Relevancy of Drug Loading to Liposomal Formulation Therapeutic Efficacy

References

• Barenholz Y, Cevc G. Structure and properties of membranes. Physical Chemistry of Biological Surfaces, A Baszkin, W Norde. Marcel Dekker, , NY 2000; 171–241
   Google Scholar
• Lasic DD. Liposomes: From Physics to Applications. Elsevier, Amsterdam 1993
   Google Scholar
• Handbook of Nonmedical Applications of Liposomes, Y Barenholz, DD Lasic. CRC Press, Boca Raton, FL 1996; Vols. I–IV
   Google Scholar
• Lasi DD. Liposomes in Gene Delivery. CRC Press, Boca Raton, FL 1997
   Google Scholar
• Barenholz Y, Cohen R. Rational design of amphiphile-based drug carriers and sterically stabilized carriers. J Liposome Res 1995; 5: 905–932
   Google Scholar
• Barenholz Y. Design of liposome-based drug carriers: From basic research to application as approved drugs. Medical Applications of Liposomes, DD Lasic, D Papahadjopoulos. Elsevier Science, Amsterdam 1998; 541–565
   Google Scholar
• Barenholz Y. Liposome application: problems and prospects. Curr Opin Colloid Interface Sci 2001; 6: 66–77
   Web of Science ®Google Scholar
• Grant GJ, Barenholz Y, Piskoun B, Bansinath M, Turndorf H, Bolotin E. DRV liposomal bupivacaine: preparation, characterization and in vivo evaluation in mice. Pharm Res 2001; 18: 336–343
   PubMed Web of Science ®Google Scholar
• Haran G, Cohen R, Bar LK, Barenholz Y. Transmembrane ammonium sulfate gradients in liposomes produce efficient and stable entrapment of amphipathic weak bases. Biochim Biophys Acta 1993; 1151: 201–215
   PubMed Web of Science ®Google Scholar
• Stein WD. Transport and Diffusion Across Cell Membranes. Academic Press, Orlando, FL 1986, Chapter 2
   Google Scholar
• Lasic DD, Ceh B, Stuart MCA, Guo L, Frederik PM, Barenholz Y. Transmembrane gradient driven phase transitions within vesicles: lessons for drug delivery. Biochim Biophys Acta 1995; 1239: 145–156
   PubMed Web of Science ®Google Scholar
• Zhang YP, Ceh B, Lasic DD. Liposomes in drug delivery. PolymericBiomaterials. 2nd ed., S Damitziu. Marcel Dekker, New York 2001; 783–821, Chapter 29
   Google Scholar
• Lichtenberg D, Barenholz Y. Liposomes: Preparation, characterization, and preservation. Methods of Biochemical Analysis, D Glick. Wiley, , NY 1988; 33: 337–462
   Google Scholar
• Bandak S, Goren D, Horowitz A, Tzemach D, Gabizon A. Pharmacological studies of cisplatin encapsulated in long-circulating liposomes in mouse tumor models. Anticancer Drugs 1999; 10: 911–920
   PubMed Web of Science ®Google Scholar
• Kirby C, Gregoriadis G. Dehydration–rehydration in vesicles: A simple method for high yield drug entrapment in liposomes. Biotechnology 1984; 2: 979–985
   Web of Science ®Google Scholar
• Kedar E, Palgi O, Golod G, Babai I, Barenholz Y. Delivery of cytokines by liposomes. III. Liposome-encapsulated GM-CSF and TNF-α show improved pharmacokinetics and biological activity and reduced toxicity in mice. J Immunother 1997; 20: 180–193
   PubMed Web of Science ®Google Scholar
• Babai I, Samira S, Barenholz Y, Zakai-Rones Z, Kedar E. A novel influenza subunit vaccine composed of liposome-encapsulated haemagglutinin/neuraminidase and IL-2 or GM-CSF. I. Vaccine characterization and efficacy studies in mice. Vaccine 1999; 17: 1223–1238
   PubMed Web of Science ®Google Scholar
• Babai I, Samira S, Barenholz Y, Zakai-Rones Z, Kedar E. A novel influenza subunit vaccine composed of liposome-encapsulated haemagglutinin/ neuraminidase and IL-2 or GM-CSF. II. Induction of TH1 and TH2 responses in mice. Vaccine 1999b; 17: 1239–1250
   PubMed Web of Science ®Google Scholar
• Babai I, Barenholz Y, Zakay-Rones Z, Greenbaum E, Samira S, Hayon I, Rochman M, Kedar E. A novel liposomal influenza vaccine (INFLUSOME-VAC) containing haemagglutinin-neuraminidase and IL-2 or GM-CSF induces protective anti-neuraminidase antibodies cross-reacting with a wide spectrum of influenza A viral strains. Vaccine 2001; 12: 505–515
   Google Scholar
• Barenholz Y, Crommelin DJA. Liposomes as pharmaceutical dosage forms. Encyclopedia of Pharmaceutical Technology, J Swarbrick, JC Boylan. Marcel Dekker, , NY 1994; Vol. 9: 1–39
   Google Scholar
• Szoka F, Jr, Papahadjopoulos D. Procedure for preparation of liposomes with large internal aqueous space and high capture by reverse-phase evaporation. Proc Natl Acad Sci USA 1978; 75: 4194–4198
   PubMed Web of Science ®Google Scholar
• Peleg-Shulman T, Gibson D, Cohen R, Abra R, Barenholz Y. Characterization of sterically stabilized cisplatin liposomes by nuclear magnetic resonance. Biochim Biophys Acta 2001; 1510: 278–291
   PubMed Web of Science ®Google Scholar
• Gabizon A, Barenholz Y. Liposomal anthracyclines—from basics to clinical approval of PEGylated liposomal doxorubicin. Liposomes: Rational Design, AS Janoff. Marcel Dekker, , NY 1999; 343–362
   Google Scholar
• Gabizon A, Catane R, Uziely B, Kaufman B, Safra T, Cohen R, Martin F, Huang A, Barenholz Y. Prolonged circulation time and enhanced accumulation in malignant exudates of doxorubicin encapsulated in polyethylene-glycol coated liposomes. Cancer Res 1994; 54: 987–992
   PubMed Web of Science ®Google Scholar
• Gabizon A, Goren D, Cohen R, Barenholz Y. Development of liposomal anthracyclines: from basics to clinical applications. J Controlled Release 1998; 53: 275–279
   PubMed Web of Science ®Google Scholar