212
Views
3
CrossRef citations to date
0
Altmetric
Articles

Amorphous silica nanoparticles caused lung injury through the induction of epithelial apoptosis via ROS/Ca2+/DRP1-mediated mitochondrial fission signaling

, , , , , , , , & show all
Pages 713-732 | Received 30 Aug 2022, Accepted 03 Nov 2022, Published online: 28 Nov 2022

References

  • Abulikemu, A., X. Zhao, Y. Qi, Y. Liu, J. Wang, W. Zhou, H. Duan, Y. Li, Z. Sun, and C. Guo. 2022. “Lysosomal Impairment-Mediated Autophagy Dysfunction Responsible for the Vascular Endothelial Apoptosis Caused by Silica Nanoparticle via ROS/PARP1/AIF Signaling Pathway.” Environmental Pollution (Barking, Essex : 1987) 304: 119202. doi:10.1016/j.envpol.2022.119202
  • Aghapour, M., A. H. V. Remels, S. D. Pouwels, D. Bruder, P. S. Hiemstra, S. M. Cloonan, and I. H. Heijink. 2020. “Mitochondria: At the Crossroads of Regulating Lung Epithelial Cell Function in Chronic Obstructive Pulmonary Disease.” American Journal of Physiology. Lung Cellular and Molecular Physiology 318 (1): L149–L164. doi:10.1152/ajplung.00329.2019
  • Barazzuol, L., F. Giamogante, and T. Cali. 2021. “Mitochondria Associated Membranes (MAMs): Architecture and Physiopathological Role.” Cell Calcium 94: 102343. doi:10.1016/j.ceca.2020.102343
  • Bielsa, S., A. Guitart, A. Esquerda, R. Fernandez-Pacheco, M. T. Baranguan, A. Ibarra, and J. M. Porcel. 2022. “Some Pleural Effusions Labeled as Idiopathic Could Be Produced by the Inhalation of Silica.” Pleura and Peritoneum 7 (1): 27–33. doi:10.1515/pp-2021-0135
  • Bitar, A., N. M. Ahmad, H. Fessi, and A. Elaissari. 2012. “Silica-Based Nanoparticles for Biomedical Applications.” Drug Discovery Today 17 (19-20): 1147–1154. doi:10.1016/j.drudis.2012.06.014
  • Boccuni, F., R. Ferrante, F. Tombolini, C. Natale, A. Gordiani, S. Sabella, and S. Iavicoli. 2020. “Occupational Exposure to Graphene and Silica Nanoparticles. Part I: workplace Measurements and Samplings.” Nanotoxicology 14 (9): 1280–1300.
  • Bravo-Sagua, R., V. Parra, C. Lopez-Crisosto, P. Diaz, A. F. Quest, and S. Lavandero. 2017. “Calcium Transport and Signaling in Mitochondria.” Comprehensive Physiology 7 (2): 623–634. doi:10.1002/cphy.c160013
  • Bruno, S. R., A. Kumar, Z. F. Mark, R. Chandrasekaran, E. Nakada, N. Chamberlain, B. Mihavics, et al. 2021. “DRP1-Mediated Mitochondrial Fission Regulates Lung Epithelial Response to Allergen.” International Journal of Molecular Sciences. 22 (20): 11125.
  • Bueno, M., J. Calyeca, M. Rojas, and A. L. Mora. 2020. “Mitochondria Dysfunction and Metabolic Reprogramming as Drivers of Idiopathic Pulmonary Fibrosis.” Redox Biology 33: 101509. doi:10.1016/j.redox.2020.101509
  • Chu, Zhiqin, Yuanjie Huang, Lili Li, Qian Tao, and Quan Li. 2012. “Physiological Pathway of Human Cell Damage Induced by Genotoxic Crystalline Silica Nanoparticles.” Biomaterials 33 (30): 7540–7546. doi:10.1016/j.biomaterials.2012.06.073
  • Chung, K. P., C. L. Hsu, L. C. Fan, Z. Huang, D. Bhatia, Y. J. Chen, S. Hisata, et al. 2019. “Mitofusins Regulate Lipid Metabolism to Mediate the Development of Lung Fibrosis.” Nature Communications 10 (1): 3390. doi:10.1038/s41467-019-11327-1
  • Cui, Jiasen, Zeng Li, Shunjiu Zhuang, Shaohong Qi, Li Li, Junwen Zhou, Wan Zhang, and Yun Zhao. 2018. “Melatonin Alleviates Inflammation-Induced Apoptosis in Human Umbilical Vein Endothelial Cells via Suppression of Ca(2+)-XO-ROS-Drp1-Mitochondrial Fission Axis by Activation of AMPK/SERCA2a Pathway.” Cell Stress & Chaperones 23 (2): 281–293. doi:10.1007/s12192-017-0841-6
  • Debia, M., M. Carpentier, and G. L'Esperance. 2021. “Characterization of Occupational Exposures to Engineered Nanoparticles during the Finishing Process of a Hardwood Floor Manufacturing Plant.” Annals of Work Exposures and Health 65 (7): 868–873. doi:10.1093/annweh/wxab003
  • Delaval, M., S. Boland, B. Solhonne, M. A. Nicola, S. Mornet, A. Baeza-Squiban, J. M. Sallenave, and I. Garcia-Verdugo. 2015. “Acute Exposure to Silica Nanoparticles Enhances Mortality and Increases Lung Permeability in a Mouse Model of Pseudomonas aeruginosa Pneumonia.” Particle and Fibre Toxicology 12: 1. doi:10.1186/s12989-014-0078-9
  • Deweirdt, J., J. F. Quignard, S. Lacomme, E. Gontier, S. Mornet, J. P. Savineau, R. Marthan, C. Guibert, and I. Baudrimont. 2020. “In Vitro Study of Carbon Black Nanoparticles on Human Pulmonary Artery Endothelial Cells: effects on Calcium Signaling and Mitochondrial Alterations.” Archives of Toxicology 94 (7): 2331–2348. doi:10.1007/s00204-020-02764-9
  • Dussert, F., P. A. Arthaud, M. E. Arnal, B. Dalzon, A. Torres, T. Douki, N. Herlin, T. Rabilloud, and M. Carriere. 2020. “Toxicity to RAW264.7 Macrophages of Silica Nanoparticles and the E551 Food Additive, in Combination with Genotoxic Agents.” Nanomaterials 10 (7): 1418.
  • Eom, H. J, and J. Choi. 2011. “SiO(2) Nanoparticles Induced Cytotoxicity by Oxidative Stress in Human Bronchial Epithelial Cell, Beas-2B.” Environmental Health and Toxicology 26: e2011013.
  • Fang, T., M. Wang, H. Xiao, and X. Wei. 2019. “Mitochondrial Dysfunction and Chronic Lung Disease.” Cell Biology and Toxicology 35 (6): 493–502. doi:10.1007/s10565-019-09473-9
  • Feno, S., G. Butera, D. Vecellio Reane, R. Rizzuto, and A. Raffaello. 2019. “Crosstalk between Calcium and ROS in Pathophysiological Conditions.” Oxidative Medicine and Cellular Longevity 2019: 9324018. doi:10.1155/2019/9324018
  • Forest, V., J. Pourchez, C. Pelissier, S. Audignon Durand, J. M. Vergnon, and L. Fontana. 2021. “Relationship between Occupational Exposure to Airborne Nanoparticles, Nanoparticle Lung Burden and Lung Diseases.” Toxics 9 (9): 204. doi:10.3390/toxics9090204
  • Godoy, J. A., J. A. Rios, P. Picon-Pages, V. Herrera-Fernandez, B. Swaby, G. Crepin, R. Vicente, J. M. Fernandez-Fernandez, and F. J. Munoz. 2021. “Mitostasis, Calcium and Free Radicals in Health.” Aging and Neurodegeneration. Biomolecules 11 (7): 1012.
  • Gohy, S. T., C. Hupin, C. Pilette, and M. Z. Ladjemi. 2016. “Chronic Inflammatory Airway Diseases: The Central Role of the Epithelium Revisited.” Clinical and Experimental Allergy : journal of the British Society for Allergy and Clinical Immunology 46 (4): 529–542. doi:10.1111/cea.12712
  • Gorlach, A., K. Bertram, S. Hudecova, and O. Krizanova. 2015. “Calcium and ROS: A Mutual Interplay.” Redox Biology 6: 260–271. doi:10.1016/j.redox.2015.08.010
  • Gualtieri, M., M. G. Grollino, C. Consales, F. Costabile, M. Manigrasso, P. Avino, M. Aufderheide, et al. 2018. “Is It the Time to Study Air Pollution Effects under Environmental Conditions? A Case Study to Support the Shift of in Vitro Toxicology from the Bench to the Field.” Chemosphere 207: 552–564. doi:10.1016/j.chemosphere.2018.05.130
  • Guo, C., J. Wang, L. Jing, R. Ma, X. Liu, L. Gao, L. Cao, et al. 2018a. “Mitochondrial Dysfunction, Perturbations of Mitochondrial Dynamics and Biogenesis Involved in Endothelial Injury Induced by Silica Nanoparticles.” Environmental Pollution (Barking, Essex : 1987) 236: 926–936. doi:10.1016/j.envpol.2017.10.060
  • Guo, C., J. Wang, M. Yang, Y. Li, S. Cui, X. Zhou, Y. Li, and Z. Sun. 2017. “Amorphous Silica Nanoparticles Induce Malignant Transformation and Tumorigenesis of Human Lung Epithelial Cells via P53 Signaling.” Nanotoxicology 11 (9-10): 1176–1194. doi:10.1080/17435390.2017.1403658
  • Guo, C., R. Ma, X. Liu, T. Chen, Y. Li, Y. Yu, J. Duan, X. Zhou, Y. Li, and Z. Sun. 2018b. “Silica Nanoparticles Promote oxLDL-Induced Macrophage Lipid Accumulation and Apoptosis via Endoplasmic Reticulum Stress Signaling.” The Science of the Total Environment 631-632: 570–579. doi:10.1016/j.scitotenv.2018.02.312
  • Guo, C., R. Ma, X. Liu, Y. Xia, P. Niu, J. Ma, X. Zhou, Y. Li, and Z. Sun. 2018c. “Silica Nanoparticles Induced Endothelial Apoptosis via Endoplasmic Reticulum Stress-Mitochondrial Apoptotic Signaling Pathway.” Chemosphere 210: 183–192. doi:10.1016/j.chemosphere.2018.06.170
  • Guo, C., Y. Liu, and Y. Li. 2021. “Adverse Effects of Amorphous Silica Nanoparticles: Focus on Human Cardiovascular Health.” Journal of Hazardous Materials 406: 124626. doi:10.1016/j.jhazmat.2020.124626
  • Guo, C., Y. Xia, P. Niu, L. Jiang, J. Duan, Y. Yu, X. Zhou, Y. Li, and Z. Sun. 2015. “Silica Nanoparticles Induce Oxidative Stress, Inflammation, and Endothelial Dysfunction in Vitro via Activation of the MAPK/Nrf2 Pathway and Nuclear Factor-kappaB Signaling.” International Journal of Nanomedicine 10: 1463–1477. doi:10.2147/IJN.S76114
  • Guo, Caixia, Man Yang, Li Jing, Ji Wang, Yang Yu, Yang Li, Junchao Duan, Xianqing Zhou, Yanbo Li, and Zhiwei Sun. 2016. “Amorphous Silica Nanoparticles Trigger Vascular Endothelial Cell Injury through Apoptosis and Autophagy via Reactive Oxygen Species-Mediated MAPK/Bcl-2 and PI3K/Akt/mTOR Signaling.” International Journal of Nanomedicine 11: 5257–5276. doi:10.2147/IJN.S112030
  • GVR 2017. NanoSilica Market Size, Share & Trends Analysis Report By Product (P Type, S Type, and Type III), By Application (Rubber, Healthcare, Food, Coatings, Plastics, Concrete, Gypsum, Battery, Electronics, Cosmetics), And Segment Forecasts, 2018 - 2025. [Online] https://www.grandviewresearch.com/industry-analysis/nanosilica-market.
  • Haase, A., N. Dommershausen, M. Schulz, R. Landsiedel, P. Reichardt, B. C. Krause, J. Tentschert, and A. Luch. 2017. “Genotoxicity Testing of Different Surface-Functionalized SiO2, ZrO2 and Silver Nanomaterials in 3D Human Bronchial Models.” Archives of Toxicology 91 (12): 3991–4007. doi:10.1007/s00204-017-2015-9
  • Han, Y., S. Ishibashi, J. Iglesias-Gonzalez, Y. Chen, N. R. Love, and E. Amaya. 2018. “Ca(2+)-Induced Mitochondrial ROS Regulate the Early Embryonic Cell Cycle.” Cell Reports 22 (1): 218–231. doi:10.1016/j.celrep.2017.12.042
  • Hasan, P., M. Saotome, T. Ikoma, K. Iguchi, H. Kawasaki, T. Iwashita, H. Hayashi, and Y. Maekawa. 2018. “Mitochondrial Fission Protein, Dynamin-Related Protein 1, Contributes to the Promotion of Hypertensive Cardiac Hypertrophy and Fibrosis in Dahl-Salt Sensitive Rats.” Journal of Molecular and Cellular Cardiology 121: 103–106. doi:10.1016/j.yjmcc.2018.07.004
  • Hou, L., J. Zhang, Y. Liu, H. Fang, L. Liao, Z. Wang, J. Yuan, et al. 2021a. “MitoQ Alleviates LPS-Mediated Acute Lung Injury through Regulating Nrf2/Drp1 Pathway.” Free Radical Biology & Medicine 165: 219–228. doi:10.1016/j.freeradbiomed.2021.01.045
  • Hou, Shanshan, Xiayu Zhang, Haiying Du, Xiaofan Ning, Hao Wu, Chunrui Li, Yuxin Liu, Zhiwei Sun, Zhongjun Du, and Minghua Jin. 2021b. “Silica Nanoparticles Induce Mitochondrial Pathway-Dependent Apoptosis by Activating Unfolded Protein Response in Human Neuroblastoma Cells.” Environmental Toxicology 36 (4): 675–685. doi:10.1002/tox.23071
  • Huang, C. C., R. S. Aronstam, D. R. Chen, and Y. W. Huang. 2010. “Oxidative Stress, Calcium Homeostasis, and Altered Gene Expression in Human Lung Epithelial Cells Exposed to ZnO Nanoparticles.” Toxicology in Vitro : An International Journal Published in Association with BIBRA 24 (1): 45–55. doi:10.1016/j.tiv.2009.09.007
  • Huang. Q., H. Cao, L. Zhan, X. Sun, G. Wang, J. Li, X. Guo, T. Ren, et al. 2017. “Mitochondrial Fission Forms a Positive Feedback Loop with Cytosolic Calcium Signaling Pathway to Promote Autophagy in Hepatocellular Carcinoma Cells.” Cancer Letters 403: 108–118. doi:10.1016/j.canlet.2017.05.034
  • Inoue, M., K. Sakamoto, A. Suzuki, S. Nakai, A. Ando, Y. Shiraki, Y. Nakahara, et al. 2021. “Size and Surface Modification of Silica Nanoparticles Affect the Severity of Lung Toxicity by Modulating Endosomal ROS Generation in Macrophages.” Particle and Fibre Toxicology 18 (1): 21. doi:10.1186/s12989-021-00415-0
  • Jablonski, R. P., S. J. Kim, P. Cheresh, D. B. Williams, L. Morales-Nebreda, Y. Cheng, A. Yeldandi, et al. 2017. “SIRT3 Deficiency Promotes Lung Fibrosis by Augmenting Alveolar Epithelial Cell Mitochondrial DNA Damage and Apoptosis.” FASEB Journal : official Publication of the Federation of American Societies for Experimental Biology 31 (6): 2520–2532. doi:10.1096/fj.201601077R
  • Kasper, J., M. I. Hermanns, C. Bantz, M. Maskos, R. Stauber, C. Pohl, R. E. Unger, and J. C. Kirkpatrick. 2011. “Inflammatory and Cytotoxic Responses of an Alveolar-Capillary Coculture Model to Silica Nanoparticles: comparison with Conventional Monocultures.” Particle and Fibre Toxicology 8 (1): 6. doi:10.1186/1743-8977-8-6
  • Ke, S., T. Zhou, P. Yang, Y. Wang, P. Zhang, K. Chen, L. Ren, and S. Ye. 2017. “Gold Nanoparticles Enhance TRAIL Sensitivity through Drp1-Mediated Apoptotic and Autophagic Mitochondrial Fission in NSCLC Cells.” International Journal of Nanomedicine 12: 2531–2551. doi:10.2147/IJN.S129274
  • Kreyling, W. G., U. Holzwarth, N. Haberl, J. Kozempel, A. Wenk, S. Hirn, C. Schleh, et al. 2017. “Quantitative Biokinetics of Titanium Dioxide Nanoparticles after Intratracheal Instillation in Rats: Part 3.” Nanotoxicology 11 (4): 454–464. doi:10.1080/17435390.2017.1306894
  • Lee, Kuan-I, Chin-Chuan Su, Kai-Min Fang, Chin-Ching Wu, Cheng-Tien Wu, and Ya-Wen Chen. 2020. “Ultrafine Silicon Dioxide Nanoparticles Cause Lung Epithelial Cells Apoptosis via Oxidative Stress-Activated PI3K/Akt-Mediated Mitochondria- and Endoplasmic Reticulum Stress-Dependent Signaling Pathways.” Scientific Reports 10 (1): 9928. doi:10.1038/s41598-020-66644-z
  • Leibe, R., I. L. Hsiao, S. Fritsch-Decker, U. Kielmeier, A. M. Wagbo, B. Voss, A. Schmidt, et al. 2019. “The Protein Corona Suppresses the Cytotoxic and Pro-Inflammatory Response in Lung Epithelial Cells and Macrophages upon Exposure to Nanosilica.” Archives of Toxicology 93 (4): 871–885. doi:10.1007/s00204-019-02422-9
  • Li, X., Y. Li, S. Lv, H. Xu, R. Ma, Z. Sun, Y. Li, and C. Guo. 2022. “Long-Term Respiratory Exposure to Amorphous Silica Nanoparticles Promoted Systemic Inflammation and Progression of Fibrosis in a Susceptible Mouse Model.” Chemosphere 300: 134633. doi:10.1016/j.chemosphere.2022.134633
  • Liao, H. Y., Y. T. Chung, C. H. Lai, S. L. Wang, H. C. Chiang, L. A. Li, T. C. Tsou, et al. 2014. “Six-Month Follow-up Study of Health Markers of Nanomaterials among Workers Handling Engineered Nanomaterials.” Nanotoxicology 8(Suppl 1): 100–110. doi:10.3109/17435390.2013.858793
  • Liu, J. Y, and C. M. Sayes. 2022. “A Toxicological Profile of Silica Nanoparticles.” Toxicology Research 11 (4): 565–582. doi:10.1093/toxres/tfac038
  • Liu, Xiaoying, Xinying Zhao, Xueyan Li, Songqing Lv, Ru Ma, Yi Qi, Alimire Abulikemu, et al. 2020a. “PM2.5 Triggered Apoptosis in Lung Epithelial Cells through the Mitochondrial Apoptotic Way Mediated by a ROS-DRP1-Mitochondrial Fission Axis.” Journal of Hazardous Materials 397: 122608. doi:10.1016/j.jhazmat.2020.122608
  • Liu, Y., H. Wei, J. Tang, J. Yuan, M. Wu, C. Yao, K. Hosoi, et al. 2020b. “Dysfunction of Pulmonary Epithelial Tight Junction Induced by Silicon Dioxide Nanoparticles via the ROS/ERK Pathway and Protein Degradation.” Chemosphere 255: 126954. doi:10.1016/j.chemosphere.2020.126954
  • Lou, D., X. Wei, P. Xiao, Q. Huo, X. Hong, J. Sun, Y. Shuai, and G. Tao. 2020. “Demethylation of the NRF2 Promoter Protects against Carcinogenesis Induced by Nano-SiO2.” Frontiers in Genetics 11: 818.
  • Ma, Ru., Yi Qi, Xinying Zhao, Xueyan Li, Xuejing Sun, Piye Niu, Yanbo Li, Caixia Guo, Rui Chen, and Zhiwei Sun. 2020. “Amorphous Silica Nanoparticles Accelerated Atherosclerotic Lesion Progression in ApoE(-/-) Mice through Endoplasmic Reticulum Stress-Mediated CD36 up-Regulation in Macrophage.” Particle and Fibre Toxicology 17 (1): 50. doi:10.1186/s12989-020-00380-0
  • Madreiter-Sokolowski, C. T., C. Thomas, and M. Ristow. 2020. “Interrelation between ROS and Ca(2+) in Aging and Age-Related Diseases.” Redox Biology 36: 101678. doi:10.1016/j.redox.2020.101678
  • Manevski, M., T. Muthumalage, D. Devadoss, I. K. Sundar, Q. Wang, K. P. Singh, H. J. Unwalla, H. S. Chand, and I. Rahman. 2020. “Cellular Stress Responses and Dysfunctional Mitochondrial-Cellular Senescence, and Therapeutics in Chronic Respiratory Diseases.” Redox Biology 33: 101443.
  • Marques Da Silva, V., M. Benjdir, P. Montagne, J. C. Pairon, S. Lanone, and P. Andujar. 2022. “Pulmonary Toxicity of Silica Linked to Its Micro- or Nanometric Particle Size and Crystal Structure: A Review.” Nanomaterials 12 (14): 2392. )doi:10.3390/nano12142392
  • Matute-Bello, G., G. Downey, B. B. Moore, S. D. Groshong, M. A. Matthay, A. S. Slutsky, W. M. Kuebler, Acute Lung Injury in Animals Study Group 2011. “An Official American Thoracic Society Workshop Report: features and Measurements of Experimental Acute Lung Injury in Animals.” American Journal of Respiratory Cell and Molecular Biology 44 (5): 725–738. doi:10.1165/rcmb.2009-0210ST
  • Mohammadpour, R., M. Yazdimamaghani, D. L. Cheney, J. Jedrzkiewicz, and H. Ghandehari. 2019. “Subchronic Toxicity of Silica Nanoparticles as a Function of Size and Porosity.” Journal of Controlled Release : official Journal of the Controlled Release Society 304: 216–232. doi:10.1016/j.jconrel.2019.04.041
  • Mora, A. L., M. Bueno, and M. Rojas. 2017. “Mitochondria in the Spotlight of Aging and Idiopathic Pulmonary Fibrosis.” The Journal of Clinical Investigation 127 (2): 405–414. doi:10.1172/JCI87440
  • Murugadoss, S., D. Lison, L. Godderis, S. Van Den Brule, J. Mast, F. Brassinne, N. Sebaihi, and P. H. Hoet. 2017. “Toxicology of Silica Nanoparticles: An Update.” Archives of Toxicology 91 (9): 2967–3010. doi:10.1007/s00204-017-1993-y
  • Natarajan, V., C. L. Wilson, S. L. Hayward, and S. Kidambi. 2015. “Titanium Dioxide Nanoparticles Trigger Loss of Function and Perturbation of Mitochondrial Dynamics in Primary Hepatocytes.” PloS One 10 (8): e0134541. doi:10.1371/journal.pone.0134541
  • Nemmar, A., P. Yuvaraju, S. Beegam, J. Yasin, E. E. Kazzam, and B. H. Ali. 2016. “Oxidative Stress, Inflammation, and DNA Damage in Multiple Organs of Mice Acutely Exposed to Amorphous Silica Nanoparticles.” International Journal of Nanomedicine 11: 919–928. doi:10.2147/IJN.S92278
  • Nunnari, J, and A. Suomalainen. 2012. “Mitochondria: In Sickness and in Health.” Cell 148 (6): 1145–1159. doi:10.1016/j.cell.2012.02.035
  • Oberdorster, G., E. Oberdorster, and J. Oberdorster. 2005. “Nanotoxicology: An Emerging Discipline Evolving from Studies of Ultrafine Particles.” Environmental Health Perspectives.113: 823–839.
  • Oh, S., B. Kim, and H. Kim. 2014. “Comparison of Nanoparticle Exposures between Fumed and Sol-Gel Nano-Silica Manufacturing Facilities.” Industrial Health 52 (3): 190–198. doi:10.2486/indhealth.2013-0117
  • Orlando, A., E. Cazzaniga, M. Tringali, F. Gullo, A. Becchetti, S. Minniti, F. Taraballi, E. Tasciotti, and F. Re. 2017. “Mesoporous Silica Nanoparticles Trigger Mitophagy in Endothelial Cells and Perturb Neuronal Network Activity in a Size- and Time-Dependent Manner.” International Journal of Nanomedicine 12: 3547–3559. doi:10.2147/IJN.S127663
  • Park, J., H. Choi, B. Kim, U. Chae, D. G. Lee, S. R. Lee, S. Lee, H. S. Lee, and D. S. Lee. 2016. “Peroxiredoxin 5 (Prx5) Decreases LPS-Induced Microglial Activation through Regulation of Ca(2+)/calcineurin-Drp1-Dependent Mitochondrial Fission.” Free Radical Biology & Medicine 99: 392–404. doi:10.1016/j.freeradbiomed.2016.08.030
  • Piantadosi, C. A, and H. B. Suliman. 2017. “Mitochondrial Dysfunction in Lung Pathogenesis.” Annual Review of Physiology 79: 495–515. doi:10.1146/annurev-physiol-022516-034322
  • Prakash, Y. S., C. M. Pabelick, and G. C. Sieck. 2017. “Mitochondrial Dysfunction in Airway Disease.” Chest 152 (3): 618–626. doi:10.1016/j.chest.2017.03.020
  • Qi, Y., H. Xu, X. Li, X. Zhao, Y. Li, X. Zhou, S. Chen, et al. 2022. “Silica Nanoparticles Induce Cardiac Injury and Dysfunction via ROS/Ca(2+)/CaMKII Signaling.” The Science of the Total Environment 837: 155733. doi:10.1016/j.scitotenv.2022.155733
  • Qi, Y., R. Ma, X. Li, S. Lv, X. Liu, A. Abulikemu, X. Zhao, Y. Li, C. Guo, and Z. Sun. 2020. “Disturbed Mitochondrial Quality Control Involved in Hepatocytotoxicity Induced by Silica Nanoparticles.” Nanoscale 12 (24): 13034–13045. doi:10.1039/d0nr01893g
  • Reddy, L. H., J. L. Arias, J. Nicolas, and P. Couvreur. 2012. “Magnetic Nanoparticles: design and Characterization, Toxicity and Biocompatibility, Pharmaceutical and Biomedical Applications.” Chemical Reviews 112 (11): 5818–5878. doi:10.1021/cr300068p
  • Refsnes, M., T. Skuland, E. Lilleaas, J. Ovrevik, and M. Lag. 2019. “Concentration-Dependent Cytokine Responses of Silica Nanoparticles and Role of ROS in Human Lung Epithelial Cells.” Basic & Clinical Pharmacology & Toxicology 125 (3): 304–314. doi:10.1111/bcpt.13221
  • Skuland, T., J. Ovrevik, M. Lag, P. Schwarze, and M. Refsnes. 2014. “Silica Nanoparticles Induce Cytokine Responses in Lung Epithelial Cells through Activation of a p38/TACE/TGF-Alpha/EGFR-Pathway and NF-kappaBeta Signalling.” Toxicology and Applied Pharmacology 279 (1): 76–86. doi:10.1016/j.taap.2014.05.006
  • Song, R., Y. Qin, S. Suh, and A. A. Keller. 2017. “Dynamic Model for the Stocks and Release Flows of Engineered Nanomaterials.” Environmental Science & Technology 51 (21): 12424–12433. doi:10.1021/acs.est.7b01907
  • Sun, L., Y. Li, X. Liu, M. Jin, L. Zhang, Z. Du, C. Guo, P. Huang, and Z. Sun. 2011. “Cytotoxicity and Mitochondrial Damage Caused by Silica Nanoparticles.” Toxicology in Vitro : An International Journal Published in Association with BIBRA 25 (8): 1619–1629. doi:10.1016/j.tiv.2011.06.012
  • Sutunkova, M. P., S. N. Solovyeva, B. A. Katsnelson, V. B. Gurvich, L. I. Privalova, I. A. Minigalieva, T. V. Slyshkina, et al. 2017. “A Paradoxical Response of the Rat Organism to Long-Term Inhalation of Silica-Containing Submicron (Predominantly Nanoscale) Particles of a Collected Industrial Aerosol at Realistic Exposure Levels.” Toxicology 384: 59–68. doi:10.1016/j.tox.2017.04.010
  • Tang, F., L. Li, and D. Chen. 2012. “Mesoporous Silica Nanoparticles: synthesis, Biocompatibility and Drug Delivery.” Advanced Materials (Deerfield Beach, Fla.) 24 (12): 1504–1534. doi:10.1002/adma.201104763
  • Tang, S., S. Ye, Y. Ma, Y. Liang, N. Liang, and F. Xiao. 2020. “Clusterin Alleviates Cr(VI)-Induced Mitochondrial Apoptosis in L02 Hepatocytes via Inhibition of Ca(2+)-ROS-Drp1-Mitochondrial Fission Axis.” Ecotoxicology and Environmental Safety 205: 111326. doi:10.1016/j.ecoenv.2020.111326
  • Wang, L., T. Yu, H. Lee, D. K. O'Brien, H. Sesaki, and Y. Yoon. 2015. “Decreasing Mitochondrial Fission Diminishes Vascular Smooth Muscle Cell Migration and Ameliorates Intimal Hyperplasia.” Cardiovascular Research 106 (2): 272–283. doi:10.1093/cvr/cvv005
  • Wang, M., J. Li, S. Dong, X. Cai, A. Simaiti, X. Yang, X. Zhu, et al. 2020. “Silica Nanoparticles Induce Lung Inflammation in Mice via ROS/PARP/TRPM2 Signaling-Mediated Lysosome Impairment and Autophagy Dysfunction.” Particle and Fibre Toxicology 17 (1): 23. doi:10.1186/s12989-020-00353-3
  • Whitley, B. N., E. A. Engelhart, and S. Hoppins. 2019. “Mitochondrial Dynamics and Their Potential as a Therapeutic Target.” Mitochondrion 49: 269–283. doi:10.1016/j.mito.2019.06.002
  • Wiegman, C. H., C. Michaeloudes, G. Haji, P. Narang, C. J. Clarke, K. E. Russell, W. Bao, Copdmap, et al. 2015. “Oxidative Stress-Induced Mitochondrial Dysfunction Drives Inflammation and Airway Smooth Muscle Remodeling in Patients with Chronic Obstructive Pulmonary Disease.” The Journal of Allergy and Clinical Immunology 136 (3): 769–780. doi:10.1016/j.jaci.2015.01.046
  • Wu, T., S. Zhang, X. Liang, K. He, T. Wei, Y. Wang, L. Zou, T. Zhang, Y. Xue, and M. Tang. 2019. “The Apoptosis Induced by Silica Nanoparticle through Endoplasmic Reticulum Stress Response in Human Pulmonary Alveolar Epithelial Cells.” Toxicology in Vitro : An International Journal Published in Association with BIBRA 56: 126–132. doi:10.1016/j.tiv.2019.01.009
  • Wu, W. T., W. T. Jung, and H. L. Lee. 2021. “Lipid Peroxidation Metabolites Associated with Biomarkers of Inflammation and Oxidation Stress in Workers Handling Carbon Nanotubes and Metal Oxide Nanoparticles.” Nanotoxicology 15 (5): 577–587. doi:10.1080/17435390.2021.1879303
  • Xu, S., H. Pi, L. Zhang, N. Zhang, Y. Li, H. Zhang, J. Tang, H. Li, et al. 2016. “Melatonin Prevents Abnormal Mitochondrial Dynamics Resulting from the Neurotoxicity of Cadmium by Blocking Calcium-Dependent Translocation of Drp1 to the Mitochondria.” Journal of Pineal Research 60 (3): 291–302. doi:10.1111/jpi.12310
  • Xu, S., H. Pi, Y. Chen, N. Zhang, P. Guo, Y. Lu, M. He, et al. 2013. “Cadmium Induced Drp1-Dependent Mitochondrial Fragmentation by Disturbing Calcium Homeostasis in Its Hepatotoxicity.” Cell Death & Disease 4: e540. doi:10.1038/cddis.2013.7
  • Yan, T, and Y. Zhao. 2020. “Acetaldehyde Induces Phosphorylation of Dynamin-Related Protein 1 and Mitochondrial Dysfunction via Elevating Intracellular ROS and Ca(2+) Levels.” Redox Biology 28: 101381. doi:10.1016/j.redox.2019.101381
  • Yang, H., Q. Y. Wu, M. Y. Li, C. S. Lao, and Y. J. Zhang. 2017. “Pulmonary Toxicity in Rats Caused by Exposure to Intratracheal Instillation of SiO2 Nanoparticles.” Biomedical and Environmental Sciences : BES 30 (4): 264–279.
  • Yu, Yang, Tingting Zhu, Yang Li, Li Jing, Man Yang, Yanbo Li, Junchao Duan, and Zhiwei Sun. 2019. “Repeated Intravenous Administration of Silica Nanoparticles Induces Pulmonary Inflammation and Collagen Accumulation via JAK2/STAT3 and TGF-Beta/Smad3 Pathways in Vivo.” International Journal of Nanomedicine 14: 7237–7247. doi:10.2147/IJN.S209458
  • Zhang, L., C. Ma, C. Zhang, M. Ma, F. Zhang, L. Zhang, Y. Chen, F. Cao, S. Li, and D. Zhu. 2016. “Reactive Oxygen Species Effect PASMCs Apoptosis via Regulation of Dynamin-Related Protein 1 in Hypoxic Pulmonary Hypertension.” Histochemistry and Cell Biology 146 (1): 71–84. doi:10.1007/s00418-016-1424-9
  • Zhang, Z., L. Zhou, Y. Zhou, J. Liu, X. Xing, J. Zhong, G. Xu, Z. Kang, and J. Liu. 2015. “Mitophagy Induced by Nanoparticle-Peptide Conjugates Enabling an Alternative Intracellular Trafficking Route.” Biomaterials 65: 56–65. doi:10.1016/j.biomaterials.2015.06.029
  • Zhao, X., S. Wei, Z. Li, C. Lin, Z. Zhu, D. Sun, R. Bai, et al. 2019a. “Autophagic Flux Blockage in Alveolar Epithelial Cells is Essential in Silica Nanoparticle-Induced Pulmonary Fibrosis.” Cell Death & Disease 10 (2): 127. doi:10.1038/s41419-019-1340-8
  • Zhao, X., Y. Wu, J. Li, D. Li, Y. Jin, P. Zhu, Y. Liu, et al. 2019b. “JNK Activation-Mediated Nuclear SIRT1 Protein Suppression Contributes to Silica Nanoparticle-Induced Pulmonary Damage via p53 Acetylation and Cytoplasmic Localisation.” Toxicology 423: 42–53. doi:10.1016/j.tox.2019.05.003
  • Zhao, X., A. Abulikemu, S. Lv, Y. Qi, J. Duan, J. Zhang, R. Chen, C. Guo, Y. Li, and Z. Sun. 2021. “Oxidative Stress- and Mitochondrial Dysfunction-Mediated Cytotoxicity by Silica Nanoparticle in Lung Epithelial Cells from Metabolomic Perspective.” Chemosphere 275: 129969. doi:10.1016/j.chemosphere.2021.129969
  • Zhao, X., H. Xu, Y. Li, Y. Liu, X. Li, W. Zhou, J. Wang, C. Guo, Z. Sun, and Y. Li. 2022a. “Silica Nanoparticles Perturbed Mitochondrial Dynamics and Induced Myocardial Apoptosis via PKA-DRP1-Mitochondrial Fission Signaling.” The Science of the Total Environment 842: 156854. doi:10.1016/j.scitotenv.2022.156854
  • Zhao, Xinying, Hailin Xu, Yan Li, Ru Ma, Yi Qi, Min Zhang, Caixia Guo, Zhiwei Sun, and Yanbo Li. 2022b. “Proteomic Profiling Reveals Dysregulated Mitochondrial Complex Subunits Responsible for Myocardial Toxicity Induced by SiNPs.” The Science of the Total Environment 857 (Pt 1): 159206. doi:10.1016/j.scitotenv.2022.159206
  • Zorov, D. B., M. Juhaszova, and S. J. Sollott. 2014. “Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release.” Physiological Reviews 94 (3): 909–950. doi:10.1152/physrev.00026.2013

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.