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Articles

Alterations in Systemic Inflammatory Response Following a Half-Marathon Race with a Combined Curcumin and Pomegranate Supplement: A Feasibility Study

, MS, , MS, , MS, , PhDORCID Icon & , PhD

References

  • Ahmed M, Henson DA, Sanderson MC, Nieman DC, Gillitt ND, Lila MA. 2014. The protective effects of a polyphenol-enriched protein powder on exercise-induced susceptibility to virus infection. Phytother Res. 28(12):1829–1836. doi:10.1002/ptr.5208.
  • Ammar A, Bailey SJ, Chtourou H, Trabelsi K, Turki M, Hökelmann A, Souissi N. 2018. Effects of pomegranate supplementation on exercise performance and post-exercise recovery in healthy adults: a systematic review. Br J Nutr. 120(11):1201–1216. doi:10.1017/S0007114518002696.
  • Ammar A, Chtourou H, Turki M, Abdelkarim O, Ayadi F, Hoekelmann A, Yaich S, Souissi N. 2018. Natural pomegranate juice reduces inflammation, muscle damage and increase platelets blood levels in active healthy Tunisian aged men. Alexandria J Med. 54(1):45–48.
  • Ammar A, Turki M, Chtourou H, Hammouda O, Trabelsi K, Kallel C, Abdelkarim O, Hoekelmann A, Bouaziz M, Ayadi F, et al. 2016. Pomegranate Supplementation Accelerates Recovery of Muscle Damage and Soreness and Inflammatory Markers after a Weightlifting Training Session. PLoS One. 11(10):e0160305. doi:10.1371/journal.pone.0160305.
  • Ammar A, Turki M, Hammouda O, Chtourou H, Trabelsi K, Bouaziz M, Abdelkarim O, Hoekelmann A, Ayadi F, Souissi N, et al. 2017. Effects of pomegranate juice supplementation on oxidative stress biomarkers following weightlifting exercise. Nutrients. 9(8):819. doi:10.3390/nu9080819.
  • Barbe MF, Barr AE. 2006. Inflammation and the pathophysiology of work-related musculoskeletal disorders. Brain Behav Immun. 20(5):423–429. doi:10.1016/j.bbi.2006.03.001.
  • Bell PG, Walshe IH, Davison GW, Stevenson EJ, Howatson G. 2015. Recovery facilitation with Montmorency cherries following high-intensity, metabolically challenging exercise. Appl Physiol Nutr Metab. 40(4):414–423. doi:10.1139/apnm-2014-0244.
  • Bergendiova K, Tibenska E, Majtan J. 2011. Pleuran (β-glucan from Pleurotus ostreatus) supplementation, cellular immune response and respiratory tract infections in athletes. Eur J Appl Physiol. 111(9):2033–2040. doi:10.1007/s00421-011-1837-z.
  • Bernecker C, Scherr J, Schinner S, Braun S, Scherbaum WA, Halle M. 2013. Evidence for an exercise induced increase of TNF-alpha and IL-6 in marathon runners. Scand J Med Sci Sports. 23(2):207–214. doi:10.1111/j.1600-0838.2011.01372.x.
  • Bessa AL, Oliveira VN, Agostini GG, Oliveira RJS, Oliveira ACS, White GE, Wells GD, Teixeira DNS, Espindola FS. 2016. Exercise intensity and recovery: Biomarkers of injury, inflammation, and oxidative stress. J Strength Cond Res. 30(2):311–319. doi:10.1519/JSC.0b013e31828f1ee9.
  • Cadegiani FA, Kater CE. 2019. Novel causes and consequences of overtraining syndrome: the EROS-DISRUPTORS study. BMC Sports Sci Med Rehabil. 11:21. doi:10.1186/s13102-019-0132-x.
  • Carpenter KC, Breslin WL, Davidson T, Adams A, McFarlin BK. 2013. Baker's yeast beta-glucan supplementation increases monocytes and cytokines post-exercise: implications for infection risk? Br J Nutr. 109(3):478–486. doi:10.1017/S0007114512001407.
  • Chun K-S, Keum Y-S, Han SS, Song Y-S, Kim S-H, Surh Y-J. 2003. Curcumin inhibits phorbol ester-induced expression of cyclooxygenase-2 in mouse skin through suppression of extracellular signal-regulated kinase activity and NF-kappaB activation. Carcinogenesis. 24(9):1515–1524. doi:10.1093/carcin/bgg107.
  • Cosgrove C, Galloway SDR, Neal C, Hunter AM, McFarlin BK, Spielmann G, Simpson RJ. 2012. The impact of 6-month training preparation for an Ironman triathlon on the proportions of naïve, memory and senescent T cells in resting blood. Eur J Appl Physiol. 112(8):2989–2998. doi:10.1007/s00421-011-2273-9.
  • Danesi F, Ferguson LR. 2017. Could pomegranate juice help in the control of inflammatory diseases? Nutrients. 9(9):958. doi:10.3390/nu9090958.
  • Davis JM, Murphy EA, Carmichael MD, Zielinski MR, Groschwitz CM, Brown AS, Gangemi JD, Ghaffar A, Mayer EP. 2007. Curcumin effects on inflammation and performance recovery following eccentric exercise-induced muscle damage. Am J Physiol Regul Integr Comp Physiol. 292(6):R2168–73. doi:10.1152/ajpregu.00858.2006.
  • Drobnic F, Riera J, Appendino G, Togni S, Franceschi F, Valle X, Pons A, Tur J. 2014. Reduction of delayed onset muscle soreness by a novel curcumin delivery system (Meriva(R)): a randomised, placebo-controlled trial. J Int Soc Sports Nutr. 11:31. doi:10.1186/1550-2783-11-31.
  • Duplanty AA, Levitt DE, Hill DW, McFarlin BK, DiMarco NM, Vingren JL. 2018. Resistance training is associated with higher bone mineral density among young adult male distance runners independent of physiological factors. J Strength Cond Res. 32(6):1594–1600. doi:10.1519/JSC.0000000000002504.
  • Feucht CL, Patel DR. 2010. Analgesics and anti-inflammatory medications in sports: use and abuse. Pediatr Clin North Am. 57(3):751–774. doi:10.1016/j.pcl.2010.02.004.
  • Gary MA, Tanner EA, Davis AA, McFarlin BK. 2019. Combined bead-based multiplex detection of RNA and protein biomarkers: Implications for understanding the time course of skeletal muscle injury and repair. Methods. 158:92–96. doi:10.1016/j.ymeth.2018.11.012.
  • Gill S, Hankey J, Wright A, Marczak S, Hemming K, Allerton D, Ansley-Robson P, Costa R. 2015. The impact of a 24-h ultra-marathon on circulatory endotoxin and cytokine profile. Int J Sports Med. 36(8):688–695. doi:10.1055/s-0034-1398535.
  • Gleeson M, Bishop N, Oliveira M, McCauley T, Tauler P, Muhamad AS. 2012. Respiratory infection risk in athletes: association with antigen-stimulated IL-10 production and salivary IgA secretion. Scand J Med Sci Sports. 22(3):410–417. doi:10.1111/j.1600-0838.2010.01272.x.
  • Gleeson M, Bishop N, Oliveira M, Tauler P. 2013. Influence of training load on upper respiratory tract infection incidence and antigen-stimulated cytokine production. Scand J Med Sci Sports. 23(4):451–457. doi:10.1111/j.1600-0838.2011.01422.x.
  • Gomez-Merino D, Drogou C, Guezennec CY, Burnat P, Bourrilhon C, Tomaszewski A, Milhau S, Chennaoui M. 2006. Comparison of systemic cytokine responses after a long distance triathlon and a 100-km run: relationship to metabolic and inflammatory processes. Eur Cytokine Netw. 17(2):117–124.
  • Gonzalez-Trujano ME, Pellicer F, Mena P, Moreno DA, Garcia-Viguera C. 2015. Antinociceptive and anti-inflammatory activities of a pomegranate (Punica granatum L.) extract rich in ellagitannins. Int J Food Sci Nutr. 66(4):395–399.
  • Haramizu S, Ota N, Hase T, Murase T. 2013. Catechins suppress muscle inflammation and hasten performance recovery after exercise. Med Sci Sports Exerc. 45(9):1694–1702.
  • Hewlings SJ, Kalman DS. 2017. Curcumin: A review of its' effects on human health. Foods. 6(10):92. doi:10.3390/foods6100092.
  • Howatson G, McHugh MP, Hill JA, Brouner J, Jewell AP, Van Someren KA, Shave RE, Howatson SA. 2010. Influence of tart cherry juice on indices of recovery following marathon running. Scand J Med Sci Sports. 20(6):843–852. doi:10.1111/j.1600-0838.2009.01005.x.
  • Jager R, Purpura M, Kerksick CM. 2019. Eight weeks of a high dose of curcumin supplementation may attenuate performance decrements following muscle-damaging exercise. Nutrients. 11(7):1692. doi:10.3390/nu11071692.
  • Kang G, Kong P-J, Yuh Y-J, Lim S-Y, Yim S-V, Chun W, Kim S-S. 2004. Curcumin suppresses lipopolysaccharide-induced cyclooxygenase-2 expression by inhibiting activator protein 1 and nuclear factor kappab bindings in BV2 microglial cells. J Pharmacol Sci. 94(3):325–328. doi:10.1254/jphs.94.325.
  • Kassambara A. 2018. ggpubr: 'ggplot2' Based Publication Ready Plots.
  • Kawanishi N, Kato K, Takahashi M, Mizokami T, Otsuka Y, Imaizumi A, Shiva D, Yano H, Suzuki K. 2013. Curcumin attenuates oxidative stress following downhill running-induced muscle damage. Biochem Biophys Res Commun. 441(3):573–578. doi:10.1016/j.bbrc.2013.10.119.
  • Levitt DE, Luk H-Y, Duplanty AA, McFarlin BK, Hill DW, Vingren JL. 2017. Effect of alcohol after muscle-damaging resistance exercise on muscular performance recovery and inflammatory capacity in women. Eur J Appl Physiol. 117(6):1195–1206. doi:10.1007/s00421-017-3606-0.
  • Lundberg TR, Howatson G. 2018. Analgesic and anti-inflammatory drugs in sports: Implications for exercise performance and training adaptations. Scand J Med Sci Sports. 28(11):2252–2262. doi:10.1111/sms.13275.
  • McFarlin BK, Carpenter KC, Davidson T, McFarlin MA. 2013. Baker's yeast beta glucan supplementation increases salivary IgA and decreases cold/flu symptomatic days after intense exercise. J Diet Suppl. 10(3):171–183. doi:10.3109/19390211.2013.820248.
  • McFarlin BK, Venable AS, Carpenter KC, Henning AL, Ogenstad S. 2017. Oral supplementation with Baker's yeast beta glucan is associated with altered monocytes, T cells and cytokines following a bout of strenuous exercise. Front Physiol. 8:786.
  • McFarlin BK, Henning AL, Venable AS, Williams RR, Best Sampson JN. 2016. A shirt containing multistage phase change material and active cooling components was associated with increased exercise capacity in a hot, humid environment. Ergonomics. 59(8):1019–1025. doi:10.1080/00140139.2015.1108460.
  • McFarlin BK, Tanner EA, Gary MA, Davis AA, Bowman EM, Gary RS. 2019. Does acute improvement in muscle recovery with curcumin supplementation translate to long-term training? J Sci Sport Exercise. 1(3):203–207. doi:10.1007/s42978-019-00045-1.
  • McFarlin BK, Venable AS, Henning AL, Sampson JNB, Pennel K, Vingren JL, Hill DW. 2016. Reduced inflammatory and muscle damage biomarkers following oral supplementation with bioavailable curcumin. BBA Clin. 5:72–78. doi:10.1016/j.bbacli.2016.02.003.
  • McFarlin BK, Venable AS. 2014. Measurement of low concentration human serum cytokines using a millipore high-sensitivity milliplex assay. J Visual Exper. https://www.jove.com/video/5088/measurement-low-concentration-human-serum-cytokines-using-millipore.
  • McLeay Y, Barnes MJ, Mundel T, Hurst SM, Hurst RD, Stannard SR. 2012. Effect of New Zealand blueberry consumption on recovery from eccentric exercise-induced muscle damage. J Int Soc Sports Nutr. 9(1):19. doi:10.1186/1550-2783-9-19.
  • Michailidis Y, Karagounis LG, Terzis G, Jamurtas AZ, Spengos K, Tsoukas D, Chatzinikolaou A, Mandalidis D, Stefanetti RJ, Papassotiriou I, et al. 2013. Thiol-based antioxidant supplementation alters human skeletal muscle signaling and attenuates its inflammatory response and recovery after intense eccentric exercise. Am J Clin Nutr. 98(1):233–245. doi:10.3945/ajcn.112.049163.
  • Nicol LM, Rowlands DS, Fazakerly R, Kellett J. 2015. Curcumin supplementation likely attenuates delayed onset muscle soreness (DOMS). Eur J Appl Physiol. 115(8):1769–1777. doi:10.1007/s00421-015-3152-6.
  • Nielsen HG, Øktedalen O, Opstad P-K, Lyberg T. 2016. Plasma cytokine profiles in long-term strenuous exercise. J Sports Med (Hindawi Publ Corp). 2016:1–7. doi:10.1155/2016/7186137.
  • O’Fallon KS, Kaushik D, Michniak-Kohn B, Dunne CP, Zambraski EJ, Clarkson PM. 2012. Effects of quercetin supplementation on markers of muscle damage and inflammation after eccentric exercise. Int J Sport Nutr Exerc Metab. 22(6):430–437.
  • R Development Core Team. 2008. R: A language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing.
  • Schoenfeld BJ. 2012. The use of nonsteroidal anti-inflammatory drugs for exercise-induced muscle damage: implications for skeletal muscle development. Sports Med. 42(12):1017–1028. doi:10.1007/BF03262309.
  • Sciberras JN, Galloway SD, Fenech A, Grech G, Farrugia C, Duca D, Mifsud J. 2015. The effect of turmeric (Curcumin) supplementation on cytokine and inflammatory marker responses following 2 hours of endurance cycling. J Int Soc Sports Nutr. 12(1):5. doi:10.1186/s12970-014-0066-3.
  • Sierra AP, Benetti M, Ghorayeb N, Sierra C, Bastos F, Junior A, Kiss M. 2015. Analysis of Participation and Performance in Half Marathon Runners. J Sports Sci. (3).
  • Sousa M, Teixeira VH, Soares J. 2014. Dietary strategies to recover from exercise-induced muscle damage. Int J Food Sci Nutr. 65(2):151–163. doi:10.3109/09637486.2013.849662.
  • Suzuki K, Peake J, Nosaka K, Okutsu M, Abbiss CR, Surriano R, Bishop D, Quod MJ, Lee H, Martin DT, et al. 2006. Changes in markers of muscle damage, inflammation and HSP70 after an Ironman Triathlon race. Eur J Appl Physiol. 98(6):525–534. doi:10.1007/s00421-006-0296-4.
  • Tanner EA, Gary MA, Davis AA, McFarlin BK. 2019. Combining single molecule counting with bead-based multiplexing to quantify biological inflammation time course following skeletal muscle injury. Methods. 158:77–80. doi:10.1016/j.ymeth.2018.11.013.
  • Wickham H. 2016. ggplot2: Elegant graphics for data analysis. New York: Springer-Verlag.
  • Withee ED, Tippens KM, Dehen R, Tibbitts D, Hanes D, Zwickey H. 2017. Effects of Methylsulfonylmethane (MSM) on exercise-induced oxidative stress, muscle damage, and pain following a half-marathon: a double-blind, randomized, placebo-controlled trial. J Int Soc Sports Nutr. 14(1):24. doi:10.1186/s12970-017-0181-z.
  • Yoon JY, Kwon HH, Min SU, Thiboutot DM, Suh DH. 2013. Epigallocatechin-3-gallate improves acne in humans by modulating intracellular molecular targets and inhibiting P. acnes. J Invest Dermatol. 133(2):429–440. doi:10.1038/jid.2012.292.

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