In neonates with vitamin D deficiency, low lymphocyte activation markers are risk factors for infection

References

• Holick MF. High prevalence of vitamin D inadequacy and implications for health. Mayo Clin Proc. 2016;81:353–373.
   Google Scholar
• van der Meer IM, Middelkoop BJ, Boeke AJ, et al. Prevalence of vitamin D deficiency among Turkish, Moroccan, Indian and sub-Sahara African populations in Europe and their countries of origin: an overview. Osteoporos Int. 2011;22:1009–1021.
   PubMed Web of Science ®Google Scholar
• Khalesi N, Bahaeddini SM, Shariat M. Prevalence of maternal vitamin D deficiency in neonates with delayed hypocalcaemia. Acta Med Iran. 2012;50:740–745.
   PubMedGoogle Scholar
• Clancy N, Onwuneme C, Carroll A, et al. Vitamin D and neonatal immune function. J Matern Fetal Neonatal Med. 2013;26:639–646.
   PubMed Web of Science ®Google Scholar
• Karatekin G, Kaya A, Salihog O, et al. Association of subclinical vitamin D deficiency in newborns with acute lower respiratory infection and their mothers. Eur J Clin Nutr. 2009;63:473–477.
   PubMed Web of Science ®Google Scholar
• Chiu CY, Yao TC, Chen SH, et al. Low cord blood vitamin D levels are associated with increased milk sensitization in early childhood. Pediatr Allergy Immunol. 2014;25:767–772.
   PubMed Web of Science ®Google Scholar
• Hewison M. Vitamin D and innate and adaptive immunity. Vitam Horm. 2011;86:23–62.
   PubMed Web of Science ®Google Scholar
• Chen S, Sims GP, Chen XX, et al. Modulatory effects of 1,25-dihydroxyvitamin D 3 on human B cell differentiation. J Immunol. 2007;179:1634–1647.
   PubMed Web of Science ®Google Scholar
• Veldman CM, Cantorna MT, DeLuca HF. Expression of 1, 25-dihydroxyvitamin D(3) receptor in the immune system. Arch Biochem Biophys. 2000;374:334–338.
   PubMed Web of Science ®Google Scholar
• von Essen MR, Kongsbak M, Schjerling P, et al. Vitamin D controls T cell antigen receptor signalling and activation of human T cells. Nat Immunol. 2010;11:344–349.
   PubMed Web of Science ®Google Scholar
• Reddy M, Eirikis E, Davis C, et al. Comparative analysis of lymphocyte activation marker expression and cytokine secretion profile in stimulated human peripheral blood mononuclear cell cultures: an in vitro model to monitor cellular immune function. J Immunol Methods. 2004;293:127–142.
   PubMed Web of Science ®Google Scholar
• López-Cabrera M, Muñoz E, Blázquez MV, et al. Transcriptional regulation of the gene encoding the human C-type lectin leukocyte receptor AIM/CD69 and functional characterization of its tumor necrosis factor-alpha-responsive elements. J Biol Chem. 1995;270:21545–21551.
   PubMed Web of Science ®Google Scholar
• Cérbulo-Vázquez A, Valdés-Ramos R, Santos-Argumedo L. Activated umbilical cord blood cells from pre-term and term neonates express CD69 and synthesize IL-2 but are unable to produce IFN-γ. Arch Med Res. 2003;34:100–105.
   PubMed Web of Science ®Google Scholar
• Hodge G, Hodge S, Han P, et al. Multiple leukocyte activation markers to detect neonatal infection. Clin Exp Immunol. 2004;135:125–129.
   PubMed Web of Science ®Google Scholar
• Jackson AL, Matsumoto H, Janszen M, et al. Restricted expression of p55 interleukin 2 receptor (CD25) on normal T cells. Clin Immunol Immunopathol. 1990;54:126–133.
   PubMedGoogle Scholar
• Shevach EM. CD4 + CD25 + suppressor T cells: more questions than answers. Nat Rev Immunol. 2002;2:389–402.
   PubMed Web of Science ®Google Scholar
• Tomkinson BE, Wagner DK, Nelson DL, et al. Activated lymphocytes during acute Epstein–barr virus infection. J Immunol. 1987;139:3802.
   PubMed Web of Science ®Google Scholar
• Opie TM, Shields LE, Andrews RG. Cell surface antigen expression in early and term gestation fetal hematopoietic progenitor cells. Stem Cells. 1998;16:343–348.
   PubMed Web of Science ®Google Scholar
• Holling TM, van der Stoep N, Quinten E, et al. Activated human T cells accomplish MHC class II expression through T cell-specific occupation of class II transactivator promoter III. J Immunol. 2002;168:763–770.
   PubMed Web of Science ®Google Scholar
• Saint-Paul L, Nguyen CH, Buffière A, et al. CD45 phosphatase is crucial for human and murine acute myeloid leukemia maintenance through its localization in lipid rafts. Oncotarget. 2016;7:64785–64797.
   PubMedGoogle Scholar
• Hermiston ML, Xu Z, Weiss A. CD45: a critical regulator of signalling thresholds in immune cells. Ann Rev Immunol. 2003;21:107–137.
   PubMed Web of Science ®Google Scholar
• Sava F, Toldi G, Treszl A, et al. Expression of lymphocyte activation markers of preterm neonates is associated with perinatal complications. BMC Immunol. 2016;17:19.
   PubMed Web of Science ®Google Scholar
• Polin RA. Management of neonates with suspected or proven early-onset bacterial sepsis. Pediatrics. 2012;129:1006–1015.
   PubMed Web of Science ®Google Scholar
• Thorne-Lyman A, Fawzi W. Vitamin D during pregnancy and maternal, neonatal and infant health outcomes: a systematic review and meta-analysis. Pediatr Perinat Epidemiol. 2012;26:75–90.
   PubMed Web of Science ®Google Scholar
• Munns C, Zacharin MR, Rodda CP, et al. Prevention and treatment of infant and childhood vitamin D deficiency in Australia and New Zealand: a consensus statement. Med J Aust. 2006;185:268–272.
   PubMed Web of Science ®Google Scholar
• Edmond K, Zaidi A. New approaches to preventing, diagnosing, and treating neonatal sepsis. PLoS Med. 2010;7:e1000213.
   PubMed Web of Science ®Google Scholar
• Thorne-Lyman A, Fawzi W. Vitamin D during pregnancy and maternal, neonatal and infant health outcomes: asystematic review and meta-analysis. Pediatr Perinat Epidemiol. 2012;26:75–90.
   PubMed Web of Science ®Google Scholar
• Cantorna MT, Snyder L, Lin YD, et al. Vitamin D and 1,25(OH)2D regulation of T cells. Nutrients. 2015;7:3011–3021.
   PubMed Web of Science ®Google Scholar
• Swain SL, McKinstry KK, Strutt TM. Expanding roles for CD4(+) t cells in immunity to viruses. Nat Rev Immunol. 2012;12:136–148.
   PubMed Web of Science ®Google Scholar
• Huang Y, Fu L, Yang Y. Age-related vitamin D deficiency is associated with the immune response in children with community-acquired pneumonia. J Nutr Sci Vitaminol (Tokyo). 2017;63:1–7.
   PubMed Web of Science ®Google Scholar
• Khoo AL, Koenen HJ, Chai LY, et al. Seasonal variation in vitamin D3 levels is paralleled by changes in the peripheral blood human T cell compartment. PLoS One. 2012;7:e29250.
   PubMed Web of Science ®Google Scholar
• Sava F, Treszl A, Hajdú J, et al. Plasma vitamin D levels at birth and immune status of preterm infants. Immunobiology. 2016;221:1289–1292.
   PubMed Web of Science ®Google Scholar
• Terrier B, Derian N, Schoindre Y, et al. Restoration of regulatory and effector T cell balance and B cell homeostasis in systemic lupus erythematosus patients through vitamin D supplementation. Arthritis Res Ther. 2012;14:R221.
   PubMed Web of Science ®Google Scholar
• Ma YH, Zhou YL, Yue CY, et al. Vitamin D deficiency contributes to the reduction and impaired function of naïve CD45RA⁺ regulatory T cell in chronic heart failure. J Immunol Res. 2015;2015:547697.
   Google Scholar
• Jeffery LE, Burke F, Mura M, et al. 1,25 dihydroxy vitamin D3 and IL-2 combine to inhibit T cell production of inflammatory cytokines and promote development of regulatory T cells expressing CTLA-4 and FoxP3. J Immunol. 2009;183:5458–5467.
   PubMed Web of Science ®Google Scholar
• Morales-Tirado V, Wichlan DG, Leimig TE, et al. 1 alpha, 25-dihydroxy vitamin D3 (vitamin D3) catalyzes suppressive activity on human natural regulatory T cells, uniquely modulates cell cycle progression, and augments FOXP3. Clin Immunol. 2011;138:212–221.
   PubMed Web of Science ®Google Scholar
• Chen J, Bruce D, Cantorna MT. Vitamin D receptor expression controls proliferation of naïve CD8+ T cells and developmentof CD8 mediated gastrointestinal inflammation. BMC Immunol. 2014;15:6.
   PubMed Web of Science ®Google Scholar
• Ritterhouse LL, Lu R, Shah HB, et al. Vitamin D deficiency in a multiethnic healthy control cohort and altered immune response in vitamin D deficient European-American kealthy controls. PLoS One. 2014;9:e94500.
   PubMed Web of Science ®Google Scholar
• Cetinkaya M, Cekmez F, Buyukkale G, et al. Lower vitamin D levels are associated with increased risk of early-onset neonatal sepsis in term infants. J Perinatol. 2015;35:39–45.
   PubMed Web of Science ®Google Scholar
• Yang LR, Li H, Yang TY, et al. Relationship between vitamin D deficiency and early-onset neonatal sepsis. Zhongguo Dang Dai Er Ke Za Zhi. 2016;18:791–795.
   PubMedGoogle Scholar
• Caudy AA, Reddy ST, Chatila T, et al. CD25 deficiency causes an immune dysregulation, polyendocrinopathy, enteropathy, X-linked-like syndrome, and defective IL-10 expression from CD4 lymphocytes. J Allergy Clin Immunol. 2007;119:482–487.
   PubMed Web of Science ®Google Scholar
• Palojärvi A, Petäjä J, Siitonen S, et al. Low monocyte HLA-DR expression as an indicator of immunodepression in very low birth weight infants. Pediatr Res. 2013;73:469–475.
   PubMed Web of Science ®Google Scholar