Advanced search
Publication Cover
Infectious Diseases Volume 53, 2021 - Issue 10
Submit an article Journal homepage
171
Views
7
CrossRef citations to date
0
Altmetric
Original Articles

Cytokine production and outcome in MDR versus non-MDR gram-negative bacteraemia and sepsis

Vasileios Karamouzosa Intensive Care Unit, University Hospital of Patras, Patras, GreeceCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-1122-4213View further author information
ORCID Icon,
Evangelos J. Giamarellos-Bourboulisb Fourth Department of Internal Medicine, National and Kapodistrian University of Athens, Athens, GreeceView further author information
,
Dimitrios Velissarisc Internal Medicine Department, University Hospital of Patras, Patras, GreeceView further author information
,
Theologia Gkavogiannib Fourth Department of Internal Medicine, National and Kapodistrian University of Athens, Athens, GreeceView further author information
&
Charalambos Gogosc Internal Medicine Department, University Hospital of Patras, Patras, GreeceView further author information
Pages 764-771 | Received 16 Jul 2020, Accepted 29 Apr 2021, Published online: 17 Jun 2021

Bibliography

  • Reinhart K, Daniels R, Kissoon N, et al. Recognizing sepsis as a global health priority — A WHO resolution. N Engl J Med. 2017;377(5):414–417.
  • Fleischmann C, Scherag A, Adhikari NKJ, et al. Assessment of global incidence and mortality of hospital-treated sepsis current estimates and limitations. Am J Respir Crit Care Med. 2016;193(3):259–272.
  • Fraimow H, Nahra R. Resistant gram-negative infections. Crit Care Clin. 2013;29(4):895–921.
  • Singer M, Deutschman CS, Seymour C, et al. The third international consensus definitions for sepsis and septic shock (sepsis-3). JAMA. 2016;315(8):801–810.
  • Giamarellos-Bourboulis EJ, Plachouras D, Tzivra A, et al. Stimulation of innate immunity by susceptible and multidrug-resistant Pseudomonas aeruginosa: an in vitro and in vivo study. Clin Exp Immunol. 2004;135(2):240–246.
  • Pantelidou I-M, Galani I, Georgitsi M, et al. Interactions of Klebsiella pneumoniae with the innate immune system vary in relation to clone and resistance phenotype. Antimicrob Agents Chemother. 2015;59(11):7036–7043.
  • Hellenic Sepsis Study Group. [accessed 3 December 2019]. Available from: http://hssg.sepsis.gr
  • Levy MM, Fink MP, Marshall JC, et al. 2001 SCCM/ESICM/ACCP/ATS/SIS international sepsis definitions conference. Crit Care Med. 2003;31(4):1250–1256.
  • Magiorakos A-P, Srinivasan A, Carey RB, et al. Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance. Clin Microbiol Infect. 2012;18(3):268–281.
  • Van Der Poll T, Van De Veerdonk FL, Scicluna BP, et al. The immunopathology of sepsis and potential therapeutic targets. Nat Rev Immunol. 2017;17(7):407–420.
  • Giamarellosbourboulis E, Koussoulas V, Panagou C, et al. Experimental sepsis using Pseudomonas aeruginosa: the significance of multi-drug resistance. Int J Antimicrob Agents. 2004;24(4):357–361.
  • Zhou Z, Ren J, Liu H, et al. Pandrug-resistant isolate of Klebsiella pneumoniae causes less damage than drug-susceptible isolates in a rabbit model. Clin Invest Med. 2011;34(1):38–44. http://www.ncbi.nlm.nih.gov/pubmed/21291634. Accessed March 19, 2018.
  • Wu HP, Chen CK, Chung K, et al. Serial cytokine levels in patients with severe sepsis. Inflamm Res. 2009;58(7):385–393.
  • Bozza FA, Salluh JI, Japiassu AM, et al. Cytokine profiles as markers of disease severity in sepsis: a multiplex analysis. Crit Care. 2007;11(2):R49.
  • Oberholzer A, Souza SM, Tschoeke SK, et al. Plasma cytokine measurements augment prognostic scores as indicators of outcome in patients with severe sepsis. Shock. 2005;23(6):488–493. http://www.ncbi.nlm.nih.gov/pubmed/15897799. Accessed December 18, 2019.
  • Lymperopoulou K, Velissaris D, Kotsaki A, et al. Angiopoietin-2 associations with the underlying infection and sepsis severity. Cytokine. 2015;73(1):163–168.
  • Blot S, Vandewoude K, De Bacquer D, et al. Nosocomial bacteremia caused by antibiotic‐resistant gram‐negative bacteria in critically ill patients: clinical outcome and length of hospitalization. Clin Infect Dis. 2002;34(12):1600–1606.
  • Parker CM, Kutsogiannis J, Muscedere J, et al. Ventilator-associated pneumonia caused by multidrug-resistant organisms or Pseudomonas aeruginosa: prevalence, incidence, risk factors, and outcomes. J Crit Care. 2008;23(1):18–26.
  • Mouloudi E, Protonotariou E, Zagorianou A, et al. Bloodstream infections caused by metallo- β -lactamase/Klebsiella pneumoniae carbapenemase–producing K. pneumoniae among intensive care unit patients in Greece: risk factors for infection and impact of type of resistance on outcomes. Infect Control Hosp Epidemiol. 2010;31(12):1250–1256.
  • Papadimitriou-Olivgeris M, Marangos M, Christofidou M, et al. Risk factors for infection and predictors of mortality among patients with KPC-producing Klebsiella pneumoniae bloodstream infections in the intensive care unit. Scand J Infect Dis. 2014;46(9):642–648.
  • Zilberberg MD, Shorr AF, Micek ST, et al. Multi-drug resistance, inappropriate initial antibiotic therapy and mortality in Gram-negative severe sepsis and septic shock: a retrospective cohort study. Crit Care. 2014;18(6):596.
  • Fisher J, Douglas JJ, Linder A, et al. Elevated plasma angiopoietin-2 levels are associated with fluid overload, organ dysfunction, and mortality in human septic shock. Crit Care Med. 2016;44(11):2018–2027.
  • Siner JM, Bhandari V, Engle KM, et al. Elevated serum Angiopoietin 2 levels are associated with increased mortality in sepsis. Shock. 2009;31(4):348–353.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.