Ricin: Mechanism of Toxicity, Clinical Manifestations, and Vaccine Development. A Review

References

• Klaassen C D. Toxic effects on plants. Casarrett and Doull's Toxicology: The Basic Science of Poisons6th ed. McGraw‐Hill, New York 2001; 968
   Google Scholar
• Hardin J W, Arena J M. Internal poisoning. Human Poisoning from Native and Cultivated Plants2nd ed. Duke University Press, Durham, NC 1974; 119–121
   Google Scholar
• Franz H. The ricin story. Advances in Lectin Research, H Franz. Springer‐Verlag, New York 1988; Vol. 1: 110–125
   Google Scholar
• Greenfield A R, Brown B R, Hutchins J B, Iandolo J J, Jackson R, Slater L, Bronze M S. Microbiological, biological, and chemical weapons of warfare and terrorism. Am J Med Sci 2002; 323: 326–340
   PubMed Web of Science ®Google Scholar
• TwilleyI CRothD WHJrLofquistR ANylon 6 ProductionUS Patent 3,558,567December 28, 1967
   Google Scholar
• KimS USonH SYoonS HPreparation of rubber compositions with excellent propertiesKorean Patent 2,000,060,113March 12, 1999
   Google Scholar
• JackwerthBBrueningSCosmetics preparation containing dicarboxylic acids as emulsifiers and moisturizersGerman Patent 2,002,012,778August 8, 2001
   Google Scholar
• Lubricating oil for metalworkingJapanese Patent 58,017,197July 23, 1981
   Google Scholar
• Franz D R, Jaax N K. Ricin toxin. Medical Aspects of Chemical and Biological U.S. Warfare. Office of the Surgeon General; Department of the Army, Washington, DC 1997; 631–642
   Google Scholar
• Watson W A, Litovitz T L, Rodgers G C, Jr, Klein‐Schwartz W, Youniss J, Rose S R, Borys D, May M E. 2002 annual report of the american association of poison control centers toxic exposure surveillance system. Am J Emerg Med Sep 2003; 21(5)353–421
   PubMed Web of Science ®Google Scholar
• Knight B. Ricin a potent homicidal poison. Br Med J 1979; Feb 3: 350–351
   Google Scholar
• Marshall E. Bracing for biological nightmare. Science 1997; 275: 745
   Web of Science ®Google Scholar
• Frigerio L, Roberts L M. The enemy within: ricin and plant cells. J Exp Bot 1998; 49(326)1473–1480
   Web of Science ®Google Scholar
• Olsnes S, Kozolv J V. Ricin. Toxicon 2001; 39: 1723–1728
   PubMed Web of Science ®Google Scholar
• Olsnes S, Wesche J, Falnes P O. Binding uptake, routing and translocation of toxins with intracellular sites of action. The Comprehensive Sourcebook of Bacterial Toxins, J E Alouf, J H Freer. Academic Press, London 1999; 73–93
   Google Scholar
• Monfort W, Villafranca J E, Monzingo A F, Ernst S, Katzin B, Rutenber E, Xuong N H, Rovertus J D. The three dimensional structure of ricin at 2.8 Å. J Biol Chem 1987; 262: 5398–5403
   PubMed Web of Science ®Google Scholar
• Rutenber E, Robertus J D. Structure of ricin b‐chain at 2.5 Å resolution. Proteins 1991; 10: 260–269
   PubMed Web of Science ®Google Scholar
• Monzingo A F, Robertus J D. X‐ray analysis of substrate analogs in the ricin a‐chain active site. J Mol Biol 1992; 227: 1136–1145
   PubMed Web of Science ®Google Scholar
• Lord J M, Roberts L M, Robertus J D. Ricin: structure, mode of action, and some current applications. FASEB J 1994; 8: 201–208
   PubMed Web of Science ®Google Scholar
• Weston S A, Tucker A D, Thatcher D R, Derbyshire D J, Pauptit R A. X‐ray structure of recombinant ricin a‐chain at 1.8 Å resolution. J Mol Biol 1994; 266: 1043–1049
   Google Scholar
• Day P J, Ernst S R, Frankel A E, Monzingo A F, Pascal J M, Molina‐Svinth M C, Rovertus J D. Structure and activity of an active substitution of ricin a chain. Biochemistry 1996; 35: 11098–11103
   PubMed Web of Science ®Google Scholar
• Sandvig K, van Deurs B. Entry of ricin and shiga toxins into cells: molecular mechanisms and medical perspective. EMBO J 2000; 19: 5943–5950
   PubMed Web of Science ®Google Scholar
• Olsnes S, Pihl A. Different biological properties of the two constituent peptide chains of ricin, a toxic protein inhibiting protein synthesis. Biochemistry 1973; 12: 3121–3126
   PubMed Web of Science ®Google Scholar
• Endo Y, Mitsui K, Motizuki M, Tsurugi K. The mechanism of ricin and related toxic lectins on eukaryotic ribosomes. The site and the characteristics of the modification in 28s ribosomal rna caused by the toxins. J Biol Chem 1987; 262(12)5908–5912
   PubMed Web of Science ®Google Scholar
• Endo Y, Tsurugi K. RNA‐N glycosidase activity of ricin a‐chain. Mechanism of action of the toxic lectin ricin on eukaryotic ribosomes. J Biol Chem 1987; 262(17)8128–8130
   PubMed Web of Science ®Google Scholar
• Manske J M, Vallera D A. Intracellular trafficking of ricin immunotoxins: the role of ricin b‐chain. Trafficking of Bacterial Toxins, C B Saelinger. CRC Press, Boca Raton, FL 1990; 169
   Google Scholar
• Wesche J, Rapak A, Olsnes S. Dependence of ricin toxicity on translocation of the toxin a‐chain from the er to the cytosol. J Biol Chem 1999; 274(48)3443–3449
   Google Scholar
• Wales R, Richardson P T, Roberts L M, Woodland H R, Lord J M. Mutational analysis of the galactose binding ability of recombinant ricin b chain. J Biol Chem 1991; 266: 19172–19179
   PubMed Web of Science ®Google Scholar
• van Deurs B, Sandvig K. Transport of protein toxins into cells: pathways used by ricin, cholera toxin and shiga toxin. FEBS Lett 2002; 529: 49–53
   PubMed Web of Science ®Google Scholar
• Sphyris N, Lord J M, Wales R, Roberts L M. Mutational analysis of the ricinus lectin b‐chains. Galactose‐binding ability of the gamma subdomain of ricinus communis agglutinin b‐chain. J Biol Chem 1995; 270: 20292–20297
   PubMed Web of Science ®Google Scholar
• van Deurs B, Tonnessen T I, Petersen O W, Sandvig K, Olsnes S. Routing of internalised ricin and ricin conjugates to the golgi complex. J Cell Biol 1986; 102: 37–47
   PubMed Web of Science ®Google Scholar
• Fodstad O, Olsnes S, Pihl A. Toxicity, distribution and elimination of the cancerostatic lectins abrin and ricin after parenteral injection into mice. Br J Cancer 1976; 34: 418–425
   PubMed Web of Science ®Google Scholar
• Ramsden C S, Drayson M B, Bell E B. The toxicity, distribution, and excretion of ricin holotoxin in rats. Toxicology 1989; 55: 161–171
   PubMed Web of Science ®Google Scholar
• Brown R FR, White D E. Ultrastructure of rat lung following inhalation of ricin aerosol. Int J Exp Pathol 1997; 78: 267–276
   PubMed Web of Science ®Google Scholar
• Wilhelmsen C, Pitt L. Lesions of acute inhaled lethal ricin intoxication in rhesus monkeys. Vet Pathol 1996; 33: 296–302
   PubMed Web of Science ®Google Scholar
• Palatnick W, Tenenbein M. Hepatotoxicity from castor bean ingestion in a child. J Toxicol Clin Toxicol 2000; 38(1)67–69
   PubMed Web of Science ®Google Scholar
• Reed R P. Castor oil seed poisoning a concern for children. Med J Aust 1998; 168: 423–424
   PubMed Web of Science ®Google Scholar
• Aplin P J, Eliseo T. Ingestion of castor oil plant seed. Med J Aust 1997; 167: 260–261
   PubMed Web of Science ®Google Scholar
• Rauber A, Heard J. Castor bean toxicity re‐examined: a new perspective. Vet Hum Toxicol 1985; 27(6)498–502
   PubMedGoogle Scholar
• Kopferschmitt J, Flesch F, Lugnier A, Sauder P, Jaeger A, Mantz J M. Acute voluntary intoxication by ricin. Human Toxicol 1983; 2: 239–242
   PubMedGoogle Scholar
• Lambert J M, Goldmacher V S, Collinson A R, Nadler L M, Blatter W A. An immunotoxin prepared with blocked ricin: a natural plant toxin adapted for therapeutic use. Cancer Res 1991; 51: 6236–6244
   PubMed Web of Science ®Google Scholar
• Fodstad O, Kvalheim G, Godal A, Lotsberg J, Aamdal S, Host H, Pihl A. Phase I study of the plant protein ricin. Cancer Res 1984; 44: 862–865
   PubMed Web of Science ®Google Scholar
• Fine D R, Shepherd H A, Griffiths G D, Green M. Sub‐lethal poisoning by self‐injection with ricin. Med Sci Law 1992; 32(1)70–72
   PubMed Web of Science ®Google Scholar
• Abdykjadur‐lufti todliche intoxikation durch die Samen der rizinpflanze. Deut Med Wochsch 1935; 416–417
   Google Scholar
• Bispham W N. Report of cases of poisoning by fruit of ricinus communis. Am J Med Sci 1903; 12: 319–321
   Google Scholar
• Meldrum W P. Poisoning by castor oil seeds. Br Med J 1900; Feb 10: 317
   Google Scholar
• POISINDEX® Editorial Staff: Castor beans (Management/Treatment Protocol). POISINDEX® System, R K Klasco. Thomson MICROMEDEX, Greenwood Village, Colorado, (Edition expires [Nov, 2003])
   Google Scholar
• Godal A, Pihl A. Radioimmunoassays of abrin and ricin in blood. J Toxicol Environ Health 1981; 8: 409–417
   PubMed Web of Science ®Google Scholar
• Poli M A, Rivera V R, Hewetson J F, Merrill G A. Detection of ricin by colorimetric and chemiluminescence ELISA. Toxicon 1994; 32(11)1371–1377
   PubMed Web of Science ®Google Scholar
• Wannemacher R W, Hewetson J F. Deglycosylated ricin toxin a‐chain vaccine. PCT Int Appl 2000; 78
   Google Scholar
• Griffiths G D, Phillips G J, Baily S C. Comparision of the quality of protection elicited by toxoid and peptide liposomal vaccine formulations against ricin as assessed by markers of inflammation. Vaccine 1999; 17(20–21)2562–2568
   PubMed Web of Science ®Google Scholar
• Griffiths G D, Bailey S C, Stephen C, Hambrook J L, Keyte M P. Local and systemic responses against ricin toxin promoted by toxoid or peptide vaccines alone or in liposomal formulations. Vaccine 1998; 16(5)530–535
   PubMed Web of Science ®Google Scholar
• Griffiths G D, Bailey S C, Hambrook J L, Keyte M, Jayasekera P, Miles J, Williamson E. Liposomally‐encapsulated ricin toxoid vaccine delivered intratracheally elicits a good immune response and protects against a lethal pulmonary dose of ricin toxin. Vaccine 1997; 15(17–18)1933–1939
   PubMed Web of Science ®Google Scholar
• Matyas G R, Alving C R. Protective prophylactic immunity against intranasal ricin challenge induced by liposomal ricin a subunit. Vaccine Res 1996; 5(3)163–172
   Google Scholar
• Yan C, Rill W L, Malli R, Hewetson J, Naseem H, Tammariello R, Kende M. Intranasal stimulation of long‐lasting immunity against aerosol ricin challenge with ricin toxoid vaccine encapsulated in polymeric microspheres. Vaccine 1996; 14(11)1031–1038
   PubMed Web of Science ®Google Scholar
• Smallshaw J E, Firan A, Fulmer J R, Ruback S L, Ghetie V, Vitetta E S. A novel recombinant vaccine which protects mice against ricin intoxication. Vaccine 2002; 20: 3422–3477
   PubMed Web of Science ®Google Scholar