8 (1): 1565. doi:10.1038/s41598-018-19275-4.
  • Gliga, A. R., S. Skoglund, I. O. Wallinder, B. Fadeel, and H. L. Karlsson. 2014. “Size-Dependent Cytotoxicity of Silver Nanoparticles in Human Lung Cells: The Role of Cellular Uptake, Agglomeration and Ag Release.” Particle and Fibre Toxicology 11:11: 11. doi:10.1186/1743-8977-11-11.
  • Grandjean, P, and P. J. Landrigan. 2006. “Developmental Neurotoxicity of Industrial Chemicals.” Lancet (London, England) 368 (9553): 2167–2178.
  • Gonzalez, E. A., D. R. Carty, F. D. Tran, A. M. Cole, and P. J. Lein. 2018. “Developmental Exposure to Silver Nanoparticles at Environmentally Relevant Concentrations Alters Swimming Behavior in Zebrafish (Danio rerio).” Environmental Toxicology and Chemistry 37 (12): 3018–3024. doi:10.1002/etc.4275.
  • Gray, J. A., Y. Shi, H. Usui, M. J. During, K. Sakimura, and R. Nicoll. 2011. “Distinct Modes of AMPA Receptor Suppression at Developing Synapses by GluN2A and GluN2B: Single-Cell NMDA Receptor Subunit Deletion in Vivo.” Neuron 71 (6): 1085–1101. doi:10.1016/j.neuron.2011.08.007.
  • Hadrup, N., K. Loeschner, A. Mortensen, A. K. Sharma, K. Qvortrup, E. H. Larsen, and H. R. Lam. 2012. “The Similar Neurotoxic Effects of Nanoparticulate and Ionic Silver in Vivo and in Vitro.” Neurotoxicology 33 (3): 416–423. doi:10.1016/j.neuro.2012.04.008.
  • Hanada, S., K. Fujioka, Y. Inoue, F. Kanaya, Y. Manome, and K. Yamamoto. 2014. “Cell-Based in Vitro Blood-Brain Barrier Model Can Rapidly Evaluate Nanoparticles’ Brain Permeability in Association with Particle Size and Surface Modification.” International Journal of Molecular Sciences 15 (2): 1812–1825. doi:10.3390/ijms15021812.
  • Harper, B., D. Thomas, S. Chikkagoudar, N. Baker, K. Tang, A. Heredia-Langner, R. Lins, and S. Harper. 2015. “Comparative Hazard Analysis and Toxicological Modeling of Diverse Nanomaterials Using the Embryonic Zebrafish (EZ) Metric of Toxicity.” Journal of Nanoparticle Research: An Interdisciplinary Forum for Nanoscale Science and Technology 17 (6): 250. doi:10.1007/s11051-015-3051-0..
  • Hassel, B, and R. Dingledine. 2012. “Glutamate and Glutamate Receptors.” In Basic Neurochemistry, edited by S. T. Brady, and G. J. Siegel, 8th ed., 342–366. Amsterdam, The Netherlands: Elsevier.
  • Heyer, D. B, and R. M. Meredith. 2017. “Environmental Toxicology: Sensitive Periods of Development and Neurodevelopmental Disorders.” Neurotoxicology 58: 23–41. doi:10.1016/j.neuro.2016.10.017.
  • Himi, T., M. Ikeda, T. Yasuhara, M. Nishida, and I. Morita. 2003. “Role of Neuronal Glutamate Transporter in the Cysteine Uptake and Intracellular Glutathione Levels in Cultured Cortical Neurons.” Journal of Neural Transmission (Vienna, Austria: 1996) 110 (12): 1337–1348. doi:10.1007/s00702-003-0049-z.
  • Hong, J. S., S. Kim, S. H. Lee, E. Jo, B. Lee, J. Yoon, I.-C. Eom, et al. 2014. “Combined Repeated-Dose Toxicity Study of Silver Nanoparticles with the Reproduction/Developmental Toxicity Screening Test.” Nanotoxicology 8 (4): 349–362. doi:10.3109/17435390.2013.780108.
  • Howe, K., M. D. Clark, C. F. Torroja, J. Torrance, C. Berthelot, M. Muffato, J. E. Collins, et al. 2013. “The Zebrafish Reference Genome Sequence and Its Relationship to the Human Genome.” Nature 496 (7446): 498–503. doi:10.1038/nature12111.
  • Hsiao, I. L., Y. K. Hsieh, C. F. Wang, I. C. Chen, and Y. J. Huang. 2015. “Trojan-Horse Mechanism in the Cellular Uptake of Silver Nanoparticles Verified by Direct Intra- and Extracellular Silver Speciation Analysis.” Environmental Science & Technology 49 (6): 3813–3821. doi:10.1021/es504705p.
  • Ikonomidou, C, and A. M. Kaindl. 2011. “Neuronal Death and Oxidative Stress in the Developing Brain.” Antioxidants & Redox Signaling 14 (8): 1535–1550. doi:10.1089/ars.2010.3581.
  • Inshakova, E, and O. Inshakov. 2017. “World Market for Nanomaterials: Structure and Trends.” MATEC Web of Conferences 129: 02013. doi:10.1051/matecconf/201712902013.
  • John, E. G, and J.-P. Guignard. 1991. “Development of Renal Excretion of Drugs during Ontogeny.” In Fetal and Neonatal Physiology, edited by R. A. Polin, and W. W. Fox, Vol. 1, 153–155. Philadelphia, PA: WB Saunders.
  • Johnston, H. J., G. Hutchison, F. M. Christensen, S. Peters, S. Hankin, and V. Stone. 2010. “A Review of the in Vivo and in Vitro Toxicity of Silver and Gold Particulates: Particle Attributes and Biological Mechanisms Responsible for the Observed Toxicity.” Critical Reviews in Toxicology 40 (4): 328–346. doi:10.3109/10408440903453074.
  • Johnston, H. J., R. Verdon, S. Gillies, D. M. Brown, T. F. Fernandes, T. B. Henry, A. G. Rossi, et al. 2018. “Adoption of in Vitro Systems and Zebrafish Embryos as Alternative Models for Reducing Rodent Use in Assessments of Immunological and Oxidative Stress Responses to Nanomaterials.” Critical Reviews in Toxicology 48 (3): 252–271. doi:10.1080/10408444.2017.1404965.
  • Juling, S., G. Bachler, N. von Götz, D. Lichtenstein, L. Böhmert, A. Niedzwiecka, S. Selve, A. Braeuning, and A. Lampen. 2016. “In Vivo Distribution of Nanosilver in the Rat: The Role of Ions and de Novo-Formed Secondary Particles.” Food and Chemical Toxicology 97: 327–335. doi:10.1016/j.fct.2016.08.016.
  • Kaegi, R., B. Sinnet, S. Zuleeg, H. Hagendorfer, E. Mueller, R. Vonbank, M. Boller, and M. Burkhardt. 2010. “Release of Silver Nanoparticles from Outdoor Facades.” Environmental Pollution158 (9): 2900–2905. doi:10.1016/j.envpol.2010.06.009.
  • Kaizuka, T, and T. Takumi. 2018. “Postsynaptic Density Proteins and Their Involvement in Neurodevelopmental Disorders.” Journal of Biochemistry 163 (6): 447–455.
  • Keller, A. A., S. McFerran, A. Lazareva, and S. Suh. 2013. “Global Life Cycle Releases of Engineered Nanomaterials.” Journal of Nanoparticle Research 15 (6): 1692. doi:10.1007/s11051-013-1692-4.
  • Krueger, M, and I. Bechmann. 2010. “CNS Pericytes: Concepts, Misconceptions, and a Way Out.” Glia 58 (1): 1–10. doi:10.1002/glia.20898.
  • Kuhlbusch, T. A., C. Asbach, H. Fissan, D. Göhler, and M. Stintz. 2011. “Nanoparticle Exposure at Nanotechnology Workplaces: A Review.” Particle and Fibre Toxicology 8: 22. doi:10.1186/1743-8977-8-22.
  • LaLumiere, R. T. 2014. “Dopamine and Memory.” In Identification of Neural Markers Accompanying Memory, 79–94. Amsterdam, Netherlands: Elsevier.
  • Landgraf, L., I. Müller, P. Ernst, M. Schäfer, C. Rosman, I. Schick, O. Köhler, et al. 2015. “Comparative Evaluation of the Impact on Endothelial Cells Induced by Different Nanoparticle Structures and Functionalization.” Beilstein Journal of Nanotechnology 6: 300–312. doi:10.3762/bjnano.6.28.
  • Landrigan, P. J. 2004. “Children as a Vulnerable Population.” International Journal of Occupational Medicine and Environmental Health 17 (1): 175–177.
  • Lauder, J. M. 1993. “Neurotransmitters as Growth Regulatory Signals: Role of Receptors and Second Messengers.” Trends in Neurosciences 16 (6): 233–239. doi:10.1016/0166-2236(93)90162-F.
  • Lazareva, A, and A. A. Keller. 2014. “Estimating Potential Life Cycle Releases of Engineered Nanomaterials from Wastewater Treatment Plants.” ACS Sustainable Chemistry & Engineering 2 (7): 1656–1665. doi:10.1021/sc500121w.
  • Lécuyer, M. A., H. Kebir, and A. Prat. 2016. “Glial Influences on BBB Functions and Molecular Players in Immune Cell Trafficking.” Biochimica et Biophysica Acta 1862 (3): 472–482. doi:10.1016/j.bbadis.2015.10.004.
  • Lee, Y., J. Choi, P. Kim, K. Choi, S. Kim, W. Shon, and K. Park. 2012. “A Transfer of Silver Nanoparticles from Pregnant Rat to Offspring.” Toxicological Research 28 (3): 139–141.
  • Lee, Y. K., E. J. Choi, T. J. Webster, S. H. Kim, and D. Khang. 2015. “Effect of the Protein Corona on Nanoparticles for Modulating Cytotoxicity and Immunotoxicity.” International Journal of Nanomedicine 10: 97–113. doi:10.2147/IJN.S72998.
  • Lesniak, A., F. Fenaroli, M. P. Monopoli, C. Åberg, K. A. Dawson, and A. Salvati. 2012. “Effects of the Presence or Absence of a Protein Corona on Silica Nanoparticle Uptake and Impact on Cells.” ACS Nano 6 (7): 5845–5857. doi:10.1021/nn300223w.
  • Levard, C., E. M. Hotze, G. V. Lowry, and G. E. Brown. 2012. “Environmental Transformations of Silver Nanoparticles: Impact on Stability and Toxicity.” Environmental Science & Technology 46 (13): 6900–6914. doi:10.1021/es2037405.
  • Li, L., G. Hartmann, M. Doblinger, and M. Schuster. 2013. “Quantification of Nanoscale Silver Particles Removal and Release from Municipal Wastewater Treatment Plants in Germany.” Environmental Science & Technology 47 (13): 7317–7323. doi:10.1021/es3041658.
  • Lima, T., K. Bernfur, M. Vilanova, and T. Cedervall. 2020. “Understanding the Lipid and Protein Corona Formation on Dfferent Sized Polymeric Nanoparticles.” Scientific Reports 10 (1): 9. doi:10.1038/s41598-020-57943-6.
  • Liu, F., M. Mahmood, Y. Xu, F. Watanabe, A. S. Biris, D. H. Hansen, A. Inselman, et al. 2015. “Effects of Silver Nanoparticles on Human and Rat Embryonic Neural Stem Cells.” Frontiers Neurosci 9: 115. doi:10.3389/fnins.2015.00115.
  • Liu, H. L., S. A. Dai, K. Y. Fu, and S. H. Hsu. 2010. “Antibacterial Properties of Silver Nanoparticles in Three Different Sizes and Their Nanocomposites with a New Waterborne Polyurethane.” International Journal of Nanomedicine 5: 1017–1028. doi:10.2147/IJN.S14572.
  • Liu, J, and R. H. Hurt. 2010. “Ion Release Kinetics and Particle Persistence in Aqueous Nano-Silver Colloids.” Environmental Science & Technology 44 (6): 2169–2175.
  • Loeschner, K., N. Hadrup, K. Qvortrup, A. Larsen, X. Gao, U. Vogel, A. Mortensen, H. R. Lam, and E. H. Larsen. 2011. “Distribution of Silver in Rats following 28 Days of Repeated Oral Exposure to Silver Nanoparticles or Silver Acetate.” Particle and Fibre Toxicology 8: 18. 10.1186/1743-8977-8-18.
  • Lyon, T. D., M. Patriarca, G. Howatson, P. J. Fleming, P. S. Blair, and G. S. Fell. 2002. “Age Dependence of Potentially Toxic Elements (Sb, Cd, Pg, Ag) in Human Liver Tissue from Paediatric Subjects.” Journal of Environmental Monitoring 4 (6): 1034–1039. doi:10.1039/b205972j.
  • Lyu, Z., S. Ghoshdastidar, K. R. Rekha, D. Suresh, J. Mao, N. Bivens, R. Kannan, T. Joshi, C. S. Rosenfeld, and A. Upendran. 2021. “Upendran A. Developmental Exposure to Silver Nanoparticles Leads to Long Term Gut Dysbiosis and Neurobehavioral Alterations.” Scientific Reports 11 (1): 6558. doi:10.1038/s41598-021-85919-7.
  • Mackevica, A., M. E. Olsson, and S. F. Hansen. 2017. “The Release of Silver Nanoparticles from Commercial Toothbrushes.” Journal of Hazardous Materials 322 (Pt A): 270–275. doi:10.1016/j.jhazmat.2016.03.067.
  • Malenka, R. C, and M. F. Bear. 2004. “LTP and LTD: An Embarrassment of Riches.” Neuron 44 (1): 5–21. doi:10.1016/j.neuron.2004.09.012.
  • Malik, A. R, and T. E. Willnow. 2019. “Excitatory Amino Acid Transporters in Physiology and Disorders of the Central Nervous System.” International Journal of Molecular Sciences 20 (22): 5671. doi:10.3390/ijms20225671.
  • McGillicuddy, E., I. Murray, S. Kavanagh, L. Morrison, A. Fogarty, M. Cormican, P. Dockery, M. Prendergast, N. Rowan, and D. Morris. 2017. “Silver Nanoparticles in the Environment: Sources, Detection and Ecotoxicology.” The Science of the Total Environment 575: 231–246. doi:10.1016/j.scitotenv.2016.10.041.
  • Melnik, E. A., Yu P. Buzulukov, V. F. Demin, V. A. Demin, I. V. Gmoshinski, N. V. Tyshko, and V. A. Tutelyan. 2013. “Transfer of Silver Nanoparticles through the Placenta and Breast Milk during in Vivo Experiments on Rat.” Acta Naturae 5 (3): 107–115. doi:10.32607/20758251-2013-5-3-107-115.
  • Miclăuş, T., C. Beer, J. Chevallier, C. Scavenius, V. E. Bochenkov, J. J. Enghild, and D. S. Sutherland. 2016. “Dynamic Protein Coronas Revealed as a Modulator of Silver Nanoparticle Sulphidation in Vitro.” Nature Communications 7: 11770. doi:10.1038/ncomms11770.
  • Mozafari, M., A. Khoradmehr, A. Danafar, M. Miresmaeili, and S. M. Kalantar. 2020. “Toxic Effects of Maternal Exposure to Silver Nanoparticles on Mice Fetal Development during Pregnancy.” Birth Defects Research 112 (1): 81–92. doi:10.1002/bdr2.1605.
  • Muoio, V., P. B. Persson, and M. M. Sendeski. 2014. “The Neurovascular Unit - Concept Review.” Acta Physiologica 210 (4): 790–798. doi:10.1111/apha.12250.
  • Nemes, A. D., K. Ayasoufi, Z. Ying, Q.-G. Zhou, H. Suh, and I. M. Najm. 2017. “Growth Associated Protein 43 (GAP-43) as a Novel Target for the Diagnosis, Treatment and Prevention of Epileptogenesis.” Scientific Reports 7 (1): 17702. doi:10.1038/s41598-017-17377-z.
  • Nieoullon, A. 2002. “Dopamine and the Regulation of Cognition and Attention.” Progress in Neurobiology 67 (1): 53–83. doi:10.1016/s0301-0082(02)00011-4.
  • O’Brien, N., and E. Cummins. 2010. “Ranking Initial Environmental and Human Health Risk Resulting from Environmentally Relevant Nanomaterials.” Journal of Environmental Science and Health. Part A, Toxic/Hazardous Substances & Environmental Engineering 45 (8): 992–1007.
  • Osborne, O. J., K. Mukaigasa, H. Nakajima, B. Stolpe, I. Romer, U. Philips, I. Lynch, et al. 2016. “Sensory Systems and Ionocytes Are Targets for Silver Nanoparticle Effects in Fish.” Nanotoxicology 10 (9): 1276–1286. doi:10.1080/17435390.2016.1206147.
  • Parichy, D. M., M. R. Elizondo, M. G. Mills, T. N. Gordon, and R. E. Engeszer. 2009. “Normal Table of Postembryonic Zebrafish Development: Staging by Externally Visible Anatomy of the Living Fish.” Developmental Dynamics: An Official Publication of the American Association of Anatomists 238 (12): 2975–3015. doi:10.1002/dvdy.22113.
  • Park, M. V. D. Z., A. M. Neigh, J. P. Vermeulen, L. J. J. de la Fonteyne, H. W. Verharen, J. J. Briedé, H. van Loveren, and W. H. de Jong. 2011. “The Effect of Particle Size on the Cytotoxicity, Inflammation, Developmental Toxicity and Genotoxicity of Silver Nanoparticles.” Biomaterials 32 (36): 9810–9817. doi:10.1016/j.biomaterials.2011.08.085.
  • Parsons, M. P, and L. A. Raymond. 2014. “Extrasynaptic NMDA Receptor Involvement in Central Nervous System Disorders.” Neuron 82 (2): 279–293. doi:10.1016/j.neuron.2014.03.030.
  • Persidsky, Y., S. H. Ramirez, J. Haorah, and G. D. Kanmogne. 2006. “Blood-Brain Barrier: Structural Components and Function under Physiologic and Pathologic Conditions.” Journal of Neuroimmune Pharmacology: The Official Journal of the Society on NeuroImmune Pharmacology 1 (3): 223–236. doi:10.1007/s11481-006-9025-3.
  • Pigott, B. M, and J. Garthwaite. 2016. “Nitric Oxide Is Required for L-Type Ca2+ Channel-Dependent Long-Term Potentiation in the.” Frontiers in Synaptic Neuroscience 8: 17.
  • Pinkerton, K. E, and J. P. Joad. 2006. “Influence of Air Pollution on Respiratory Health during Perinatal Development.” Clinical and Experimental Pharmacology & Physiology 33 (3): 269–272. doi:10.1111/j.1440-1681.2006.04357.x.
  • Powers, C. M., T. A. Slotkin, F. J. Seidler, A. R. Badireddy, and S. Padilla. 2011. “Silver Nanoparticles Alter Zebrafish Development and Larval Behavior: Distinct Roles for Particle Size, Coating and Composition.” Neurotoxicology and Teratology 33 (6): 708–714. doi:10.1016/j.ntt.2011.02.002.
  • Prakash, P., S. Royana, P. Sankarsan, and S. Rajeev. 2017. “The Review of Small Size Silver Nanoparticle Neurotoxicity: A Repeat Study.” Journal of Cytology & Histology 08 (03): 468. doi:10.4172/2157-7099.1000468.
  • Pulit-Prociak, J, and M. Banach. 2016. “Silver Nanoparticles – a Material of the Future…?” Open Chemistry 14 (1): 76–91. doi:10.1515/chem-2016-0005.
  • Quadros, M. E, and L. C. Marr. 2011. “Silver Nanoparticles and Total Aerosols Emitted by Nanotechnology-Related Consumer Spray Products.” Environmental Science & Technology 45 (24): 10713–10719.
  • Quadros, M. E., R. Pierson, N. S. Tulve, R. Willis, K. Rogers, T. A. Thomas, and L. C. Marr. 2013. “Release of Silver from Nanotechnology-Based Consumer Products for Children.” Environmental Science & Technology 47 (15): 8894–8901. doi:10.1021/es4015844.
  • Rahman, M., S. Laurent, and N. Tawil. 2013. “Protein-Nanoparticle Interactions. The Bio-Nano Interface.” In Springer Series in Biophysics, edited by B. Martinac, Vol. 15, 1–64. Berlin, Germany: Springer-Verlag.
  • Rashno, M., F. Tabatabaeie, S. R. Khaksary Mahabady, M  , and Ghaderi, S. 2014. “Maternal Exposure to Silver Nanoparticles in Mice: Effects on Dams’ Reproductive Performance and Pups’ Neurobehavioral.” Ontogeny Anatomical Science 11: 41–52.
  • Roberts, R. A., D. L. Laskin, C. V. Smith, F. M. Robertson, E. M. G. Allen, J. A. Doorn, and W. Slikker. 2009. “Nitrative and Oxidative Stress in Toxicology and Disease.” Toxicological Sciences: An Official Journal of the Society of Toxicology 112 (1): 4–16. doi:10.1093/toxsci/kfp179.
  • Rock, K. D, and H. B. Patisau. 2018. “Environmental Mechanisms of Neurodevelopmental Toxicity.” Current Environmental Health Reports 5 (1): 145–157. doi:10.1007/s40572-018-0185-0.
  • Rodier, P. M. 1994. “Vulnerable Periods and Processes during Central Nervous System Development.” Environmental Health Perspectives.102 (2): 121–124. doi:10.1289/ehp.94102121.
  • Semple, B. D., K. Blomgren, K. Gimlin, D. M. Ferriero, and L. J. Noble-Haeusslein. 2013. “Brain Development in Rodents and Humans: Identifying Benchmarks of Maturation and Vulnerability to Injury across Species.” Progress in Neurobiology 106–107: 1–16. doi:10.1016/j.pneurobio.2013.04.001.
  • Setyawati, M. I., X. Yuan, J. Xie, and D. T. Leong. 2014. “The Influence of Lysosomal Stability of Silver Nanomaterials on Their Toxicity to Human Cells.” Biomaterials 35 (25): 6707–6715.
  • Serlin, Y., I. Shelef, B. Knyazer, and A. Friedman. 2015. “Anatomy and Physiology of the Blood-Brain Barrier.” Seminars in Cell & Developmental Biology 38: 2–6. doi:10.1016/j.semcdb.2015.01.002.
  • Sharma, H. S., S. F. Ali, S. M. Hussain, J. J. Schlager, and A. Sharma. 2009. “Influence of Engineered Nanoparticles from Metals on the Blood-Brain Barrier Permeability, Cerebral Blood Flow, Brain Edema and Neurotoxicity. An Experimental Study in the Rat and Mice Using Biochemical and Morphological Approaches.” Journal of Nanoscience and Nanotechnology 9 (8): 5055–5072. doi:10.1166/jnn.2009.gr09.
  • Sharma, H. S., S. Hussain, J. Schlager, S. F. Ali, and A. Sharma. 2010. “Influence of Nanoparticles on Blood-Brain Barrier Permeability and Brain Edema Formation in Rats.” Acta Neurochirurgica. Supplement 106: 359–364. doi:10.1007/978-3-211-98811-4_65.
  • Singh, R. P, and P. Ramarao. 2012. “Cellular Uptake, Intracellular Trafficking and Cytotoxicity of Silver Nanoparticles.” Toxicology Letters 213 (2): 249–259. doi:10.1016/j.toxlet.2012.07.009.
  • Skalska, J., M. Frontczak-Baniewicz, and L. Strużyńska. 2015. “Synaptic Degeneration in Rat Brain after Prolonged Oral Exposure to Silver Nanoparticles.” Neurotoxicology 46: 145–154. doi:10.1016/j.neuro.2014.11.002.
  • Skalska, J., B. Dąbrowska-Bouta, and L. Strużyńska. 2016. “Oxidative Stress in Rat Brain but Not in Liver following Oral Administration of a Low Dose of Nanoparticulate Silver.” Food and Chemical Toxicology 97: 307–315. doi:10.1016/j.fct.2016.09.026.
  • Skalska, J., B. Dąbrowska-Bouta, M. Frontczak-Baniewicz, G. Sulkowski, and L. Strużyńska. 2020. “A Low Dose of Nanoparticulate Silver Induces Mitochondrial Dysfunction and Autophagy in Adult Rat Brain.” Neurotoxicity Research 38 (3): 650–664. doi:10.1007/s12640-020-00239-4.
  • Speshock, J. 2018. “Review of the Toxicological Effects of Silver Nanomaterials on the Model Aquatic Organism Danio Rerio.” Frontiers in Nanoscience and Nanotechnology 4 (2): 1–4. doi:10.15761/FNN.1000172.
  • Stilling, R. M., T. G. Dinan, and J. F. Cryan. 2014. “Microbial Genes, Brain & Behaviour—Epigenetic Regulation of the Gut-Brain Axis.” Genes, Brain, and Behavior 13 (1): 69–86. doi:10.1111/gbb.12109.
  • Strähle, U., S. Scholz, R. Geisler, P. Greiner, H. Hollert, S. Rastegar, A. Schumacher, et al. 2012. “Zebrafish Embryos as an Alternative to Animal Experiments—a Commentary on the Definition of the Onset of Protected Life Stages in Animal Welfare Regulations.” Reproductive Toxicology (Elmsford, NY) 33 (2): 128–132. doi:10.1016/j.reprotox.2011.06.121.
  • Struzynska, L, and J. Skalska. 2018. “Mechanisms Underlying Neurotoxicity of Silver Nanoparticles.” Advances in Experimental Medicine and Biology 1048: 227–250. doi:10.1007/978-3-319-72041-8_14.
  • Sussman, E. M., P. Jayanti, B. J. Dair, and B. J. Casey. 2015. “Assessment of Total Silver and Silver Nanoparticle Extraction from Medical Devices.” Food and Chemical Toxicology 85: 10–19. doi:10.1016/j.fct.2015.08.013.
  • Syafiuddin, A., S. Salmiati, T. Hadibarata, A. B. H. Kueh, M. R. Salim, and M. A. A. Zaini. 2018. “Silver Nanoparticles in the Water Environment in Malaysia: Inspection, Characterization, Removal, Modeling, and Future Perspective.” Scientific Reports 8 (1): 986. doi:10.1038/s41598-018-19375-1.
  • Tabatabaei, S. R., M. Moshrefi, and M. Askaripour. 2015. “Prenatal Exposure to Silver Nanoparticles Causes Depression like Responses in Mice.” Indian Journal of Pharmaceutical Sciences 77 (6): 681–686. doi:10.4103/0250-474X.174983.
  • Tang, J., L. Xiong, S. Wang, J. Wang, L. Liu, J. Li, Z. Wan, and T. Xi. 2008. “Influence of Silver Nanoparticles on Neurons and Blood-Brain Barrier via Subcutaneous Injection in Rats.” Applied Surface Science.255 (2): 502–504. doi:10.1016/j.apsusc.2008.06.058.
  • Tang, S., M. Wang, K. E. Germ, H.-M. Du, W.-J. Sun, W.-M. Gao, and G. D. Mayer. 2015. “Health Implications of Engineered Nanoparticles in Infants and Children.” World Journal of Pediatrics 11 (3): 197–206. doi:10.1007/s12519-015-0028-0.
  • Temizel-Sekeryan, S, and A. L. Hicks. 2020. “Global Environmental Impacts of Silver Nanoparticle Production Methods Supported by Life Cycle Assessment.” Resources, Conservation & Recycling 156: 104676. doi:10.1016/j.resconrec.2019.104676.
  • Trask, C. L, and B. E. Kosofsky. 2000. “Developmental Consideration of Neurotoxic Exposures.” Neurologic Clinics 18 (3): 541–562. doi:10.1016/S0733-8619(05)70210-3.
  • Treuel, L., M. Malissek, S. Grass, J. Diendorf, D. Mahl, W. Meyer-Zaika, and M. Epple. 2012. “Quantifying the Influence of Polymer Coatings on the Serum Albumin Corona Formation around Silver and Gold Nanoparticles.” Journal of Nanoparticle Research 14 (9): 1102. doi:10.1007/s11051-012-1102-3.
  • Trickler, W. J., S. M. Lantz, R. C. Murdock, A. M. Schrand, B. L. Robinson, G. D. Newport, J. J. Schlager, et al. 2010. “Silver Nanoparticle Induced Blood-Brain Barrier Inflammation and Increased Permeability in Primary Rat Brain Microvessel Endothelial Cells.” Toxicological Sciences: An Official Journal of the Society of Toxicology 118 (1): 160–170. doi:10.1093/toxsci/kfq244.
  • Tulve, N. S., A. B. Stefaniak, M. E. Vance, K. Rogers, S. Mwilu, R. F. LeBouf, D. Schwegler-Berry, R. Willis, T. A. Thomas, and L. C. Marr. 2015. “Characterization of Silver Nanoparticles in Selected Consumer Products and Its Relevance for Predicting Children’s Potential Exposures.” International Journal of Hygiene and Environmental Health 218 (3): 345–357. doi:10.1016/j.ijheh.2015.02.002.
  • van Aerle, R., A. Lange, A. Moorhouse, K. Paszkiewicz, K. Ball, B. D. Johnston, E. de-Bastos, T. Booth, C. R. Tyler, and E. M. Santos. 2013. “Molecular Mechanisms of Toxicity of Silver Nanoparticles in Zebrafish Embryos.” Environmental Science & Technology 47 (14): 8005–8014. doi:10.1021/es401758d.
  • Xia, G., T. Liu, Z. Wang, Y. Hou, L. Dong, J. Zhu, and J. Qi. 2016. “The Effect of Silver Nanoparticles on Zebrafish Embryonic Development and Toxicology.” Artificial Cells, Nanomedicine, and Biotechnology 44 (4): 1116–1121. doi:10.3109/21691401.2015.1011803.
  • Xin, Q., J. M. Rotchell, J. Cheng, J. Yi, and Q. Zhang. 2015. “Silver Nanoparticles Affect the Neural Development of Zebrafish Embryos.” Journal of Applied Toxicology 35 (12): 1481–1492.
  • Weldon, B. A., J. J. Park, S. Hong, T. Workman, R. Dills, J. H. Lee, W. C. Griffith, T. J. Kavanagh, and E. M. Faustman. 2018. “Using Primary Organotypic Mouse Midbrain Cultures to Examine Developmental Neurotoxicity of Silver Nanoparticles across Two Genetic Strains.” Toxicology and Applied Pharmacology 354: 215–224. doi:10.1016/j.taap.2018.04.017.
  • Wen, R., X. Yang, L. Hu, C. Sun, Q. Zhou, and G. Jiang. 2016. “Brain-Targeted Distribution and High Retention of Silver by Chronic Intranasal Instillation of Silver Nanoparticles and Ions in Sprague-Dawlwy Rats.” Journal of Applied Toxicology 36 (3): 445–453. doi:10.1002/jat.3260.
  • Wick, P., A. Malek, P. Manser, D. Meili, X. Maeder-Althaus, L. Diener, P. A. Diener, A. Zisch, H. F. Krug, and U. von Mandach. 2010. “Barrier Capacity of Human Placenta for Nanosized Materials.” Environmental Health Perspectives 118 (3): 432–436. doi:10.1289/ehp.0901200.
  • Wu, J., C. Yu, Y. Tan, Z. Hou, M. Li, F. Shao, and X. Lu. 2015. “Effects of Prenatal Exposure to Silver Nanoparticles on Spatial Cognition and Hippocampal Neurodevelopment in Rats.” Environmental Research 138: 67–73. doi:10.1016/j.envres.2015.01.022.
  • Yang, T., T. Paulose, B. W. Redan, J. C. Mabon, and T. V. Duncan. 2021. “Food and Beverage Ingredients Induce the Formation of Silver Nanoparticles in Products Stored within Nanotechnology-Enabled Packaging.” ACS Applied Materials & Interfaces 13 (1): 1398–1412. doi:10.1021/acsami.0c17867.
  • Ye, D., M. N. Raghnaill, M. Bramini, E. Mahon, C. Åberg, A. Salvati, and K. A. Dawson. 2013. “Nanoparticle Accumulation and Transcytosis in Brain Endothelial Cell Layers.” Nanoscale 5 (22): 11153–11165. doi:10.1039/c3nr02905k.
  • Yin, N., B. Hu, R. Yang, S. Liang, S. Liang, and F. Faiola. 2018. “Assessment of the Developmental Neurotoxicity of Silver Nanoparticles and Silver Ions with Mouse Embryonic Stem Cells in Vitro.” Journal of Interdisciplinary Nanomedicine 3 (3): 133–145. doi:10.1002/jin2.49.
  • Yu, W.-J., J.-M. Son, J. Lee, S.-H. Kim, I.-C. Lee, H.-S. Baek, I.-S. Shin, C. Moon, S.-H. Kim, and J.-C. Kim. 2014. “Effects of Silver Nanoparticles on Pregnant Dams and Embryo-Fetal Development in Rats.” Nanotoxicology 8 (1): 85–91. doi:10.3109/17435390.2013.857734.
  • Zhang, X. F., Z. G. Liu, W. Shen, and S. Gurunathan. 2016. “Silver Nanoparticles: Synthesis, Characterization, Properties, Applications, and Therapeutic Approaches.” International Journal of Molecular Sciences 17 (9): 1534. doi:10.3390/ijms17091534.
  • Zhou, Q, and M. Sheng. 2013. “NMDA Receptors in Nervous System Diseases.” Neuropharmacology 74: 69–75. doi:10.1016/j.neuropharm.2013.03.030.

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