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Research Article

Functional and Regulatory Characteristics of Eukaryotic Type II DNA Topoisomerase

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Pages 1-37 | Published online: 29 Sep 2008

REFERENCES

  • Ackerman, P., Glover, C. V. C., and Osheroff, N. 1985. Phosphorylation of DNA topoisomerase II by casein kinase II: modulation of eukaryotic topoisomerase II activity in vitro. Proc. Natl. Acad. Sci. U.S.A. 82: 3164–3168.
  • Ackerman, P., Glover, C.V.C., and Osheroff, N. 1988. Phosphorylation of DNA topoisomerase II in vivo and in total homogenates of Drosophila Kc cells. The role of casein kinase II. J. Biol. Chem. 263: 12653–12660.
  • Adachi, Y., Kas, E., and Laemmli, U. K. 1989. Preferential, cooperative binding of DNA toposiomerase II to scaffold-associated regions. EMBO J. 8: 3997–4006.
  • Adachi, Y., Luke, M., and Laemmli, U. K 1991. Chromosome assembly in vitro: topoisomerase II is required for condensation. Cell 64: 137–148.
  • Adachi, N., Miyaike, M., Ikeda, H., and Kikuchi, A. 1992. Characterization of cDNA encoding the mouse DNA topoisomerase II that can complement the budding yeast top2 mutation. Nucleic Acids Res. 20: 5297–5303.
  • Adachi, N., Kobayashi, M., and Koyama, H. 1997. Cell cycle-dependent regulation of the mouse DNA topoisomerase IIa gene promoter. Biochem. Biophys. Res. Comm. 230: 105–109.
  • Arndt-Jovin, D. J., Udvardy, A., Garner, M. M, Ritter, S., and Jovin, T. M 1993. Z-DNA binding and inhibition by GTP of Droso- phila topoisomerase II. Biochemistry 32: 4862–4872.
  • Austin, C. A., Marsh, K. L, Wasserman, R. A, Willmore, E., Sayer, P. J, Wang, J. C, and Fisher, M. L 1995. Expression, domain structure, and enzymatic properties of an active recombinant human DNA topoisomerase IIp. J. Biol. Chem. 270: 15739–15746.
  • Bae, Y.-S., Kawasaki, I., Ikeda, H., and Liu, L. F 1988. Illegitimate recombination mediated by calf thymus DNA topoisomerase II in vitro. Proc. Natl. Acad. Sci. U.S.A. 85: 2076–2080.
  • Baird, C. L., Harkins, T., Morris, S. K, and Lindsley, J. E, 1999. Topoisomerase II drives DNA transport by hydrolyzing one ATP. Proc. Natl. Acad. Sci. U.S.A. 96: 13685–13690.
  • Bechert, T., Diekmann, S., and Arndt-Jovin, D. 1994. Human 170 kDa and 180 kDa topoisomerases II bind preferentially to curved and left-handed linear DNA. J. Biomol. Struct. Dyn. 12: 605–623.
  • Bell, C. A., Dykstra, C.C., Naiman, N.A., Cory, M., Fairley, T.A., and Tidwell, R.R. 1993. Structure-activity studies of dicationically substitiuted bis-benzimidazoles against Giardia lamblia: correlation of antigiardial activity with DNA binding affinity and giardial topoisomerase II inhibition. Antimicrob. Agents Chemother. 37: 2668–2673.
  • Benedetti, P., Silvestri, A., Fiorani, P., and Wang, J. C 1997. Structure of yeast DNA topoisomerase II and its truncation derivatives by transmission electron microscopy. J. Biol. Chem. 272: 12132–12137.
  • Berger, J. M. and Wang, J. C 1996. Recent developments in DNA topoisomerase II structure and mechanism. Curr. Opin. Struct. Biol. 6: 84–90.
  • Berger, J. M., Gamblin, S. J, Harrison, S. C, and Wang, J. C 1996. Structure and mechanism of DNA topoisomerase II. Nature 379: 225–232.
  • Berger, J. M. 998. Structure of DNA topoisomerases. Biochim. Biophys. Acta 1400:3–18.
  • Bergerat, A., de Massy, B., Gadelle, D., Varoutas, P.-C., Nicolas, A., and Forterre, P. 1997. An atypical topoisomerase II from Archaea with implications for meiotic recombination. Nature 386: 414–417.
  • Besterman, J. M., Elwell, L. P, Blanchard, S. G, and Cory, M. 1987. Amiloride intercalates into DNA and inhibits DNA topoisomerase II. J. Biol. Chem. 262: 13352–13358.
  • Bhat, M. A., Philip, A. V, Glover, D. M, and Bellen, H. J 1996. Chromatid segregation at anaphase requires the barren product, a novel chromosome-associated protein that interacts with topoisomerase II. Cell 87: 1103–1114.
  • Bhat, U. G., Raychaudhuri, P., and Beck, W.T. 1999, Functional interaction between human topoisomerase IIa and retinoblastoma protein. Proc. Natl. Acad. Sci. U.S.A. 96: 7859–7864.
  • Biersack, H., Jensen, S., Gromova, I., Nielsen, I. S, Westergaard, O., and Andersen, A. H 1996. Active heterodimers are formed from human DNA topoisomerase II alpha and II b isoforms. Proc. Natl. Acad. Sci. U.S.A. 93: 8288–8293.
  • Bigioni, M., Zunino, F., Tinelli, S., Austin, C. A, Willmore, E., and Capranico, G. 1996. Position-specific effects of base mismatch on mammalian topoisomerase II DNA cleaving activity. Biochemistry 35: 153–159.
  • Bjergbaek, L., Kingma, P. Nielsen, I.S., Wang, Y., Westergaard, O., Osheroff, N., and Anderson, A. H 2000. Communication between the ATPase and cleavage/religation domains of human topoisomerase IIa. J. Biol. Chem. 275: 13041–13048.
  • Boege, F., Kjeldsen, E., Gieseler, F., Alsner, J., and Biersack, H. 1993. Position-specific effects of base mismatch on mammalian topoisomerase II DNA cleaving activity. Eur. J. Biochem. 218: 575–584.
  • Bojanowski, K., Filhol, O., Cochet, C., Chambaz, E. M, and Larsen, A. K 1993. DNA topoisomerase II and casein kinase II associate in a molecular complex that is catalyti- cally active. J. Biol. Chem. 268: 22920–22926.
  • Bojanowski, K., Maniotis, A. J, Plisov, S., Larsen, A. K, and Ingber, D. E 1998. DNA topoisomerase II can drive changes in higher order chromosome structure without enzymatically modifying DNA. J. Cell. Biochem. 69: 127–142.
  • Brandt, T. L., Fraser, D. J, Leal, S., Halandras, P. M, Kroll, A. M, and Kroll, D. J 1997. c-Myb trans-activates the human DNA topoisomerase IIa gene promoter. J. Biol. Chem. 272: 6278–6284.
  • Brill, S. J., DiNardo, S., Voelkel-Meiman, K., and Sternglanz, R. 1987. Need for DNA topoisomerase activity as a swivel for DNA replication for transcription of ribosomal RNA. Nature 326: 414–416.
  • Brill, S. J. and Sternglanz, R. 1988. Transcription-dependent DNA supercoiling in yeast DNA topoisomerase mutants. Cell 54: 403–411.
  • Buchenau, P., Saumweber, H., and Arndt-Jovin, D. J 1993. Consequences of topoisomerase II inhibition in early embryogenesis of Drosophila revealed by in vivo confocal laser scanning microscopy. J. Cell Sci. 104: 1175–1185.
  • Burden, D. A., Kingma, P. S, Froelich-Ammon, S. J, Bjornsti, M.-A., Patchan M. W., Thompson, R. B, and Osheroff, N. 1996. Topoisomerase II—etoposide interactions direct the formation of drug-induced en- zyme-DNA cleavage complexes. J. Biol. Chem. 271: 29238–29224.
  • Burden, D. A. and Osheroff, N. 1999. In vitro evolution of preferred topoisomerase II DNA cleavage sites. J. Biol. Chem. 274: 5227–5235.
  • Campain, J. A., Gottesman, M. M, and Pastan, I. 1994. A novel mutant topoisomerase IIa present in VP-16-resistant human melanoma cell lines has a deletion of alanine 429. Biochemistry 33: 11327–11332.
  • Capranico, G., Jaxel, C., Roberge, M., Kohn, K. W, and Pommier, Y. 1990. Nucleosome positioning as a critical determinant for the DNA cleavage sites of mammalian DNA topoisomerase II in reconstituted simian virus 40 chromatin. Nucleic Acids Res. 18: 4553–4559.
  • Capranico, G., Tinelli, S., Austin, C. A, Fisher, M. L, and Zunino, F. 1992. Different patterns of gene expression of topoisomerase II isoforms in differentiated tissues during murine development. Biochim. Biophys. Acta 1132: 43–48.
  • Carballo, M., Ginc, R., Santos, M., and Puigdomenech, P. 1991. Characterization of toposiomerase I and II activities in nuclear extracts during callogenesis in immature embryos of Zea mays. PlantMol. Biol. 16: 59–70.
  • Cardenas, M. E., Dang, Q., Glover, C. V. C., and Gasser, S. M 1992. Casein kinase II phosphorylates the eukaryote-specific C- terminal domain of topoisomerase II in vivo. EMBO J. 11: 1785–1796.
  • Cardenas, M. E. and Gasser, S. M 1993. Regulation of topoisomerase II by phosphory- lation: a role for casein kinase II. J. Cell Sci. 104: 219–225.
  • Cardenas, M. E., Walter, R., Hanna, D. R, and Gasser, S. M 1993. Casein kinase II copurifies with yeast DNA topoisomerase II and re-activates the dephosphorylated enzyme. J. Cell. Sci. 104: 533–543.
  • Caron, P.C., Watt, P., and Wang, J. C 1994. The C-terminal domain of Saccharomyces cerevisae DNA topoisomerase II. Mol. Cell. Biol. 14: 3197–3207.
  • Chakraborty, A. K. and Majumder, H.K. 1987. Decatenation of kinetoplast DNA by an ATP- dependent DNA topoisomerase from kine- toplast haemoflagellate Leismania donovani. Mol. Biochem. Parasitol. 26: 215–224.
  • Chakraborty, A. K. and Majumder, H.K. 1991. An ATP-dependent catenating enzyme from the kinetoplast haemoflagellate Leismania donovani. Biochem. Biophys. Res. Comm. 180: 279–285.
  • Champoux, J. J. and Dulbecco, R. 1972. An activity from mammalian cells that untwists superhelical DNA — a possible swivel for DNA replication. Proc. Natl. Acad. Sci. U.S.A. 69: 143–146.
  • Charron, M., and Hancock, R. 1991. Chromosome recombination and defective genome segregation induced in Chinese hamster cells by the topoisomerase II inhibitor VM-26. Chromosoma 100: 97–102.
  • Chavalitshewinkoon, P., Leelaphiwat, S., and Wilairat, P. 1994. Partial purification and characterization of DNA topoisomerase II from Plasmodium falciparum. Southeast Asian J. Trop. Med. Public Health. 25: 32–36.
  • Cheesman, S., McAleese, S., Goman, M., Johnson, D., Horrocks, P., Ridley, R.G., and Kilbey, B. J 1994. The gene encoding topoisomerase II from Plasmodium falciparum. Nucleic Acids Res. 22: 2547–2541.
  • Chen, G. L., Yang, L., Rowe, T. C, Halligan, B. D, Tewey, K. M, and Liu, L. F 1984. Nonintercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II. J. Biol. Chem. 259: 13560–13566.
  • Choi, I. Y., Chung, I. K, and Muller, M. T 1995. Eukaryotic topoisomerase II cleavage is independent of duplex DNA conformation. Biochim. Biophys. Acta 1264: 209–214.
  • Christman, M. F., Dietrich, F. S, and Fink, G. R 1988. Mitotic recombination in the rDNA of S. cerevisiae is suppressed by the combined action of DNA topoisomerases I and II. Cell 55: 413–425.
  • Chu, Y. and Hsu, M.-T. 1992 Ellipticine increases the superhelical density of intracellular SV40 DNA by intercalation. Nucleic Acids Res. 20: 4033–4038.
  • Chung, T. D., Drake, F. H, Tan, K. B, Per, S. R, Crooke, S. T, and Mirabelli, C. K 1989. Characterization and immunologi- cal identification of cDNA clones encoding two human DNA topoisomerase II isozymes. Proc. Natl. Acad. Sci. U.S.A. 86: 9431–9435.
  • Chung, I. K., Mehta, V. B, Spitzner, J. R, and Muller, M. T 1992. Eukaryotic topoisomerase II cleavage of parallel stranded DNA tetraplexes. Nucleic Acids Res. 20: 1973–1977.
  • Corbett, A. H., Zechiedrich, E. L, Lloyd, R. S, and Osheroff, N. 1991. Inhibition of eu- karyotic topoisomerase II by ultraviolet- induced cyclobutane pyrimidine dimers. J. Biol. Chem. 266: 19666–19671.
  • Corbett, A. H., Zechiedrich, E. L, and Osheroff, N. 1992a. A role for the passage helix in the DNA cleavage reaction of eukaryotic topoisomerase II. J. Biol. Chem. 267: 683–686.
  • Corbett, A. H., DeVore, R. F, and Osheroff, N. 1992b. Effect of casein kinase II-mediated phosphorylation on the catalytic cycle of topoisomerase II. Regulation of enzyme activity by enhancement of ATP hydrolysis. J. Biol. Chem. 267:20513–20518.
  • Corbett, A. H., Fernald, N. W, and Osheroff, N. 1993. Protein kinase C modulates the catalytic activity of topoisomerase II by enhancing the rate of ATP hydrolysis: evidence for a common mechanism of regulation by phosphorylation. Biochemistry 32: 2090–2097.
  • Cowell, I. G., Okorokov. A. L., Cutts, S. A, Padget, K., Bell, M., Milner, J., and Austin, C. A 2000. Human topoisomerase IIa and IIP interact with the C-terminal region of p53. Exp. Cell Res. 255: 86–94.
  • Crenshaw, D. G. and Hsieh, T.-S. 1993. Function of the hydrophilic carboxy terminus of type II DNA topoisomerase from Droso- phila melanogaster. J. Biol. Chem. 268: 21335–21343.
  • Dang, Q., Alghisi, G.-C., and Gasser, S. M 1994. Phosphorylation of the C-terminal domain of yeast topoisomerase II by casein kinase II affects DNA-protein interaction. J. Mol. Biol. 243: 10–24.
  • Darby, M. K., Schmitt, B., Jongstra-Bilen, J., and Vosberg, H. P 1985. Inhibition of calf thymus type II DNA topoisomerase by poly(ADP-ribosylation). EMBO J. 4: 2129–2134.
  • Davies, S. L., Jenkins, J. R, and Hickson, I. D1993. Human cells express two differentially spliced forms of topoisomerase II P mRNA. Nucleic Acids Res. 21: 3719–3723.
  • deKretser, D. M. and Kerr, J. B 1988. The Physiology of Reproduction. pp 837-931. (Knobil, E. and J. Neill., Eds.). Raven Press, New York.
  • Del Bino, G., Skierski, J. S, and Darzynkiewicz, Z. 1991. The concentration-dependent diversity of effects of DNA topoisomerase I and II inhibitors on the cell cycle of HL- 60 cells. Exp. Cell Res. 195: 485–491.
  • Dereuddre, S., Fry, S., Delaporte, C., and Jaquemin-Sablon, A. 1995. Cloning and characterization of full-length cDNAs coding for DNA topoisomerase IIP from Chinese hamster lung cells sensitive and resistant to 9-OH-ellipticine. Biochim. Biophys. Acta 1264: 178–182.
  • DeVore, R. F., Corbett, A. H, and Osheroff, N. 1992. Phosphorylation of topoisomerase II by casein kinase II and protein kinase C: effects on enzyme-mediated DNA cleavage/ religation and sensitivity to the anti- neoplastic drugs etoposide and 4'-(9- acridinylamino)methane-sulfon-m- anisidide. Cancer Res. 52: 2156–2161.
  • DiGate, R. J. and Marians, K. J 1988. Identification of a potent decatenating enzyme from Escherichia coli. J. Biol. Chem. 263: 13366–13373.
  • DiNardo, S., Voelkel, K. A, and Sternglanz, R. 1984. DNA topoisomerase II mutant of Saccharomyces cerevisiae: topoisomerase II is required for segregation of daughter molecules at the termination of DNA replication. Proc. Natl. Acad. Sci. U.S.A. 81: 2616–2620.
  • Douc-Rasy, S., Kayser, A., Riou, J. F, and Riou, G. 1986. ATP-independent type II topoisomerase from trypanosomes. Proc. Natl. Acad. Sci. U.S.A. 83: 7152–7156.
  • Downes, C. S., Mullinger, A. M, and Johnson, R. T 1991. Inhibitors of DNA topoisomerase II prevent chro- matid separation in mammalian cells but do not prevent exit from mitosis. Proc. Natl. Acad. Sci. U.S.A. 88: 8895–8899.
  • Downes, C. S., Clarke, D. J, Mullinger, A. M, Gimenez-Ablan, J. F, Creighton, A. M, and Johnson, R. T 1994. A topoisomerase II-dependent G2 cycle checkpoint in mammalian cells. Nature 372: 467–470.
  • Drake, F. H., Zimmerman, J. P, McCabe, F. L, Bartus, H. F, Per, S. R, Sullivan, D. M, Ross, W. E, Mattern, M. R, Johnson, R. K, Crooke, S. T, and Mirabelli, C. K 1987. Purification of topoisomerase II from amsacrine-resistant P388 leukemia cells. Evidence for two forms of the enzyme. J. Biol. Chem. 262: 16739–16747.
  • Drake, F. H., Hofmann, G. A, Bartus, H. F, Mattern, M. R, Crooke, S. T, and Mirabelli C. K. 1989. Biochemical and pharmacological properties of p170 and p180 forms of topoisomerase II. Biochemistry 28: 8154–8160.
  • Droge, P. 1994. Protein tracking-induced super- coiling of DNA: a tool to regulate DNA transactions in vivo? BioEssays 16: 91–99.
  • Durrieu, F., Samejima, K., Fortune, J. M, Kadels- Lewis, S., Osheroff, N., and Earnshaw, W. C 2000. DNA topoisomerase IIa interacts with CAD nuclease and is involved in chro- matin condensation during apoptotic execution. Curr. Biol. 10: 923–926.
  • Earnshaw, W. C., Halligan, B., Cooke, C. A, Heck, M. M. S., and Liu, L. F 1985. Topoisomerase II is a structural component of mitotic chromosome scaffolds. J. Cell Biol. 100: 1706–1715.
  • Earnshaw, W. C. and Heck, M. M S. 1985. Localization of topoisomerase II in mi- totic Chromosomes. J. Cell Biol. 100: 1716–1725.
  • Falck, J., Jensen, P. B, and Sehested, M. 1999. Evidence for a repressional role of an inverted CCAAT box in cell cycle-dependent transcription of the human DNA topoisomerase IIa gene. J. Biol. Chem. 274: 18753–18758.
  • Felix, C. A. 1998. Secondary leukemias induced by topoisomerase-targeted drugs. Biochim. Biophys. Acta 1400: 233–255.
  • Fragoso, S. P. and Goldenberg, S. 1992. Cloning and characterization of the gene encoding Trypanosoma cruzei DNA topoisomerase II. Mol. Biochem. Parasitol. 55: 127–134.
  • Froelich-Ammon, S. J., Gale, K. C, and Osheroff, N. 1994 Site-specific cleavage of a DNA hairpin by topoisomerase II. J. Biol. Chem. 269: 7719–7725.
  • Froelich-Ammon, S. J., Patchan, M. W, Osheroff, N., and Thompson, R. B 1995a. Topoisomerase II binds to ellipticine in the absence or presence of DNA. Characterization of enzyme-drug interactions by fluorescence spectroscopy. J. Biol. Chem. 270: 14998–15004.
  • Froelich-Ammon, S. J., Burden, D. A, Patchan, M. W, Elsea, S. H, Thompson, R. B, and Osheroff, N. 1995b. Increased drug affinity as the mechanistic basis for drug hypersensitivity of a mutant type II topoisomerase. J. Biol. Chem. 270: 28018–28021.
  • Furukawa, M., Uchiumi, T., Nomoto, M., Takano, H., Morimoto, R., Naito, S., Kuwano, M., and Kohno, K. 1998. The role of an inverted CCAAT element in transcriptional activation of the human DNA topoisomerase IIa gene by heat shock. J. Biol. Chem. 273: 10550–10555.
  • Galande, S. and Muniyappa, K. 1996. Purification and functional characterization of type II DNA topoisomerase from rat testis and comparison with topoisomerase II from liver. Biochim. Biophy. Acta 1308: 58–66.
  • Galande, S. and Muniyappa, K. 1997. Effects of nucleosomes and anti-tumor drugs on the catalytic activity of type II DNA topoisomerase from rat testis. Biochem. Pharmacol. 53: 1229–1238.
  • Gale, K. C. and Osheroff, N. 1990. Uncoupling the DNA cleavage and religation activities of topoisomerase II with a single- stranded nucleic acid substrate: evidence for an active enzyme-cleaved DNA intermediate. Biochemistry 29: 9538–9545.
  • Gale, K. C. and Osheroff, N. 1992. Intrinsic intermolecular DNA ligation activity of eukaryotic topoisomerase II. Potential roles in recombination. J. Biol. Chem. 267: 12090–12097.
  • Ganapathi, R., Zwelling, L., Constantinou, A., Ford, J., and Grabowski, D. 1993. Altered phosphorylation, biosynthesis and degradation of the 170 kDa isoform of topoisomerase II in amsacrine-resistant human leukemia cells. Biochem. Biophys. Res. Comm. 192: 1274–1280.
  • Gardiner, L. P., Roper, D. I, Hammonds, T. R, and Maxwell, A. 1998. The N-terminal domain of human topoisomerase IIa is a DNA-dependent ATPase. Biochemistry 37: 16997–17004.
  • Gasser, S. M., Laroche, T., Falquet, J., Boy de la Tour, E., and Laemmli, U. K 1986. Metaphase chromosome structure. J. Mol. Biol. 188: 613–629.
  • Gellert, M., Mizuuchi, K., O'Dea, M. H, and Nash, H. A 1976. DNA gyrase: an enzyme that introduces superhelical turns into DNA. Proc. Natl. Acad. Sci. U.S.A. 73: 3872–3876.
  • Giaever, G., Lynn, R., Goto, T., and Wang, J. C 1986. The complete nucleotide sequence of the structural gene TOP2 of yeast DNA topoisomerase II. J. Biol. Chem. 261: 12448–12454.
  • Glikin, G. C., Jovin, T. M, and Arndt-Jovin, D. J 1991. Interactions of Drosophila DNA topoisomerase II with left-handed Z-DNA in supercoiled minicircles. Nucleic Acids Res. 19: 7139–7144.
  • Goswami, P. C., Roti, J. L, and Hunt, C. R 1996. The cell cycle-coupled expression of topoisomerase IIa during S phase is regulated by mRNA stability and is disrupted by heat shock or ionizing radiation. Mol. Cell. Biol. 16: 1500–1508.
  • Goswami, P. C., Sheren, J., Albee, L. D, Parsian, A., Sim, J. E, Ridnour, L. A, Higashikubo, R., Gius, D., Hunt, C. R, and Spitz, D. R 2000. Cell cycle coupled variation in topoisomerase IIa mRNA is regulated by the 3'-untranslated region. Possible role of redox-sensitive protein binding in mRNA accumulation. J. Biol. Chem. 275: 38384–38392.
  • Goto, T. and Wang, J. C 1984. Yeast DNA topoisomerase II is encoded by a single- copy essential gene. Cell 36: 1073–1080.
  • Goto, T., Laipis, P., and Wang, J. C 1984. The purification and characterization of DNA topoisomerases I and II of the yeast Sac- charomyces cerevisiae. J. Biol. Chem. 259: 10422–10429.
  • Gromova, I. I., Thomsen, B., and Razin, S. V 1995. Different topoisomerase II antitu- mor drugs direct similar specific long- range fragmentation of an amplified c- MYC gene locus in living cells and in high-salt-extracted nuclei. Proc. Natl. Acad. Sci. U.S.A. 92: 102–106
  • Gromova, I. I., Biersack, H., Jansen, S., Nielsen, O. F, Westergaard, O., and Andersen, A. H 1998. Characterization of DNA topoisomerase IIa/p heterodimers in HeLa cells. Biochemistry 37: 16645–16652.
  • Grue, P., GraBer, A., Sehested, M., Jensen, P. B, Uhse, A., Straub, T., Ness, W., and Boege, F. 1998. Essential mitotic functions of DNA topoisomerase IIa are not adopted by topoisomerase IIP in human H69 cells. J. Biol. Chem. 273: 33660–33666.
  • Haber, J. E. 1997. A super new twist on the initiation of meiotic recombination: Cell 89: 163–166.
  • Halmer, L., Vestner, B., and Gruss, C.1998. Involvement of topoisomerases in the initiation of simian virus 40 minichromosome replication. J. Biol. Chem. 273: 34792–34798
  • Hammonds, T. R. and Maxwell, A. 1997. The DNA dependence of the ATPase activity of human DNA topoisomerase IIa. J. Biol. Chem. 272: 32696–32703.
  • Harkins, T. T. and Lindsley, J. E 1998. Pre- steady-state analysis of ATP hydrolysis by Saccharomyces cerevisiae DNA topoisomerase II. I A DNA-dependent burst in ATP hydrolysis. Biochemistry 37: 7292–7298.
  • Harkins, T. T., Lewis, T. J, and Lindsley, J. E 1998. Pre-steady-state analysis of ATP hydrolysis by Saccharomyces cerevisiae DNA topoisomerase II. II. Kinetic mechanism for the sequential hydrolysis of two ATP. Biochemistry 37: 7299–7312.
  • Heck, M. M. S., Hittleman, W. N, and Earnshaw, W. C 1989. In vivo phosphorylation of the 170 kDa form of eukaryotic DNA topoisomerase II. J. Biol. Chem. 264: 15161–15164.
  • Hirano, T. and Mitchison, T. J 1993. Topoisomerase II does not play a scaffolding role in the organization of mitotic chromosomes assembled in Xenopus egg extracts. J. Cell Biol. 120: 601–612.
  • Hochhauser, D., Stanway, C. A, Harris, A. L, and Hickson, I. D 1992. Cloning and characterization of the 5'-flanking region of the human topoisomerase II alpha gene. J. Biol. Chem. 267: 18961–18965.
  • Holden, J. A., Dresler, S. L, and Low, R. L 1990. Identification of DNA topoisomerase-II activity in terminally differentiated mammalian organs and in non-growing cultured cells. Enzyme 43: 197–206.
  • Holm, C., Goto, T., Wang, J. C, and Botstein, D. 1985. DNA topoisomerase II is required at the time of mitosis in yeast. Cell 41: 553–563.
  • Holm, C., Stearns, T., and Botstein, D. 1989. DNA topoisomerase II must act at mitosis to prevent nondisjunction and chromosome breakage. Mol. Cell. Biol. 9: 159–169.
  • Howard, M. T., Lee, M. P, Hsieh, T.-S., and Griffith, J. D 1991. Drosophila topoisomerase II-DNA interactions are affected by DNA structure. J. Mol. Biol. 217: 53–62.
  • Hsieh, T.-S. and Brutlag, D. 1980. ATP-de- pendent DNA topoisomerase from D. melanogaster reversibly catenates duplex DNA rings. Cell 21: 115–125.
  • Hsiung, Y., Elsea, S. H, Osheroff, N., and Nitiss, J. L 1995. A mutation in yeast TOP2 homologous to a quinolone-resistant mutation in bacteria. Mutation of the amino acid homologous to Ser83 of Escherichia coli gyrA alters sensitivity to eukaryotic topoisomerase inhibitors. J. Biol. Chem. 270: 20359–20364.
  • Hunter, T. 1987. A thousand and one protein kinases. Cell 50: 823–829.
  • Ikeda, H. 1986a. Bacteriophage T4 DNA topoisomerase mediates illegitimate recombination in vitro. Proc. Natl. Acad. Sci. U.S.A. 83: 922–926.
  • Ikeda, H. 1986b. Illegitimate recombination mediated by T4 DNA topoisomerase in vitro. Recombinants between phage and plasmid DNA molecules. Mol. Gen. Genet. 202: 518–520.
  • Ikeda, H., Aoki, K., and Naito, A. 1982. Illegitimate recombination mediated in vitro by DNA gyrase of Escherichia coli: structure of recombinant DNA molecules: Proc. Natl. Acad. Sci. U.S.A. 79: 3724–3728.
  • Isaacs, R. J., Harris, A. L, and Hickson, I. D 1996. Regulation of the human topoisomerase IIa gene promoter in confluence-arrested cells. J. Biol. Chem. 271: 16741–16747.
  • Isaacs, R. J., Davies, S. L, Sandri, M. I, Redwood, C., Wells, N. J, and Hickson, I. D 1998. Physiological regulation of eukaryotic topoisomerase II. Biochim. Biophys. Acta 1400: 121–137.
  • Ishida, R., Iwai, M., Marsh, K. L, Austin, C. A, Yano, T., Shibata, M., Najaki, N., and Hara, A. 1996. Threonine 1342 in human topoisomerase IIa is phosphorylated throughout the cell cycle. J. Biol. Chem. 271: 30077–30082.
  • Ishida, R., Sato, M., Narita, T., Utsumi, K. R, Nishimoto, T., Morita, T., Nagata, H., and Andoh, T. 1994 Inhibition of DNA topoisomerase II by ICRF 193 induces polyploidization by uncoupling chromosome dynamics from other cell cycle events. J. Cell Biol. 126:1341–1351.
  • Ishimi, Y., Sugasawa, K., Hanaoka, F., Eki, T., and Hurwitz, J. 1992. Topoisomerase II plays an essential role as a swivelase in the late stage of SV40 chromosome replication in vitro. J. Biol. Chem. 267: 462–466.
  • Jensen, S., Anderson, A.H., Kjeldsen, E., Biersack, H., Olsen, E. H. N., Andersen, T. B, Westergaard, O., and Jakobsen, B. K 1996. Analysis of functional domain organization in DNA topoisomerase II from humans and Saccharomyces cerevisiae. Mol. Cell. Biol. 16: 3866–3877.
  • Juenke, J. M. and Holden, J. A 1993. The distribution of DNA topoisomerase II isoforms in differentiated adult mouse tissues. Biochim. Biophy. Acta 1216:191–196.
  • Kas, E. and Laemmli, U. K 1992. In vivo topoisomerase II cleavage of the Droso- phila histone and satellite III repeats: DNA sequence and structural characteristics. EMBO J. 11: 705–716.
  • Kato, J., Nishimura, Y., Imamura, R., Niki, H., Hiraga, S., and Suzuki, H. 1990. New topoisomerase essential for chromosome segregation in E. coli. Cell 63: 393–404.
  • Kato, J., Suzuki, H., and Ikeda, H. 1992. Purification and characterization of DNA topoisomerase IV in Escherichia coli. J. Biol. Chem. 267: 25676–25684.
  • Kaufmann, S. H. 1998. Cell death induced by topoisomerase-targeted drugs: more questions than answers. Biochim. Biophys. Acta 1400: 195–211.
  • Kikuchi, A. and Asai, K. 1984. Reverse gyrase — a topoisomerase which introduces positive superhelical turns into DNA. Nature 309: 677–681
  • Kim, R. A. and Wang, J. C 1989a. Function of DNA topoisomerases as replication swivels in Saccharomyces cerevisiae. J. Mol. Biol. 208: 257–267.
  • Kim, R. A. and Wang, J. C, 1989b. A sub- threshold level of DNA topoisomerases leads to excision of yeast rDNA as extra- chromosomal rings. Cell 57: 975–985.
  • Kimura, K., Saijo, M., Ui, M., and Enomoto, T. 1994a. Growth state- and cell cycle-dependent fluctuation in the expression of two forms of DNA topoisomerase II and possible specific modification of the higher molecular weight form in the M phase. J. Biol. Chem. 269: 1173–1176.
  • Kimura, K., Nozaki, N., Saijo, M., Kikuchi, A., Ui, M., and Enomoto, T. 1994b. Identification of the nature of modification that causes the shift of DNA topoisomerase IIP to apparent higher molecular weight forms in the M phase. J. Biol. Chem. 269: 24523–24526
  • Kimura, K., Saijo, M., Tanaka, M., and Enomoto, T. 1996a. Phosphorylation-independent stimulation of DNA topoisomerase IIa activity. J. Biol. Chem. 271: 10990–10995.
  • Kimura, K., Nozaki, N., Enomoto, T., Tanaka, M., and Kikuchi, A. 1996b. Analysis of M phase-specific phosphorylation of DNA topoisomerase II. J. Biol. Chem. 271: 21439–21445.
  • Kingma, P. S. Corbett, A. H, Burcham, P C., Marnett, L. J, and Osheroff, N. 1995. Abasic sites stimulate double- stranded DNA cleavage mediated by topoisomerase II. DNA lesions as endogenous topoisomerase II poisons. J. Biol. Chem. 270: 21441–21444.
  • Kingma, P. S. and Osheroff, N. 1997a. Apurinic sites are position-specific topoisomerase II poisons. J. Biol. Chem. 272: 1148–1155.
  • Kingma, P. S. and Osheroff, N. 1997b. Spontaneous DNA damage stimulates topoisomerase II-mediated DNA cleavage. J. Biol. Chem. 272: 7488–7493.
  • Kingma, P. S. and Osheroff, N. 1998. The response of eukaryotic topoisomerases to DNA damage. Biochim. Biophys. Acta 1400: 223–232.
  • Klein, F., Laroche, T., Cardenas, M. E, Hofmann, J. F-X., Schweizer, D., and Gasser, S. M 1992. Localization of RAP1 and topoisomerase II in nuclei and meiotic chromosomes of yeast. J. Cell Biol. 117: 935–948.
  • Kobayashi, M., Adachi, N., and Koyama, H. 1998. Characterization of the 3' untranslated region of mouse DNA topoisomerase IIa mRNA. Gene 215: 329–337.
  • Kozyavkin, S. A., Krah, R., Gellert, M., Stetter, K. O, Lake, J. A, and Slesarev, A. I 1994. A reverse gyrase with an unusual structure. A type I DNA topoisomerase from the hyperthermophile Methanopyrus kandleri is a two-subunit protein. J. Biol. Chem. 269: 11081–11089.
  • Kroll, D. J. 1997. Homologous and heterolo- gous protein-protein interactions of human DNA topoisomerase IIa. Arch. Biochem. Biophys. 345: 175–184.
  • Kroll, D. J. and Rowe, T. C 1991. Phosphory- lation of DNA topoisomerase II in a human tumor cell line. J. Biol. Chem. 266: 7957–7961.
  • Kroll, D. J., Sullivan, D. M, Gutierrez- Hartmann, A., and Hoeffler, J. P 1993. Modification of DNA topoisomerase II activity via direct interactions with the cyclic adenosine- 3',5'-monophosphate response element-binding protein and related transcription factors. Mol. Endocrinol. 7: 305–318.
  • Kurz, E. U., Leader, K. B, Kroll, D. J, Clark, M. and Gieseler, F. 2000. Modulation of human DNA topoisomerase IIa function by interaction with 14-3-3£. J. Biol. Chem. 275:13948–13954.
  • Kwon, Y., Shin, B. S, and Chung, I. K 2000. The p53 tumor suppressor stimulates the catalytic activity of human topoisomerase IIa by enhancing the rate of ATP hydrolysis. J. Biol. Chem. 275: 18503–18510.
  • Lamhasni, S., Larsen, A. K, Barray, M., Monnot, M., Delain, E., and Fermandjian, S. 1995. Changes of self-association, secondary structure, and biological activity properties of topoisomerase II under varying salt conditions. Biochemistry 34: 3632–3639
  • Lang, A. J., Mirski, S. E. L., Cummings, H. J, Yu, Q., Gerlach, J. H, and Cole, S. P C. 1998. Structural organization of the human TOP2A and TOP2B genes. Gene 221: 255–266.
  • Larsen, A. and Skladanowski, A. 1998. Cellular resistance to topoisomerase-targeted drugs: from drug uptake to cell death. Biochim. Biophys. Acta 1400: 257–274.
  • Lassota, P., Singh, G., and Kramer, R. 1996. Mechanism of topoisomerase II inhibition by staurosporine and other protein kinase inhibitors. J. Biol. Chem. 271: 26418–26423.
  • Lee, M. P., Sander, M., and Hsieh, T.-S. 1989. Nuclease protection by Drosophila DNA toposiomerase II. J. Biol. Chem. 264: 21779–21787.
  • Leteurtre, F., Kohlhagen, G., Fesen, M. R, Tanizawa, A., Kohn, K. W, and Pommier, Y. 1994. Effects of DNA methylation on topoisomerase I and II cleavage activities. J. Biol. Chem. 269: 7893–7900.
  • Li, T-K., Chen, A. Y, Yu, C., Mao, Y., Wang, H., and Liu, L. F 1999. Activation of topoisomerase II-mediated excision of chromosomal DNA loops during oxida- tive stress. Genes Dev. 13: 1553–1560.
  • Lindsley, J. E. 1996. Intradimerically tethered DNA topoisomerase II is catalytically active in DNA transport. Proc. Natl. Acad. Sci. U.S.A. 93: 2975–2980.
  • Lindsley, J. E. and Wang, J. C 1991. Proteoly- sis patterns of epitopically labeled yeast DNA topoisomerase II suggest an allos- teric transition in the enzyme induced by ATP binding. Proc. Natl. Acad. Sci. U.S.A. 88: 10485–10489.
  • Lindsley, J. E. and Wang, J. C 1993a. Study of allosteric communication between protomers by immunotagging. Nature 361: 749–750.
  • Lindsley, J. E. and Wang, J. C 1993b. On the coupling between ATP usage and DNA transport by yeast DNA topoisomerase II. J. Biol. Chem. 268: 8096–8104.
  • Liu, L. F., Rowe, T. C, Yang, L., Tewey, K. M, and Chen, G. L 1983. Cleavage of DNA by mammalian DNA topoisomerase II. J. Biol. Chem. 258: 15365–15370.
  • Liu, L. F. and Wang, J. C 1987. Supercoiling of the DNA template during transcription. Proc. Natl. Acad. Sci. U.S.A. 84: 7024–7027.
  • Lynn, R., Giaever, G., Swanberg, S. L, and Wang, J. C 1986. Tandem regions ofyeast DNA topoisomerase II share homology with different subunits of bacterial gyrase. Science 233: 647–649.
  • Maxwell, A. and Gellert, M. 1986. Mechanistic aspects of DNA topoisomerases. Adv. Protein Chem. 38: 69–107.
  • McPherson, S. M. G. and Longo, F. J 1993. Nicking of rat spermatid and spermatozoa DNA: possible involvement of DNA topoisomerase II. Dev. Biol. 158: 122–130.
  • Melendy, T. and Ray, D. S 1989. Novobiocin affinity purification of a mitochondrial type II DNA topoisomerase from trypanosomatid Crithidia fasciculata. J. Biol. Chem. 264: 1870–1876.
  • Melendy, T., Sheline, C., and Ray, D. S 1988. Localization of a type II DNA topoisomerase to two sites at the periphery of a kinetoplast DNA of Crithidia fasciculata. Cell 55: 1083–1088.
  • Meyer, K. N., Kjeldsen, E., Straub, T., Knudsen, B. K, Kikuchi, A., Hickson, I. D, Kreipe, H., and Boege, F. 1997. Cell cycle-coupled relocation of types I and II topoisomerases and modulation of catalytic enzyme activities. J. Cell Biol. 136: 775–788.
  • Mirski, S. E. L., Gehrlach, J. H, Cummings, H. J, Zirngibl, R., Greer, P. A, and Cole, S. P C. 1997. Bipartite nuclear localization signals in the C terminus of human topoisomerase IIa. Exp. Cell Res. 237: 452–455.
  • Mo, Y.-Y. and Beck, W. T 1999. Association of human DNA topoisomerase IIa with mitotic chromosomes in mammalian cells is independent of its catalytic activity. Exp. Cell Res. 252: 50–62.
  • Moens, P. B. and Earnshaw, W. C 1989. Anti- topoisomerase II recognizes meiotic chromosome cores. Chromosoma 98: 317–322.
  • Morais Cabral, J. H., Jackson, A. P, Smith, C. V, Shikotra, N., Maxwell, A., and Liddington, R. C 1997. Crystal structure of the breakage-reunion domain of DNA gyrase. Nature 388: 903–906.
  • Nakano, H., Yamazaki, T., Miyatake, S., Nozaki, N., Kikuchi, A., and Saito, T. 1996. Specific interaction of topoisomerase IIP and the CD3 £ chain of the T cell receptor complex. J. Biol. Chem. 271: 6483–6489.
  • Nenortas, E.C., Bodley, A-L., and Shapiro, T.A. 1998. DNA topoisomerases: a new twist for antiparasitic chemotherapy. Biochim. Biophys. Acta 1400: 349–354.
  • Newport, J. 1987. Nuclear reconstitution in vitro: stages of assembly around protein-free DNA. Cell 48: 205–217.
  • Newport, J. and Spann, T. 1987. Disassembly of the nucleus in mitotic extracts: membrane vesicularization, lamin disassembly, and chromosome condensation are independent processes. Cell 48: 219–230.
  • Ng, S.-W., Eder, J. P, Scnipper, L. E, and Chan, V. T W. 1995. Molecular cloning and characterization of the promoter for the Chinese hamster DNA topoisomerase IIa gene. J. Biol. Chem. 270: 25850–25858.
  • Ng, S.-W., Liu, Y., and Schnipper, L. E 1997. Cloning and characterization of the 5'- flanking sequence for the human DNA topoisomerase IIP gene. Gene 203: 113–119.
  • Nolan, J. M., Lee, M. P, Wyckoff, E., and Hsieh, T.-S. 1986. Isolation and characterization of the gene encoding Droso- phila DNA topoisomerase II. Proc. Natl. Acad. Sci. U.S.A. 83: 3664–3668.
  • Osheroff, N., Shelton, E. R, and Brutlag, D. L 1983. DNA topoisomerase II from Drosophila melanogaster. Relaxation of supercoiled DNA. J. Biol. Chem. 258: 9536–9543.
  • Osheroff, N. 1986. Eukaryotic topoisomerase II. Characterization of enzyme turnover. J. Biol. Chem. 261: 9944–9950.
  • Pasion, S. G., Hines, J. C, Aebersold, R., and Ray, D. S 1992. Molecular cloning and expression of the gene encoding the ki- netoplast-associated type II DNA topoisomerase of Crithidia fasciculata. Mol. Biochem. Parasitol. 50: 57–67.
  • Park, S. H., Yoon, J. H, Kwon, Y. D, and Park, S. D 1993. Nucleotide sequence analysis of the cDNA for rat DNA topoisomerase II. Biochem. Biophys. Res. Comm. 193: 787–793.
  • Park, S.-H., Yoon, J. H, Cho, H.-A., Kwon, Y. D, Seong, R. H, Hong, S. H, and Park, S. D 1995. Isolation and characterization of the promoter region of rat DNA topoisomerase IIa gene. J. Biochem. 118: 725–733.
  • Pommier, Y., Zwelling, L. A, Kao-Shan, C.-S., Whang-Peng, J., and Bradley, M. O 1985. Correlations between intercalator-induced DNA strand breaks and sister chromatid exchanges, mutations, and cytotoxicity in Chinese hamster cells. Cancer Res. 45: 3143–3149.
  • Pommier, Y., Kerrigan, D., Schwartz, R. E, Swack, J. A, and McCurdy, A. 1986. Altered DNA topoisomerase II activity in Chinese hamster cells resistant to topoisomerase II inhibitors. Cancer Res. 46: 3075–3081.
  • Rattner, J. B., Hendzel, M. J, Furbee, C. S, Muller, M. T, and Bazett-Jones, D. P 1996. Topoisomerase IIa is associated with the mammalian centromere in a cell cycle- and species-specific manner and is required for proper centromere/ kinetochore structure. J. Cell Biol. 134: 1097–1107.
  • Reddy, M. K., Nair, S., Tewari, K. K, Mudgil, Y., Yadav, B. S, and Sopory, S. K 1999. Cloning and characterization of a cDNA encoding topoisomerase II in pea and analysis of its expression in relation to cell proliferation. Plant Mol. Biol. 41: 125–137.
  • Redwood, C., Davies, S. L, Wells, N. J, Fry, A. M, and Hickson, I. D 1998. Casein ki- nase II stabilizes the activity of human topoisomerase IIa in a phosphorylation- independent manner. J. Biol. Chem. 273: 3635–3642.
  • Riou, J. F., Gabillot, M., Phillipe, M., Schrevel, J., and Riou, G. 1986. Purification and characterization of Plasmodium berghei DNA topoisomerase I and II: drug action, inhibition of decatenation and relaxation, and stimulation of DNA cleavage. Biochemistry 25:1471–1479.
  • Ritke, M. K., Allan, W. P, Fattman, C., Gunduz, N., and Yalowich, J. C 1994. Reduced phosphorylation of topoisomerase II in etoposide-resistant human leukemia K562 cells. Mol. Pharmacol. 46: 58–66.
  • Roberge, M., Th'ng, J., Hamaguchi, J., and Bradbury, E. M 1990. The topoisomerase II inhibitor VM-26 induces marked changes in histone H1 kinase activity, hi- stones H1 and H3 phosphorylation, and chromosome condensation in G2 phase and mitotic BHK cells. J. Cell Biol. 111: 1753–1762.
  • Robinson, M. J. and Osheroff, N. 1991. Effects of antineoplastic drugs on the post-strand- passage DNA cleavage/religation equilibrium of topoisomerase II. Biochemistry 30:1807–1813.
  • Robinson, M. J., Corbett, A. H, and Osheroff, N. 1993. Effects of topoisomerase II-targeted drugs on enzyme-mediated DNA cleavage and ATP hydrolysis: evidence for distinct drug interaction domains on topoisomerase II. Biochemistry 32: 3638–3643.
  • Roca, J. 1995. The mechanisms of DNA topoisomerases. Trends Biochem. Sci. 20: 156–160.
  • Roca, J. and Wang, J. C 1992 The capture of a DNA double helix by an ATP-dependent protein clamp: a key step in DNA transport by type II DNA topoisomerases. Cell 71: 833–840.
  • Roca, J. and Wang, J. C 1994. DNA transport by a type II DNA topoisomerase: evidence in favor of a two-gate mechanism. Cell 77: 609–616.
  • Roca, J., Berger, J. M, and Wang, J. C 1993. On the simultaneous binding of eukary- otic DNA topoisomerase II to a pair of double-stranded DNA helices. J. Biol. Chem. 268: 14250–14255.
  • Roca, J., Ishida, R., Berger, J. M, Andoh, T., and Wang, J. C 1994. Antitumor bisdioxopiperazines inhibit yeast DNA topoisomerase II by trapping the enzyme in the form of a closed protein clamp. Proc. Natl. Acad. Sci. U.S.A. 91: 1781–1785.
  • Roca, J., Berger, J. M, Harrison, S. C, and Wang, J. C 1996. DNA transport by a type II topoisomerase: direct evidence for a two-gate mechanism. Proc. Natl. Acad. Sci. U.S.A. 93: 4057–4062.
  • Rose, D., Thomas, W., and Holm, C. 1990. Segregation of recombined chromosomes in meiosis I requires topoisomerase II. Cell 60: 1007–1017.
  • Rottmann, M., Schroder, H C., Gramzow, M., Renneisen, K., Kurelec, B., Dorn, A., Friese, U., and Muller, W. E G. 1987. Specific phosphorylation of proteins in pore complex-laminae from the sponge Geodia cydonium by the homologous aggregation factor and phorbol ester. Role of protein kinase C in the phosphorylation of DNA topoisomerase II. EMBO J. 6: 3939–3944.
  • Saijo, M., Enomoto, T., Hanaoka, F., and Ui, M. 1990. Purification and characterization of type II DNA topoisomerase from mouse FM3A cells: phosphorylation of topoisomerase II and modification of its activity. Biochemistry 29: 583–590.
  • Sander, M. and Hsieh, T.-S. 1983. Double strand DNA cleavage by type II DNA topoisomerase from Drosophilamelanogaster. J. Biol. Chem. 258: 8421–8428.
  • Sander, M., Nolan, J. M, and Hsieh, T.-S. 1984. A protein kinase activity tightly associated with Drosophila type II DNA topoisomerase. Proc. Natl. Acad. Sci. U.S.A. 81: 6938–6942.
  • Sander, M. and Hsieh, T.-S. 1985. Drosophila topoisomerase II double-strand DNA cleavage: analysis of DNA sequence ho- mology at the cleavage site. Nucleic Acids. Res. 13: 1057–1072.
  • Sander, M., Hsieh, T.-S., Udvardy, A., and Schedl, P. 1987. Sequence dependence of Drosophila topoisomerase II in plasmid relaxation and DNA binding. J. Mol. Biol. 194: 219–229.
  • Sandri, M. I., Isaacs, R. J, Ongkeko, W. M, Harris, A. L, Hickson, I. D, Broggini, M., and Vikhanskaya, F. 1996 p53 regulates the minimal promoter of the human topoisomerase IIa gene. Nucleic Acids Res. 24: 4464–4470.
  • Schultz, M. C., Brill, S. J, Ju, Q., Sternglanz, R., and Reeder, R. H 1992. Topoisomerases and yeast rRNA transcription: negative super- coiling stimulates initiation and topoisomerase activity is required for elongation. Genes Dev. 6: 1332–1341.
  • Schultz, P., Olland, S., Oudet, P., and Hancock, R. 1996. Structure and conformational changes in DNA topoisomerase II visualized by electron microscopy. Proc. Natl. Acad. Sci. U.S.A. 93: 5936–5940.
  • Scovassi, A. I., Mariani, C., Negroni, M., Negri, C., and Bertazzoni, U. 1993. ADP- ribosylation of nonhistone proteins in HeLa cells: modification of DNA topoisomerase II. Exp. Cell Res. 206: 177–181.
  • Shamu, C. E. and Murray, M. W 1992. Sister chromatid separation in frog egg extracts requires DNA topoisomerase II activity during anaphase. J. Cell. Biol. 117: 921–934.
  • Shapiro, P. S., Whalen, A. M, Tolwinski, N. S, Wilsbacher, J., Froelich-Ammon, S. J, Garcia, M., Osheroff, N., and Ahn, N. G 1999 Extracellular signal-regulated kinase activates topoisomerase IIa through a mechanism independent of phosphoryla- tion. Mol. Cell. Biol. 19: 3551–3560.
  • Shapiro, T. A. and Englund, P. T 1990. Selective cleavage of kinetoplast DNA minicircles promoted by antitrypanosomal drugs. Proc. Natl. Acad. Sci. U.SA. 87: 950–954.
  • Shelton, E. R., Osheroff, N., and Brutlag, D. L 1983. DNA topoisomerase II from Droso- phila melanogaster. Purification and physical characterization. J. Biol. Chem. 258: 9530–9535.
  • Shiozaki, K. and Yanagida, M. 1991. A functional 125-kDa core polypeptide of fission yeast DNA topoisomerase II. Mol. Cell. Biol. 11: 6093–6102.
  • Shiozaki, K. and Yanagida, M. 1992. Functional dissection of the phosphorylated termini of fission yeast DNA topoisomerase II. J. Cell Biol. 119: 1023–1036.
  • Shlomai, J., Zadok, A., and Frank, D. 1984. A unique ATP-dependent DNA topoisomerase from trypanosomatids. Adv. Exp. Med. Biol. 179: 409–422.
  • Sinclair, D. A. and Guarente, L. 1997. Extrachoromosomal rDNA circles cause aging in yeast. Cell 91: 1033–1042.
  • Snapka, R. M., Powelson, M. A, and Strayer, J. M 1988. Swiveling and decatenation of replicating simian virus 40 genomes in vivo. Mol. Cell. Biol. 8: 515–521.
  • SOrensen, B. S., Jensen, P. S, Andersen, A. S, Christiansen, K., Alsner, J., Thomsen, B., and Westergaard, O. 1990. Stimulation of topoisomerase II mediated DNA cleavage at specific sequence elements by the 2- nitroimidazole Ro 15-0216. Biochemistry 29: 9507–9515.
  • SOrensen, B. S., Sinding, J., Andersen, A. S, Alsner, J., Jensen, P. B, and Westergaard, O. 1992. Mode of action of topoisomerase II-targeting agents at a specific DNA sequence. J. Mol. Biol. 228: 778–786.
  • Spell, R. M. and Holm, C. 1994. Nature and distribution of chromosomal intertwinings in Saccharomyces cerevisiae. Mol. Cell. Biol. 14: 1465–1476.
  • Spitzner, J. R. and Muller, M. T 1988. A consensus sequence for cleavage by vertebrate DNA topoisomerase II: Nucleic Acids Res. 16: 5533–5556.
  • Spitzner, J. R., Chung, I. K, and Muller, M. T 1990. Eukaryotic topoisomerase II preferentially cleaves alternating purine-py- rimidine repeats. Nucleic Acids Res. 18: 1–11.
  • Spitzner, J. R., Chung, I. K, Gootz, T. D, McGuirk, P. R, and Muller, M. T 1995. Analysis of eukaryotic topoisomerase II cleavage sites in the presence of the quinolone CP-115,953 reveals drug-dependent and -independent recognition elements. Mol. Pharmacol. 48: 238–249.
  • Strauss, P. R. and Wang, J. C 1990. The TOP2 gene of Trypanosoma brucei: a single copy gene that shares extensive homology with other TOP2 genes encoding eukaryotic topoisomerase II.Mol. Biochem. Parasitol. 38: 141–150.
  • Sundin, O. and Varshavsky, A. 1981. Arrest of segregation leads to accumulation of highly intertwined catenated dimers: dissection of the final stages of SV40 DNA replication. Cell 25: 659–669.
  • Swedlow, J. R., Sedat, J. W, and Agard, D. A 1993. Multiple chromosomal populations of topoisomerase II detected in vivo by time-lapse, three-dimensional wide-field microscopy. Cell 73: 97–108.
  • Taagepera, S., Rao, P. N, Drake, F. H, and Gorbsky, G. J 1993. DNA topoisomerase II alpha is the major chromosome protein recognized by the mitotic phosphoprotein antibody MPM-2. Proc. Natl. Acad. Sci. U.SA. 90: 8407–8411.
  • Tan, K. B., Dorman, T. E, Falls, K. M, Chung, T. D. Y., Mirabelli, C. K, Crooke, S. T, and Mao, J. 1992. Topoisomerase IIa and topoisomerase IIP genes: characterization and mapping to chromosomes 17 and 3, respectively. Cancer Res. 52: 231–234.
  • Tennyson, R. and Lindsley, J. E 1997. Type II DNA topoisomerase from Saccharomyces cerevisiae is a stable dimer. Biochemistry 36: 6107–6114.
  • Tewey, K. M., Chen, G. L, Nelson, E. M, and Liu, L. F 1984. Intercalative antitu- mor drugs interfere with the breakage- reunion reaction of mammalian DNA topoisomerase II. J. Biol. Chem. 259: 9182–9187.
  • Thomas, W., Spell, R. M, Ming, M. E, and Holm, C. 1991. Genetic analysis of the gyrase A-like domain of DNA topoisomerase II of Saccharomyces cerevisiae. Genetics 128: 703–716.
  • Thomsen, B., Bendixen, C., Lund, K., Andersen, A., Sorensen, B. S, and Westergaard, O. 1990. Characterization of the interaction between topisomerase II and DNA by transcriptional footprinting. J. Mol. Biol. 215: 237–244.
  • Tsai-Pflugfelder, M., Liu, L. F, Liu, A. A, Tewey, K. M, Whang-Peng, J., Knutsen, T., Huebner, K., Croce, C. M, and Wang, J. C 1988. Cloning and sequencing of cDNA encoding human DNA topoisomerase II and localization of the gene to chromosome region 17q21-22. Proc. Natl. Acad. Sci. U.S.A. 85: 7177–7181.
  • Tsutsui, K., Tsutsui, K., Okada, S., Watanabe, M., Shohmori, T., Seki, S., and Inoue, Y. 1993. Molecular cloning of partial cDNAs for rat DNA topoisomerase II isoforms and their differential expression in brain development. J. Biol. Chem. 268: 19076–19083.
  • Udvardy, A., Schedl, P., Sander, M., and Hsieh, T.-S. 1986. Topoisomerase II cleavage in chromatin. J. Mol. Biol. 191: 231–246.
  • Udvardy, A. and Schedl, P. 1991. Chromatin structure, not DNA sequence specificity, is the primary determinant of topoisomerase II sites of action in vivo. Mol. Cell. Biol. 11: 4973–4984
  • Udvardy, A. and Schedl, P. 1993. The dynamics of chromatin condensation: redistribution of topoisomerase II in the 87A7 heat shock locus during induction and recovery. Mol. Cell. Biol. 13: 7522–7530.
  • Uemura, T. and Yanagida, M. 1986. Mitotic spindle pulls but fails to separate chromosomes in type II DNA topoisomerase mutants: uncoordinated meiosis. EMBO J. 5: 1003–1010
  • Uemura, T., Morikawa, K., and Yanagida, M. 1986. The nucleotide sequence of the fission yeast DNA topoisomerase II gene: structural and functional relationships to other DNA topoisomerases. EMBO J. 5: 2355–2361.
  • Uemura, T., Ohkura, H., Adachi, Y., Morino, K., Shizoki, K., and Yanagida, M. 1987. DNA topoisomerase II is required for condensation and separation of mitotic chromosomes in Schizosaccharomyves pombe. Cell 50: 917–925.
  • Vassetzky, Y. S., Dang, Q., Benedetti, P., and Gasser, S. M 1994. Topoisomerase II forms multimers in vitro: effects of metals, P-glycerophosphate, and phosphorylation of its C-terminal domain. Mol. Cell. Biol. 14: 6962–6974.
  • Vinograd, J., Lebowitz, R., Radloff, R., Watson, R., and Laipis, P. 1965. The twisted circular form of polyoma viral DNA. Proc. Natl. Acad. Sci. U.S.A. 53: 1104–1111.
  • Wang, J. C. 1971. Interaction between DNA and Escherichia coli protein w. J. Mol. Biol. 55: 523–533.
  • Wang, J. C. 1985. DNA topoisomerases. Annu. Rev. Biochem. 54: 665–697.
  • Wang, J. C. 1987. DNA topoisomerases: nature's solution to the topological ramifications of the double-helix structure of DNA. Harvey Lectures 81: 93–110.
  • Wang, J. C. 1996. DNA topoisomerases. Annu. Rev. Biochem. 65: 635–692.
  • Wang, J. C. 1997. DNA topoisomerases. New break for archaeal enzyme. Nature 386: 329–330.
  • Wang, Q. J., Zambetti, G. P, and Suttle, D. P 1997. Inhibition of DNA topoisomerase II alpha gene expression by the p53 tumor suppressor. Mol. Cell. Biol. 17: 389–397.
  • Wang, X., Watt, P. M, Louis, E. J, Borts, R. H, and Hickson, I. D 1996. Pat1: a topoisomerase II-associated protein required for faithful chromosome transmission in Saccharomyces cerevisiae. Nucleic Acids Res. 24: 4791–4797.
  • Warburton, P. E. and Earnshaw, W. C 1997. Untangling the role of DNA topoisomerase II in mitotic chromosome structure and function. BioEssays 19: 97–99.
  • Watt, P. M. and Hickson, I. D 1994. Structure and function of type II DNA topoisomerases. Biochem. J. 303: 681–695.
  • Watt, P. M., Louis, E. J, Borts, R. H, and Hickson, I. D 1995. Sgs1: a eukaryotic homolog of E. coli RecQ that interacts with topoisomerase II in vivo and is required for faithful chromosome segregation. Cell 81: 253–260.
  • Weil, R. and Vinograd, J. 1963. The cyclic helix and cyclic coil forms of polyoma viral DNA. Proc. Natl. Acad. Sci. U.SA. 50: 730–738.
  • Wells, N. J., Addison, C. M, Fry, A. M, Ganapathi, R., and Hickson, I. D 1994. Serine 1524 is a major site of phosphory- lation on human topoisomerase II alpha protein in vivo and is a substrate for casein kinase II in vitro. J. Biol. Chem. 269: 29746–29751.
  • Wells, N. J., Fry, A. M, Guano, F., Norbury, C., and Hickson, I. D 1995. Cell cycle phase- specific phosphorylation of human topoisomerase II alpha. Evidence of a role for protein kinase C. J. Biol. Chem. 270: 28357–28363.
  • Wells, N. J. and Hickson, I. D 1995. Human toposiomerase IIa is phosphorylated in a cell-cycle phase-dependent manner by a proline-directed kinase. Eur. J. Biochem. 231: 491–497
  • Wells, N. J. and Hickson, I. D 1995 Human topoisomerase IIa is phosphorylated in a cell-cycle phase-dependent manner by a proline-directed kinase. Eur. J. Biochem. 231: 491–497.
  • Whalen, A. M., McConnell, M., and Fisher, P. A 1991. Developmental regulation of Drosophila DNA topoisomerase II. J. Cell Biol 112: 203–213.
  • Wigley, D. B. 1996. A wasp head with a relaxing bite. Structure 4: 117–120.
  • Wood, E. R. and Earnshaw, W. C 1990. Mitotic chromatin condensation in vitro using somatic cell extracts and nuclei with variable levels of endogenous topoisomerase II. J. Cell Biol. 111: 2839–2850.
  • Wyckoff, E., Natalie, D., Nolan, J. M, Lee, M., and Hsieh, T.-S. 1989. Structure of the Drosophila DNA topoisomerase II gene. Nucleotide sequence and homology among topoisomerases II. J. Mol. Biol. 205: 1–13.
  • Xie, S. and Lam, E. 1994a. Characterization of a DNA topoisomerase II cDNA from Arabidopsis thaliana. Plant Mol. Biol. 106: 1701–102.
  • Xie, S. and Lam, E. 1994b. Abundance of nuclear DNA topoisomerase is correlated with proliferation in Arabidopsis thaliana. Nucleic Acids Res. 22: 5729–5736.
  • Yang, L., Wold, M. S, Li, J. J, Kelly, T. J, and Liu, L. F 1987. Roles of DNA topoisomerases in simian virus 40 DNA replication in vitro. Proc. Natl. Acad. Sci. U.S.A. 84: 950–954.
  • Yang, X., Li., W., Prescott, E. D, Burden, S. J, and Wang, J. C 2000. Topoisomerase IIP and neural development. Science 287: 131–134.
  • Yoon, J. H., Park, S. -H., Cho, H. -A., Seong, R. H, Hong, S. H, and Park, S. D 1996. Complementation of a yeast top2ts mutation by a cDNA encoding rat DNA topoisomerase IIa. Mol. Gen. Genet. 253: 81–88.
  • Yoon, H. J., Choi, I. Y, Kang, M. R, Kim, S. S, Muller, M. T, Spitzner, J. R, and Chung, I. K 1998. DNA topoisomerase II cleavage of telomeres in vitro and in vivo. Biochim. Biophys. Acta 1395: 110–120.
  • Yoon, J. H., Kim, J. K, Rha, G. B, Oh, M., Park, S.-H., Seong, R. H, Hong, S. H, and Park, S. D 1999. Sp1 mediates cell proliferation-dependent regulation of rat DNA topoisomerase IIa gene promoter. Biochem. J. 344: 367–374.
  • Zechiedrich, E. L., Christiansen, K., Andersen, A. H, Westergaard, O., and Osheroff, N. 1988. Double-stranded DNA cleavage/ religation reaction of eukaryotic topoisomerase II: evidence for a nicked DNA intermediate. Biochemistry 28: 6229–6236.
  • Zechiedrich, E. L. and Osheroff, N. 1990. Eu- karyotic topoisomerases recognize nucleic acid topology by preferentially interacting with DNA crossovers. EMBO J. 9: 4555–4562.
  • Zhou, R.-H., Wang, P., Zou, Y., Jackson-Cook, C. K, and Povirk, L.F. 1997. A precise interchromosomal reciprocal exchange between hot spots for cleavable complex formation by topoisomerase II in amsacrine- treated Chinese hamster ovary cells. Cancer Res. 57: 4699–4702.

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