Metal-free domino amination-Knoevenagel condensation approach to access new coumarins as potent nanomolar inhibitors of VEGFR-2 and EGFR

References

• Avendano, C.; Carlos Menendez, J. Medicinal Chemistry of Anticancer Drugs, 1st ed.; Elsevier: 2008; pp 1–7, ISBN: 978-0-444-52824-7.
   Google Scholar
• Boraei, A.T.A.; Ashour, H.K.; El-Tamany, E.-S.H.; Abdelmoaty, N.; El-Falouji, A.I.; Gomaa, M.S. Design and Synthesis of New Phthalazine-Based Derivatives as Potential EGFR Inhibitors for the Treatment of Hepatocellular Carcinoma. Bioorg. Chem 2019, 85, 293–307. doi: https://doi.org/10.1016/j.bioorg.2018.12.039.
   PubMed Web of Science ®Google Scholar
• Amin, K.M.; Barsoum, F.F.; Awadallah, F.M.; Mohamed, N.E. Identification of New Potent Phthalazine Derivatives with VEGFR-2 and EGFR Kinase Inhibitory Activity. Eur. J. Med. Chem. 2016, 123, 191–201. doi: https://doi.org/10.1016/j.ejmech.2016.07.049.
   PubMed Web of Science ®Google Scholar
• Zhang, H.-Q.; Gong, F.-H.; Fei, H.-J.; Li, C.-G.; Zhang, C.; Wang, Y.-J.; Xu, Y.-G.; Hu, R.; Suna, L.-P. Design and Discovery of 4-Anilinoquinazoline-Acylamino Derivatives as EGFR and VEGFR-2 Dual TK Inhibitors. Eur. J. Med. Chem. 2016, 109, 371–379. doi: https://doi.org/10.1016/j.ejmech.2015.12.032.
   PubMed Web of Science ®Google Scholar
• Modi, S.J.; Kulkarni, V.M. Vascular Endothelial Growth Factor Receptor (VEGFR-2)/KDR Inhibitors: Medicinal Chemistry Perspective. Medicine in Drug Discovery 2019, 2, 100009. doi: https://doi.org/10.1016/j.medidd.2019.100009.
   Google Scholar
• Sordella, R.; Bell, D.W.; Haber, D.A.; Settleman, J. Gefitinib-sensitizing EGFR Mutations in Lung Cancer Activate Anti-Apoptotic Pathways. Science 2004, 305, 1163–1167. doi: https://doi.org/10.1126/science.1101637.
   PubMed Web of Science ®Google Scholar
• El-Metwally, S.A.; Abou-El-Regal, M.M.; Eissa, I.H.; Mehany, A.B.M.; Mahdy, H.A.; Elkady, H.; Elwan, A.; Elkaeed, E.B. Discovery of Thieno[2,3-d]Pyrimidine-Based Derivatives as Potent VEGFR-2 Kinase Inhibitors and Anti-Cancer Agents. Bioorg. Chem 2021, 112, 104947. doi: https://doi.org/10.1016/j.bioorg.2021.104947.
   PubMed Web of Science ®Google Scholar
• Alanazi, M.M.; Mahdy, H.A.; Alsaif, N.A.; Obaidullah, A.J.; Alkahtani, H.M.; Al-Mehizia, A.A.; Alsubaie, S.M.; Dahab, M.A.; Eissa, I.H. New bis([1,2,4]Triazolo)[4,3-a:3′,4′-c]Quinoxaline Derivatives as VEGFR-2 Inhibitors and Apoptosis Inducers: Design, Synthesis, in Silico Studies, and Anticancer Evaluation. Bioorg. Chem 2021, 112, 104949. doi: https://doi.org/10.1016/j.bioorg.2021.104949.
   PubMed Web of Science ®Google Scholar
• Eissa, I.H.; Ibrahim, M.K.; Metwaly, A.M.; Belal, A.; Mehany, A.B.M.; Abdelhady, A.A.; Elhendawy, M.A.; Radwan, M.M.; ElSohly, M.A.; Mahdy, H.A. Design, Molecular Docking, in Vitro, and in Vivo Studies of new Quinazolin-4(3H)-Ones as VEGFR-2 Inhibitors with Potential Activity Against Hepatocellular Carcinoma. Bioorg. Chem. 2021, 107, 104532. doi: https://doi.org/10.1016/j.bioorg.2020.104532.
   PubMed Web of Science ®Google Scholar
• Aziz, M.A.; Serya, R.A.T.; Lasheen, D.S.; Abdel-Aziz, A.K.; Esmat, A.; Mansour, A.M.; Singab, A.B.; Abouzid, K.A.M. Discovery of Potent VEGFR-2 Inhibitors Based on Furopyrimidine and Thienopyrimidne Scaffolds as Cancer Targeting Agents. Sci. Rep. 2016, 6, 24460. doi: https://doi.org/10.1038/srep24460.
   PubMed Web of Science ®Google Scholar
• Saleh, N.M.; Abdel-Rahman, AA-H; Omar, A.M.; Khalifa, M.M.; El-Adl, K. Pyridine-Derived VEGFR-2 Inhibitors: Rational Design, Synthesis, Anticancer Evaluations, in Silico ADMET Profile, and Molecular Docking. Arch. Pharm 2021, 354, 2100085. doi: https://doi.org/10.1002/ardp.202100085.
   PubMed Web of Science ®Google Scholar
• Gabera, A.A.; Bayoumia, A.H.; El-morsya, A.M.; Sherbinya, F.F.; Mehanyb, A.B.M.; Eissa, I.H. Design, Synthesis and Anticancer Evaluation of 1H-Pyrazolo[3,4-d] Pyrimidine Derivatives as Potent EGFRWT and EGFRT790M Inhibitors and Apoptosis Inducers. Bioorg. Chem 2018, 80, 375–395. doi: https://doi.org/10.1016/j.bioorg.2018.06.017.
   PubMed Web of Science ®Google Scholar
• Kurt, B.Z.; Sonmez, F.; Ozturk, D.; Akdemir, A.; Angeli, A.; Supuran, C.T. Synthesis of Coumarin-Sulfonamide Derivatives and Determination of Their Cytotoxicity, Carbonic Anhydrase Inhibitory and Molecular Docking Studies. Eur. J. Med. Chem. 2019, 183, 111702. doi: https://doi.org/10.1016/j.ejmech.2019.111702.
   PubMed Web of Science ®Google Scholar
• Wang, Z.-C.; Qin, Y.-J.; Wang, P.-F.; Yang, Y.-A.; Wen, Q.; Zhang, X.; Qiu, H.-Y.; Duan, Y.-T.; Wang, Y.-T.; Sang, Y.-L.; Zhu, H.-L. Sulfonamides Containing Coumarin Moieties Selectively and Potently Inhibit Carbonic Anhydrases II and IX: Design, Synthesis, Inhibitory Activity and 3D-QSAR Analysis. Eur. J. Med. Chem. 2013, 66, 1–11. doi: https://doi.org/10.1016/j.ejmech.2013.04.035.
   PubMed Web of Science ®Google Scholar
• Bubols, G.B.; Vianna, D.R.; Medina-Remon, A.; Poser, G.V.; Lamuela-Raventos, R.M., Eifler-Lima, V.L., et al. The Antioxidant Activity of Coumarins and Flavonoids. Mini Rev. Med. Chem 2013, 13, 318–334.
   PubMed Web of Science ®Google Scholar
• Matos, M.J.; Vazquez-Rodriguez, S.; Santana, L.; Uriarte, E.; Fuentes-Edfuf, C., Santos, Y., et al. Synthesis and Structure-Activity Relationships of Novel Amino/Nitro Substituted 3-Arylcoumarins as Antibacterial Agents. Molecules 2013, 18, 1394–1404. doi: https://doi.org/10.3390/molecules18021394.
   PubMed Web of Science ®Google Scholar
• Matos, M.J.; Vina, D.; Vazquez-Rodriguez, S.; Uriarte, E.; Santana, L. Focusing on New Monoamine Oxidase Inhibitors: Differently Substituted Coumarins as an Interesting Scaffold. Curr. Top. Med. Chem. (Sharjah, United Arab Emirates) 2012, 12, 2210–2239. doi: https://doi.org/10.2174/1568026611212200008.
   PubMed Web of Science ®Google Scholar
• Hwu, J.R.; Huang, W.-C.; Lin, S.-Y.; Tan, K.-T.; Hu, Y.-C.; Shieh, F.-K.; Bachurin, S.O.; Ustyugov, A.; Tsay, S.-C. Chikungunya Virus Inhibition by Synthetic Coumarin-Guanosine Conjugates. Eur. J. Med. Chem. 2019, 166, 136–143. doi: https://doi.org/10.1016/j.ejmech.2019.01.037.
   PubMed Web of Science ®Google Scholar
• Kapoor, S. The Anti-Neoplastic Effects of Coumarin: An Emerging Concept. Cytotechnology 2013, 65, 787–788. doi: https://doi.org/10.1007/s10616-013-9538-6.
   PubMed Web of Science ®Google Scholar
• Diana, C.G.A.P.; Artur, M.S.S. Anticancer Natural Coumarins as Lead Compounds for the Discovery of New Drugs. Curr. Top. Med. Chem. 2017, 17, 3190–3198.
   PubMed Web of Science ®Google Scholar
• Emami, S.; Dadashpour, S. Current Developments of Coumarin-Based Anti-Cancer Agents in Medicinal Chemistry. Eur. J. Med. Chem. 2015, 102, 611–630. doi: https://doi.org/10.1016/j.ejmech.2015.08.033.
   PubMed Web of Science ®Google Scholar
• Halawa, A.H.; Abd El-Gilil, S.M.; Bedair, A.H.; Eliwa, E.M.; Frese, M.; Sewald, N.; Shaaban, M.; El-Agrody, A.M. Synthesis of Diverse Amide Linked Bis-indoles and Indole Derivatives Bearing Coumarin-Based Moiety: Cytotoxicity and Molecular Docking Investigations. Med. Chem. Res. 2018, 27, 796–806. doi: https://doi.org/10.1007/s00044-017-2103-7.
   Google Scholar
• Zhang, L.; Xu, Z. Coumarin-containing Hybrids and Their Anticancer Activities. Eur. J. Med. Chem. 2019, 181, 111587. doi: https://doi.org/10.1016/j.ejmech.2019.111587.
   PubMed Web of Science ®Google Scholar
• Halawa, A.H.; Eliwa, E.M.; Hassan, A.A.; Nassar, H.S.; El-Eisawy, R.A.; Ismail, M.; Frese, M.; Shaaban, M.; El-Agrody, A.M.; Bedair, A.H.; Sewald, N. Synthesis, in Vitro Cytotoxicity Activity Against the Human Cervix Carcinoma Cell Line and in Silico Computational Predictions of New 4-Arylamino-3-Nitrocoumarin Analogues. J. Mol. Struct. 2020, 1200, 127047. doi: https://doi.org/10.1016/j.molstruc.2019.127047.
   Web of Science ®Google Scholar
• Bansal, Y.; Sethi, P.; Bansal, G. Coumarin: A Potential Nucleus for Anti-Inflammatory Molecules. Med. Chem. Res. 2013, 22, 3049–3060. doi: https://doi.org/10.1007/s00044-012-0321-6.
   Web of Science ®Google Scholar
• Raman, N.; Pravin, N. DNA Fastening and Ripping Actions of Novel Knoevenagel Condensed Dicarboxylic Acid Complexes in Antitumor Journey. Eur. J. Med. Chem. 2014, 80, 57–70. doi: https://doi.org/10.1016/j.ejmech.2014.04.032.
   PubMed Web of Science ®Google Scholar
• Biradar, J.S.; Sasidhar, B.S. Solvent-free, Microwave Assisted Knoevenagel Condensation of Novel 2,5-Disubstituted Indole Analogues and Their Biological Evaluation. Eur. J. Med. Chem. 2011, 46, 6112–6118. doi: https://doi.org/10.1016/j.ejmech.2011.10.004.
   PubMed Web of Science ®Google Scholar
• Ryabukhin, S.V.; Plaskon, A.S.; Volochnyuk, D.M.; Pipko, S.E.; Shivanyuk, A.N.; Tolmachev, A.A. Combinatorial Knoevenagel Reactions. J. Comb. Chem. 2007, 9, 1073–1078. doi: https://doi.org/10.1021/cc070073f.
   PubMed Web of Science ®Google Scholar
• Menegatti R. Green Chemistry – Aspects for the Knoevenagel Reaction, In Green Chemistry Environmentally Benign Approaches, Kidwai, M., Ed.; InTech, 2012, ISBN: 978-953-51-0334-9.
   Google Scholar
• Senoo, T.; Inoue, A.; Mori, K. Facile Synthesis of π-Conjugated Heteroaromatic Compounds via Weak-Base-Promoted Transition-Metal-Free C–N Coupling. Synthesis. (Mass) 2020, 52.
   Web of Science ®Google Scholar
• Chikayuki, Y.; Miyashige, T.; Yonekawa, S.; Kirita, A.; Matsuo, N.; Teramoto, H.; Sasaki, S.; Higashiyama, K.; Yamauchi, T. Transition-Metal-Free Synthesis of Pyridine Derivatives by Thermal Cyclization of N-Propargyl Enamines. Synthesis. (Mass) 2020, 52, A–I.
   Web of Science ®Google Scholar
• Sahu, P.K.; Sahu, P.K.; Kaurav, M.S.; Messali, M.; Almutairi, S.M.; Sahu, P.L.; Agarwal, D.D. Metal-Free Construction of Fused Pyrimidines via Consecutive C-C and C-N Bond Formation in Water. ACS Omega 2018, 3, 15035–15042. doi: https://doi.org/10.1021/acsomega.8b01993.
   PubMed Web of Science ®Google Scholar
• Gupta, P.K.; Hussain, M.K.; Asad, M.; Kant, R.; Mahar, R.; Shukla, S.K.; Hajela, K. A Metal-Free Tandem Approach to Prepare Structurally Diverse N-Heterocycles: Synthesis of 1,2,4-Oxadiazoles and Pyrimidinones. New J. Chem. 2014, 38, 3062–3070. doi: https://doi.org/10.1039/c4nj00361f.
   Web of Science ®Google Scholar
• Tietze, L.F. Domino Reactions: Concepts for Efficient Organic Synthesis; Wiley-VCH, March 2014. ISBN: 978-3-527-33432-2.
   Google Scholar
• Bruneau, A.; Roche, M.; Alami, M.; Messaoudi, S. 2-Aminobiphenyl Palladacycles: The “Most Powerful” Precatalysts in C-C and C-Heteroatom Cross-Couplings. ACS Catal. 2015, 5, 1386–1396. doi: https://doi.org/10.1021/cs502011x.
   Web of Science ®Google Scholar
• Ivanov, I.C.; Angelova, V.T.; Vassilev, N.; Tiritiris, I.; Iliev, B. Synthesis of 4-Aminocoumarin Derivatives with N-Substitutents Containing Hydroxy or Amino Groups. Z. Naturforsch. 2013, 68, 1031–1040. doi: https://doi.org/10.5560/ZNB.2013-3102.
   Google Scholar
• Sulaiman Al-Ayed, A. Synthesis of New Substituted Chromen[4,3-c]Pyrazol-4-Ones and Their Antioxidant Activities. Molecules 2011, 16, 10292–10302. doi: https://doi.org/10.3390/molecules161210292.
   PubMed Web of Science ®Google Scholar
• Xu, Z.; Ge, J.; Wang, T.; Luo, T.; Liu, H.; Yu, X. Highly Stereoselective Synthesis of 2-Aminobenzylidene Derivatives by a Convergent 3-Component Approach. Synlett. 2014, 25, 2913–2917. doi: https://doi.org/10.1055/s-0034-1378906.
   Web of Science ®Google Scholar
• Vishnu, S.; Srikanth, P.; Tiwari, A.K.; Kumar, D.A.; Raju, B.C. Carbohydrate Hydrolyzing Enzymes Inhibitory and Free Radical Scavenging Activities of Substituted 2H-Chromene-3-Carboxylates, 2H-Chromenyl Knoevenagel Derivatives and 6H-Chromenoquinolinones. Indian J. Chem 2015, 54B, 1332–1341. http://hdl.handle.net/123456789/33034.
   Google Scholar
• Vasbinder, M.M.; Alimzhanov, M.; Augustin, M.; Bebernitz, G.; Bell, K.; Chuaqui, C.; Deegan, T.; Ferguson, A.D.; Goodwin, K.; Huszar, D.; Kawatkar, A.; Kawatkar, S.; Read, J.; Shi, J.; Steinbacher, S.; Steuber, H.; Su, Q.; Toader, D.; Wang, H.; Woessner, R.; Wu, A.; Ye, M.; Zinda, M. Identification of Azabenzimidazoles as Potent JAK1 Selective Inhibitors. Bioorg. Med. Chem. Lett. 2016, 26, 60–67. doi: https://doi.org/10.1016/j.bmcl.2015.11.031.
   PubMedGoogle Scholar
• Song, P.; Peng, P.; Han, M.; Cao, X.; Ma, X.; Liu, T.; Zhou, Y.; Hu, Y. Design, Synthesis and Biological Evaluation of Thienopyridinones as Chk1 Inhibitors. Bioorg. Med. Chem. 2014, 22, 4882–4892. doi: https://doi.org/10.1016/j.bmc.2014.06.044.
   PubMedGoogle Scholar
• Pastor, J.; Oyarzabal, J.; Saluste, G.; Alvarez, R.M.; Rivero, V.; Ramos, F.; Cendón, E.; Blanco-Aparicio, C.; Ajenjo, N.; Cebriá, A.; Albarrán, M.I.; Cebrián, D.; Corrionero, A.; Fominaya, J.; Montoya, G.; Mazzorana, M. Hit to Lead Evaluation of 1,2,3-Triazolo[4,5-b]Pyridines as PIM Kinase Inhibitors. Bioorganic Med. Chem. Lett 2012, 22, 1591–1597. doi: https://doi.org/10.1016/j.bmcl.2011.12.130.
   PubMedGoogle Scholar
• Renhowe, P.A.; Pecchi, S.; Shafer, C.M.; Machajewski, T.D.; Jazan, E.M.; Taylor, C.; Antonios-McCrea, W.; McBride, C.M.; Frazier, K.; Wiesmann, M.; Lapointe, G.R.; Feucht, P.H.; Warne, R.L.; Heise, C.C.; Menezes, D.; Aardalen, K.; Ye, H.; He, M.; Le, V.; Vora, J.; Jansen, J.M.; Wernette-Hammond, M.E.; Harris, A.L. Design, Structure-Activity Relationships and in Vivo Characterization of 4-Amino-3-Benzimidazol-2-Ylhydroquinolin-2-Ones: A Novel Class of Receptor Tyrosine Kinase Inhibitors. J. Med. Chem. 2009, 52, 278–292. doi: https://doi.org/10.1021/jm800790t.
   PubMed Web of Science ®Google Scholar
• Silvaa, V.B.; Orth, E.S. Are Imidazoles Versatile or Promiscuous in Reactions with Organophosphates? Insights from the Case of Parathion. J. Braz. Chem. Soc 2019, 30, 2114–2124.
   Web of Science ®Google Scholar
• Vyasamudri, S.; Yang, D.-Y. Base-Dependent Divergent Annulation of 4–Chloro-3-Formyl-Coumarin and Tetrahydroisoquinoline: Application to the Synthesis of Isolamellarins and Hydroxypyrrolones. J. Org. Chem. 2019, 84, 3662–3670. doi: https://doi.org/10.1021/acs.joc.8b03259.
   PubMed Web of Science ®Google Scholar
• Angelova, V.T.; Frey, W.; Ivanov, I.C.; Vassilev, N.; Glasnov, T.N. One-pot Synthesis of a Chromeno-[4,3,2-de]-1,6-Naphthyridine Derivative from 4-Chlorocoumarin-3-Carbaldehyde. Bulg. Chem. Commun. 2014, 46, 53–58.
   Google Scholar
• Shaabani, A.; Hooshmand, S.E. Malononitrile Dimer as a Privileged Reactant in Design and Skeletal Diverse Synthesis of Heterocyclic Motifs. Mol. Diversity 2018, 22, 207–224. doi: https://doi.org/10.1007/s11030-017-9807-y.
   PubMed Web of Science ®Google Scholar
• Yang, Z.; Lu, N.; Wei, Z.; Cao, J.; Liang, D.; Duan, H.; Lin, Y. Base-Promoted Intermolecular Cyclization of Substituted 3–Aryl(Heteroaryl)-3-Chloroacrylaldehydes and Tetrahydroisoquinolines: An Approach to Access Pyrrolo[2,1–a]Isoquinolines. J. Org. Chem. 2016, 81, 11950–11955. doi: https://doi.org/10.1021/acs.joc.6b01781.
   PubMed Web of Science ®Google Scholar
• Sammet, B.; Bogner, T.; Nahrwold, M.; Weiss, C.; Sewald, N. Approaches for the Synthesis of Functionalized Cryptophycins. J. Org. Chem. 2010, 75, 6953–6960. doi: https://doi.org/10.1021/jo101563s.
   PubMed Web of Science ®Google Scholar
• Shaaban, K.A.; Elshahawi, S.I.; Wang, X.; Horn, J.; Kharel, M.K.; Leggas, M.; Thorson, J.S. Cytotoxic Indolocarbazoles from Actinomadura Melliaura ATCC 39691. J. Nat. Prod 2015, 78, 1723–1729. doi: https://doi.org/10.1021/acs.jnatprod.5b00429.
   PubMed Web of Science ®Google Scholar
• Shaaban, K.A.; Wang, X.; Elshahawi, S.I.; Ponomareva, L.V.; Sunkara, M.; Copley, G.C.; Hower, J.C.; Morris, A.J.; Kharel, M.K.; Thorson, J.S.; Herbimycins, D–F. Ansamycin Analogues from Streptomyces sp. RM-7-15. J. Nat. Prod 2013, 76, 1619–1626. doi: https://doi.org/10.1021/np400308w.
   PubMed Web of Science ®Google Scholar
• Wang, X.; Shaaban, K.A.; Elshahawi, S.I.; Ponomareva, L.V.; Sunkara, M.; Zhang, Y.; Copley, G.C.; Hower, J.C.; Morris, A.J.; Kharel, M.K.; Thorson, J.S. Frenolicins C–G, Pyranonaphthoquinones from Streptomyces sp. RM-4-15. J. Nat. Prod. 2013, 76, 1441–1447. doi: https://doi.org/10.1021/np400231r.
   PubMed Web of Science ®Google Scholar
• Mokhtari, R.B.; Homayouni, T.S.; Baluch, N.; Morgatskaya, E.; Kumar, S.; Das, B.; Yeger, H. Combination Therapy in Combating Cancer. Oncotarget. 2017, 8, 38022–38043. doi: https://doi.org/10.18632/oncotarget.16723.
   PubMedGoogle Scholar
• Bai, Z.G.; Zhang, Z.T. A Systematic Review and Meta-Analysis on the Effect of Angiogenesis Blockade for the Treatment of Gastric Cancer. OncoTargets Ther 2018, 11, 7077–7087. doi: https://doi.org/10.2147/OTT.S169484.
   PubMed Web of Science ®Google Scholar
• Shaaban, M.; Yassin, F.Y.; Soltan, M.M. Calamusins J-K: new Anti-Angiogenic Sesquiterpenes from Sarcophyton Glaucum. Nat. Prod. Res. 2020 in press.
   Web of Science ®Google Scholar
• Khan, I.; Hatiboglu, M.A. Can COVID-19 Induce Glioma Tumorogenesis Through Binding Cell Receptors? Med. Hypotheses 2020, 144, 110009. doi: https://doi.org/10.1016/j.mehy.2020.110009.
   PubMed Web of Science ®Google Scholar
• Daina, A.; Michielin, O.; Zoete, V. SwissADME: A Free Web Tool to Evaluate Pharmacokinetics, Drug-Likeness and Medicinal Chemistry Friendliness of Small Molecules. Sci. Rep. 2017, 7, 42717–42730. doi: https://doi.org/10.1038/srep42717.
   PubMed Web of Science ®Google Scholar
• Arnott, J.A.; Planey, S.L. The Influence of Lipophilicity in Drug Discovery and Design. Expert Opin. Drug Discov. 2012, 7, 863–875. doi: https://doi.org/10.1517/17460441.2012.714363.
   PubMed Web of Science ®Google Scholar
• Savjani, K.T.; Gajjar, A.K.; Savjani, J.K. Drug Solubility: Importance and Enhancement Techniques. ISRN. Pharm. 2012, 2012, 195727.
   PubMedGoogle Scholar
• Daina, A.; Michielin, O.; Zoete, V. SwissTargetPrediction: Updated Data and new Features for Efficient Prediction of Protein Targets of Small Molecules. Nucleic Acids Res. 2019, 1–8.
   PubMed Web of Science ®Google Scholar
• Vora, C.; Gupta, S. Targeted Therapy in Cervical Cancer. ESMO Open 2019, 3, e000462.
   PubMed Web of Science ®Google Scholar
• Batran, R.Z.; Dawood, D.H.; El-Seginy, S.A.; Ali, M.M.; Maher, T.J.; Gugnani, K.S.; Rondon-Ortiz, A.N. New Coumarin Derivatives as Anti-Breast and Anti-Cervical Cancer Agents Targeting VEGFR-2 and p38a MAPK. Arch. Pharm. Chem. Life Sci 2017, 350, e1700064. doi: https://doi.org/10.1002/ardp.201700064.
   Web of Science ®Google Scholar
• Hsu, K.; Chen, Y.; Lin, S.; Yang, J. iGEMDOCK: a Graphical Environment of Enhancing GEMDOCK Using Pharmacological Interactions and Post-Screening Analysis. BMC Bioinformatics 2011, 12, S33–S44. doi: https://doi.org/10.1126/science.1101637.
   PubMed Web of Science ®Google Scholar
• Pao, W.; Miller, V.; Zakowski, M.; Doherty, J.; Politi, K.; Sarkaria, I.; Singh, B.; Heelan, R.; Rusch, V.; Fulton, L.; Mardis, E.; Kupfer, D.; Wilson, R.; Kris, M.; Varmus, H. EGF Receptor Gene Mutations Are Common in Lung Cancers from “Never Smokers” and are Associated with Sensitivity of Tumors to Gefitinib and Erlotinib. Proc. Natl Acad. Sci. USA 2004, 101, 13306–13311. doi: https://doi.org/10.1073/pnas.0405220101.
   PubMed Web of Science ®Google Scholar
• Lynch, T.J.; Bell, D.W.; Sordella, R.; Gurubhagavatula, S.; Okimoto, R.A.; Brannigan, B.W.; Harris, P.L.; Haserlat, S.M.; Supko, J.G.; Haluska, F.G.; Louis, D.N.; Christiani, D.C.; Settleman, J.; Haber, D.A. Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non-Small-Cell Lung Cancer to Gefitinib. N. Engl. J. Med. 2004, 350, 2129–2139. doi: https://doi.org/10.1056/nejmoa040938.
   PubMed Web of Science ®Google Scholar
• Halgren, T.A. Merck Molecular Force Field. I. Basis, Form, Scope, Parameterization, and Performance of MMFF94. J. Comput. Chem. 1996, 17, 490–519. doi: https://doi.org/10.1002/(SICI)1096-987X(199604).
   Web of Science ®Google Scholar