Prebiotic utilisation provides Lactiplantibacillus plantarum a competitive advantage in vitro, but is not reflected by an increased intestinal fitness

References

• Markowiak P, Ślizewska K. Effects of probiotics, prebiotics, and synbiotics on human health. Nutrients. 2017;9:1021. doi:10.3390/nu9091021.
   PubMed Web of Science ®Google Scholar
• Davis LMG, Martínez I, Walter J, Hutkins R. A dose dependent impact of prebiotic galactooligosaccharides on the intestinal microbiota of healthy adults. Int J Food Microbiol. 2010;144(2):285–10. doi:10.1016/j.ijfoodmicro.2010.10.007.
   PubMed Web of Science ®Google Scholar
• Bouhnik Y, Raskine L, Simoneau G, Vicaut E, Neut C, Flourié B, Brouns F, Bornet FR. The capacity of nondigestible carbohydrates to stimulate fecal bifidobacteria in healthy humans: A double-blind, randomized, placebo-controlled, parallel-group, dose-response relation study. Am J Clin Nutr. 2004;80(6):1658–1664. doi:10.1093/ajcn/80.6.1658.
   PubMed Web of Science ®Google Scholar
• Costalos C, Kapiki A, Apostolou M, Papathoma E. The effect of a prebiotic supplemented formula on growth and stool microbiology of term infants. Early Hum Dev. 2008;84(1):45–49. doi:10.1016/j.earlhumdev.2007.03.001.
   PubMed Web of Science ®Google Scholar
• Kleessen B, Schwarz S, Boehm A, Fuhrmann H, Richter A, Henle T, Krueger M. Jerusalem artichoke and chicory inulin in bakery products affect faecal microbiota of healthy volunteers. Br J Nutr. 2007;98(3):540–549. doi:10.1017/S0007114507730751.
   PubMed Web of Science ®Google Scholar
• Ten Bruggencate SJM, Bovee-Oudenhoven IMJ, Lettink-Wissink MLG, Katan MB, Van Der Meer R. Dietary fructo-oligosaccharicles and inulin decrease resistance of rats to salmonella: Protective role of calcium. Gut. 2004;53(4):530–535. doi:10.1136/gut.2003.023499.
   PubMed Web of Science ®Google Scholar
• Ten Bruggencate SJM, Bovee-Oudenhoven IMJ, Lettink-Wissink MLG, Katan MB, van der Meer R. Dietary fructooligosaccharides affect intestinal barrier function in healthy men. J Nutr. 2006;136(1):70–74. doi:10.1093/jn/136.1.70.
   PubMed Web of Science ®Google Scholar
• Ten Bruggencate SJM, Bovee-Oudenhoven IMJ, Lettink-Wissink MLG, Van Der Meer R. Dietary fructo-oligosaccharides dose-dependently increase translocation of salmonella in rats. J Nut. 2003;133(7):2313–2318. doi:10.1093/jn/133.7.2313.
   PubMed Web of Science ®Google Scholar
• Bovee-Oudenhoven IM, Wissink ML, Wouters JT, Van der Meer R. Dietary calcium phosphate stimulates intestinal lactobacilli and decreases the severity of as salmonella infection in rats. J Nutr. 1999;129(3):607–612. doi:10.1093/jn/129.3.607.
   PubMed Web of Science ®Google Scholar
• Bovee-Oudenhoven IMJ, Lettink-Wissink MLG, Van Doesburg W, Witteman BJM, Van der Meer R. Diarrhea caused by enterotoxigenic Escherichia coli infection of humans is inhibited by dietary calcium. Gastroenterology. 2003;125(2):469–476. doi:10.1016/S0016-5085(03)00884-9.
   PubMed Web of Science ®Google Scholar
• Scholtens PAMJ, Alles MS, Willemsen LEM, van den Braak C, Bindels JG, Boehm G, Govers MJAP. Dietary fructo-oligosaccharides in healthy adults do not negatively affect faecal cytotoxicity: a randomised, double-blind, placebo-controlled crossover trial. Br J Nutr. 2006;95(6):1143–1149. doi:10.1079/BJN20061765.
   PubMed Web of Science ®Google Scholar
• Fuhren J, Schwalbe M, Rösch C, Nijland R, Wels M, Schols HA, Kleerebezem M. Dietary inulin increases lactiplantibacillus plantarum strain Lp900 persistence in rats depending on the dietary-calcium level. Appl Environ Microbiol. 2021;87(9):e00122–21. doi:10.1128/AEM.00122-21.
   PubMed Web of Science ®Google Scholar
• Bachmann H, Molenaar D, Kleerebezem M, Van Hylckama Vlieg JE. High local substrate availability stabilizes a cooperative trait. Isme J. 2011;5(5):929–932. doi:10.1038/ismej.2010.179.
   PubMed Web of Science ®Google Scholar
• Fuhren J, Schwalbe M, Peralta-Marzal L, Rösch C, Schols HA, Kleerebezem M. Phenotypic and genetic characterization of differential galacto-oligosaccharide utilization in Lactobacillus plantarum. Sci Rep. 2020;10(1):1–11. doi:10.1038/s41598-020-78721-4.
   PubMed Web of Science ®Google Scholar
• Fuhren J, Schwalbe M, Boekhorst J, Rösch C, Schols HA, Kleerebezem M. Dietary calcium phosphate strongly impacts gut microbiome changes elicited by inulin and galacto-oligosaccharides consumption. Microbiome. 2021;9(1):218. doi:10.1186/s40168-021-01148-0.
   PubMed Web of Science ®Google Scholar
• Fuhren J, Rösch C, ten Napel M, Schols HA, Kleerebezem M, McBain AJ. Synbiotic matchmaking in Lactobacillus plantarum: substrate screening and gene-trait matching to characterize strain-specific carbohydrate utilization. Appl Environ Microbiol. 2020;86(18):e01081–20. doi:10.1128/AEM.01081-20.
   PubMed Web of Science ®Google Scholar
• Reeves PG, Nielsen FH, Fahey GC. AIN-93 purified diets for laboratory rodents: final report of the American Institute of nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr. 1993;123(11):1939–1951. doi:10.1093/jn/123.11.1939.
   PubMed Web of Science ®Google Scholar
• Yu Z, Morrison M. Improved extraction of PCR-quality community DNA from digesta and fecal samples. Biotechniques. 2004;36(5):808–812. doi:10.2144/04365ST04.
   PubMed Web of Science ®Google Scholar
• van Bokhorst-van de Veen H, van Swam I, Wels M, Bron PA, Kleerebezem M, Driks A. Congruent strain specific intestinal persistence of Lactobacillus plantarum in an intestine-mimicking in vitro system and in human volunteers. PLoS One. 2012;7(9):e44588. doi:10.1371/journal.pone.0044588.
   PubMed Web of Science ®Google Scholar
• Zhang J, Kobert K, Flouri T, Stamatakis A. PEAR: a fast and accurate illumina paired-end reAd mergeR. Bioinformatics. 2014;30(5):614–620. doi:10.1093/bioinformatics/btt593.
   PubMed Web of Science ®Google Scholar
• Edgar RC. MUSCLE: multiple sequence alignment with high accuracy and high throughput. Nucleic Acids Res. 2004;32(5):1792–1797. doi:10.1093/nar/gkh340.
   PubMed Web of Science ®Google Scholar
• Ter Braak CJF, Smilauer P. CANOCO reference manual and canodraw for windows user’s guide: software for canonical community ordination (version 4.5). 2002. www.canoco.com,33,Biometris(WUMAT).
   Google Scholar
• Govers MJAP, Van Der Meer R. Effects of dietary calcium and phosphate on the intestinal interactions between calcium, phosphate, fatty acids, and bile acids. Gut. 1993;34(3):365–370. doi:10.1136/gut.34.3.365.
   PubMed Web of Science ®Google Scholar
• Govers MJAP, Termont DSML, Lapre JA, Kleibeuker JH, Vonk RJ, van der Meer R. Calcium in milk products precipitates intestinal fatty acids and secondary bile acids and thus inhibits colonic cytotoxicity in humans. Cancer Res. 1996;56:3270–3275.
   PubMed Web of Science ®Google Scholar
• Begley M, Gahan CGM, Hill C. The interaction between bacteria and bile. FEMS Microbiol Rev. 2005;29(4):625–651. doi:10.1016/j.femsre.2004.09.003.
   PubMed Web of Science ®Google Scholar
• Hardin G. The competitive exclusion principle. Science (1979). 1960;131(3409):1292–1297. doi:10.1126/science.131.3409.1292.
   PubMed Web of Science ®Google Scholar
• Rattanapprasert M, van Pijkeren JP, Ramer-Tait AE, Quintero M, Kok CR, Walter J, Hutkins RW. Genes involved in galactooligosaccharide metabolism in Lactobacillus reuteri and their ecological role in the gastrointestinal tract. Appl Environ Microbiol. 2019;85(22):1–15. doi:10.1128/AEM.01788-19.
   Web of Science ®Google Scholar
• Rossi M, Corradini C, Amaretti A, Nicolini M, Pompei A, Zanoni S, Matteuzzi D. Fermentation of fructooligosaccharides and inulin by bifidobacteria: A comparative study of pure and fecal cultures. Appl Environ Microbiol. 2005;71(10):6150–6158. doi:10.1128/AEM.71.10.6150-6158.2005.
   PubMed Web of Science ®Google Scholar
• Böger M, Van Leeuwen SS, Lammerts Van Bueren A, Dijkhuizen L. Structural identity of galactooligosaccharide molecules selectively utilized by single cultures of probiotic bacterial strains. J Agric Food Chem. 2019;67(50):13969–13977. doi:10.1021/acs.jafc.9b05968.
   PubMed Web of Science ®Google Scholar
• Honda H, Nagaoka S, Kawai Y, Kemperman R, Kok J, Yamazaki Y, Tateno Y, Kitazawa H, Saito T. Purification and characterization of two phospho-β-galactosidases, LacG1 and LacG2, from Lactobacillus gasseri ATCC33323 T. J Gen Appl Microbiol. 2012;58(1):11–17. doi:10.2323/jgam.58.11.
   PubMed Web of Science ®Google Scholar