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Acta Orthopaedica Volume 77, 2006 - Issue 5
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Original

Metabolism and catabolism in hip fracture patients: Nutritional and anabolic intervention—a review

Margareta Hedström Division of Orthopedics, Karolinska University Hospital Huddinge, Sweden; CLINTEC, Karolinska Intitutet, Stockholm, SwedenCorrespondence[email protected]
,
Olle Ljungqvist Center of Gastrointestinal Disease, Ersta Hospital, Sweden; Division of Surgery, Sweden; CLINTEC, Karolinska Intitutet, Stockholm, Sweden
&
Tommy Cederholm Departments of Public Health and Geriatrics, Clinical Nutrition and Metabolism Unit, Uppsala University Hospital, Uppsala, Sweden
Pages 741-747 | Received 20 Jul 2005, Accepted 24 Mar 2006, Published online: 08 Jul 2009

  • Akner G, Cederholm T. Treatment of protein-energy malnutrition in chronic non-malignant disorders. Am J Clin Nutrition 2001; 74: 6–24
  • Avenell A, Handoll H H G. Nutritional supplementation for hip fracture aftercare in the elderly. Cochrane Database Syst Rev. 2005
  • Bach M, Rockwood K, Zetterberg C, Thamsborg G, Hebert R, Devogealer J-P, Christiansen JS, Rizzoli R, et al. The effects of MK-0677, an oral growth hormone secretagogue, in patients with hip fracture. J Am Geriatr Soc 2004; 52: 516–23
  • Bachrach-Lindström M, Unosson M, Ek A C, Arnquist H J. Assessment of nutritional status using biochemical and anthropometric variables in a nutritional intervention study of women with hip fractures. Clin Nutr 2001; 20: 217–23
  • Bastow M D, Rawlings J, Allison S P. Benefits of supplementary tube feeding after fractured neck of femur: a randomised trial. BMJ (3 Suppl) 1983; 18: 139–44
  • Björkelund C, Hultén B, Lissner L, Rothenberg E, Larsson B, Bengtsson C, Steen B, Tibblin G. New height and weight standards for the middle aged and aged. Weight increases more than height. Lakartidningen 1997; 94: 332–5
  • Boonen S, Rosen C, Bouillon R, Sommer A, Mckay M, Rosen D, Adam Broos P, Lenaerts J, Raus J, Vanderschueren D, Geusens P. Musceloskeletal effects of the recombinant human IGF/IGF binding protein-3 complex in osteoporotic patients with proximal femoral fracture; a double-blind, placebo-controlled pilot study. J Clin Endocrinol Metab 2002; 87: 1593–9
  • Bruce D, Laurance I, McGuiness M, Ridley M, Goldswain P. Nutritional supplements after hip fracture: poor compliance effectiveness:. Clin Nutr 2003; 5: 497–500
  • Campillo B, Paillaud E, Bories P N, Noel M, Porquet D, Le Parco J C. Serum levels of insulin-like growth factor I in the three months following surgery for a hip fracture in elderly; relationship with nutritional status and inflammatory reaction. Clin Nutr 2000; 19: 349–54
  • Cederholm T, Hellström K. Reversibility of protein-energy malnutrition in a group of chronically ill elderly outpatients. Clin Nutr 1995; 14: 81–7
  • Cederholm T, Wretlind B, Hellström K, Andersson B, Engström L, Brismar K, Scheynius A, Forslid J, Palmblad J. Enchanced generation of interleukins 1β and 6 may contribute to cachexia of chronic disease. Am J Clin Nutr 1997; 65: 876–82
  • Creutzberg E C, Schols A M, Weling-Scheepers C A, Buurman W A, Wouters E F. Characterization of non response to high caloric oral nutritional therapy in depleted patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2000; 161: 745–52
  • Delmi M, Rapin C-H, Bengoa J, Delmas P. D., Vasey H, Bonjour J. Dietary supplementation in elderly patients with fractured neck of the femur. Lancet 1990; 335: 1013–6
  • Dorotka R, Schoechtner H, Buchinger W. The influence of immediate surgical treatment of proximal femoral fractures on mortality and quality of life. J Bone Joint Surg (Br) 2003; 85: 1107–13
  • Eneroth M, Olsson U B, Thorngren K G. Insufficient fluid and energy intake in hospitalised patients with hip fracture. A prospective randomised study of 80 pateints. Clin Nutr 2005; 24: 297–303
  • Espaulella J, Guyer H, Diaz-Escriu F, Mellado-Navas J A, Castells M, Pladevall M. Nutritional supplementation of elderly hip fracture patients. A randomised, double-blind placebo-controlled trial. Age Ageing 2000; 29: 425–31
  • Fiatorone M A, O'Neill E F, Ryan N D, Clements K M, Solares G R, Nelson M E, et al. Exercise training and nutritional supplementation for physical frailty in very elderly patients. N Engl J Med 1994; 330: 1769–75
  • Flodin L, Svensson S, Cederholm T. Body mass index as a predictor of 1 year mortality in geriatric patients. Clin Nutrition 2000; 19: 121–5
  • Fox K M, Magaziner J, Hawkes W G, Yu-Yahiro J, Hebel J R, Zimmerman S I, Holder L, Michael R. Loss of bone density and lean body mass after hip fracture. Osteoporosis Int 2000; 11: 31–5
  • Hartgrink H, Wille J, Konig P, Hermans J, Breslau P J. Pressure sores and tube feeding in patients with a fracture of the hip: a randomized clinical trial. Clin Nutr 1998; 6: 287–92
  • Hedström M, Sääf M, Dalén N. Low IGF-I levels in hip fracture patients. Acta Orthop Scand 1999; 70: 145–8
  • Hedström M, Sjöberg K, Brosjö E, Åström K, Sjöberg H, Dalén N. Positive effects of anabolic steroids, vitamin D and calcium on muscle mass, bone mineral density and clinical function after a hip fracture. J Bone Joint Surg (Br) 2002; 84: 497–503
  • Hedström M, Sääf M, Brosjö E, Sjöberg K, Hurtig C, Wesslau A, Dalén N. Positive effects of short-term growth hormone treatment on lean bodymass and BMD after a hip fracture. A double-blind placebo-controlled pilot study. Acta Orthop Scand 2004; 75: 394–401
  • Houwing R, Rozendaal M, Wouters-Wesseling W, Buskens E, Keller P, Haalboom J. A randomised, double-blind assessment of the effect of nutritional supplementation of the prevention of pressure ulcers in hip-fracture patients. Clin Nutr 2003; 22: 401–5
  • Johnsson P, Martinez G, Svensson O, Cederholm T. Nutritionsstatus och preoperativt näringsintag hos äldre patienter med osteoporotisk höftfraktur. Läkarsällskapets handlingar Hygiea 1999; 108: 256
  • Karlsson M, Nilsson J Å, Sernbo I, Redlund-Johnell I, Johnell O, Obrant K. Changes of bone mineral mass and soft tissue composition after hip fracture. Bone 1996; 18: 19–22
  • Lawson R M, Doshi M K, Ingoe L E, Colligan J M, Barton J R, Cobden I. Compliance of orthopedic patients with postoperative oral nutritional Supplementation. Clin Nutr 2000; 19: 171–5
  • Ljungqvist O, Nygren J, Thorell A, Brodin U, Efendic S. Preoperative nutrition -elective surgery in the fed or overnight fasted state. linical Nutrition (Suppl 1) 2001; 167
  • Lumbers M, Driver T, Howland J, Older W, Williams M. Nutritional status and clinical outcome in elderly female surgical orthopaedic patients. Clin Nutr 1996; 15: 101–7
  • Milne A C, Potter J, Avenell A. Protein and energy supplementation in elderly people at risk from malnutrition. Cochrane Database Syst Rev. 2002, CD003288
  • Neumann M, Friedmann J, Roy M A, Jensen G L. Provision of high-protein supplement for patients recovering hip fracture. Nutrition 2004; 20: 415–9
  • Paillaud E, Phuong-Nhi B, Le Parco J C, Campillo B. Nutritional status and energy expenditure in elderly patients with recent hip fracture during 2-month follow-up. Br J Nutr 2000; 83: 97–103
  • Patterson B M, Cornell C N, Carbone B, Levine B, Chapman D. Protein depletion and metabolic stress in elderly patients who have a fracture of the the hip. J Bone Joint Surg (Am) 1992; 74: 251–60
  • Rasmussen S, Kristensen B, Foldager S, Myhrman L, Kehlet H. Accelerated recovery program after hip fracture surgery. Ugeskr Laeger 2002; 30: 29–33
  • Schurch M A, Rizzoli R, Slosman D, Vadas L, Vergnaud P, Bonjour J P. Protein supplements increase serum insulin like growth factor-I levels and attenuate proximal femur bone loss in patients with hip fracture. Ann Intern Med 1998; 128: 801–9
  • Sloan J P, Wing P, Dian L, Meneilly G S. A pilot study of anabolic steroids in elderly patients with hip fractures. JAGS 1992; 40: 1105–11
  • Sullivan D, Patch G, Wallis R, Lipschitz D. Impact of nutritional status on morbidity and mortality in a select population of geriatric patients. Am J Clin Nutr 1990; 51: 749–58
  • Sullivan D, Nelson C L, Bopp M M, Puskarich-May C L, Walls R C. Nightly enteral nutrition support of elderly fracture patients: a phase I trial. J Am Coll Nutr 1998; 17: 155–61
  • Sullivan H, Nelson C, Klimberg S, Bopp M. Nightly enteral nutrition support of elderly hip fracture patients: A pilot study. J Am Coll Nutr 2004; 23: 683–91
  • Takala J, Ruokonen E, Webster N R, Nielasen M S, Zandstra D F, Vundenlinck G. Increased mortality associated with growth hormone treatment in critically ill adults. N Engl J Med 1999; 4341: 785–92
  • Thissen J P, Underwood L, Keteslegers J M. Regulation of insulin-like growth factor-I in starvation and injury. Nutr Reviews 1999; 57: 167–76
  • Thorell A, Nygren J, Ljungqvist O. Insulin resistance: a marker of surgical stress. Curr Opin Clin Nutr Metab Care 1999; 2(1)69–78
  • Thorngren K G, Ceder L, Svensson O. Predicting results of rehabilitation after hip fracture. Clin Orthop 1993, 287: 76–81
  • Tidermark J, Ponzer S, Carlsson P, Söderqvist A, Brismar K, Tengstrand B, Cederholm T. Effects of protein-rich supplementationand nandrolone in lean elderly women with femoral neck fractures. Clin Nutr 2004; 4: 587–96
  • Tkatch L, Rapin C H, Rizzoli R, Slosman D, Nydegger V, Vasey H, Bonjour J P. Benefits of oral protein supplementation in elderly patients with fracture of the proximal femur. J Am Coll Nutr 1992; 11: 519–25
  • Van den Berghe G, Wouters P, Weekers F, Verwaest C, Bruyninckx F, et al. Intensive insulin therapy in the critically ill patients. N Engl J Med 2001; 345(19)1359–67
  • Van der Lely A J, Lamberts S W, Jauch K W, Swierstra B S, Hertlein H, Danielle deVries D, Birkett M A, Bates B A, Blum W F, Attanasio A F. Use of human GH in elderly patients with accidental hip fracture. Eur Endocrinol 2000; 143: 585–92
  • Weissman C. The metabolic respone to stress: an overview and update. Anestesiology 1990; 73: 308–27
  • Wilmore D W, Kehlet H. Management of patients in fast track surgery. BMJ 2001; 322: 473–6
  • Yeo A L, Levy D, Martin F C, Souksen P, Strugess L, Wheeler M, Yo A. Frailty and biochemical effects of recombinant human growth hormone in women after surgery for hip fracture. Growth Horm IGF Res 2003; 13: 361–70

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