Immunomodulatory and Antitumor Actions of Medicinal Plant Tinospora cordifolia Are Mediated Through Activation of Tumor‐Associated Macrophages

References

• Ben‐Effraim S. One hundred years of cancer immunotherapy: a critical appraisal. Tumor Biol. 1999; 20: 1, [CSA]
   Google Scholar
• Singh S. M., Parajuli P., Shrivastava A., Sodhi A. Alteration of the immune response by tumor cells: underlying mechanisms. Int. J. Immunopathol. 1997; 10: 27, [CSA]
   Web of Science ®Google Scholar
• Parajuli P., Singh S. M. Modulation of hemopoiesis in normal and tumor‐bearing mice on in vivo administration of FK565. Int. J. Immunopathol. Pharmacol. 1995; 8: 103, [CSA]
   Web of Science ®Google Scholar
• Oldham R. K. Biological response modifiers. J. Natl. Cancer Invest. 1983; 70: 789, [CSA]
   PubMedGoogle Scholar
• Adams D. O., Hamilton T. A. The cell biology of macrophage activation. Annu. Rev. Immunol. 1984; 2: 283, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
   PubMed Web of Science ®Google Scholar
• Foss F. M. Immunologic mechanism of antitumor activity. Semin. Oncol. 2002; 3: 5–11
   Google Scholar
• Bingle C., Brown N. J., Lewis C. E. The role of tumor associated macrophages in tumor progression implications of new anticancer therapies. J. Pathol. 2002; 196: 254, [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Chu C. S., Woo F. Y., Rubin S. C., June C. H., Caroll R. G., Schlenger K. Tumor associated macrophages as a source of functional dendritic cells in ovarian cancer patients. Clin. Immunol. 2002; 102: 291, [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Mantovani A., Bottazzi B., Colotta F., Sozzani S., Ruco L. Origin and function of tumor associated macrophages. Immunol. Today 1992; 13: 265, [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMedGoogle Scholar
• Mantovani A., Bottazzi B., Sozzani S., Peri G., Allavena P., Gangdong G., Vicchi A., Colotta F. Cytokine regulation of tumor associated macrophages. Res. Immunol. 1993; 144: 280, [PUBMED], [INFOTRIEVE], [CSA]
   PubMedGoogle Scholar
• Ding A. H., Nathan C. F., Stuehr D. J. Release of reactive nitrogen intermediates and oxygen intermediates from murine peritoncal macrophages: comparison of the activation cytokines and independent production. J. Immunol. 1988; 141: 2407, [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Parajuli P., Singh S. M. Alteration in IL‐1 and arginase activity of tumor‐associated macrophage: a role in the promotion of tumor growth. Cancer Lett. 1996; 107: 249, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
   PubMed Web of Science ®Google Scholar
• Parajuli P., Singh S. M., Kumar A., Sodhi A. Alterations in the tumoricidal functions of murine tumor associated macrophages during progressive growth of tumor in vivo. Cancer J. 1997; 10: 222
   Web of Science ®Google Scholar
• Kumar A., Singh S. M., Parajuli P. Modulatory effects of Dalton's Lymphoma cells on the production of reactive nitrogen intermediates, IL‐1 and TNF by murine peritoneal macrophages. Neoplasma 1994; 44: 363
   Google Scholar
• Kumar A., Singh S. M. Effect of Dalton's lymphoma on the antigen presentation of murine peritoneal macrophages. Cancer Lett. 1995; 92: 151, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
   PubMed Web of Science ®Google Scholar
• Kumar A., Singh S. M. Effect of tumor growth on the blastogenic response of spleenocytes: a role of macrophage derived NO. Immunol. Invest. 1996; 35: 413
   Google Scholar
• Parajuli P., Singh S. M. Ascitic growth of a T‐cell lymphoma in mice alters the humoral and cellular response to exogenous antigen. Tumor Biol. 1997; 18: 104, [CSA]
   PubMedGoogle Scholar
• Shanker A., Singh S. M., Sodhi A. Ascitic growth of a spontaneous transplantable T cell lymphoma induces thymic involution 2. Induction of apoptosis in thymocytes. Tumor Biol. 2000; 21: 315, [CROSSREF], [CSA]
   PubMed Web of Science ®Google Scholar
• Shanker A., Singh S. M., Sodhi A. Impairment of T cell function with the progressive ascitic growth of transplantable T cell lymphoma of spontaneous origin. FEMS Immunol. Med. Microbiol. 2000; 27: 247, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
   PubMedGoogle Scholar
• Engles F., Renirie B. F., Hart B. A., Labadie R. P., Nijkampa F. P. Effect of apocynin, a drug isolated from roots of Picrorhiza Kurroa on arachdonic acid metabolism. FEBS Lett. 1992; 305: 245
   Web of Science ®Google Scholar
• Ingolfsdottir K., Jorcic K., Fischer B., Wagner H. Immunomodulatory active polysaccharide from Cetraria islandica. Planta Med. 1994; 60: 527, [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Dahanukar S. A., Kulkarani R. A., Rege N. N. Pharmacology of Medicinal plants and natural products. Indian J. Pharmacol. 2000; 32: S81
   Google Scholar
• Archana R., Namasivayam A. Effect of ocimum sanctum on noise induced changes in immune parameters. Pharm. Pharmacol. Commun. 2000; 6: 145
   Google Scholar
• Prashar R., Kumar A. Chemotherapeutic action of Ocimum Sanctum on 2, 12‐Dimethylbenz(a)anthracene DMBA‐induced papillomagenesis in the skin of mice. Int. J. Pharmacogn. 1995; 33: 181
   Google Scholar
• SaiRam M., Sharma S. K., Ilavazhagan G., Kumar D., Selvamurthy W. Immunomodulatory effects of NIM‐76, a volatile oil fraction from Neem oil. 1997; 55: 131
   Google Scholar
• Upadhyay S. N., Dhawan S., Garg S., Talwar G. P. Immunomodulatory effects of neem oil. Int. J. Immunopharmacol. 1992; 14: 1187, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
   PubMed Web of Science ®Google Scholar
• Thatte U. M., Dahanukar S. A. Immunotherapeutic modification of experimental infections by Indian medicinal plants. Physiother Res. 1989; 3: 43
   Google Scholar
• Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assay. J. Immunol. Meth. 1983; 65: 55, [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Currie A. D., Steward A. G., William A. S. Alveolar Macrophages bind and phagocytose allergen containing pollen starch granules via C‐type lectin and integrin receptors: implication for airway inflammatory disease. J. Immunol. 2000; 164: 3878, [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Oda T., Maeda H. A. new simple fluorometric assay for phagocytosis. J. Immunol. Methods 1986; 88(2)175, [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Agrawal S., Singh N. K., Aggrawal R. C., Sodhi A., Tondon P. Synthesis, structure and antitumor activity of N′‐Salicylocyl‐N′‐(2‐furythiocarbonyl)hydrazine and its copper (II) complex. J. Med. Chem. 1986; 29: 199, [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Geran R. E., Greenberg N. H., Macdonald M. M., Schumaker A. M., Abbott B. J. Protocols for screening chemical agents and naturals products against animal tumors and other biological systems. Cancer Chemother. Rep. 1972; 3: 1
   Google Scholar
• Rosenau W., Burke G. C., Anderson R. Effect of lymphotoxin on target cell plasma membrane lipids. Cell. Immunol. 1981; 60: 144, [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Dahanukar S. A., Thatte U. M., Pai N. R., More P. B., Karandikar S. M. Immunotherapeutic modification by Tinospora cordifolia of abdominal sepsis induced by caecal ligation in rats. Indian J. Gastroenterol. 1988; 7: 21, [PUBMED], [INFOTRIEVE]
   PubMedGoogle Scholar
• Desai V. R., Kamat J. P., Sainis K. B. An immunomodulator from Tinospora cordifolia with antioxidant activity in cell free systems. Proc. Indian Acad. Sci. 2002; 713
   Google Scholar
• Barker R. N., Erwig L. P., Hill K. S., Devine A., Pearce W. P., Rees A. J. Antigen presentation by macrophages is enhanced by the uptake of necrotic, but not apoptotic, cells. Clin. Exp. Immunol. 2002; 127: 220, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
   PubMed Web of Science ®Google Scholar
• Kumar A., Singh S. M., Sodhi A. Endotoxin‐induced protein phosphorylation in macrophages is modulated by tumor cells. Int. J. Immunopharmacol. 1998; 20: 99, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
   PubMed Web of Science ®Google Scholar
• Mills C. D. Molecular basis of “suppressor” macrophages. Arginine metabolism via the nitric oxide synthase pathway. J. Immunol. 1991; 149: 2709
   Google Scholar
• Thatte U., Bagadey S., Dhanukar S. Modulation of programmed cell death by medicinal plants. Cell. Mol. Biol. 2000; 46: 199, [CSA]
   PubMed Web of Science ®Google Scholar
• White E. Life, death and the pursuit of apoptosis. Genes Dev. 1996; 10: 1–15, [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar