The dual role of NK cells in antitumor reactions triggered by ionizing radiation in combination with hyperthermia

References

• Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011; 144:646-74; PMID:21376230; http://dx.doi.org/10.1016/j.cell.2011.02.013
   PubMed Web of Science ®Google Scholar
• Kroemer G, Galluzzi L, Kepp O, Zitvogel L. Immunogenic cell death in cancer therapy. Ann Rev Immunol 2013; 31:51-72; PMID:23157435; http://dx.doi.org/10.1146/annurev-immunol-032712-100008
   PubMed Web of Science ®Google Scholar
• Van Cruchten S, Van Den Broeck W. Morphological and biochemical aspects of apoptosis, oncosis and necrosis. Anatomia Histologia Embryologia 2002; 31:214-23; PMID:12196263; http://dx.doi.org/10.1046/j.1439-0264.2002.00398.x
   PubMed Web of Science ®Google Scholar
• Vande Walle L, Lamkanfi M. Inflammasomes: caspase-1-activating platforms with critical roles in host defense. Front Microbiol 2011; 2:3; PMID:21687402; http://dx.doi.org/10.3389/fmicb.2011.00003
   PubMed Web of Science ®Google Scholar
• Chera S, Buzgariu W, Ghila L, Galliot B. Autophagy in Hydra: a response to starvation and stress in early animal evolution. Biochimica Et Biophysica Acta 2009; 1793:1432-43; PMID:19362111; http://dx.doi.org/10.1016/j.bbamcr.2009.03.010
   PubMed Web of Science ®Google Scholar
• Kaczmarek A, Vandenabeele P, Krysko DV. Necroptosis: the release of damage-associated molecular patterns and its physiological relevance. Immunity 2013; 38:209-23; PMID:23438821; http://dx.doi.org/10.1016/j.immuni.2013.02.003
   PubMed Web of Science ®Google Scholar
• Schorn C, Janko C, Latzko M, Chaurio R, Schett G, Herrmann M. Monosodium urate crystals induce extracellular DNA traps in neutrophils, eosinophils, and basophils but not in mononuclear cells. Front Immunol 2012; 3:277; PMID:22969769; http://dx.doi.org/10.3389/fimmu.2012.00277
   PubMed Web of Science ®Google Scholar
• Zitvogel L, Hannani D, Aymeric L, Kepp O, Martins I, Kroemer G. Antitumoral immunization during cancer chemotherapy. Bull Acad Natl Med 2012; 196:1075-86; PMID:23596856
   PubMed Web of Science ®Google Scholar
• Honeychurch J, Dive C, Illidge TM. Synchronous apoptosis in established tumors leads to the induction of adaptive immunity. Oncoimmunol 2013; 2:e24501; PMID:23894711; http://dx.doi.org/10.4161/onci.24501
   Google Scholar
• Inoue H, Tani K. Multimodal immunogenic cancer cell death as a consequence of anticancer cytotoxic treatments. Cell Death Differ 2014; 21:39-49; PMID:23832118; http://dx.doi.org/10.1038/cdd.2013.84
   PubMed Web of Science ®Google Scholar
• Frey B, Rubner Y, Kulzer L, Werthmoller N, Weiss EM, Fietkau R, Gaipl US. Antitumor immune responses induced by ionizing irradiation and further immune stimulation. Cancer Immunol Immunother 2014; 63:29-36; PMID:24052136; http://dx.doi.org/10.1007/s00262-013-1474-y
   PubMed Web of Science ®Google Scholar
• Tan SM, Kapp M, Flechsig C, Kapp K, Rachor JE, Eyrich M, Loeffler J, Einsele H, Grigoleit GU. Stimulating surface molecules, Th1-polarizing cytokines, proven trafficking–a new protocol for the generation of clinical-grade dendritic cells. Cytotherapy 2013; 15:492-506; PMID:23480952; http://dx.doi.org/10.1016/j.jcyt.2012.12.002
   PubMed Web of Science ®Google Scholar
• Multhoff G, Botzler C, Wiesnet M, Muller E, Meier T, Wilmanns W, Issels RD. A stress-inducible 72-kDa heat-shock protein (HSP72) is expressed on the surface of human tumor cells, but not on normal cells. Int J Cancer J Int Du Cancer 1995; 61:272-9; PMID:7705958; http://dx.doi.org/10.1002/ijc.2910610222
   PubMed Web of Science ®Google Scholar
• Gehrmann M, Marienhagen J, Eichholtz-Wirth H, Fritz E, Ellwart J, Jaattela M, Zilch T, Multhoff G. Dual function of membrane-bound heat shock protein 70 (Hsp70), Bag-4, and Hsp40: protection against radiation-induced effects and target structure for natural killer cells. Cell Death Differ 2005; 12:38-51; PMID:15592361; http://dx.doi.org/10.1038/sj.cdd.4401510
   PubMed Web of Science ®Google Scholar
• Schmitt E, Gehrmann M, Brunet M, Multhoff G, Garrido C. Intracellular and extracellular functions of heat shock proteins: repercussions in cancer therapy. J Leukocyte Biol 2007; 81:15-27; PMID:16931602; http://dx.doi.org/10.1189/jlb.0306167
   PubMed Web of Science ®Google Scholar
• Delaney G, Jacob S, Featherstone C, Barton M. The role of radiotherapy in cancer treatment: estimating optimal utilization from a review of evidence-based clinical guidelines. Cancer 2005; 104:1129-37; PMID:16080176; http://dx.doi.org/10.1002/cncr.21324
   PubMed Web of Science ®Google Scholar
• Wang H, Yu KN, Hou J, Liu Q, Han W. Radiation-induced bystander effect: Early process and rapid assessment. Cancer Lett 2015; 356:137-44; PMID:24139967; http://dx.doi.org/10.1016/j.canlet.2013.09.031
   PubMed Web of Science ®Google Scholar
• Gaipl US, Multhoff G, Scheithauer H, Lauber K, Hehlgans S, Frey B, Rodel F. Kill and spread the word: stimulation of antitumor immune responses in the context of radiotherapy. Immunother 2014; 6:597-610; PMID:24896628; http://dx.doi.org/10.2217/imt.14.38
   PubMed Web of Science ®Google Scholar
• Demaria S, Ng B, Devitt ML, Babb JS, Kawashima N, Liebes L, Formenti SC. Ionizing radiation inhibition of distant untreated tumors (abscopal effect) is immune mediated. Int J Radiat Oncol Biol Phys 2004; 58:862-70; PMID:14967443; http://dx.doi.org/10.1016/j.ijrobp.2003.09.012
   PubMed Web of Science ®Google Scholar
• Golden EB, Chhabra A, Chachoua A, Adams S, Donach M, Fenton-Kerimian M, Friedman K, Ponzo F, Babb JS, Goldberg J et al. Local radiotherapy and granulocyte-macrophage colony-stimulating factor to generate abscopal responses in patients with metastatic solid tumours: a proof-of-principle trial. Lancet Oncol 2015; 16:795-803; PMID:26095785; http://dx.doi.org/10.1016/S1470-2045(15)00054-6
   PubMed Web of Science ®Google Scholar
• Postow MA, Callahan MK, Barker CA, Yamada Y, Yuan J, Kitano S, Mu Z, Rasalan T, Adamow M, Ritter E et al. Immunologic correlates of the abscopal effect in a patient with melanoma. N Eng J Med 2012; 366:925-31; PMID:22397654; http://dx.doi.org/10.1056/NEJM-oa1112824
   PubMed Web of Science ®Google Scholar
• Gameiro SR, Jammeh ML, Wattenberg MM, Tsang KY, Ferrone S, Hodge JW. Radiation-induced immunogenic modulation of tumor enhances antigen processing and calreticulin exposure, resulting in enhanced T-cell killing. Oncotarget 2014; 5:403-16; PMID:24480782; http://dx.doi.org/10.18632/oncotarget.1719
   PubMed Web of Science ®Google Scholar
• Hodge JW, Ardiani A, Farsaci B, Kwilas AR, Gameiro SR. The tipping point for combination therapy: cancer vaccines with radiation, chemotherapy, or targeted small molecule inhibitors. Sem Oncol 2012; 39:323-39; PMID:22595055; http://dx.doi.org/10.1053/j.semin-oncol.2012.02.006
   PubMed Web of Science ®Google Scholar
• Golden EB, Frances D, Pellicciotta I, Demaria S, Helen Barcellos-Hoff M, Formenti SC. Radiation fosters dose-dependent and chemotherapy-induced immunogenic cell death. Oncoimmunol 2014; 3:e28518; PMID:25071979; http://dx.doi.org/10.4161/onci.28518
   PubMed Web of Science ®Google Scholar
• Bloy N, Pol J, Manic G, Vitale I, Eggermont A, Galon J, Tartour E, Zitvogel L, Kroemer G, Galluzzi L. Trial Watch: Radioimmunotherapy for oncological indications. Oncoimmunol 2014; 3:e954929; PMID:25941606; http://dx.doi.org/10.4161/21624011.2014.954929
   PubMedGoogle Scholar
• van der Zee J. Heating the patient: a promising approach? Ann Oncol 2002; 13:1173-84; PMID:12181239; http://dx.doi.org/10.1093/annonc/mdf280
   PubMed Web of Science ®Google Scholar
• Krawczyk PM, Eppink B, Essers J, Stap J, Rodermond H, Odijk H, Zelensky A, van Bree C, Stalpers LJ, Buist MR et al. Mild hyperthermia inhibits homologous recombination, induces BRCA2 degradation, and sensitizes cancer cells to poly (ADP-ribose) polymerase-1 inhibition. Proc Natl Acad Sci USA 2011; 108:9851-6; PMID:21555554; http://dx.doi.org/10.1073/pnas.1101053108
   PubMed Web of Science ®Google Scholar
• Datta NR, Ordonez SG, Gaipl US, Paulides MM, Crezee H, Gellermann J, Marder D, Puric E, Bodis S. Local hyperthermia combined with radiotherapy and-/or chemotherapy: Recent advances and promises for the future. Cancer Treatment Rev 2015; 41(9):742-53; PMID:26051911; http://dx.doi.org/10.1016/j.ctrv.2015.05.009
   PubMed Web of Science ®Google Scholar
• Frey B, Weiss EM, Rubner Y, Wunderlich R, Ott OJ, Sauer R, Fietkau R, Gaipl US. Old and new facts about hyperthermia-induced modulations of the immune system. Int J Hyperthermia 2012; 28:528-42; PMID:22690925; http://dx.doi.org/10.3109/02656736.2012.677933
   PubMed Web of Science ®Google Scholar
• Dayanc BE, Beachy SH, Ostberg JR, Repasky EA. Dissecting the role of hyperthermia in natural killer cell mediated anti-tumor responses. Int J hyperthermia 2008; 24:41-56; PMID:18214768; http://dx.doi.org/10.1080/02656730701858297
   PubMed Web of Science ®Google Scholar
• Knippertz I, Stein MF, Dorrie J, Schaft N, Muller I, Deinzer A, Steinkasserer A, Nettelbeck DM. Mild hyperthermia enhances human monocyte-derived dendritic cell functions and offers potential for applications in vaccination strategies. Int J Hyperther 2011; 27:591-603; PMID:21846195; http://dx.doi.org/10.3109/02656736.2011.589234
   PubMed Web of Science ®Google Scholar
• Schildkopf P, Frey B, Ott OJ, Rubner Y, Multhoff G, Sauer R, Fietkau R, Gaipl US. Radiation combined with hyperthermia induces HSP70-dependent maturation of dendritic cells and release of pro-inflammatory cytokines by dendritic cells and macrophages. Radiother Oncol 2011; 101:109-15; PMID:21704416; http://dx.doi.org/10.1016/j.radonc.2011.05.056
   PubMed Web of Science ®Google Scholar
• Triantopoulou S, Efstathopoulos E, Platoni K, Uzunoglou N, Kelekis N, Kouloulias V. Radiotherapy in conjunction with superficial and intracavitary hyperthermia for the treatment of solid tumors: survival and thermal parameters. Clin Transl Oncol 2013; 15:95-105; PMID:23180345; http://dx.doi.org/10.1007/s12094-012-0947-3
   PubMed Web of Science ®Google Scholar
• Werthmoller N, Frey B, Wunderlich R, Fietkau R, Gaipl US. Modulation of radiochemoimmunotherapy-induced B16 melanoma cell death by the pan-caspase inhibitor zVAD-fmk induces anti-tumor immunity in a HMGB1-, nucleotide- and T-cell-dependent manner. Cell Death Dis 2015; 6:e1761; PMID:25973681; http://dx.doi.org/10.1038/cddis.2015.129
   PubMed Web of Science ®Google Scholar
• Homet Moreno B, Parisi G, Robert L, Ribas A. Anti-PD-1 Therapy in Melanoma. Sem Oncol 2015; 42:466-73; PMID:25965365; http://dx.doi.org/10.1053/j.seminoncol.2015.02.008
   PubMed Web of Science ®Google Scholar
• Ko SH, Ueno T, Yoshimoto Y, Yoo JS, Abdel-Wahab OI, Abdel-Wahab Z, Chu E, Pruitt SK, Friedman HS, Dewhirst MW et al. Optimizing a novel regional chemotherapeutic agent against melanoma: hyperthermia-induced enhancement of temozolomide cytotoxicity. Clin Cancer Res 2006; 12:289-97; PMID:16397054; http://dx.doi.org/10.1158/1078-0432.CCR-05-0210
   PubMed Web of Science ®Google Scholar
• Lim JY, Brockstedt DG, Lord EM, Gerber SA. Radiation therapy combined with -based cancer vaccine synergize to enhance tumor control in the B16 melanoma model. Oncoimmunol 2014; 3:e29028; PMID:25083327; http://dx.doi.org/10.4161/onci.29028
   PubMedGoogle Scholar
• Kiessling R, Klein E, Wigzell H. “Natural” killer cells in the mouse. I. Cytotoxic cells with specificity for mouse Moloney leukemia cells. Specificity and distribution according to genotype. Eur J Immunol 1975; 5:112-7; PMID:1234049; http://dx.doi.org/10.1002/eji.1830050208
   PubMed Web of Science ®Google Scholar
• Karre K, Ljunggren HG, Piontek G, Kiessling R. Selective rejection of H-2-deficient lymphoma variants suggests alternative immune defence strategy. Nature 1986; 319:675-8; PMID:3951539; http://dx.doi.org/10.1038/319675a0
   PubMed Web of Science ®Google Scholar
• Ullrich E, Koch J, Cerwenka A, Steinle A. New prospects on the NKG2D/NKG2DL system for oncology. Oncoimmunol 2013; 2:e26097; PMID:24353908; http://dx.doi.org/10.4161/onci.26097
   PubMed Web of Science ®Google Scholar
• Vivier E, Raulet DH, Moretta A, Caligiuri MA, Zitvogel L, Lanier LL, Yokoyama WM, Ugolini S. Innate or adaptive immunity? The example of natural killer cells. Science 2011; 331:44-9; PMID:21212348; http://dx.doi.org/10.1126/science.1198687
   PubMed Web of Science ®Google Scholar
• Hayakawa Y, Huntington ND, Nutt SL, Smyth MJ. Functional subsets of mouse natural killer cells. Immunol Rev 2006; 214:47-55; PMID:17100875; http://dx.doi.org/10.1111/j.1600-065X.2006.00454.x
   PubMed Web of Science ®Google Scholar
• Chiossone L, Chaix J, Fuseri N, Roth C, Vivier E, Walzer T. Maturation of mouse NK cells is a 4-stage developmental program. Blood 2009; 113:5488-96; PMID:19234143; http://dx.doi.org/10.1182/blood-2008-10-187179
   PubMed Web of Science ®Google Scholar
• Di Santo JP. Natural killer cell developmental pathways: a question of balance. Annu Rev Immunol 2006; 24:257-86; PMID:16551250; http://dx.doi.org/10.1146/annurev.immunol.24.021605.090700
   PubMed Web of Science ®Google Scholar
• Meinhardt K, Kroeger I, Bauer R, Ganss F, Ovsiy I, Rothamer J, Buttner M, Atreya I, Waldner M, Bittrich M et al. Identification and characterization of the specific murine NK cell subset supporting graft–leukemia- and reducing graft–host-effects. Oncoimmunol 2015; 4:e981483; PMID:25949862; http://dx.doi.org/10.4161/21624-02X.2014.981483
   PubMedGoogle Scholar
• Hayakawa Y, Watt SV, Takeda K, Smyth MJ. Distinct receptor repertoire formation in mouse NK cell subsets regulated by MHC class I expression. J Leukocyte Biol 2008; 83:106-11; PMID:17940219; http://dx.doi.org/10.1189/jlb.0707496
   PubMed Web of Science ®Google Scholar
• Martin-Fontecha A, Thomsen LL, Brett S, Gerard C, Lipp M, Lanzavecchia A, Sallusto F. Induced recruitment of NK cells to lymph nodes provides IFN-gamma for T(H)1 priming. Nat Immunol 2004; 5:1260-5; PMID:15531883; http://dx.doi.org/10.1038/ni1138
   PubMed Web of Science ®Google Scholar
• Smyth MJ, Hayakawa Y, Takeda K, Yagita H. New aspects of natural-killer-cell surveillance and therapy of cancer. Nat Rev Cancer 2002; 2:850-61; PMID:12415255; http://dx.doi.org/10.1038/nrc928
   PubMed Web of Science ®Google Scholar
• Osada T, Clay T, Hobeika A, Lyerly HK, Morse MA. NK cell activation by dendritic cell vaccine: a mechanism of action for clinical activity. Cancer Immunol Immunother 2006; 55:1122-31; PMID:16273350; http://dx.doi.org/10.1007/s00262-005-0089-3
   PubMed Web of Science ®Google Scholar
• Soderquest K, Walzer T, Zafirova B, Klavinskis LS, Polic B, Vivier E, Lord GM, Martin-Fontecha A. Cutting edge: CD8+ T cell priming in the absence of NK cells leads to enhanced memory responses. J Immunol 2011; 186:3304-8; PMID:21307295; http://dx.doi.org/10.4049/jimmunol.1004122
   PubMed Web of Science ®Google Scholar
• Kepp O, Senovilla L, Vitale I, Vacchelli E, Adjemian S, Agostinis P, Apetoh L, Aranda F, Barnaba V, Bloy N et al. Consensus guidelines for the detection of immunogenic cell death. Oncoimmunol 2014; 3:e955691; PMID:25941621; http://dx.doi.org/10.4161/21624011.2014.955691
   PubMed Web of Science ®Google Scholar
• Hehr T, Wust P, Bamberg M, Budach W. Current and potential role of thermoradiotherapy for solid tumours. Onkologie 2003; 26:295-302; PMID:12845217; http://dx.doi.org/; http://dx.doi.org/10.1159/0000-71628
   PubMedGoogle Scholar
• Rubner Y, Wunderlich R, Ruhle PF, Kulzer L, Werthmoller N, Frey B, Weiss EM, Keilholz L, Fietkau R, Gaipl US. How does ionizing irradiation contribute to the induction of anti-tumor immunity? Front Oncol 2012; 2:75; PMID:22848871; http://dx.doi.org/10.3389/fonc.2012.00075
   PubMedGoogle Scholar
• Aris M, Barrio MM. Combining immunotherapy with oncogene-targeted therapy: a new road for melanoma treatment. Front Immunol 2015; 6:46; PMID:25709607; http://dx.doi.org/10.3389/fimmu.2015.00046
   PubMed Web of Science ®Google Scholar
• Lindsay CR, Spiliopoulou P, Waterston A. Blinded by the light: why the treatment of metastatic melanoma has created a new paradigm for the management of cancer. Therapeutic Adv Med Oncol 2015; 7:107-21; PMID:25755683; http://dx.doi.org/10.1177/1758834014566619
   PubMed Web of Science ®Google Scholar
• Ozao-Choy J, Lee DJ, Faries MB. Melanoma vaccines: mixed past, promising future. Surg Clin N Am 2014; 94:1017-30,; PMID:25245965; http://dx.doi.org/10.1016/j.suc.2014.07.005
   PubMed Web of Science ®Google Scholar
• Rosenberg SA, Restifo NP. Adoptive cell transfer as personalized immunotherapy for human cancer. Science 2015; 348:62-8; PMID:25838374; http://dx.doi.org/10.1126/science.aaa4967
   PubMed Web of Science ®Google Scholar
• Lauber K, Bohn E, Krober SM, Xiao YJ, Blumenthal SG, Lindemann RK, Marini P, Wiedig C, Zobywalski A, Baksh S et al. Apoptotic cells induce migration of phagocytes via caspase-3-mediated release of a lipid attraction signal. Cell 2003; 113:717-30; PMID:12809603; http://dx.doi.org/10.1016/S0092-8674(03)00422-7
   PubMed Web of Science ®Google Scholar
• Scaffidi P, Misteli T, Bianchi ME. Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature 2002; 418:191-5; PMID:12110890; http://dx.doi.org/10.1038/nature00858
   PubMed Web of Science ®Google Scholar
• Apetoh L, Ghiringhelli F, Tesniere A, Obeid M, Ortiz C, Criollo A, Mignot G, Maiuri MC, Ullrich E, Saulnier P et al. Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy. Nat Med 2007; 13:1050-9; PMID:17704786; http://dx.doi.org/10.1038/nm1622
   PubMed Web of Science ®Google Scholar
• Messmer D, Yang H, Telusma G, Knoll F, Li J, Messmer B, Tracey KJ, Chiorazzi N. High mobility group box protein 1: an endogenous signal for dendritic cell maturation and Th1 polarization. J Immunol 2004; 173:307-13; http://dx.doi.org/10.4049/jimmunol.173.1.307
   PubMed Web of Science ®Google Scholar
• DeMarco RA, Fink MP, Lotze MT. Monocytes promote natural killer cell interferon gamma production in response to the endogenous danger signal HMGB1. Mol Immunol 2005; 42:433-44; PMID:15607795; http://dx.doi.org/10.1016/j.molimm.2004.07.023
   PubMed Web of Science ®Google Scholar
• Radons J, Multhoff G. Immunostimulatory functions of membrane-bound and exported heat shock protein 70. Exercise Immunol Rev 2005; 11:17-33; PMID:16385841
   PubMed Web of Science ®Google Scholar
• Elsner L, Muppala V, Gehrmann M, Lozano J, Malzahn D, Bickeboller H, Brunner E, Zientkowska M, Herrmann T, Walter L et al. The heat shock protein HSP70 promotes mouse NK cell activity against tumors that express inducible NKG2D ligands. J Immunol 2007; 179:5523-33; PMID:17911639; http://dx.doi.org/10.4049/jimmunol.179.8.5523
   PubMed Web of Science ®Google Scholar
• Dumitriu IE, Bianchi ME, Bacci M, Manfredi AA, Rovere-Querini P. The secretion of HMGB1 is required for the migration of maturing dendritic cells. J Leukocyte Biol 2007; 81:84-91; PMID:17035340; http://dx.doi.org/10.1189/jlb.0306171
   PubMed Web of Science ®Google Scholar
• Cottone L, Capobianco A, Gualteroni C, Perrotta C, Bianchi ME, Rovere-Querini P, Manfredi AA. 5-Fluorouracil causes leukocytes attraction in the peritoneal cavity by activating autophagy and HMGB1 release in colon carcinoma cells. Int J Cancer J Int Du Cancer 2015; 136:1381-9; PMID:25098891; http://dx.doi.org/10.1002/ijc.29125
   PubMed Web of Science ®Google Scholar
• Capobianco A, Manfredi AA, Monno A, Rovere-Querini P, Rugarli C. Melanoma and lymphoma rejection associated with eosinophil infiltration upon intratumoral injection of dendritic and NK/LAK cells. J Immunother 2008; 31:458-65; PMID:18463539; http://dx.doi.org/10.1097/CJI.0b013e318174a512
   PubMed Web of Science ®Google Scholar
• Hayakawa Y, Smyth MJ. CD27 dissects mature NK cells into two subsets with distinct responsiveness and migratory capacity. J Immunol 2006; 176:1517-24; PMID:16424180; http://dx.doi.org/10.4049/jimmunol.176.3.1517
   PubMed Web of Science ®Google Scholar
• Meinhardt K, Kroeger I, Abendroth A, Muller S, Mackensen A, Ullrich E. Influence of NK cell magnetic bead isolation methods on phenotype and function of murine NK cells. J Immunol Met 2012; 378:1-10; PMID:22306357; http://dx.doi.org/10.1016/j.jim.2012.01.008
   PubMed Web of Science ®Google Scholar
• Geisler K, Reischer A, Kroeger I, Jacobs B, Meinhardt K, Bauer R, Ryffel B, Mackensen A, Ullrich E. Nilotinib combined with interleukin-2 mediates antitumor and immunological effects in a B16 melanoma model. Oncol Rep 2014; 31:2015-20; PMID:24626639; http://dx.doi.org/10.3892/or.2014.3070
   PubMed Web of Science ®Google Scholar
• Takeda K, Nakayama M, Sakaki M, Hayakawa Y, Imawari M, Ogasawara K, Okumura K, Smyth MJ. IFN-gamma production by lung NK cells is critical for the natural resistance to pulmonary metastasis of B16 melanoma in mice. J Leukocyte Biol 2011; 90:777-85; PMID:21712396; http://dx.doi.org/10.1189/jlb.0411208
   PubMed Web of Science ®Google Scholar
• Deng W, Gowen BG, Zhang L, Wang L, Lau S, Iannello A, Xu J, Rovis TL, Xiong N, Raulet DH. Antitumor immunity. A shed NKG2D ligand that promotes natural killer cell activation and tumor rejection. Science 2015; 348:136-9; PMID:25745066; http://dx.doi.org/10.1126/science.1258867
   PubMed Web of Science ®Google Scholar
• Walzer T, Dalod M, Robbins SH, Zitvogel L, Vivier E. Natural-killer cells and dendritic cells: “l'union fait la force.” Blood 2005; 106:2252-8; PMID:15933055; http://dx.doi.org/10.1182/blood-2005-03-1154
   PubMed Web of Science ®Google Scholar
• Dovedi SJ, Adlard AL, Lipowska-Bhalla G, McKenna C, Jones S, Cheadle EJ, Stratford IJ, Poon E, Morrow M, Stewart R et al. Acquired resistance to fractionated radiotherapy can be overcome by concurrent PD-L1 blockade. Cancer Res 2014; 74:5458-68; PMID:25274032; http://dx.doi.org/10.1158/0008-5472.CAN-14-1258
   PubMed Web of Science ®Google Scholar
• Frey B, Gaipl US. Radio-immunotherapy: the focused beam expands. Lancet Oncol 2015; 16:742-3; PMID:26095779; http://dx.doi.org/10.1016/S1470-2045(15)00055-8
   PubMed Web of Science ®Google Scholar
• Frey B, Rubner Y, Wunderlich R, Weiss EM, Pockley AG, Fietkau R, Gaipl US. Induction of abscopal anti-tumor immunity and immunogenic tumor cell death by ionizing irradiation - implications for cancer therapies. Curr Med Chem 2012; 19:1751-64; PMID:22414083; http://dx.doi.org/10.2174/092986712800099811
   PubMed Web of Science ®Google Scholar
• Geran RI, Greenberg NH, Macdonald MM, Abbott BJ. Modified protocol for the testing of new synthetics in the L1210 lymphoid leukemia murine model in the DR&D program, DCT, NCI. Natl Cancer Inst Monograph 1977; 45:151-3; PMID:927490.
   PubMedGoogle Scholar
• Weiss EM, Meister S, Janko C, Ebel N, Schlucker E, Meyer-Pittroff R, Fietkau R, Herrmann M, Gaipl US, Frey B. High hydrostatic pressure treatment generates inactivated mammalian tumor cells with immunogeneic features. J Immunotoxicol 2010; 7:194-204; PMID:20205624; http://dx.doi.org/10.3109/15476911003657414
   PubMed Web of Science ®Google Scholar
• Parks DR, Roederer M, Moore WA. A new “Logicle” display method avoids deceptive effects of logarithmic scaling for low signals and compensated data. Cytometry Part A 2006; 69:541-51; PMID:16604519; http://dx.doi.org/10.1002/cyto.a.20258
   PubMed Web of Science ®Google Scholar
• Tung JW, Parks DR, Moore WA, Herzenberg LA, Herzenberg LA. Identification of B-cell subsets: an exposition of 11-color (Hi-D) FACS methods. Met Mol Biol 2004; 271:37-58; PMID:15146111; http://dx.doi.org/10.1385/1-59259-796-3:037
   PubMedGoogle Scholar