Use of broad-spectrum antibiotics impacts outcome in patients treated with immune checkpoint inhibitors

References

• Lee YK, Mazmanian SK. Has the microbiota played a critical role in the evolution of the adaptive immune system? Science. 2010;330:1768–1773. doi:10.1126/science.1195568.
   PubMed Web of Science ®Google Scholar
• Lloyd-Price J, Abu-Ali G, Huttenhower C. The healthy human microbiome. Genome Med. 2016;8:51. doi:10.1186/s13073-016-0307-y.
   PubMed Web of Science ®Google Scholar
• Peterson DA, Frank DN, Pace NR, Gordon JI. Metagenomic approaches for defining the pathogenesis of inflammatory bowel diseases. Cell Host Microbe. 2008;3:417–427. doi:10.1016/j.chom.2008.05.001.
   PubMed Web of Science ®Google Scholar
• Ahn J, Sinha R, Pei Z, Dominianni C, Wu J, Shi J, Goedert JJ, Hayes RB, Yang L. Human gut microbiome and risk for colorectal cancer. J Natl Cancer Inst. 2013;105:1907–1911. doi:10.1093/jnci/djt300.
   PubMed Web of Science ®Google Scholar
• Jangi S, Gandhi R, Cox LM, Li N, Von Glehn F, Yan R, Patel B, Mazzola MA, Liu S, Glanz BL, et al. Alterations of the human gut microbiome in multiple sclerosis. Nat Comm. 2016;7:12015. doi:10.1038/ncomms12015.
   PubMed Web of Science ®Google Scholar
• Upadhyaya S, Banerjee G. Type 2 diabetes and gut microbiome: at the intersection of known and unknown. Gut Microbes. 2015;6:85–92. doi:10.1080/19490976.2015.1024918.
   PubMed Web of Science ®Google Scholar
• Bäckhed F, Ding H, Wang T, Hooper LV, Koh GY, Nagy A, Semenkovich CF, Gordon JI. The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci USA. 2004;101:15718–15723. doi:10.1073/pnas.0407076101.
   PubMed Web of Science ®Google Scholar
• Riiser A. The human microbiome, asthma, and allergy. Allergy Asthma Clin Immunol. 2015;11:35. doi:10.1186/s13223-015-0099-4.
   PubMed Web of Science ®Google Scholar
• Lim SH, Morris A, Li K, Fitch AC, Fast L, Goldberg L, Quesenberry M, Sprinz P, Methé B. Intestinal microbiome analysis revealed dysbiosis sickle cell disease. Am J Hematol. 2018;93:E91–E93. doi:10.1002/ajh.25019.
   PubMed Web of Science ®Google Scholar
• Iino Y, Toriyama M, Natori K, You A. Erythromycin inhibition of lipopolysaccharide-stimulated tumor necrosis factor alpha production by human monocytes in vitro. Ann Otol Rhinol Laryngol. 1992;101:16–20. doi:10.1177/0003489492101S1005.
   Web of Science ®Google Scholar
• Morikawa K, Oseko F, Morikawa S, Iwamoto K. Immunomodulatory effects of three macrolides, midecamycin acetate, josamycin, and clarithromycin, on human T-lymphocyte function in vitro. Antimicrob Agents Chemother. 1994;38:2643–2647.
   PubMed Web of Science ®Google Scholar
• Morikawa K, Watabe H, Araake M, Morikawa S. Modulatory effects of antibiotics on cytokine production by human monocytes in vitro. Antimicrob Agents Chemother. 1996;40:1366–1370.
   PubMed Web of Science ®Google Scholar
• Roche Y, Gougerot-Pocidalo MA, Fay M, Etienne D, Forest N, Pocidalo JJ. Comparative effects of quinolones on human mononuclear leucocyte functions. J Antimicrob Chemother. 1987;19:781–790.
   PubMed Web of Science ®Google Scholar
• Korzeniowski OM. Effects of antibiotics on the mammalian immune system. Infect Dis Clin N Am. 1987;3:469–478.
   Google Scholar
• Tang X, Wang X, Zhao YY, Curtis JM, Brindley DN. Doxycycline attenuates breast cancer related inflammation by decreasing plasma lysophosphatidate concentrations and inhibiting NF-κB activation. Mol Cancer. 2017;16:36. doi:10.1186/s12943-017-0607-x.
   PubMed Web of Science ®Google Scholar
• Routy B, Le Chatelier E, Derosa L, Duong CPM, Alou MT, Daillère R, Fluckiger A, Messaoudene M, Rauber C, Roberti MP, et al. Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors. Science. 2018;359:91–97. doi:10.1126/science.aan3706.
   PubMed Web of Science ®Google Scholar
• Lalani AA, Xie W, Lin X, Steinharter JA, Martini DJ, Duquette A, Bosse D, McKay RR, Simantov R, Wei XX, et al. Antibiotic use and outcomes with systemic therapy in metastatic renal cell carcinoma (mRCC). J Clin Oncol. 2018;36(Suppl.):607. doi:10.1200/JCO.2018.36.6_suppl.607.
   Google Scholar
• Tinsley N, Zhou C, Villa S, Tan G, Lorigan P, Blackhall FH, Elliott T, Krebs M, Carter L, Thistlethwaite F, et al. Cumulative antibiotic use and efficacy of immune checkpoint inhibitors in patients with advanced cancer. J Clin Oncol. 2018;36(Suppl.):3010.
   Google Scholar
• Derosa L, Hellmann MD, Spaziano M, Halpenny D, Fidelle M, Rizvi H, Long N, Plodkowski AJ, Arbour KC, Chaft JE, et al. Negative association of antibiotics on clinical activity of immune checkpoint inhibitors in patients with advanced renal cell and non-small cell lung cancer. Ann Oncol. 2018 Mar 30. [Epub ahead of print]. doi:10.1093/annonc/mdy103.
   PubMedGoogle Scholar
• Sivan A, Corrales L, Hubert N, Williams JB, Aquino-Michaels K, Earley ZM, Benyamin FW, Lei YM, Jabri B, Alegre ML, et al. Commensal Bifidobacterium promotes immunity and facilitates anti-PD-L1 efficacy. Science. 2015;350:1084–1089. doi:10.1126/science.aac4255.
   PubMed Web of Science ®Google Scholar
• Chaput N, Lepage P, Coutzac C, Soularue E, Le Roux K, Monot C, Boselli L, Routier E, Cassard L, Collins M, et al. Baseline gut microbiota predicts clinical response and colitis in metastatic melanoma patients treated with ipilimumab. Ann Oncol. 2017;28:1368–1379. doi:10.1093/annonc/mdx108.
   PubMed Web of Science ®Google Scholar
• Gopalakrishnan V, Spencer CN, Nezi L, Reuben A, Andrews MC, Karpinets TV, Prieto PA, Vicente D, Hoffman K, Wei SC, et al. Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients. Science. 2018;359:97–103. doi:10.1126/science.aan4236.
   PubMed Web of Science ®Google Scholar
• Viaud S, Saccheri F, Mignot G, Yamazaki T, Daillère R, Hannani D, Enot DP, Pfirschke C, Engblom C, Pittet MJ, et al. The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide. Science. 2013;342:971–976. doi:10.1126/science.1240537.
   PubMed Web of Science ®Google Scholar
• Ménard S, Candalh C, Bambou JC, Terpend K, Cerf-Bensussan N, Heyman M. Lactic acid bacteria secrete metabolites retaining anti-inflammatory properties after intestinal transport. Gut. 2004;53:821–828.
   PubMed Web of Science ®Google Scholar
• Gollapudi SV, Chuah SK, Harvey T, Thadepalli HD, Thadepalli H. In vivo effects of rufloxacin and ciprofloxacin on T-cell subsets and tumor necrosis factor production in mice infected with Bacteroides fragilis. Antimicrob Agents Chemother. 1993;37:1711–1712.
   PubMed Web of Science ®Google Scholar
• Nagano Y, Itoh K, Honda K. The induction of Treg cells by gut-indigenous Clostridium. Curr Opin Immunol. 2012;24:392–397. doi:10.1016/j.coi.2012.05.007.
   PubMed Web of Science ®Google Scholar
• Telesford KM, Yan W, Ochoa-Reparaz J, Pant A, Kircher C, Christy MA, Begum-Haque S, Kasper DL, Kasper LH. A commensal symbiotic factor derived from Bacteroides fragilis promotes human CD39(+)Foxp3(+) T cells and Treg function. Gut Microbes. 2015;6:234–242. doi:10.1080/19490976.2015.1056973.
   PubMed Web of Science ®Google Scholar
• Rabe H, Nordström I, Andersson K, Lundell AC, Rudin A. Staphylococcus aureus convert neonatal conventional CD4(+) T cells into FOXP3(+) CD25(+) CD127(low) T cells via the PD-1/PD-L1 axis. Immunology. 2014;141:467–481. doi:10.1111/imm.12209.
   PubMed Web of Science ®Google Scholar
• Komai-Koma M, Gilchrist DS, Xu D. Direct recognition of LPS by human but not murine CD8+ T cells via TLR4 complex. Eur J Immunol. 2009;39:1564–1572. doi:10.1002/eji.200838866.
   PubMed Web of Science ®Google Scholar
• Eisenhauer EA, Therasse P, Bogaerts J, Schwartz LH, Sargent D, Ford R, Dancey J, Arbuck S, Gwyther S, Mooney M, et al. New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). Eur J Cancer. 2009;45:228–247. doi:10.1016/j.ejca.2008.10.026.
   PubMed Web of Science ®Google Scholar