Nano-encapsulated metformin-curcumin in PLGA/PEG inhibits synergistically growth and hTERT gene expression in human breast cancer cells

References

• Eatemadi A, Darabi M, Afraidooni L, et al. Comparison, synthesis and evaluation of anticancer drug-loaded polymeric nanoparticles on breast cancer cell lines. Artif Cells Nanomed Biotechnol. 2016;44:1008–1017.
   PubMed Web of Science ®Google Scholar
• Anari E, Akbarzadeh A, Zarghami N. Chrysin-loaded PLGA-PEG nanoparticles designed for enhanced effect on the breast cancer cell line. Artif Cells Nanomed Biotechnol. 2015;44:1410–1416.
   PubMed Web of Science ®Google Scholar
• Ghalhar MG, Akbarzadeh A, Rahmati M, et al. Comparison of inhibitory effects of 17-AAG nanoparticles and free 17-AAG on HSP90 gene expression in breast cancer. Asian Pac J Cancer Prev. 2014;15:7113–7118.
   PubMedGoogle Scholar
• Zeighamian V, Darabi M, Akbarzadeh A, et al. PNIPAAm-MAA nanoparticles as delivery vehicles for curcumin against MCF-7 breast cancer cells. Artif Cells Nanomed Biotechnol. 2016;44:735–742.
   PubMed Web of Science ®Google Scholar
• Rahmati-Yamchi M, Zarghami N, Rahbani M, Montazeri A. Plasma leptin, hTERT gene expression, and anthropometric measures in obese and non-obese women with breast cancer. Breast Cancer Basic Clin Res. 2011;5:27.
   PubMedGoogle Scholar
• Daniel M, Peek GW, Tollefsbol TO. Regulation of the human catalytic subunit of telomerase (hTERT). Gene. 2012;498:135–146.
   PubMed Web of Science ®Google Scholar
• Cheng Y-B, Guo L-P, Yao P, et al. C. Telomerase and hTERT: can they serve as markers for gastric cancer diagnosis? World J Gastroenterol. 2014;20:6615.
   PubMed Web of Science ®Google Scholar
• Javan-Maasomi Z, Pilehvar-Soltanahmadi Y, Dadashpour M, et al. Synergistic anticancer effects of silibinin and chrysin in T47D breast cancer cells. Asian Pac J Cancer Prev. 2017;18:1283–1287.
   PubMedGoogle Scholar
• Lv S, Tang Z, Li M, et al. Co-delivery of doxorubicin and paclitaxel by PEG-polypeptide nanovehicle for the treatment of non-small cell lung cancer. Biomaterials. 2014;35:6118–6129.
   PubMed Web of Science ®Google Scholar
• Du Q, Hu B, An H-M, et al. Synergistic anticancer effects of curcumin and resveratrol in Hepa1-6 hepatocellular carcinoma cells. Oncol Rep. 2013;29:1851–1858.
   PubMed Web of Science ®Google Scholar
• He Z, Huang J, Xu Y, et al. Co-delivery of cisplatin and paclitaxel by folic acid conjugated amphiphilic PEG-PLGA copolymer nanoparticles for the treatment of non-small lung cancer. Oncotarget. 2015;6:42150.
   PubMed Web of Science ®Google Scholar
• Duong HHP, Yung L-YL. Synergistic co-delivery of doxorubicin and paclitaxel using multi-functional micelles for cancer treatment. Int J Pharm. 2013;454:486–495.
   PubMed Web of Science ®Google Scholar
• Alibakhshi A, Ranjbari J, Pilehvar-Soltanahmadi Y, et al. An update on phytochemicals substances in molecular target therapy of cancer: potential inhibitory effect on telomerase activity. Curr Med Chem. 2016;23:2380–2393.
   PubMed Web of Science ®Google Scholar
• Naksuriya O, Okonogi S, Schiffelers RM, et al. Curcumin nanoformulations: a review of pharmaceutical properties and preclinical studies and clinical data related to cancer treatment. Biomaterials. 2014;35:3365–3383.
   PubMed Web of Science ®Google Scholar
• Kourelis TV, Siegel RD. Metformin and cancer: new applications for an old drug. Med Oncol. 2012;29:1314–1327.
   PubMed Web of Science ®Google Scholar
• Kazemi-Lomedasht F, Rami A, Zarghami N. Comparison of inhibitory effect of curcumin nanoparticles and free curcumin in human telomerase reverse transcriptase gene expression in breast cancer. Adv Pharm Bull. 2013;3:127–130.
   PubMedGoogle Scholar
• Xiong Y, Zhao Y, Miao L, et al. Co-delivery of polymeric metformin and cisplatin by self-assembled core-membrane nanoparticles to treat non-small cell lung cancer. J Control Release. 2016;244:63–73.
   PubMed Web of Science ®Google Scholar
• Badrzadeh F, Akbarzadeh A, Zarghami N, et al. Comparison between effects of free curcumin and curcumin loaded NIPAAm-MAA nanoparticles on telomerase and PinX1 gene expression in lung cancer cells. Asian Pac J Cancer Prev. 2014;15:8931–8936.
   PubMed Web of Science ®Google Scholar
• Amirsaadat S, Pilehvar-Soltanahmadi Y, Zarghami F, et al. Silibinin-loaded magnetic nanoparticles inhibit hTERT gene expression and proliferation of lung cancer cells. Artif Cells Nanomed Biotechnol 2017. [Epub ahead of print]. doi: 10.1080/21691401.2016.1276922.
   PubMed Web of Science ®Google Scholar
• Sadeghzadeh H, Pilehvar-Soltanahmadi Y, Akbarzadeh A, et al. The effects of nanoencapsulated curcumin-Fe3O4 on proliferation and hTERT gene expression in lung cancer cells. Anticancer Agents Med Chem. 2017;17:1–11
   Web of Science ®Google Scholar
• Mohammadian F, Pilehvar-Soltanahmadi Y, Mofarrah M, et al. Down regulation of miR-18a, miR-21 and miR-221 genes in gastric cancer cell line by chrysin-loaded PLGA-PEG nanoparticles. Artif Cells Nanomed Biotechnol. 2016;44:1972–1978.
   PubMed Web of Science ®Google Scholar
• Alimohammadi YH, Joo SW. PLGA-based nanoparticles as cancer drug delivery systems. Asian Pac J Cancer Prev. 2014;15:517–535.
   PubMedGoogle Scholar
• Wang B, Yu X-C, Xu S-F, et al. Paclitaxel and etoposide co-loaded polymeric nanoparticles for the effective combination therapy against human osteosarcoma. J Nanobiotechnol. 2015;13:1.
   PubMed Web of Science ®Google Scholar
• Santander-Ortega MJ, Csaba N, González L, et al. Protein-loaded PLGA–PEO blend nanoparticles: encapsulation, release and degradation characteristics. Colloid Polym Sci. 2010;288:141–150.
   Web of Science ®Google Scholar
• Athira GK, Jyothi AN. Preparation and characterization of curcumin loaded cassava starch nanoparticles with improved cellular absorption. Int J Pharm Pharm Sci. 2014;6:171–176.
   Google Scholar
• Mohan PK, Sreelakshmi G, Muraleedharan C, et al. Water soluble complexes of curcumin with cyclodextrins: characterization by FT-Raman spectroscopy. Vib Spectrosc. 2012;62:77–84.
   Web of Science ®Google Scholar
• Aslan B, Ozpolat B, Sood AK, et al. Nanotechnology in cancer therapy. J Drug Target. 2013;21:904–913.
   PubMed Web of Science ®Google Scholar
• Chou T-C. Drug combination studies and their synergy quantification using the Chou-Talalay method. Cancer Res. 2010;70:440–446.
   PubMed Web of Science ®Google Scholar
• Nasiri M, Zarghami N, Koshki KN, et al. Curcumin and silibinin inhibit telomerase expression in T47D human breast cancer cells. Asian Pac J Cancer Prev. 2013;14:3449–3453.
   PubMed Web of Science ®Google Scholar
• Holysz H, Lipinska N, Paszel-Jaworska A, et al. Telomerase as a useful target in cancer fighting – the breast cancer case. Tumor Biol. 2013;34:1371–1380.
   PubMed Web of Science ®Google Scholar
• Lee JH, Chung IK. Curcumin inhibits nuclear localization of telomerase by dissociating the Hsp90 co-chaperone p23 from hTERT. Cancer Lett. 2010;290:76–86.
   PubMed Web of Science ®Google Scholar
• Montazeri M, Pilehvar-Soltanahmadi Y, Mohaghegh M, et al. Antiproliferative and apoptotic effect of dendrosomal curcumin nanoformulation in P53 Mutant and wide-type cancer cell lines. Anticancer Agents Med Chem. 2017;17:662–673
   PubMed Web of Science ®Google Scholar
• Montazeri M, Sadeghizadeh M, Pilehvar-Soltanahmadi Y, et al. Dendrosomal curcumin nanoformulation modulate apoptosis-related genes and protein expression in hepatocarcinoma cell lines. Int J Pharm. 2016;509:244–254.
   PubMed Web of Science ®Google Scholar
• Hasima N, B Aggarwal B. Targeting proteasomal pathways by dietary curcumin for cancer prevention and treatment. Curr Med Chem. 2014;21:1583–1594.
   PubMed Web of Science ®Google Scholar
• Alibakhshi A, Ranjbari J, Pilehvar-Soltanahmadi Y, et al. An update on phytochemicals in molecular target therapy of cancer: potential inhibitory effect on telomerase activity. Curr Med Chem. 2016;23:2380–2393.
   PubMed Web of Science ®Google Scholar
• Cerone MA, Londoño-Vallejo JA, Autexier C. Telomerase inhibition enhances the response to anticancer drug treatment in human breast cancer cells. Mol Cancer Ther. 2006;5:1669–1675.
   PubMed Web of Science ®Google Scholar