Characterization of Leucas aspera and evaluation of antioxidant activities before and after being subjected to digestion enzymes

References

• Acamovic, T., and J.D. Brooker. 2005. Biochemistry of plant secondary metabolites and their effects in animals. Proc. Nutr. Soc. 64:403–412.
   PubMed Web of Science ®Google Scholar
• Alluis, B., N. Perol, H. El Hajji, and O. Dangles. 2000. Water-soluble flavonol (=3-Hydroxy-2-phenyl-4H-1-benzopyran-4-one) derivatives: Chemical synthesis, colouring, and antioxidant properties. Helv. Chim. Acta 83(2):428–443. doi: 10.1002/(SICI)1522-2675(20000216)83:2<428::AID-HLCA428>3.0.CO;2-J.
   Web of Science ®Google Scholar
• Alminger, M., A.M. Aura, T. Bohn, C. Dufour, S.N. El, A. Gomes, S. Karakaya, M.C. Martinez-Cuesta, G.J. McDougall, T. Requena, et al. 2014. In vitro models for studying secondary plant metabolite digestion and bioaccessibility. Comp. Rev. Food Sci. Food Saf. 13:413–436. doi: 10.1111/1541-4337.12081.
   PubMed Web of Science ®Google Scholar
• Benzie, F., and J. Strain. 1996. The ferric reducing ability of plasma (FRAP) as a measure of “Antioxidant power”: The FRAP assay. Anal. Biochem. 239:70–76. doi: 10.1006/abio.1996.0292.
   PubMed Web of Science ®Google Scholar
• Blois, M.S. 1958. Antioxidant determinations by the use of a stable free radical. Nature. 181:1199–1200. doi: 10.1038/1811199a0.
   Web of Science ®Google Scholar
• Broadhurst, R.B., and W.T. Jones. 1978. Analysis of condensed tannins using acidified vanillin. J. Sci. Food Agric. 29(9):788–794. doi: 10.1002/(ISSN)1097-0010.
   Web of Science ®Google Scholar
• Cimini, M.G., M.N. Brundena, and J.K. Gibson. 1992. Effects of ibutilide fumarate, a novel antiarrhythmic agent, and its enantiomers on isolated rabbit myocardium. Eur. J. Pharm. 222(1):93–98. doi: 10.1016/0014-2999(92)90467-I.
   PubMed Web of Science ®Google Scholar
• Dewanjee, S., A. Maiti, A.K. Das, S.C. Mandal, and S.P. Dey. 2009. Swietenine: A potential oral hypoglycemic from Swietenia macrophylla seed. Fitoterapia. 80:249–251. doi: 10.1016/j.fitote.2009.02.004.
   PubMed Web of Science ®Google Scholar
• Ding, X., and P.A. Murray. 2005. Cellular mechanisms of thromboxane A2-mediated contraction in pulmonary veins. Am. J. Physiol. Lung Cell. Mol. Physiol. 289(5):825–833. doi: 10.1152/ajplung.00177.2005.
   Web of Science ®Google Scholar
• Elumalai, D., M. Hemavathi, P. Hemalatha, C.V. Deepaa, and P.K. Kaleena. 2015. Larvicidal activity of catechin isolated from Leucas aspera against Aedes aegypti, Anopheles stephensi, and Culex quinquefasciatus (Diptera: Culicidae). Parasitol. Res 115(3):1203–1212. doi: 10.1007/s00436-015-4856-6.
   PubMed Web of Science ®Google Scholar
• Feldman, J.M., and H.E. Lebovitz. 1969. Biological activities of tolbutamide and its metabolites: A dissociation of insulin-releasing and hypoglycemic activity. Diabetes 18(8):529–537. doi: 10.2337/diab.18.8.529.
   PubMed Web of Science ®Google Scholar
• Figueroa-Méndez, R., and S. Rivas-Arancibia. 2015. Vitamin C in health and disease: Its role in the metabolism of cells and redox state in the brain. Front. Physiol. 6:article 397. doi: 10.3389/fphys.2015.00397.
   PubMed Web of Science ®Google Scholar
• Formagio, A.S.N., C.R.F. Volobuff, M. Santiago, C.A.L. Cardoso, M.D.C. Vieira, and Z.V. Pereira. 2014. Evaluation of antioxidant activity, total flavonoids, tannins and phenolic compounds in Psychotria leaf extracts. Antioxidants 3(4):745–757. doi: 10.3390/antiox3040745.
   Google Scholar
• Ganeshpurkar, A., and A.K. Saluja. 2017. The pharmacological potential of rutin. Saudi Pharm. J. 25:149–164. doi: 10.1016/j.jsps.2016.04.025.
   PubMed Web of Science ®Google Scholar
• Garratt, D. 1964. The quantitative analysis of drugs. Chapman and Hall, Tokyo, Japan.
   Google Scholar
• Gibson, R.S. 2007. The role of diet- and host-related factors in nutrient bioavailability and thus in nutrient-based dietary requirement estimates. Food Nutr. Bull. 28(1):S77–S100. doi: 10.1177/15648265070281S108.
   PubMed Web of Science ®Google Scholar
• Gonzales, G.B., G. Smagghe, C. Grootaert, M. Zotti, K. Raes, and J.V. Camp. 2015. Flavonoid interactions during digestion, absorption, distribution and metabolism: A sequential structure-activity/property relationship-based approach in the study of bioavailability and bioactivity. Drug Metab. Rev 47(2):175–190. doi: 10.3109/03602532.2014.1003649.
   PubMed Web of Science ®Google Scholar
• Gupta, S., and J. Prakash. 2009. Studies on Indian green leafy vegetables for their antioxidant activity. Plant Foods Hum. Nutr. 64(1):39–45. doi: 10.1007/s11130-008-0096-6.
   PubMed Web of Science ®Google Scholar
• Hollman, P.C.H. 2004. Absorption, bioavailability, and metabolism of flavonoids. Pharm. Biol 42(Supplement):74–83. doi: 10.3109/13880200490893492.
   Google Scholar
• Hur, S.J., B.O. Lim, E.A. Decker, and D.J. McClements. 2011. In vitro human digestion models for food applications. Food Chem. 125:1–12. doi: 10.1016/j.foodchem.2010.08.036.
   Web of Science ®Google Scholar
• Jahan-Mihan, A., B.L. Luhovyy, D.E. Khoury, and G.H. Anderson. 2011. Dietary proteins as determinants of metabolic and physiologic functions of the gastrointestinal tract. Nutrients. 3:574–603. doi: 10.3390/nu3050574.
   PubMed Web of Science ®Google Scholar
• Karakaya, S., H. Ozbek, S. Gözcü, Z. Güvenalp, H. Yuca, H. Duman, C. Kazaz, and S.K. Ceyda. 2018. α-Amylase and α-glucosidase inhibitory activities of the extracts and constituents of Ferulago blancheana, F. pachyloba and F. trachycarpa roots. Bangladesh J. Pharmacol. 13:35–40. doi: 10.3329/bjp.v13i1.33668.
   Web of Science ®Google Scholar
• Karia, S., N. Shah, A. De Sousa, and S. Sonavane. 2013. Tiapride for the treatment of auditory hallucinations in schizophrenia. Indian J. Psychol. Med. 35:397–399. doi: 10.4103/0253-7176.122238.
   PubMedGoogle Scholar
• Khadhri, A., I. Bouali, S. Belkhir, R. Mokded, S. Smiti, P. Fale, M.E. Araujo, and M.L. Serralheiro. 2017. In vitro digestion, antioxidant and antiacetylcholinesterase activities of two species of Ruta: Ruta chalepensis and Ruta montana. Pharm. Biol. 55(1):101–107. doi: 10.1080/13880209.2016.1230634.
   PubMed Web of Science ®Google Scholar
• Kiela, P.R., and F.K. Ghishan. 2016. Physiology of intestinal absorption and secretion. Best Pract. Res. Clin. Gastroenterol. 30(2):145–159. doi: 10.1016/j.bpg.2016.02.007.
   PubMed Web of Science ®Google Scholar
• Latha, B., Y. Rumaisa, C.K. Soumya, S. Shafeena, and N. Sadhiya. 2013. Phytochemical studies on Leucas aspera. J. Chem. Pharm. Res 5(4):222–228.
   Google Scholar
• Laubie, M., H. Schmitt, J. Canellas, J. Roquebert, and P. Demichel. 1974. Centrally mediated bradycardia and hypotension induced by narcotic analgesics: Dextromoramide and fentanyl. Eur. J. Pharmacol. 28(1):66–75.
   PubMed Web of Science ®Google Scholar
• Lee, M.T., W.C. Lin, B. Yu, and T.T. Lee. 2017. Antioxidant capacity of phytochemicals and their potential effects on oxidative status in animals - A review. Asian-Austral. J. Anim. Sci. 30(3):299–308. doi: 10.5713/ajas.16.0438.
   PubMed Web of Science ®Google Scholar
• Lowry, O.H., N.J. Rosebrough, A.L. Farr, and R.J. Randall. 1951. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193(1):265–275.
   PubMed Web of Science ®Google Scholar
• Mackintosh, C.A., and D.R. Walters. 2003. Antifungal activity of some deoxyhypusine synthase inhibitors. Mycopathologia 156:329–332.
   PubMed Web of Science ®Google Scholar
• Maurice, T., O.W.B. Marlyse, N.J. Robert, M. Pierre, K. Victor, O. Sterner, M. Michelle, and N.A. Ephrem. 2013. Antimicrobial prenylated xanthones and anthraquinones from barks and fruits of Psorospermum adamauense (Engl). Nat. Prod. J. 3:60–65.
   Google Scholar
• Meera, C., S. Meenakumari, M. Thirumavalavan, and R. Pachaiappan. 2017. Isolation and characterization of α-amylase inhibitor from Leucas aspera (Willd) Link: α-amylase assay combined with FPLC chromatography for expedited identification. J. Plant Biochem. Biotechnol. 26(3):346–355. doi: 10.1007/s13562-017-0397-7.
   Web of Science ®Google Scholar
• Meyer-Barner, M., I. Meineke, K. Schreeb, and C. Gleiter. 2002. Pharmacokinetics of doxepin and desmethyldoxepin: An evaluation with the population approach. Eur. J. Clin. Pharmacol. 58(4):253–257. doi: 10.1007/s00228-002-0448-3.
   PubMed Web of Science ®Google Scholar
• Milugo, T.K., L.K. Omosa, J.O. Ochanda, B.O. Owuor, F.A. Wamunyokoli, J.O. Oyugi, and J.W. Ochieng. 2013. Antagonistic effect of alkaloids and saponins on bioactivity in the quinine tree (Rauvolfia caffra sond.): Further evidence to support biotechnology in traditional medicinal plants. BMC Complement. Altern. Med. 13(article):285. doi: 10.1186/1472-6882-13-285.
   Google Scholar
• Minekus, M., M. Alminger, P. Alvito, S. Ballance, T. Bohn, C. Bourlieu, F. Carriere, R. Boutrou, M. Corredig, D. Dupont, et al. 2014. A standardised static in vitro digestion method suitable for food - An international consensus. Food Funct 5(6):1113–1124. doi: 10.1039/c3fo60702j.
   PubMed Web of Science ®Google Scholar
• Misra, S., and M.K. Misra. 2014. Nutritional evaluation of some leafy vegetable used by the tribal and rural people of South Odisha. India. J. Nat. Prod. Plant Res. 4(1):23–28.
   Google Scholar
• Mtolo, M., A. Gerrano, and J. Mellem. 2017. Effect of simulated gastrointestinal digestion on the phenolic compound content and in vitro antioxidant capacity of processed Cowpea (V. unguiculata) cultivars. J. Food 15(3):391–399.
   Google Scholar
• Mukherjee, S.P., and M.A. Choudhuri. 1983. Implications of water stress‐induced changes in the levels of endogenous ascorbic acid and hydrogen peroxide in Vigna seedlings. Physiol. Plant 58(2):166–170. doi: 10.1111/ppl.1983.58.issue-2.
   Web of Science ®Google Scholar
• Owens, J., F.D. Provenza, R.D. Wiedmeier, and J.J. Villalba. 2012. Influence of saponins and tannins on intake and nutrient digestion of alkaloid-containing foods. J. Sci. Food Agric. 92(11):2373–2378. doi: 10.1002/jsfa.5643.
   PubMed Web of Science ®Google Scholar
• Peters-Golden, M., and W.R. Henderson. 2007. Leukotrienes. New Eng. J. Med. 357:1841–1854. doi: 10.1056/NEJMra071371.
   PubMed Web of Science ®Google Scholar
• Plummer, D. 1978. An introduction to practical biochemistry. McGraw-Hill, London.
   Google Scholar
• Preethi, R., V.V. Devanathan, and M. Loganathan. 2010. Antimicrobial and antioxidant efficacy of some medicinal plants against food borne pathogens. Adv. Biol. Res. 4(2):122–125.
   Google Scholar
• Rajakumar, N., and M.B. Shivanna. 2009. Ethno-medicinal application of plants in the eastern region of Shimoga district, Karnataka, India. J. Ethnopharmacol. 126:64–73. doi: 10.1016/j.jep.2009.08.010.
   PubMed Web of Science ®Google Scholar
• Ravindran, R., S. Juliet, A.R. Sunil, K.G. Kumar, S.R. Nair, K.K. Amithamol, M. Shynu, A.K. Rawat, and S. Ghosh. 2011. Eclosion blocking effect of ethanolic extract of Leucas aspera (Lamiaceae) on Rhipicephalus (Boophilus) annulatus. Vet. Parasitol. 179:287–290. doi: 10.1016/j.vetpar.2011.02.021.
   PubMed Web of Science ®Google Scholar
• Re, R., N. Pellegrini, A. Proteggente, A. Pannala, M. Yang, and C. Rice-Evans. 1999. Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radic. Biol. Med. 26:1231–1237.
   PubMed Web of Science ®Google Scholar
• Shahid, M., F. Subhan, N. Ahmad, and R.D.E. Sewell. 2017. The flavonoid 6-methoxyflavone allays cisplatin-induced neuropathic allodynia and hypoalgesia. Biomed. Pharmacother. 95:1725–1733. doi: 10.1016/j.biopha.2017.09.108.
   PubMed Web of Science ®Google Scholar
• Singh, H., M.K. Lily, and K. Dangwal. 2017. Viburnum mullaha D. DON fruit (Indian cran-berry): A potential source of polyphenol with rich antioxidant, antielastase, anti-collagenase, and anti-tyrosinase activities. Int. J. Food Prop 20(8):1729–1739. doi: 10.1080/10942912.2016.1217878.
   Web of Science ®Google Scholar
• Singleton, V., and J. Rossi. 1965. Colorimetry of total phenolics with phosphomolybdic phosphotungstic acid reagents. Am. J Enol. Vitic. 16:144–158.
   Google Scholar
• Steinberg, D., J. Avigan, and E.B. Feigelson. 1961. Effects of triparanol (mer-29) on cholesterol biosynthesis and on blood sterol levels in man. J. Clin. Invest. 40(5):884–893. doi: 10.1172/JCI104323.
   PubMed Web of Science ®Google Scholar
• Tan, S.P., Q.V. Vuong, C.E. Stathopoulos, S.E. Parks, and P.D. Roach. 2014. Optimized aqueous extraction of saponins from bitter melon for production of a saponin-enriched bitter melon powder. J. Food Sci. 79:E1372–E1381. doi: 10.1111/1750-3841.12514.
   PubMed Web of Science ®Google Scholar
• Trease, G.E., and W.C. Evans. 1996. Pharmacognosy. 13th ed. Bailliere-Tindall, London.
   Google Scholar
• Urban, N., L. Wang, S. Kwiek, J. Rademann, W.M. Kuebler, and M. Schaefer. 2016. Identification and validation of larixyl acetate as a potent trpc6 inhibitor. Mol. Pharmacol. 89(1):197–213. doi: 10.1124/mol.115.100792.
   PubMed Web of Science ®Google Scholar
• Velickovic, T.D.C., and D.J. Stanic-Vucinic. 2018. The role of dietary phenolic compounds in protein digestion and processing technologies to improve their antinutritive properties. Comp. Rev. Food Sci. Food Saf. 17(1):82–103. doi: 10.1111/1541-4337.12320.
   PubMed Web of Science ®Google Scholar
• Venugopala, K.N., V. Rashmi, and B. Odhav. 2013. Review on natural coumarin lead compounds for their pharmacological activity. BioMed Res. Int. 2013:article 963248. doi: 10.1155/2013/963248.
   PubMed Web of Science ®Google Scholar
• Wakil, A., A.S. Rigby, A.L. Clark, A. Kallvikbacka-Bennett, and S.L. Atkin. 2008. Low dose cabergoline for hyperprolactinaemia is not associated with clinically significant valvular heart disease. Eur. J. Endocrinol. 159(4):R11–14. doi: 10.1530/EJE-08-0271.
   PubMed Web of Science ®Google Scholar
• Yesodharan, K., and K.A. Sujana. 2007. Ethnomedicinal knowledge among malamalasar tribe of parambikulam wildlife sanctuary,Kerala. Indian J. Tradit. Know. 6(3):481–485.
   Web of Science ®Google Scholar
• Yu, W., Y. Zhao, and B. Shu. 2004. The radical scavenging activities of Radix puerariae isoflavonoids: A chemiluminescence study. Food Chem. 86:525–529. doi: 10.1016/j.foodchem.2003.09.005.
   Web of Science ®Google Scholar
• Zanettini, R., A. Antonini, G. Gatto, R. Gentile, S. Tesei, and G. Pezzoli. 2007. Valvular heart disease and the use of dopamine agonists for Parkinson’s disease. New Eng. J. Med. 356(1):39–46. doi: 10.1056/NEJMoa054830.
   PubMed Web of Science ®Google Scholar
• Zaree, R., M. Farhadi, Z. Mohammdzadeh, and G.R. Goudarzi. 2013. Extraction and comparison of alkaloids in different organs during different phonological periods of Nitraria schoberi. Annals Biol. Res. 4(2):130–135.
   Google Scholar
• Zhang, Y.-J., R.-Y. Gan, S. Li, Y. Zhou, A.-N. Li, D.-P. Xu, and H.-B. Li. 2015. Antioxidant phytochemicals for the prevention and treatment of chronic diseases. Molecules. 20:21138–21156. doi: 10.3390/molecules201219753.
   PubMed Web of Science ®Google Scholar
• Zhishen, J., T. Mengcheng, and W. Jianming. 1999. The determination of flavonoid contents in mulberry and their scavenging effects on superoxide radicals. Food Chem. 64:555–559. doi: 10.1016/S0308-8146(98)00102-2.
   Web of Science ®Google Scholar