Transgenic TGR(mREN2)27 Rats as a Model for Disturbed Circadian Organization at the Level of the Brain, the Heart, and the Kidneys

References

• Albrecht U., Sun Z. S., Eichele G., Lee C. C. A differential response of two putative mammalian circadian regulators, mper1 and mper2, to light. Cell 1997; 91: 1055–1064
   PubMed Web of Science ®Google Scholar
• Bachmann S., Peters J., Engler E., Ganten D., Mullins J. Transgenic rats carrying the mouse renin gene‐morphological characterization of a low‐renin hypertension model. Kidney Int. 1992; 41: 24–36
   PubMed Web of Science ®Google Scholar
• Baltatu O., Lippoldt A., Hansson A., Ganten D., Bader M. Local renin‐angiotensin system in the pineal gland. Mol. Brain Res. 1998; 54: 237–242
   PubMedGoogle Scholar
• Campbell D. J., Rong P., Kladis A., Rees B., Ganten D., Skinner S. L. Angiotensin and bradykinin peptides in the TGR(mRen‐2)27 rat. Hypertension 1995; 25: 1014–1020
   PubMed Web of Science ®Google Scholar
• Daan S., Pittendrigh C. S. A functional analysis of circadian pacemakers in nocturnal rodents: II. The variability of phase response curves. J. Comp. Physiol. 1976; 106: 253–266
   Web of Science ®Google Scholar
• Enzminger H., Witte K., Lemmer B. Impaired α1‐adrenoceptor regulation of melatonin synthesis and cGMP formation in cultured pinealocytes from TGR(mREN2)27 rats. Chronobiol. Int. 2001a; 18: 1093–1094
   Google Scholar
• Enzminger H., Witte K., Lemmer B. Altered melatonin production in TGR(mREN2)27 rats: on the regulation by adrenergic agonists, antagonists, and angiotensin II in cultured pinealocytes. J. Pineal Res. 2001b; 31: 256–263
   PubMedGoogle Scholar
• Enzminger H., Witte K., Lemmer B. Adrenergic regulation of melatonin synthesis in cultered pinealocytes from TGR(mREN2)27 rats. Naunyn‐Schmiedeberg's Arch. Pharmacol. 2001c; 363(suppl)R30
   Google Scholar
• Finocchiaro L. M.E., Goldstein D. J., Finkielman S., Nahmod V. E. Interaction of angiotensin II with the cholinergic and noradrenergic systems in the rat pineal gland: regulation of indole metabolism. J. Endocrinol. 1990; 126: 59–66
   PubMed Web of Science ®Google Scholar
• Goldman B. D., Darrow J. M. The pineal gland and mammalian photoperiodism. Neuroendocrinology 1983; 37: 386–396
   PubMed Web of Science ®Google Scholar
• Grimm D., Hauptfleisch S., Lemmer B. Effect of a lightpulse on plasma ACTH, corticosterone, aldosterone and renin activity in Sprague‐Dawley rats. Naunyn‐Schmiedeberg's Arch. Pharmacol. 2002; 365(suppl 1)R82
   Google Scholar
• Gross V., Lippoldt A., Schneider W., Luft F. Effect of captopril and angiotensin II receptorblockade on pressure natriuresis in transgenic TGR(mREN2)27 rats. Hypertension 1995; 26: 471–479
   PubMedGoogle Scholar
• Hauptfleisch S., Lemmer B. Influence of an overexpressed renin‐angiotensin‐system on melatonin synthesis. Int. Congr. Chronobiol, Washington D.C., 1999. Abstr. 72
   Google Scholar
• Hauptfleisch S., Lemmer B. Circadian adrenal expression of the mouse renin2 transgene mRNA may responsible for the inverse blood pressure rhythm in the transgenic hypertensive TGR(mREN2)27 rat strain. Naunyn‐Schmiedeberg's Arch. Pharmacol. 2001; 363(suppl)R17
   Google Scholar
• Hauptfleisch S., Lemmer B. How can an elevated renin‐angiotensin‐system affect the circadian clock?. 7th Colloquium of the DFG Schwerpunktprogramm, Fraueninsel, 2002. Abstr.p. 24, 31.7.‐3.8
   Google Scholar
• Hauptfleisch S., Schummer B., Lemmer B. Is a neuronal pacemaker involved in the regulation of blood pressure rhythm? Expression pattern of mRNA in the suprachiasmatic nuclei in normotensive and transgenic hypertensive rats. Am. J. Hypertens. 1998a; 11: 140A
   Google Scholar
• Hauptfleisch S., Schummer B., Lemmer B. Expression of c‐fos messenger‐RNA involved in the regulation of blood pressure in normotensive and transgenic hypertensive rats. Naunyn‐Schmiedeberg's Arch. Pharmacol. 1998b; 357: R17
   Google Scholar
• Hauptfleisch S., Schummer B., Lemmer B. The influence of a hyperactive renin‐angiotensin‐system on the AT1‐receptor mRNA and the melatonin synthesis in the pineal gland. Naunyn‐Schmiedeberg's Arch. Pharmacol. 1999; 359(suppl)R78
   Google Scholar
• Hauptfleisch S., Enzminger H., Schiffer S., Lemmer B. An overexpressed renin‐angiotensin‐system and its impact on the circadian clock. Chronobiol. Int. 2001; 18: 1114–1115
   Google Scholar
• Ho A. K., Chik C. L. Post‐receptor mechanism in dual receptors regulation of second messengers in rat pineal gland. Progress in Clinical and Biological Research, A. Epple, C. G. Scanes, M. Stetson. Wiley‐Liss, New York 1990; 139–145
   Google Scholar
• Kornhauser J. M., Mayo K. E., Takahashi J. S. Light, immediate‐early genes, and circadian rhythms. Behav. Genet. 1996; 26: 221–240
   PubMed Web of Science ®Google Scholar
• Lemmer B. Genetic aspects of chronobiologic rhythms in cardiovascular disease. From Molecule to Men—Molecular Basis of Congenital Cardiovascular Disorders, M. Zehender, G. Breithardt, H. Just. Steinkopff, Darmstadt/Springer, Heidelberg 2000; 201–213
   Google Scholar
• Lemmer B., Mattes A., Böhm M., Ganten D. Circadian blood pressure variation in transgenic hypertensive rats. Hypertension 1993; 22: 97–101
   PubMed Web of Science ®Google Scholar
• Lemmer B., Witte K., Makabe T., Ganten D., Mattes A. Effects of enalaprilat on circadian profiles in blood pressure and heart rate of spontaneously and transgenic hypertensive rats. J. Cardiovasc. Pharmacol. 1994; 23: 311–314
   PubMed Web of Science ®Google Scholar
• Lemmer B., Schnecko A., Witte K. Transgenic rats as a model for cardiovascular chronopharmacology. Biological Clocks—Mechanisms and Applications, Y. Touitou. Elsevier, Amsterdam, New York 1998; 453–460
   Google Scholar
• Lemmer B., Hauptfleisch S., Witte K. Loss of 24 h rhythm and light induced c‐fos mRNA expression in the suprachiasmatic nucleus of transgenic hypertensive TRG(mREN2)27 rats and effects on cardiovascular rhythms. Brain Res. 2000a; 883: 250–257
   PubMed Web of Science ®Google Scholar
• Lemmer B., Witte K., Schänzer A., Findeisen A. Circadian rhythms in the renin‐angiotensin system and adrenal steroids may contribute to the inverse blood pressure rhythm in hypertensive TGR(mREN‐2)27 rats. Chronobiol. Int. 2000b; 17: 645–658
   PubMed Web of Science ®Google Scholar
• Lemmer B., Hauptfleisch S., Schiffer S., Witte K. Rhythm generation in cardiovascular functions related to transcription factors and effects of light pulses. Chronobiol. Int. 2001a; 18: 1149
   Google Scholar
• Lemmer B., Rueff T., Reiter S., Huser L., Hauptfleisch S., Witte K. Influence of circadian time and age on glomerular angiotensin II receptors in normotensive Sprague‐Dawley and transgenic hypertensive TGR(mREN2)27 rats. Chronobiol. Int. 2001b; 18: 447–459
   PubMed Web of Science ®Google Scholar
• Lemmer B., Schiffer S., Enzminger H., Hauptfleisch S. Disturbed central and peripheral regulation of the catecholamine and renin‐angiotensin systems in vivo and in vitro in transgenic hypertensive TGR(mRen2)27 rats. 7th Colloquium of the DFG Schwerpunktprogramm, Fraueninsel, 31.7–3.8, Abstr. p. 23. 2002
   Google Scholar
• Lippoldt A., Gross V., Bohlender J., Ganten U., Luft F. Lifelong angotensin‐converting enzyme inhibition, pressure natriuresis, and renin‐angiotensin system gene expression in transgenic (mREN2)27 rats. J. Am. Soc. Nephrol. 1996; 7: 2119–2129
   PubMedGoogle Scholar
• Lowry O., Rosebrough A., Farr A., Randall R. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 1951; 193: 265–275
   PubMed Web of Science ®Google Scholar
• Maronde E., Pfeffer M., Olcese J., Molina C. A., Schlotter F., Dehghani F., Korf H. W., Stehle J. H. Transcription factors in neuroendocrine regulation: rhythmic changes in pCREB and ICER levels frame melatonin synthesis. J. Neurosci. 1999; 19: 3326–3336
   PubMed Web of Science ®Google Scholar
• Mattes A., Witte K., Hohmann W., Lemmer B. PHARMFIT—a non‐linear fitting program for pharmacology. Chronobiol. Int. 1991; 8: 460–476
   PubMed Web of Science ®Google Scholar
• Mullins J. J., Peters J., Ganten D. Fulminant hypertension in transgenic rats harbouring the mouse Ren‐2 gene. Nature 1990; 344: 541–544
   PubMed Web of Science ®Google Scholar
• Nickenig G., Laufs U., Schnabel P., Knorr A., Paul M., Böhm M. Down‐regulation of aortic and cardiac AT1 receptor gene expression in transgenic (mRen‐2)27 rats. Br.J. Pharmacol. 1997; 121: 134–140
   PubMed Web of Science ®Google Scholar
• Olcese J. Neuropeptide Y: an endogenous inhibitor of norepinephrine‐ stimulated melatonin secretion in the rat pineal gland. J. Neurochem. 1991; 57: 943–947
   PubMedGoogle Scholar
• Pfeffer M., Maronde E., Molina C. A., Korf H.‐W., Stehle J. H. Inducible cyclic AMP early repressor protein in rat pinealocytes: a highly sensitive natural reporter for regulated gene transcription. Mol. Pharmacol. 1999; 56: 279–289
   PubMedGoogle Scholar
• Pittendrigh C. S. On the mechanism of the entainment of a circadian rhythm by light cycles. Circadian Clocks, J. Aschoff. North‐Holland Publishing Company, Amsterdam 1965; 277–297
   Google Scholar
• Pons M., Schnecko A., Witte K., Lemmer B., Waterhouse J., Cambar J. Circadian rhythms in renal function in hypertensive TGR(mREN2)27 rats and their normotensive controls. Am. J. Physiol. 1996; 271: R1002–R1009
   PubMedGoogle Scholar
• Rusak B., McNaughton L., Robertson H. A., Hunt S. P. Circadian variation in photic regulation of immediate‐early gene mRNAs in rat suprachiasmatic nucleus cells. Brain Res. Mol. Brain Res. 1992; 14: 124–130
   PubMedGoogle Scholar
• Schiffer S., Pummer S., Witte K., Lemmer B. Cardiovascular regulation in TGR(mREN2)27 rats: 24 h variation in plasma catecholamines, angiotensin peptides, and in telemetric heart rate variability. Chronobiol. Int. 2001a; 18: 461–474
   PubMed Web of Science ®Google Scholar
• Schiffer S., Enzminger H., Hauptfleisch S., Witte K., Lemmer B. Day–night differences in catecholamine turnover and tyrosine‐hydroxylase mRNA in normotensive Sprague‐Dawley (SPRD) and hypertensive TGR(mREN2)27 rats. Chronobiol. Int. 2001b; 18: 1186–1187
   Google Scholar
• Schmidt C., Ganten D., Klenk A., Buselmaier W. Mapping of candidate genes for hypertension by fluorescence in situ hybridization on the genome of transgenic rats and mice. Clin. Exper. Hypertens. 1998; 20: 185–204
   PubMed Web of Science ®Google Scholar
• Schnecko A., Witte K., Lemmer B. Effect of the angiotensin II receptor antagonist losartan on 24‐hour blood pressure profiles of primary and secondary hypertensive rats. J. Cardiovasc. Pharmacol. 1995; 26: 214–221
   PubMed Web of Science ®Google Scholar
• Schummer B., Hauptfleisch S., Siegsmund M., Schummer M., Lemmer B. Highly accurate quantification of mRNA expression by means of Titan™ one tube RT‐PCR and capillary electrophoresis. Biochemica 1998; 2: 31–33
   Google Scholar
• Shigeyoshi Y., Taguchi K., Yamamoto S., Takekida S., Yan L., Tei H., Moriya T., Shibata S., Loros J. J., Dunlap J. C., Okamura H. Light‐induced resetting of a mammalian circadian clock is associated with rapid induction of the mPer1 transcript. Cell 1997; 91: 1043–1053
   PubMed Web of Science ®Google Scholar
• Springate J., Feld L., Ganten A. Renal function in hypertensive rats transgenic for mouse renin. Am. J. Physiol. 1993; 365: 731–F737
   Google Scholar
• Stehle J. H., Foulkes N. S., Molina C. A., Simmoneaux V., Pevet P., SassoneCorsi P. Adrenergic signals direct rhythmic expression of transcriptional repressor CREM in the pineal gland. Nature 1993; 365: 214–320
   Google Scholar
• Sutin E. L., Kilduff T. S. Circadian and light‐induced expression of immediate early gene mRNAs in the rat suprachiasmatic nucleus. Brain Res. Mol. Brain Res. 1992; 15: 281–290
   PubMedGoogle Scholar
• Thomas M. A., Fleissner G., Hauptfleisch S., Lemmer B. Subcellular identification of angiotensin II and angiotensin II‐immunoreactivity in the central nervous system of rats. Brain Res. 2003a; 962: 92–104
   PubMedGoogle Scholar
• Thomas M. A., Hauptfleisch S., Fleissner G., Lemmer B. Localization of angiotensin II (AT1)‐receptorimmunoreactive fibers in the hypothalamus of rats: angiotensin II‐sensitive tanycytes in the ependyma of the third ventricle?. Brain Res. 2003b; 967: 281–284
   PubMedGoogle Scholar
• Tokita Y., Franco‐Saenz R., Mulrow P. J., Ganten D. Effects of nephrectomy and adrenalectomy on the renin‐angiotensin system of transgenic rats TGR(mRen‐2)27. Endocrinology 1994; 134: 253–257
   PubMed Web of Science ®Google Scholar
• Vanecek J., Sugden D., Weller J. Atypical synergistic α1‐ and β‐adrenergic regulation of andenosine 3′,5′‐monophosphate and guanosine 3′,5′‐monophosphate in rat pinealocytes. Endocrinology 1985; 116: 2167–2173
   PubMed Web of Science ®Google Scholar
• White B., Klein D. C. Stimulation of cyclic GMP accumulation by sodium nitroprusside is potentiated via a Gs mechanism in intact pinealocytes. J. Neurochem. 1995; 64: 711–717
   PubMedGoogle Scholar
• Witte K., Lemmer B. Free‐running rhythms in blood pressure and heart rate in normotensive Sprague‐Dawley rats.J. Interdiscipl. Cycle Res. 1993; 24: 328–334
   Web of Science ®Google Scholar
• Witte K., Lemmer B. Free‐running rhythms in blood pressure and heart rate in normotensive and transgenic hypertensive rats. Chronobiol. Int. 1995; 12: 237–247
   Web of Science ®Google Scholar
• Witte K., Lemmer B. Development of inverse circadian blood pressure pattern in transgenic hypertensive TGR(mRen2)27 rats. Chronobiol. Int. 1999; 16: 293–303
   PubMed Web of Science ®Google Scholar
• Witte K., Hasenberg T., Rueff T., Hauptfleisch S., Schilling L., Lemmer B. Day–night variation in the in vitro contractility of aorta and mesenteric and renal arteries in transgenic hypertensive rats. Chronobiol. Int. 2001; 18: 665–681
   PubMed Web of Science ®Google Scholar
• Witte K., Schnecko A., Buijs R. M., van der Vliet J., Scalbert E., Delagrange P., Guardiola‐Lemaitre B., Lemmer B. Effects of SCN‐lesions on circadian blood pressure rhythm in normotensive and transgenic hypertensive rats. Chronobiol. Int. 1998; 15: 135–145
   PubMed Web of Science ®Google Scholar
• Zuther P., Lemmer B. WIN‐ABPM‐FIT—a comprehensive, rapid and easy‐to‐use program to analyze 24‐h blood pressure data from humans and telemetric data from animals. Naunyn‐Schmiedeberg's Arch. Pharmacol. 2003; 367(suppl 1)A484
   Google Scholar