The long-term outcomes and safety of severe aplastic anemia treated with porcine antilymphocyte globulin plus cyclosporine, with or without thrombopoietin receptor agonists: a double-center retrospective study

References

• Young NS. Aplastic Anemia. N Engl J Med. [2018 Oct 25];379(17):1643–1656. doi: 10.1056/NEJMra1413485
   PubMed Web of Science ®Google Scholar
• Hosokawa K, Muranski P, Feng X, et al. Memory stem T cells in autoimmune disease: high frequency of circulating CD8+ memory stem cells in acquired aplastic anemia. J Immunol. 2016 Feb 15;196(4):1568–1578. doi: 10.4049/jimmunol.1501739
   PubMed Web of Science ®Google Scholar
• Sloand E, Kim S, Maciejewski JP, et al. Intracellular interferon-gamma in circulating and marrow T cells detected by flow cytometry and the response to immunosuppressive therapy in patients with aplastic anemia. Blood. 2002 Aug 15;100(4):1185–1191. doi: 10.1182/blood-2002-01-0035
   PubMed Web of Science ®Google Scholar
• Bacigalupo A. How I treat acquired aplastic anemia. Blood. 2017 Mar 16;129(11):1428–1436. doi: 10.1182/blood-2016-08-693481
   PubMed Web of Science ®Google Scholar
• Zhang MX, Wang Q, Wang XQ. Hematopoietic stem-cell transplantation versus immunosuppressive therapy in patients with adult acquired severe aplastic anemia: a cost-effectiveness analysis. Int J Gen Med. 2021;14:3529–3537. doi: 10.2147/IJGM.S310844
   PubMed Web of Science ®Google Scholar
• Gómez-Almaguer D, Jaime-Pérez JC, Ruiz-Arguelles GJ. Antibodies in the treatment of aplastic anemia. Arch Immunol Ther Exp (Warsz). 2012 Apr;60(2):99–106. doi: 10.1007/s00005-012-0164-3
   PubMed Web of Science ®Google Scholar
• Tjon JM, Langemeijer SMC, Halkes CJM. Anti thymocyte globulin-based treatment for acquired bone marrow failure in adults. Cells. 2021 Oct 27;10(11):2905. doi: 10.3390/cells10112905
   PubMed Web of Science ®Google Scholar
• Scheinberg P, Nunez O, Weinstein B, et al. Horse versus rabbit antithymocyte globulin in acquired aplastic anemia. N Engl J Med. 2011 Aug 4;365(5):430–438. doi: 10.1056/NEJMoa1103975
   PubMed Web of Science ®Google Scholar
• Di Bona E, Rodeghiero F, Bruno B, et al. Rabbit antithymocyte globulin (r-ATG) plus cyclosporine and granulocyte colony stimulating factor is an effective treatment for aplastic anaemia patients unresponsive to a first course of intensive immunosuppressive therapy Gruppo Italiano Trapianto di Midollo Osseo (GITMO). Br J Haematol. 1999 Nov;107(2):330–334. doi: 10.1046/j.1365-2141.1999.01693.x
   PubMed Web of Science ®Google Scholar
• Scheinberg P, Nunez O, Young NS. Retreatment with rabbit anti-thymocyte globulin and ciclosporin for patients with relapsed or refractory severe aplastic anaemia. Br J Haematol. 2006 Jun;133(6):622–627. doi: 10.1111/j.1365-2141.2006.06098.x
   PubMed Web of Science ®Google Scholar
• Bing H, Siyi Y, Wei Z, et al. The use of anti-human T lymphocyte porcine immunoglobulin and cyclosporine a to treat patients with acquired severe aplastic anemia. Acta Haematol. 2010;124(4):245–250. doi: 10.1159/000321790
   PubMed Web of Science ®Google Scholar
• Killick SB, Bown N, Cavenagh J, et al. Guidelines for the diagnosis and management of adult aplastic anaemia. Br J Haematol. 2016 Jan;172(2):187–207. doi: 10.1111/bjh.13853
   PubMed Web of Science ®Google Scholar
• Camitta BM. What is the definition of cure for aplastic anemia? Acta Haematol. 2000;103(1):16–18. doi: 10.1159/000040999
   PubMed Web of Science ®Google Scholar
• Camitta BM, Rappeport JM, Parkman R, et al. Selection of patients for bone marrow transplantation in severe aplastic anemia. Blood. 1975 Mar;45(3):355–363. doi: 10.1182/blood.V45.3.355.355
   PubMed Web of Science ®Google Scholar
• Lan Y, Chang L, Yi M, et al. Long-term outcomes of 172 children with severe aplastic anemia treated with rabbit antithymocyte globulin and cyclosporine. Ann Hematol. 2021 Jan;100(1):53–61. doi: 10.1007/s00277-020-04296-9
   PubMed Web of Science ®Google Scholar
• Scheinberg P, Wu CO, Nunez O, et al. Long-term outcome of pediatric patients with severe aplastic anemia treated with antithymocyte globulin and cyclosporine. J Pediatr. 2008 Dec;153(6):814–819. doi: 10.1016/j.jpeds.2008.06.004
   PubMed Web of Science ®Google Scholar
• Scheinberg P, Wu CO, Nunez O, et al. Predicting response to immunosuppressive therapy and survival in severe aplastic anaemia. Br J Haematol. 2009 Jan;144(2):206–216. doi: 10.1111/j.1365-2141.2008.07450.x
   PubMed Web of Science ®Google Scholar
• Scheinberg P, Wu CO, Nunez O, et al. Treatment of severe aplastic anemia with a combination of horse antithymocyte globulin and cyclosporine, with or without sirolimus: a prospective randomized study. Haematologica. 2009 Mar;94(3):348–354. doi: 10.3324/haematol.13829
   PubMed Web of Science ®Google Scholar
• Goronkova O, Novichkova G, Salimova T, et al. Efficacy of combined immunosuppression with or without eltrombopag in children with newly diagnosed aplastic anemia. Blood Adv. 2023 Mar 28;7(6):953–962. doi: 10.1182/bloodadvances.2021006716
   PubMed Web of Science ®Google Scholar
• Nishikawa E, Yagasaki H, Hama A, et al. Long-term outcomes of 95 children with moderate aplastic anemia treated with horse antithymocyte globulin and cyclosporine. Pediatr Blood Cancer. 2017 May;64(5). doi: 10.1002/pbc.26305
   Web of Science ®Google Scholar
• Jing LP, Zhang L, Zhou K, et al. Pharmacokinetic study of anti-human T-cell porcine immunoglobulin combined with cyclosporine a immunosuppressive therapy in patients with severe aplastic anemia. Zhonghua Xue Ye Xue Za Zhi. 2022 Apr 14;43(4):300–304. doi: 10.3760/cma.j.issn.0253-2727.2022.04.006
   PubMedGoogle Scholar
• Yang W, Liu X, Zhao X, et al. Antihuman T lymphocyte porcine immunoglobulin combined with cyclosporine as first-line immunosuppressive therapy for severe aplastic anemia in China: a large single-center, 10-year retrospective study. Ther Adv Hematol. 2023;14:20406207221146031. doi: 10.1177/20406207221146031
   Web of Science ®Google Scholar
• Chen M, Liu C, Qiao X, et al. Comparative study of porcine anti-human lymphocyte immunoglobulin and rabbit anti-human thymocyte immunoglobulin as a first-line treatment of acquired severe aplastic anemia. Leuk Res. 2018 Feb;65:55–60. doi: 10.1016/j.leukres.2018.01.001
   PubMed Web of Science ®Google Scholar
• Liu LP, Chen XJ, Yang WY, et al. Predicting response to porcine antilymphocyte globulin plus cyclosporine a in children with acquired severe aplastic anemia. Pediatr Res. 2019 Sep;86(3):360–364. doi: 10.1038/s41390-019-0437-1
   PubMed Web of Science ®Google Scholar
• Zaimoku Y, Patel BA, Shalhoub R, et al. Predicting response of severe aplastic anemia to immunosuppression combined with eltrombopag. Haematologica. 2022 Jan 1;107(1):126–133. doi: 10.3324/haematol.2021.278413
   PubMed Web of Science ®Google Scholar
• Li R, Zhou J, Liu Z, et al. Predicting response of severe aplastic anemia to rabbit-antithymocyte immunoglobulin based immunosuppressive therapy combined with Eltrombopag. Front Immunol. 2022;13:884312. doi: 10.3389/fimmu.2022.884312
   PubMed Web of Science ®Google Scholar
• Rogers ZR, Nakano TA, Olson TS, et al. Immunosuppressive therapy for pediatric aplastic anemia: a North American pediatric aplastic anemia Consortium study. Haematologica. 2019 Oct;104(10):1974–1983. doi: 10.3324/haematol.2018.206540
   PubMed Web of Science ®Google Scholar
• Marsh JC, Bacigalupo A, Schrezenmeier H, et al. Prospective study of rabbit antithymocyte globulin and cyclosporine for aplastic anemia from the EBMT severe aplastic anaemia working party. Blood. 2012 Jun 7;119(23):5391–5396. doi: 10.1182/blood-2012-02-407684
   PubMed Web of Science ®Google Scholar
• Erickson-Miller CL, Delorme E, Tian SS, et al. Preclinical activity of eltrombopag (SB-497115), an oral, nonpeptide thrombopoietin receptor agonist. Stem Cells. 2009 Feb;27(2):424–430. doi: 10.1634/stemcells.2008-0366
   PubMed Web of Science ®Google Scholar
• Townsley DM, Scheinberg P, Winkler T, et al. Eltrombopag added to standard immunosuppression for aplastic anemia. N Engl J Med. 2017 Apr 20;376(16):1540–1550. doi: 10.1056/NEJMoa1613878
   PubMed Web of Science ®Google Scholar
• Imada K, Obara N, Iida H, et al. Eltrombopag in combination with rabbit anti-thymocyte globulin/cyclosporine a in immunosuppressive therapy-naïve patients with aplastic anemia in Japan. Intern Med. 2021 Apr 15;60(8):1159–1168. doi: 10.2169/internalmedicine.6063-20
   PubMed Web of Science ®Google Scholar
• PeffaultdeLatour R, Kulasekararaj A, Iacobelli S, et al. Eltrombopag added to immunosuppression in severe aplastic anemia. N Engl J Med. 2022 Jan 6;386(1):11–23. doi: 10.1056/NEJMoa2109965
   PubMed Web of Science ®Google Scholar
• Young NS, Wu C, Shalhoub R, et al. Outcomes in pediatric patients with severe aplastic anemia treated with standard immunosuppression and eltrombopag. Blood. 2019;134(Supplement_1):454–454. doi: 10.1182/blood-2019-124811
   Google Scholar
• Yang N, Ma XR, Zhang H, et al. Therapeutic effects of porcine versus rabbit antithymocyte globulins for treatment of severe aplastic anemia. Nan Fang Yi Ke Da Xue Xue Bao. 2016 Mar;36(3):303–308.
   PubMedGoogle Scholar
• Wei J, Huang Z, Guo J, et al. Porcine antilymphocyte globulin (p-ALG) plus cyclosporine a (CsA) treatment in acquired severe aplastic anemia: a retrospective multicenter analysis. Ann Hematol. 2015 Jun;94(6):955–962. doi: 10.1007/s00277-015-2308-0
   PubMed Web of Science ®Google Scholar
• Kadia TM, Borthakur G, Garcia-Manero G, et al. Final results of the phase II study of rabbit anti-thymocyte globulin, ciclosporin, methylprednisone, and granulocyte colony-stimulating factor in patients with aplastic anaemia and myelodysplastic syndrome. Br J Haematol. 2012 May;157(3):312–320. doi: 10.1111/j.1365-2141.2012.09064.x
   PubMed Web of Science ®Google Scholar
• Ma X, Wang J, Zhang W, et al. Comparison of porcine anti-human lymphocyte globulin and rabbit anti-human thymocyte globulin in the treatment of severe aplastic anemia: a retrospective single-center study. Eur J Haematol. 2016 Mar;96(3):260–268. doi: 10.1111/ejh.12584
   PubMed Web of Science ®Google Scholar