Interim results of an ecological experiment — Conjugate vaccination against the pneumococcus and serotype replacement

References

• Simell B, Auranen K, Käyhty H, Goldblatt D, Dagan R, O'Brien KL. The fundamental link between pneumococcal carriage and disease. Expert Rev Vaccines 2012; 11:841-55; PMID:22913260; http://dx.doi.org/10.1586/erv.12.53
   PubMed Web of Science ®Google Scholar
• Barbour ML, Mayon-White RT, Coles C, Crook DWM, Moxon ER. The Impact Of Conjugate Vaccine On Carriage Of Haemophilus Influenzae Type B. J Infect Dis 1995; 171:93-8; PMID:7798687; http://dx.doi.org/10.1093/infdis/171.1.93
   PubMed Web of Science ®Google Scholar
• Obaro SK, Adegbola R, Banya W, Greenwood B. Carriage of pneumococci after pneumococcal vaccination. The Lancet 1996; 348:271-2; http://dx.doi.org/10.1016/S0140-6736(05)65585-7
   PubMed Web of Science ®Google Scholar
• Black S, Shinefield H, Fireman B, Lewis E, Ray P, Hansen JR, Elvin L, Ensor KM, Hackell J, Siber G. Efficacy, safety and immunogenicity of heptavalent pneumococcal conjugate vaccine in children. Pediatr Infect Dis J 2000; 19:187-95; PMID:10749457; http://dx.doi.org/10.1097/00006454-200003000-00003
   PubMed Web of Science ®Google Scholar
• Black SB, Shinefield HR, Ling S, Hansen J, Fireman B, Spring D, Noyes J, Lewis E, Ray P, Lee J. Effectiveness of heptavalent pneumococcal conjugate vaccine in children younger than five years of age for prevention of pneumonia. Pediatr Infect Dis J 2002; 21:810-5; PMID:12352800; http://dx.doi.org/10.1097/00006454-200209000-00005
   PubMed Web of Science ®Google Scholar
• Eskola J, Kilpi T, Palmu A, Jokinen J, Eerola M, Haapakoski J, Herva E, Takala A, Käyhty H, Karma P, et al. Efficacy of a Pneumococcal Conjugate Vaccine against Acute Otitis Media. N Engl J Med 2001; 344:403-9; PMID:11172176; http://dx.doi.org/10.1056/NEJM200102083440602
   PubMed Web of Science ®Google Scholar
• Pilishvili T, Lexau C, Farley MM, Hadler J, Harrison LH, Bennett NM, Reingold A, Thomas A, Schaffner W, Craig AS, et al. Sustained Reductions in Invasive Pneumococcal Disease in the Era of Conjugate Vaccine. J Infect Dis 2010; 201:32-41; PMID:19947881; http://dx.doi.org/10.1086/648593
   PubMed Web of Science ®Google Scholar
• Van Effelterre T, Moore MR, Fierens F, Whitney CG, White L, Pelton SI, Hausdorff WP. A dynamic model of pneumococcal infection in the United States: Implications for prevention through vaccination. Vaccine 2010; 28:3650-60; PMID:20359560; http://dx.doi.org/10.1016/j.vaccine.2010.03.030
   PubMed Web of Science ®Google Scholar
• Weinberger DM, Malley R, Lipsitch M. Serotype replacement in disease after pneumococcal vaccination. The Lancet 2011; 378:1962-73; http://dx.doi.org/10.1016/S0140-6736(10)62225-8
   PubMed Web of Science ®Google Scholar
• Feikin DR, Kagucia EW, Loo JD, Link-Gelles R, Puhan MA, Cherian T, Levine OS, Whitney CG, O'Brien KL, Moore MR, et al. Serotype-Specific Changes in Invasive Pneumococcal Disease after Pneumococcal Conjugate Vaccine Introduction: A Pooled Analysis of Multiple Surveillance Sites. PLoS Med 2013; 10:e1001517; PMID:24086113; http://dx.doi.org/10.1371/journal.pmed.1001517
   PubMed Web of Science ®Google Scholar
• Nurhonen M, Auranen K. Optimal Serotype Compositions for Pneumococcal Conjugate Vaccination under Serotype Replacement. PLoS Comput Biol 2014; 10:e1003477; PMID:24550722; http://dx.doi.org/10.1371/journal.pcbi.1003477
   PubMed Web of Science ®Google Scholar
• Flasche S, Le Polain de Waroux O, O'Brien KL, Edmunds WJ. The serotype distribution among healthy carriers before vaccination is essential for predicting the impact of pneumococcal conjugate vaccine on invasive disease. PLoS Comput Biol 2015; 11:e1004173; PMID:25879748; http://dx.doi.org/10.1371/journal.pcbi.1004173
   PubMedGoogle Scholar
• Miller E, Andrews NJ, Waight PA, Slack MP, George RC. Herd immunity and serotype replacement 4 years after seven-valent pneumococcal conjugate vaccination in England and Wales: an observational cohort study. Lancet Infect Dis 2011; 11:760-8; PMID:21621466; http://dx.doi.org/10.1016/S1473-3099(11)70090-1
   PubMed Web of Science ®Google Scholar
• De Wals P, Lefebvre B, Markowski F, Deceuninck G, Defay F, Douville-Fradet M, Landry M. Impact of 2 + 1 pneumococcal conjugate vaccine program in the province of Quebec, Canada. Vaccine 2014; 32:1501-6; PMID:24486346; http://dx.doi.org/10.1016/j.vaccine.2013.11.028
   PubMed Web of Science ®Google Scholar
• McFetridge R, Meulen AS, Folkerth SD, Hoekstra JA, Dallas M, Hoover PA, Marchese RD, Zacholski DM, Watson WJ, Stek JE, et al. Safety, tolerability, and immunogenicity of 15-valent pneumococcal conjugate vaccine in healthy adults. Vaccine 2015; 33:2793-9; PMID:25913828; http://dx.doi.org/10.1016/j.vaccine.2015.04.025
   PubMed Web of Science ®Google Scholar
• Dagan R, Juergens C, Trammel J, Patterson S, Greenberg D, Givon-Lavi N, Porat N, Gurtman A, Gruber WC, Scott DA. Efficacy of 13-valent pneumococcal conjugate vaccine (PCV13) versus that of 7-Valent PCV (PCV7) against nasopharyngeal colonization of antibiotic-nonsusceptible streptococcus pneumoniae. J Infect Dis 2015; 211:1144-53; PMID:25355940; http://dx.doi.org/10.1093/infdis/jiu576
   PubMed Web of Science ®Google Scholar
• Bergh MR van den, Spijkerman J, Swinnen KM, François NA, Pascal TG, Borys D, Schuerman L, IJzerman EPF, Bruin JP, Ende A van der, et al. Effects of the 10-Valent pneumococcal nontypeable haemophilus influenzae protein D–conjugate vaccine on nasopharyngeal bacterial colonization in young children: A randomized controlled trial. Clin Infect Dis 2013; 56:e30-9; PMID:23118268; http://dx.doi.org/10.1093/cid/cis922
   PubMed Web of Science ®Google Scholar
• Jokinen J, Rinta-Kokko H, Siira L, Palmu AA, Virtanen MJ, Nohynek H, Virolainen-Julkunen A, Toropainen M, Nuorti JP. Impact of Ten-Valent Pneumococcal Conjugate Vaccination on Invasive Pneumococcal Disease in Finnish Children – A Population-Based Study. PLoS One 2015; 10:e0120290; PMID:25781031; http://dx.doi.org/10.1371/journal.pone.0120290
   PubMed Web of Science ®Google Scholar
• Scott A. The Pneumococcal Conjugate Vaccine Impact Study (PCVIS) [Internet]. Kemri Wellcome Trust 2015 [cited 2015 Jul 22]; Available from: http://www.kemri-wellcome.org/index.php/en/studies_inner/75.
   Google Scholar
• Valenzuela MT, Seoane M, Canals A, Pidal P, Hormazábal JC, Araya P, Terrazas S, Díaz J. Laboratory surveillance of Streptococcus pneumoniae from invasive disease, Chile 2007-2012. Rev Chil Infectol 2014; 31:651-8; http://dx.doi.org/10.4067/S0716-10182014000600002
   PubMed Web of Science ®Google Scholar
• New Zealand Public Health Surveillance. IPD Quarterly Report: Oct-Dec 2014 [Internet]. 2014 [cited 2015 Jul 22]; Available from: https://surv.esr.cri.nz/surveillance/IPD.php?we_objectID=4081
   Google Scholar
• Knol M, Wagenvoort G, Sanders EAM, Elberse KEM, Vlaminckx B, de Melcker H, van der Ende A. Invasive Pneumococcal Disease 3 Years after Introduction of 10-Valent Pneumococcal Conjugate Vaccine, the Netherlands. Emerg Infect Dis 2015; 21: 2040-4; Ahead – of – Print; PMID:26488415; http://dx.doi.org/10.3201/eid2111.140780
   PubMed Web of Science ®Google Scholar
• Lepoutre A, Varon E, Georges S, Dorléans F, Janoir C, Gutmann L, Lévy-Bruhl D. Impact of the pneumococcal conjugate vaccines on invasive pneumococcal disease in France, 2001–2012. Vaccine 2015; 33:359-66; PMID:25448105; http://dx.doi.org/10.1016/j.vaccine.2014.11.011
   PubMed Web of Science ®Google Scholar
• Waight PA, Andrews NJ, Ladhani SN, Sheppard CL, Slack MPE, Miller E. Effect of the 13-valent pneumococcal conjugate vaccine on invasive pneumococcal disease in England and Wales 4 years after its introduction: an observational cohort study. Lancet Infect Dis 2015; 15:535-43; PMID:25801458; http://dx.doi.org/10.1016/S1473-3099(15)70044-7
   PubMed Web of Science ®Google Scholar
• Harboe ZB, Dalby T, Weinberger DM, Benfield T, Mølbak K, Slotved HC, Suppli CH, Konradsen HB, Valentiner-Branth P. Impact of 13-Valent Pneumococcal Conjugate Vaccination in Invasive Pneumococcal Disease Incidence and Mortality. Clin Infect Dis 2014; 59:1066-73; PMID:25034421; http://dx.doi.org/10.1093/cid/ciu524
   PubMed Web of Science ®Google Scholar
• von Gottberg A, de Gouveia L, Tempia S, Quan V, Meiring S, von Mollendorf C, Madhi SA, Zell ER, Verani JR, O'Brien KL, et al. Effects of Vaccination on Invasive Pneumococcal Disease in South Africa. N Engl J Med 2014; 371:1889-99; PMID:25386897; http://dx.doi.org/10.1056/NEJMoa1401914
   PubMed Web of Science ®Google Scholar
• Imöhl M, Möller J, Reinert RR, Perniciaro S, Linden M van der, Aktas O. Pneumococcal meningitis and vaccine effects in the era of conjugate vaccination: results of 20 years of nationwide surveillance in Germany. BMC Infect Dis 2015; 15:61; PMID:25885764; http://dx.doi.org/10.1186/s12879-015-0787-1
   PubMed Web of Science ®Google Scholar
• Olarte L, Barson WJ, Barson RM, Lin PL, Romero JR, Tan TQ, Givner LB, Bradley JS, Hoffman JA, Hultén KG, et al. Impact of the 13-Valent Pneumococcal Conjugate Vaccine on Pneumococcal Meningitis in US Children. Clin Infect Dis 2015; 61(5):767-75; civ368; PMID:25972022
   PubMed Web of Science ®Google Scholar
• Steens A, Bergsaker MAR, Aaberge IS, Rønning K, Vestrheim DF. Prompt effect of replacing the 7-valent pneumococcal conjugate vaccine with the 13-valent vaccine on the epidemiology of invasive pneumococcal disease in Norway. Vaccine 2013; 31:6232-8; PMID:24176490; http://dx.doi.org/10.1016/j.vaccine.2013.10.032
   PubMed Web of Science ®Google Scholar
• Moore MR, Link-Gelles R, Schaffner W, Lynfield R, Lexau C, Bennett NM, Petit S, Zansky SM, Harrison LH, Reingold A, et al. Effect of use of 13-valent pneumococcal conjugate vaccine in children on invasive pneumococcal disease in children and adults in the USA: analysis of multisite, population-based surveillance. Lancet Infect Dis 2015; 15:301-9; PMID:25656600; http://dx.doi.org/10.1016/S1473-3099(14)71081-3
   PubMed Web of Science ®Google Scholar
• Darenberg J, Lindstrand A, Galanis J, Browall S, Sjöström K, Morfeldt E, Wilson J, Naucler P, Blennow M, Örtqvist Å, et al. Pneumococcal conjugate vaccination in stockholm leaves invasive disease incidence unaffected in the elderly and increases serotype diversity [Abstract ISPPD-0468]. In: pneumonia 2014; 3:214 - International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9th. 2014
   Google Scholar
• van der Linden M, Falkenhorst G, Perniciaro S, Imöhl M. Effects of Infant Pneumococcal Conjugate Vaccination on Serotype Distribution in Invasive Pneumococcal Disease among Children and Adults in Germany. PLoS ONE 2015; 10:e0131494; PMID:26132078; http://dx.doi.org/10.1371/journal.pone.0131494
   PubMed Web of Science ®Google Scholar
• INSTITUT NATIONAL DE SANTÉ PUBLIQUE. Programme de surveillance du pneumocoque : rapport 2012 [Internet]. 2012 [cited 2015 Jul 20]; Available from: https://www.inspq.qc.ca/pdf/publications/1734_ProgSurvPneumoQc_RappAnnu2012.pdf
   Google Scholar
• Public Health England. Health protection – collection. Pneumococcal disease: guidance, data and analysis [cited 2015 Oct 26]; Available from: https://www.gov.uk/government/collections/pneumococcal-disease-guidance-data-and-analysis
   Google Scholar
• Weinberger DM, Dagan R, Givon-Lavi N, Regev-Yochay G, Malley R, Lipsitch M. Epidemiologic Evidence for Serotype-Specific Acquired Immunity to Pneumococcal Carriage. J Infect Dis 2008; 197:1511-8; PMID:18471062; http://dx.doi.org/10.1086/587941
   PubMed Web of Science ®Google Scholar
• Weinberger DM, Trzciński K, Lu Y-J, Bogaert D, Brandes A, Galagan J, Anderson PW, Malley R, Lipsitch M. Pneumococcal Capsular Polysaccharide Structure Predicts Serotype Prevalence. PLoS Pathog 2009; 5:e1000476; PMID:19521509; http://dx.doi.org/10.1371/journal.ppat.1000476
   PubMed Web of Science ®Google Scholar
• Li Y, Weinberger DM, Thompson CM, Trzciński K, Lipsitch M. Surface Charge of Streptococcus pneumoniae Predicts Serotype Distribution. Infect Immun 2013; 81:4519-24; PMID:24082068; http://dx.doi.org/10.1128/IAI.00724-13
   PubMed Web of Science ®Google Scholar
• Brueggemann AB, Peto TEA, Crook DW, Butler JC, Kristinsson KG, Spratt BG. Temporal and Geographic Stability of the Serogroup-Specific Invasive Disease Potential of Streptococcus pneumoniae in Children. J Infect Dis 2004; 190:1203-11; PMID:15346329; http://dx.doi.org/10.1086/423820
   PubMed Web of Science ®Google Scholar
• Brueggemann AB, Griffiths DT, Meats E, Peto T, Crook DW, Spratt BG. Clonal Relationships between Invasive and Carriage Streptococcus pneumoniae and Serotype- and Clone-Specific Differences in Invasive Disease Potential. J Infect Dis 2003; 187:1424-32; PMID:12717624; http://dx.doi.org/10.1086/374624
   PubMed Web of Science ®Google Scholar
• Hanage WP, Auranen K, Syrjänen R, Herva E, Mäkelä PH, Kilpi T, Spratt BG. Ability of Pneumococcal Serotypes and Clones To Cause Acute Otitis Media: Implications for the Prevention of Otitis Media by Conjugate Vaccines. Infect Immun 2004; 72:76-81; PMID:14688083; http://dx.doi.org/10.1128/IAI.72.1.76-81.2004
   PubMed Web of Science ®Google Scholar
• Benfield T, Skovgaard M, Schønheyder HC, Knudsen JD, Bangsborg J, Østergaard C, Slotved H-C, Konradsen HB, Thomsen RW, Lambertsen L. Serotype Distribution in Non-Bacteremic Pneumococcal Pneumonia: Association with Disease Severity and Implications for Pneumococcal Conjugate Vaccines. PLoS ONE 2013; 8:e72743; PMID:24009703; http://dx.doi.org/10.1371/journal.pone.0072743
   Web of Science ®Google Scholar
• Burgos J, Luján M, Larrosa MN, Fontanals D, Bermudo G, Planes AM, Puig M, Rello J, Falcó V, Pahissa A. Risk factors for respiratory failure in pneumococcal pneumonia: the importance of pneumococcal serotypes. Eur Respir J 2014; 43:545-53; PMID:23845720; http://dx.doi.org/10.1183/09031936.00050413
   PubMed Web of Science ®Google Scholar
• Alanee SRJ, McGee L, Jackson D, Chiou CC, Feldman C, Morris AJ, Ortqvist A, Rello J, Luna CM, Baddour LM, et al. Association of Serotypes of Streptococcus pneumoniae with Disease Severity and Outcome in Adults: An International Study. Clin Infect Dis 2007; 45:46-51; PMID:17554699; http://dx.doi.org/10.1086/518538
   PubMed Web of Science ®Google Scholar
• Fletcher MA, Schmitt H-J, Syrochkina M, Sylvester G. Pneumococcal empyema and complicated pneumonias: global trends in incidence, prevalence, and serotype epidemiology. Eur J Clin Microbiol Infect Dis 2014; 33:879-910; PMID:24563274; http://dx.doi.org/10.1007/s10096-014-2062-6
   PubMed Web of Science ®Google Scholar
• Hutchinson GE. Homage to Santa Rosalia or Why Are There So Many Kinds of Animals? Am Nat 1959; 93:145-59; http://dx.doi.org/10.1086/282070
   Web of Science ®Google Scholar
• Chase JM, Leibold MA. Ecological Niches: Linking Classical and Contemporary Approaches. University of Chicago Press; 2003
   Google Scholar
• Hanage WP, Finkelstein JA, Huang SS, Pelton SI, Stevenson AE, Kleinman K, Hinrichsen VL, Fraser C. Evidence that pneumococcal serotype replacement in Massachusetts following conjugate vaccination is now complete. Epidemics 2010; 2:80-4; PMID:21031138
   PubMed Web of Science ®Google Scholar
• Weinberger DM, Bruden DT, Grant LR, Lipsitch M, O'Brien KL, Pelton SI, Sanders EAM, Feikin DR. Using Pneumococcal Carriage Data to Monitor Postvaccination Changes in Invasive Disease. Am J Epidemiol 2013; 178:1488-95; PMID:24013204; http://dx.doi.org/10.1093/aje/kwt156
   PubMed Web of Science ®Google Scholar
• Watterson GA. The Homozygosity Test of Neutrality. Genetics 1978; 88:405-17; PMID:17248803
   PubMed Web of Science ®Google Scholar
• Ewens WJ. The sampling theory of selectively neutral alleles. Theor Popul Biol 1972; 3:87-112; PMID:4667078; http://dx.doi.org/10.1016/0040-5809(72)90035-4
   PubMed Web of Science ®Google Scholar
• Colijn C, Cohen T, Fraser C, Hanage W, Goldstein E, Givon-Lavi N, Dagan R, Lipsitch M. What is the mechanism for persistent coexistence of drug-susceptible and drug-resistant strains of Streptococcus pneumoniae? J R Soc Interface 2010; 7:905-19; PMID:19940002; http://dx.doi.org/10.1098/rsif.2009.0400
   PubMed Web of Science ®Google Scholar
• Lipsitch M, Colijn C, Cohen T, Hanage WP, Fraser C. No coexistence for free: Neutral null models for multistrain pathogens. Epidemics 2009; 1:2-13; PMID:21352747; http://dx.doi.org/10.1016/j.epidem.2008.07.001
   PubMed Web of Science ®Google Scholar
• Mitchell PK, Lipsitch M, Hanage WP. Carriage burden, multiple colonization and antibiotic pressure promote emergence of resistant vaccine escape pneumococci. Philos Trans R Soc B Biol Sci 2015; 370:20140342; PMID:25918447; http://dx.doi.org/10.1098/rstb.2014.0342
   Google Scholar
• Mehtälä J, Antonio M, Kaltoft MS, O'Brien KL, Auranen K. Competition between Streptococcus pneumoniae strains: implications for vaccine-induced replacement in colonization and disease. Epidemiol Camb Mass 2013; 24:522-9; http://dx.doi.org/10.1097/EDE.0b013e318294be89
   PubMed Web of Science ®Google Scholar
• Hausdorff WP. The roles of pneumococcal serotypes 1 and 5 in paediatric invasive disease. Vaccine 2007; 25:2406-12; PMID:17055620; http://dx.doi.org/10.1016/j.vaccine.2006.09.009
   PubMed Web of Science ®Google Scholar
• Torné AN, Dias JG, Quinten C, Hruba F, Busana MC, Lopalco PL, Gauci AJA, Pastore-Celentano L. European enhanced surveillance of invasive pneumococcal disease in 2010: Data from 26 European countries in the post-heptavalent conjugate vaccine era. Vaccine 2014; 32:3644-50; http://dx.doi.org/10.1016/j.vaccine.2014.04.066
   PubMed Web of Science ®Google Scholar
• Abdullahi O, Karani A, Tigoi CC, Mugo D, Kungu S, Wanjiru E, Jomo J, Musyimi R, Lipsitch M, Scott JAG. Rates of Acquisition and Clearance of Pneumococcal Serotypes in the Nasopharynges of Children in Kilifi District, Kenya. J Infect Dis 2012; 206:1020-9; PMID:22829650; http://dx.doi.org/10.1093/infdis/jis447
   PubMed Web of Science ®Google Scholar
• Normark BH, Kalin M, Örtqvist Å, Åkerlund T, Liljequist BO, Hedlund J, Svenson SB, Zhou J, Spratt BG, Normark S, et al. Dynamics of Penicillin-Susceptible Clones in Invasive Pneumococcal Disease. J Infect Dis 2001; 184:861-9; PMID:11550126; http://dx.doi.org/10.1086/323339
   PubMed Web of Science ®Google Scholar
• Hedlund J, Sörberg M, Normark BH, Kronvall G. Capsular Types and Antibiotic Susceptibility of Invasive Streptococcus pneumoniae Among Children in Sweden. Scand J Infect Dis 2003; 35:452-8; PMID:14514143; http://dx.doi.org/10.1080/00365540310013315
   PubMed Web of Science ®Google Scholar
• Lagos R, Muñoz A, Martin OS, Maldonado A, Hormazabal JC, Blackwelder WC, Levine MM. Age- and Serotype-Specific Pediatric Invasive Pneumococcal Disease: Insights from Systematic Surveillance in Santiago, Chile, 1994–2007. J Infect Dis 2008; 198:1809-17; PMID:18959497; http://dx.doi.org/10.1086/593334
   PubMed Web of Science ®Google Scholar
• Chang Q, Stevenson AE, Croucher NJ, Lee GM, Pelton SI, Lipsitch M, Finkelstein JA, Hanage WP. Stability of the pneumococcal population structure in Massachusetts as PCV13 was introduced. BMC Infect Dis 2015; 15:68; PMID:25887323; http://dx.doi.org/10.1186/s12879-015-0797-z
   Google Scholar
• Kandasamy R, Gurung M, Thapa A, Ndimah S, Adhikari N, Murdoch DR, Kelly DF, Waldron DE, Gould KA, Thorson S, et al. Multi-Serotype Pneumococcal Nasopharyngeal Carriage Prevalence in Vaccine Naïve Nepalese Children, Assessed Using Molecular Serotyping. PLoS ONE 2015; 10:e0114286; PMID:25643355; http://dx.doi.org/10.1371/journal.pone.0114286
   PubMed Web of Science ®Google Scholar
• Kamng'ona AW, Hinds J, Bar-Zeev N, Gould KA, Chaguza C, Msefula C, Cornick JE, Kulohoma BW, Gray K, Bentley SD, et al. High multiple carriage and emergence of Streptococcus pneumoniae vaccine serotype variants in Malawian children. BMC Infect Dis 2015; 15:234; PMID:26088623; http://dx.doi.org/10.1186/s12879-015-0980-2
   Google Scholar
• Cremers AJH, Kokmeijer I, Groh L, de Jonge MI, Ferwerda G. The role of ZmpC in the clinical manifestation of invasive pneumococcal disease. Int J Med Microbiol IJMM 2014; 304:984-9; PMID:25023076; http://dx.doi.org/10.1016/j.ijmm.2014.06.005
   PubMed Web of Science ®Google Scholar
• Cobey S, Lipsitch M. Niche and neutral effects of acquired immunity permit coexistence of pneumococcal serotypes. Science 2012; 335:1376-80; PMID:22383809; http://dx.doi.org/10.1126/science.1215947
   PubMed Web of Science ®Google Scholar
• Ben-Shimol S, Greenberg D, Givon-Lavi N, Schlesinger Y, Somekh E, Aviner S, Miron D, Dagan R. Early impact of sequential introduction of 7-valent and 13-valent pneumococcal conjugate vaccine on IPD in Israeli children . Vaccine 2014; 32:3452-9; PMID:24690148; http://dx.doi.org/10.1016/j.vaccine.2014.03.065
   PubMed Web of Science ®Google Scholar
• Public Health England. Pneumococcal disease: cases caused by strains covered by Prevenar 13 vaccine - GOV.UK [Internet]. GOV.UK2015 [cited 2015 Sep 29]; Available from: https://www.gov.uk/government/publications/pneumococcal-disease-cases-caused-by-strains-covered-by-prevenar-13-vaccine/pneumococcal-disease-cases-caused-by-strains-covered-by-prevenar-13-vaccine
   Google Scholar
• Nzenze SA, von Gottberg A, Shiri T, van Niekerk N, de Gouveia L, Violari A, Nunes MC, Madhi SA. Temporal Changes in Pneumococcal Colonization in HIV-infected and HIV-uninfected Mother-Child Pairs Following Transitioning From 7-valent to 13-valent Pneumococcal Conjugate Vaccine, Soweto, South Africa. J Infect Dis 2015; 212:1082-92; PMID:25784729; http://dx.doi.org/10.1093/infdis/jiv167
   PubMed Web of Science ®Google Scholar
• Hammitt LL, Akech DO, Morpeth SC, Karani A, Kihuha N, Nyongesa S, Bwanaali T, Mumbo E, Kamau T, Sharif SK, et al. Population effect of 10-valent pneumococcal conjugate vaccine on nasopharyngeal carriage of Streptococcus pneumoniae and non-typeable Haemophilus influenzae in Kilifi, Kenya: findings from cross-sectional carriage studies. Lancet Glob Health 2014; 2:e397-405; PMID:25103393; http://dx.doi.org/10.1016/S2214-109X(14)70224-4
   PubMed Web of Science ®Google Scholar
• Lehmann D, Willis J, Moore HC, Giele C, Murphy D, Keil AD, Harrison C, Bayley K, Watson M, Richmond P, et al. The Changing Epidemiology of Invasive Pneumococcal Disease in Aboriginal and Non-Aboriginal Western Australians from 1997 through 2007 and Emergence of Nonvaccine Serotypes. Clin Infect Dis 2010; 50:1477-86; PMID:20420501; http://dx.doi.org/10.1086/652440
   PubMed Web of Science ®Google Scholar
• Hennessy TW, Singleton RJ, Bulkow LR, Bruden DL, Hurlburt DA, Parks D, Moore M, Parkinson AJ, Schuchat A, Butler JC. Impact of heptavalent pneumococcal conjugate vaccine on invasive disease, antimicrobial resistance and colonization in Alaska Natives: progress towards elimination of a health disparity. Vaccine 2005; 23:5464-73; PMID:16188350; http://dx.doi.org/10.1016/j.vaccine.2005.08.100
   PubMed Web of Science ®Google Scholar
• Singleton RJ, Hennessy TW, Bulkow LR, et al. Invasive pneumococcal disease caused by nonvaccine serotypes among alaska native children with high levels of 7-valent pneumococcal conjugate vaccine coverage. JAMA 2007; 297:1784-92; PMID:17456820; http://dx.doi.org/10.1001/jama.297.16.1784
   PubMed Web of Science ®Google Scholar
• Bruce MG, Singleton R, Bulkow L, Rudolph K, Zulz T, Gounder P, Hurlburt D, Bruden D, Hennessy T. Impact of the 13-valent pneumococcal conjugate vaccine (pcv13) on invasive pneumococcal disease and carriage in Alaska. Vaccine 2015; 33:4813-9; PMID:26247901; http://dx.doi.org/10.1016/j.vaccine.2015.07.080
   PubMed Web of Science ®Google Scholar
• Madhi SA, Izu A, Nunes MC, Violari A, Cotton MF, Jean-Philippe P, Klugman KP, von Gottberg A, van Niekerk N, Adrian PV. Longitudinal study on Streptococcus pneumoniae, Haemophilus influenzae and Staphylococcus aureus nasopharyngeal colonization in HIV-infected and -uninfected infants vaccinated with pneumococcal conjugate vaccine. Vaccine 2015; 33:2662-9; PMID:25910923; http://dx.doi.org/10.1016/j.vaccine.2015.04.024
   PubMed Web of Science ®Google Scholar
• Roca A, Dione MM, Bojang A, Townend J, Egere U, Darboe O, Howie SRC, Hill PC, Adegbola RA, Greenwood BM, et al. Nasopharyngeal Carriage of Pneumococci Four Years after Community-Wide Vaccination with PCV-7 in The Gambia: Long-Term Evaluation of a Cluster Randomized Trial. PLoS ONE 2013; 8:e72198; PMID:24086259; http://dx.doi.org/10.1371/journal.pone.0072198
   PubMed Web of Science ®Google Scholar
• Roca A, Hill PC, Townend J, Egere U, Antonio M, Bojang A, Akisanya A, Litchfield T, Nsekpong DE, Oluwalana C, et al. Effects of Community-Wide Vaccination with PCV-7 on Pneumococcal Nasopharyngeal Carriage in The Gambia: A Cluster-Randomized Trial. PLoS Med 2011; 8:e1001107; PMID:22028630; http://dx.doi.org/10.1371/journal.pmed.1001107
   PubMed Web of Science ®Google Scholar
• Wyres KL, Lambertsen LM, Croucher NJ, McGee L, Gottberg A von, Liñares J, Jacobs MR, Kristinsson KG, Beall BW, Klugman KP, et al. Pneumococcal Capsular Switching: A Historical Perspective. J Infect Dis 2013; 207:439-49; PMID:23175765; http://dx.doi.org/10.1093/infdis/jis703
   PubMed Web of Science ®Google Scholar
• Donkor ES, Bishop CJ, Antonio M, Wren B, Hanage WP. High Levels of Recombination among Streptococcus pneumoniae Isolates from the Gambia. mBio 2011; 2:e00040-11; PMID:21693638; http://dx.doi.org/10.1128/mBio.00222-11
   PubMed Web of Science ®Google Scholar
• Hausdorff WP, Hoet B, Adegbola RA. Predicting the impact of new pneumococcal conjugate vaccines: serotype composition is not enough. Expert Rev Vaccines 2015; 14:413-28; PMID:25266168; http://dx.doi.org/10.1586/14760584.2015.965160
   PubMed Web of Science ®Google Scholar
• Verani JR, Domingues CMAS, Moraes JC de. Indirect cohort analysis of 10-valent pneumococcal conjugate vaccine effectiveness against vaccine-type and vaccine-related invasive pneumococcal disease. Vaccine [Internet] [cited 2015 Oct 28]; Available from: http://www.sciencedirect.com/science/article/pii/S0264410´15014188
   Web of Science ®Google Scholar
• Geno KA, Gilbert GL, Song JY, Skovsted IC, Klugman KP, Jones C, Konradsen HB, Nahm MH. Pneumococcal Capsules and Their Types: Past, Present, and Future. Clin Microbiol Rev 2015; 28:871-99; PMID:26085553; http://dx.doi.org/10.1128/CMR.00024-15
   PubMed Web of Science ®Google Scholar
• Prymula R, Peeters P, Chrobok V, Kriz P, Novakova E, Kaliskova E, Kohl I, Lommel P, Poolman J, Prieels J-P, et al. Pneumococcal capsular polysaccharides conjugated to protein D for prevention of acute otitis media caused by both Streptococcus pneumoniae and non-typable Haemophilus influenzae: a randomised double-blind efficacy study. The Lancet 2006; 367:740-8; http://dx.doi.org/10.1016/S0140-6736(06)68304-9
   PubMed Web of Science ®Google Scholar
• Hausdorff WP, Bryant J, Paradiso PR, Siber GR. Which Pneumococcal Serogroups Cause the Most Invasive Disease: Implications for Conjugate Vaccine Formulation and Use, Part I. Clin Infect Dis 2000; 30:100-21; PMID:10619740; http://dx.doi.org/10.1086/313608
   PubMed Web of Science ®Google Scholar
• Andrews NJ, Waight PA, Burbidge P, Pearce E, Roalfe L, Zancolli M, Slack M, Ladhani SN, Miller E, Goldblatt D. Serotype-specific effectiveness and correlates of protection for the 13-valent pneumococcal conjugate vaccine: a postlicensure indirect cohort study. Lancet Infect Dis 2014; 14:839-46; PMID:25042756; http://dx.doi.org/10.1016/S1473-3099(14)70822-9
   Google Scholar
• Robinson DA, Turner JS, Facklam RR, Parkinson AJ, Breiman RF, Gratten M, Steinhoff MC, Hollingshead SK, Briles DE, Crain MJ. Molecular Characterization of a Globally Distributed Lineage of Serotype 12F Streptococcus pneumoniae Causing Invasive Disease. J Infect Dis 1999; 179:414-22; PMID:9878026; http://dx.doi.org/10.1086/314589
   PubMed Web of Science ®Google Scholar
• Robbins JB, Austrian R, Lee CJ, Rastogi SC, Schiffman G, Henrichsen J, Mäkelä PH, Broome CV, Facklam RR, Tiesjema RH. Considerations for formulating the second-generation pneumococcal capsular polysaccharide vaccine with emphasis on the cross-reactive types within groups. J Infect Dis 1983; 148:1136-59; PMID:6361173; http://dx.doi.org/10.1093/infdis/148.6.1136
   PubMed Web of Science ®Google Scholar
• Kaplan SL, Barson WJ, Lin PL, Romero JR, Bradley JS, Tan TQ, Hoffman JA, Givner LB, Mason EO. Early Trends for Invasive Pneumococcal Infections in Children After the Introduction of the 13-valent Pneumococcal Conjugate Vaccine: Pediatr Infect Dis J 2013; 32:203-7; PMID:23558320; http://dx.doi.org/10.1097/INF.0b013e318275614b
   PubMed Web of Science ®Google Scholar
• Taiwan CDC. Taiwan CDC report - 2014/2015 [Internet]. [cited 2015 Jul 22]; Available from: https://www.cdc.gov.tw/professional/list.aspx?treeid=098F3BC4756F62CC&nowtreeid=90960C331E13A586
   Google Scholar
• Guevara M, Ezpeleta C, Gil-Setas A, Torroba L, Beristain X, Aguinaga A, García-Irure JJ, Navascués A, García-Cenoz M, Castilla J. Reduced incidence of invasive pneumococcal disease after introduction of the 13-valent conjugate vaccine in Navarre, Spain, 2001–2013. Vaccine 2014; 32:2553-62; PMID:24674661; http://dx.doi.org/10.1016/j.vaccine.2014.03.054
   PubMed Web of Science ®Google Scholar
• Meichtry J, Born R, Küffer M, Zwahlen M, Albrich WC, Brugger SD, Mühlemann K, Hilty M. Serotype epidemiology of invasive pneumococcal disease in Swiss adults: A nationwide population-based study. Vaccine 2014; 32:5185-91; PMID:25077419; http://dx.doi.org/10.1016/j.vaccine.2014.07.060
   PubMed Web of Science ®Google Scholar
• Institut scientifique de Santé Publique. Maladies infectieuses pédiatriques à prévention vaccinale. Rapport annuel 2013 [Internet]. 2013 [cited 2015 Jul 20]; Available from: https://www.wiv-isp.be/SiteCollectionDocuments/Maladies%20infectieuses%20p%C3%A9diatriques%20%C3%A0%20pr%C3%A9vention%20vaccinale.%20Rapport%20annuel%202013.pdf
   Google Scholar