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Reviews

Safe use of statins: focus on muscle toxicity

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Pages 16-22 | Received 23 Sep 2016, Accepted 28 Sep 2016, Published online: 14 Oct 2016

References

  • Pasternak RC, Smith SC Jr, Bairey-Merz CN, et al. ACC/AHA/NHLBI clinical advisory on the use and safety of statins. Stroke. 2002;33:2337–2341.10.1161/01.str.0000034125.94759.41
  • Huerta-Alardin AL, Varon J, Marik PE. Bench-to-bedside review: rhabdomyolysis an overview for clinicians. Crit. Care. 2005;9:158–169.
  • Giannoglou GD, Chatzizisis YS, Misirli G. The syndrome of rhabdomyolysis: pathophysiology and diagnosis. Eur. J. Intern. Med. 2007;19:90–100.10.1016/j.ejim.2006.09.020
  • Chavez LO, Leon M, Einav S, et al. Beyond muscle destruction: a systematic review of rhabdomyolysis for clinical practice. Crit. Care. 2016;20:135. doi:10.1186/s13054-016-1314-5.
  • Bagley WH, Yang H, Shah KH. Rhabdomyolysis. Intern. Emerg. Med. 2007;2:210–218.10.1007/s11739-007-0060-8
  • Chen CY, Lin YR, Zhao LL, et al. Clinical spectrum of rhabdomyolysis presented to pediatric emergency department. BMC Pediatr. 2013;13:134. doi:10.1186/1471-2431-13-134.
  • Chatzizisis YS, Misirli G, Hatzitolios AI, et al. The syndrome of rhabdomyolysis: complications and treatment. Eur. J. Intern. Med. 2008;19:568–574.10.1016/j.ejim.2007.06.037
  • Antons KA, Williams CD, Baker SK, et al. Clinical perspectives of statin-induced rhabdomyolysis. Am. J. Med. 2006;119:400–409.10.1016/j.amjmed.2006.02.007
  • Hadjis T, Grieff M, Lockhat D, et al. Calcium metabolism in acute renal failure due to rhabdomyolysis. Clin. Nephrol. 1993;39:22–27.
  • Vanholder R, Sever MS, Erek E, et al. Rhabdomyolysis. J. Am. Soc. Nephrol. 2000;11:1553–1561.
  • Khan FY. Rhabdomyolysis: a review of the literature. Neth. J. Med. 2009;67:272–283.
  • Schlattner U, Tokarska-Schlattner M, Wallimann T. Mitochondrial creatine kinase in human health and disease. Biochim. Biophys. Acta. 2006;1762:164–180.10.1016/j.bbadis.2005.09.004
  • Zhang MH. Rhabdomyolosis and its pathogenesis. World J. Emerg. Med. 2012;3:11–15.10.5847/wjem.j.issn.1920-8642.2012.01.002
  • Boutaud O, Roberts LJ 2nd. Mechanism-based therapeutic approaches to rhabdomyolysis-induced renal failure. Free Radical Biol. Med. 2011;51:1062–1067.10.1016/j.freeradbiomed.2010.10.704
  • Poels PJ, Gabreëls FJ. Rhabdomyolysis: a review of the literature. Clin. Neurol. Neurosurg. 1993;95:175–192.10.1016/0303-8467(93)90122-W
  • Brumback RA, Feeback DL, Leech RW. Rhabdomyolysis in childhood: a primer on normal muscle function and selected metabolic myopathies characterized by disordered energy production. Pediatr. Clin. North Am. 1992;39:821–858.10.1016/S0031-3955(16)38377-8
  • Criddle LM. Rhabdomyolysis. pathophysiology, recognition, and management. Crit. Care Nurse. 2003;23:14–22.
  • Torres PA, Helmestetter JA, Kaye AM, et al. Rhabdomyolysis: pathogenesis, diagnosis, and treatment. Ochsner J. 2014;15:58–69.
  • Knochel JP. Mechanisms of rhabdomyolysis. Curr. Opin. Rheumatol. 1993;5:725–731.10.1097/00002281-199305060-00006
  • Sauret JM, Marinides G, Wang GK. Rhabdomyolysis. Am. Fam. Physician. 2002;65:907–912.
  • Gabow PA, Kaehny WD, Kelleher SP. The spectrum of rhabdomyolysis. Medicine (Baltimore). 1982;61:141–152.10.1097/00005792-198205000-00002
  • Lane JT, Boudreau RJ, Kinlaw WB. Disappearance of muscular calcium deposits during resolution of prolonged rhabdomyolysis-induced hypercalcemia. Am. J. Med. 1990;89:523–525.10.1016/0002-9343(90)90385-Q
  • Bosch X, Poch E, Grau JM. Rhabdomyolysis and acute kidney injury. N. Engl. J. Med. 2009;361:62–72.10.1056/NEJMra0801327
  • Petejova N, Martinek A. Acute kidney injury due to rhabdomyolysis and renal replacement therapy: a critical review. Crit. Care. 2014;18:224. doi:10.1186/cc13897.
  • Zimmerman JL, Shen MC. Rhabdomyolysis. Chest. 2013;144:1058–1065.10.1378/chest.12-2016
  • Shimada M, Dass B, Ejaz AA. Paradigm shift in the role of uric acid in acute kidney injury. Semin Nephrol. 2011;31:453–458.10.1016/j.semnephrol.2011.08.010
  • De Vera MA, Bhole V, Burns LC, et al. Impact of statin adherence on cardiovascular disease and mortality outcomes: a systematic review. Br. J. Clin. Pharmacol. 2014;78:684–698.10.1111/bcp.2014.78.issue-4
  • Baigent C, Keech A, Kearney PM, et al. Cholesterol treatment trialists’ (CTT) collaborators efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins. Lancet. 2005;366:1267–1278.
  • Marais GE, Larson KK. Rhabdomyolysis and acute renal failure induced by combination lovastatin and gemfibrozil therapy. Ann. Intern. Med. 1990;112:228–230.10.7326/0003-4819-112-3-228
  • Oshima Y. Characteristics of drugs-associated rhabdomyolysis: analysis of 8,610 cases reported to the U.S. food and drug administration. Intern. Med. 2011;50:845–853.10.2169/internalmedicine.50.4484
  • Joy TR, Hegele RA. Narrative review: statin-related myopathy. Ann. Intern. Med. 2009;150:858–868.10.7326/0003-4819-150-12-200906160-00009
  • Guyton JR. Benefit versus risk in statin treatment. Am. J. Cardiol. 2006;97:95C–97C.10.1016/j.amjcard.2005.12.016
  • Chang JT, Staffa JA, Parks M, et al. Rhabdomyolysis with HMG-CoA reductase inhibitors and gemfibrozil combination therapy. Pharmacoepidemiol. Drug Saf. 2004;13:417–426.10.1002/(ISSN)1099-1557
  • Hoffman KB, Kraus C, Dimbil M, et al. A survey of the FDA’s AERS database regarding muscle and tendon adverse events linked to the statin drug class. Plos One. 2012;7:e42866.10.1371/journal.pone.0042866
  • Sakaeda T, Kadoyama K, Okuno Y. Statin-associated muscular and renal adverse events: data mining of the public version of the FDA adverse event reporting system. Plos One. 2011;6:e28124.10.1371/journal.pone.0028124
  • Cham S, Evans MA, Denenberg JO, et al. Statin-associated muscle-related adverse effects: a case series of 354 patients. Pharmacotherapy. 2010;30:541–553.10.1592/phco.30.6.541
  • Alsheikh-Ali AA, Ambrose MS, Kuvin JT, et al. The safety of rosuvastatin as used in common clinical practice: a postmarketing analysis. Circulation. 2005;111:3051–3057.10.1161/CIRCULATIONAHA.105.555482
  • Rallidis LS, Fountoulaki K, Anastasiou-Nana M. Review managing the underestimated risk of statin-associated myopathy. Int. J. Cardiol. 2012;159:169–176.10.1016/j.ijcard.2011.07.048
  • Law M, Rudnicka AR. Statin safety: a systematic review. Am. J. Cardiol. 2006;97:52C–60C.10.1016/j.amjcard.2005.12.010
  • Davidson MH, Clark JA, Glass LM, et al. Statin safety: an appraisal from the adverse event reporting system. Am. J. Cardiol. 2006;97:32C–43C.10.1016/j.amjcard.2005.12.008
  • Staffa JA, Chang J, Green L. Cerivastatin and reports of fatal rhabdomyolysis. N. Engl. J. Med. 2002;346:539–540.10.1056/NEJM200202143460721
  • McKenney JM, Davidson MH, Jacobson TA, et al. National Lipid Association Statin Safety Assessment Task Force. Final conclusions and recommendations of the National Lipid Association Statin Safety Assessment Task Force. Am. J. Cardiol. 2006;97:89C–94C.10.1016/j.amjcard.2006.02.030
  • Norata GD, Tibolla G, Catapano AL. Statins and skeletal muscles toxicity: from clinical trials to everyday practice. Pharmacol. Res. 2014;88:107–113.10.1016/j.phrs.2014.04.012
  • Iwere RB, Hewitt J. Myopathy in older people receiving statin therapy: a systematic review and meta-analysis. Br. J. Clin. Pharmacol. 2015;80:363–371.10.1111/bcp.12687
  • Antons KA, Williams CD, Baker SK, et al. Clinical perspectives of statin-induced rhabdomyolysis. Am. J. Med. 2006;119:400–409.10.1016/j.amjmed.2006.02.007
  • Harper CR, Jacobson TA. The broad spectrum of statin myopathy: from myalgia to rhabdomyolysis. Curr. Opin. Lipidol. 2007;18:401–408.10.1097/MOL.0b013e32825a6773
  • van Staa TP, Carr DF, O’Meara H, et al. Predictors and outcomes of increases in creatine phosphokinase concentrations or rhabdomyolysis risk during statin treatment. Br. J. Clin. Pharmacol. 2014;78:649–659.10.1111/bcp.2014.78.issue-3
  • Raju SB, Varghese K, Madhu K. Management of statin intolerance. Indian J. Endocrinol. Metab. 2013;17:977–982.
  • Jacobson TA. Toward “pain-free” statin prescribing: clinical algorithm for diagnosis and management of myalgia. Mayo Clin. Proc. 2008;83:687–700.10.1016/S0025-6196(11)60897-5
  • Katsiki N, Athyros VG, Karagiannis A. Exploring the management of statin intolerant patients: 2016 and beyond. Curr. Vasc. Pharmacol. 2016 Feb 26 [Epub ahead of print].
  • Vrablik M, Zlatohlavek L, Stulc T, et al. Statin-associated myopathy: from genetic predisposition to clinical management. Physiol. Res. 2014;63(Suppl 3):S327–S334.
  • Ragia G, Kolovou V, Tavridou A, et al. Lack of association of the p450 oxidoreductase *28 single nucleotide polymorphism with the lipid-lowering effect of statins in hypercholesterolemic patients. Mol. Diagn. Ther. 2014;18:323–331.
  • Kolovou G, Kolovou V, Ragia G, et al. CYP3A5 genotyping for assessing the efficacy of treatment with simvastatin and atorvastatin. Genet. Mol. Biol. 2015;38:129–137.10.1590/S1415-4757382220140239
  • Frudakis TN, Thomas MJ, Ginjupalli SN, et al. CYP2D6*4 polymorphism is associated with statin-induced muscle effects. Pharmacogenet. Genomics. 2007;17:695–707.10.1097/FPC.0b013e328012d0a9
  • Zuccaro P, Mombelli G, Calabresi L, et al. Tolerability of statins is not linked to CYP450 polymorphisms, but reduced CYP2D6 metabolism improves cholesteraemic response to simvastatin and fluvastatin. Pharmacol. Res. 2007;55:310–317.10.1016/j.phrs.2006.12.009
  • Emmanuele V, López LC, Berardo A, et al. Heterogeneity of coenzyme Q10 deficiency: patient study and literature review. Arch Neurol. 2012;69:978–983.
  • Oh J, Ban MR, Miskie BA, et al. Genetic determinants of statin intolerance. Lipids Health Dis. 2007;6:7. doi: 10.1186/1476-511X-6-7.
  • SEARCH Collaborative Group, Link E, Parish S, et al. SLCO1B1 variants and statin-induced myopathy–a genomewide study. N. Engl. J. Med. 2008;359:789–799.
  • Stroes ES, Thompson PD, Corsini A, et al. Statin-associated muscle symptoms: impact on statin therapy-European Atherosclerosis Society Consensus Panel Statement on assessment, aetiology and management. Eur. Heart J. 2015;36:1012–1022.10.1093/eurheartj/ehv043
  • Bruckert E, Hayem G, Dejager S, et al. Mild to moderate muscular symptoms with high-dosage statin therapy in hyperlipidemic patients —the PRIMO study. Cardiovasc. Drugs Ther. 2005;19:403–414.10.1007/s10557-005-5686-z
  • Ghatak A, Faheem O, Thompson PD. The genetics of statin-induced myopathy. Atherosclerosis. 2010;210:337–343.10.1016/j.atherosclerosis.2009.11.033
  • Banach M, Serban C, Ursoniu S, et al. Statin therapy and plasma coenzyme Q10 concentrations–a systematic review and meta-analysis of placebo-controlled trials. Pharmacol. Res. 2015;99:329–336.10.1016/j.phrs.2015.07.008
  • Banach M, Serban C, Sahebkar A, et al. Effects of coenzyme Q10 on statin-induced myopathy: a meta-analysis of randomized controlled trials. Mayo Clin. Proc. 2015;90:24–34.10.1016/j.mayocp.2014.08.021
  • Owczarek J, Jasińska M, Orszulak-Michalak D. Drug-induced myopathies. An overview of the possible mechanisms. Pharmacol. Rep. 2005;57:23–34.
  • Mas E, Mori TA. Coenzyme Q(10) and statin myalgia: what is the evidence? Curr. Atheroscler. Rep. 2010;12:407–413.10.1007/s11883-010-0134-3
  • Khayznikov M, Hemachrandra K, Pandit R, et al. Statin intolerance because of myalgia, myositis, myopathy, or myonecrosis can in most cases be safely resolved by vitamin D supplementation. N. Am. J. Med. Sci. 2015;7:86–93.
  • Banach M, Rizzo M, Toth PP, et al. Statin intolerance - an attempt at a unified definition. Position paper from an International Lipid Expert Panel. Expert. Opin. Drug Saf. 2015;14:935–955.10.1517/14740338.2015.1039980
  • Banach M, Rizzo M, Toth PP, et al. Statin intolerance - an attempt at a unified definition. Position paper from an International Lipid Expert Panel. Arch. Med. Sci. 2015;11:1–23.10.5114/aoms.2015.49807
  • Glueck CJ, Budhani SB, Masineni SS, et al. Vitamin D deficiency, myositis-myalgia, and reversible statin intolerance. Curr. Med. Res. Opin. 2011;27:1683–1690.10.1185/03007995.2011.598144
  • Michalska-Kasiczak M, Sahebkar A, Mikhailidis DP, et al. Analysis of vitamin D levels in patients with and without statin-associated myalgia - a systematic review and meta-analysis of 7 studies with 2420 patients. Int. J. Cardiol. 2015;178:111–116.10.1016/j.ijcard.2014.10.118
  • Katsiki N, Athyros VG, Karagiannis A, et al. Vitamin D deficiency, statin-related myopathy and other links with vascular risk. Curr. Med. Res. Opin. 2011;27:1691–1692.10.1185/03007995.2011.598922
  • Phan K, Gomez YH, Elbaz L, et al. Statin dose in renal failure? Which statin to select? Statin treatment non-adherence and discontinuation: clinical implications and potential solutions. Curr. Pharm. Des. 2014;20:6314–6324.10.2174/1381612820666140620162629
  • Agouridis AP, Nair DR, Mikhailidis DP. Strategies to overcome statin intolerance. Expert. Opin. Drug Metab. Toxicol. 2015;11:851–855.10.1517/17425255.2015.1027685
  • Tziomalos K, Athyros VG, Mikhailidis DP. Statin discontinuation: an underestimated risk? The downside of statin discontinuation in high risk patients. Curr. Med. Res. Opin. 2008;24:3059–3062.10.1185/03007990802469102