61
Views
1
CrossRef citations to date
0
Altmetric
Research Article

Factorial Design in the Spheronization of Ibuprofen Microparticulates Using the Rotor Disk Fluid‐Bed Technology

, , , & , Ph.D.
Pages 49-62 | Received 23 Jan 2003, Accepted 10 May 2003, Published online: 02 Apr 2004

References

  • O'Connor R. E., Schwartz J. B. I. Ghebre‐SelassieExtrusion and Spheronization Technology. Phamaceutical Pelletisation Technology, . Dekker, New York 1989, Ch. 7
  • Reynolds A. D. A new technique for the production of spherical particles. Manuf. Chem. Aerosol News 1970; 41: 40–43
  • Conine J. P., Hedley H. R. Preparation of small solid pharmaceutical spheres. Drug Cosmet. Ind. 1970; 106: 38–41
  • Parikh D. M. Fluid‐Bed Processing in the 1990s. Pharm. Technol. Suppl. October, 1996, http://www.niroinc.com/html/pharma/pfbarticle.html
  • Olsen K., Mehta A. Fluid bed agglomeration and coating technology—State of the art. Int. J. Pharm. 1995; 116: 131–146
  • Newton J. M. The preparation of spherical granules by extrusion spheronization. STP Pharma 1990; 6: 396–398
  • Schaefer T., Worst O. Control of fluidized bed granulation. I. Effects of spray angle, nozzle height and starting materials on granule size and size distribution. Arch. Pharm. Chemi, Sci. 1977; 5: 51–60
  • Rashid H. A., Heinamaki J., Antikainen O., Yliruusi J. Influence of the centrifugal granulating process on the properties of layered pellets. Eur. J. Pharm. Biopharm. 2001; 51: 227–234
  • Malinowski H. J., Smith W. E. Use of factorial design to evaluate granulations prepared by spheronization. J. Pharm. Sci. 1975; 64: 1688–1692
  • Vertommen J., Kinget R. Influence of five selected processing and formulation variables on the particle size, particle size distribution, and friability of pellets produced in a rotary processor. Drug Dev. Ind. Pharm. 1997; 23: 39–46
  • Vertommen J., Kinget R. Influence of five selected processing and formulation variables on the release of riboflavin from pellets produced in a rotary processor. STP Pharma Sci. 1996; 6: 335–340
  • Robinson R. L., Hollenbeck R. G. Manufacture of spherical acetaminophen pellets: Comparison of rotary processing with multi‐step extrusion and spheronization. Pharm. Technol. 1991; 15: 48–56
  • Gohel M. C., Patel M. M., Patel M. R., Gajjar J. Studies in pellet preparation and development of modified release dosage forms of isosorbide dinitrate. East. Pharm. 1996; 39: 33–135
  • Rashid H. A., Heinamaki J., Antikainen O., Yliruusi J. Effects of process variables on the size, shape, and surface characteristics of microcrystalline cellulose beads prepared in a centrifugal granulator. Drug Dev. Ind. Pharm. 1999; 25: 605–611
  • Gajdos B. Rotary granulators‐evaluation of process technology for pellet production using a factorial experimental design. Drugs Made Ger. 1984; 27, pp. 30–34, 36
  • Ghebre‐Sellassie I., Gordon R. H., Fawzi M. B., Nesbitt R. U. Evaluation of a high speed pelletization process and equipment. Drug Dev. Ind. Pharm. 1985; 11: 1523–1541
  • Chukwumezie B. N., Wojcik M., Malak P., Adeyeye M. C. Feasibility studies in spheronization and scale‐up of ibuprofen microparticulates using the fluid‐bed technology. AAPS PharmSciTech 2002; 3: 1–12
  • Ogawa S., Kamijima T., Miyamoto Y., Miyajima M., Sato H., Takayama K., Nagai T. A new attempt to solve the scale‐up problem for granulation using response surface methodology. J. Pharm. Sci. 1994; 83: 439–443
  • Vertommen J., Rombaut P., Kinget R. Internal and external structure of pellets made in a rotary processor. Int. J. Pharm. 1998; 161: 25–236
  • Hicks C. R. Fundamental Concepts in the Design of Experiments4th Ed. Oxford University Press. 1994; 121–137, Chapter 5
  • Doornbos D. A. Optimization in pharmaceutical sciences. Pharm. Weekbl., Sci. Ed. 1981; 3: 33–61
  • Keppel G. Design and Analysis: A Researcher's Handbook3rd Ed. Prentice Hall. 1991; 482
  • Law M. F.L., Deasy P. B. Use of canonical and other analyses for the optimization of an extrusion‐spheronization process of indomethacin. Int. J. Pharm. 1997; 146: 1–9
  • Eddington N. D., Ashraf M., Augsburger L. L., Leslie J. L., Fossler M. J., Lesko L. J., Shah V. P., Rekhi G. S. Identification of formulation and manufacturing variables that influence in vitro dissolution and in vivo bioavailability of propranolol hydrochloride tablets. Pharm. Dev. Technol. 1998; 3: 535–547
  • J. PhilippeLes Methodes Statistiques en Pharmacie et en Chimie (Applications a la Production et au Controle), . Masson, Paris 1967; 195–223
  • Ortigosa C. La Planification Experimentale dans les Sciences Pharmaceutiques. Lyon Pharm. 1991; 42: 495–500
  • Bains D., Boutell S. L., Newton J. M. The influence of moisture content on the preparation of spherical granules of barium sulfate and microcrystalline cellulose. Int. J. Pharm. 1991; 69: 233–237
  • Sousa J. J., Sousa A., Podczeck F., Newton J. M. Influence of process conditions on drug release from pellets. Int. J. Pharm. 1996; 144: 159–169
  • Kristensen J., Schaefer T., Kleinebudde P. Direct pelletization in a rotary processor controlled by torque measurements. II: Effects of changes in the content of microcrystalline cellulose. AAPS PharmSciTech 2000; 2(3)2
  • Metha A. M. I. Ghebre‐SellasieEvaluation and Characterization of Pellets. Pharmaceutical Pelletization Technology, . Dekker, New York 1989; 241–265
  • Vertommen J., Michoel A., Rombaut P., Kinget R. Production of pseudoephedrine HCl pellets in a high shear mixer‐granulator. Eur. J. Pharm. Biopharm. 1994; 40: 32–35
  • Sonaglio D., Bataille B., Ortigosa C., Jacob M. Factorial design in the feasibility of producing microcel MC 101 pelletes by extrusion/spheronization. Int. J. Pharm. 1995; 115: 53–60
  • Vertommen J., Rombaut P., Kinget R. Shape and surface smoothness of pellets made in a rotary processor. Int. J. Pharm. 1997; 146: 21–29
  • Eichler K. Current trends in solid dose manufacture. Pharm. Manuf. Rev. February, 1997, ISSN, 0955‐3894
  • Schaefer T., Worts O. Control of fluidized bed granulation. III. Effects of inlet air temperature and liquid flow rate on granule size and size distribution. Control of moisture content of granules in the drying phase. Arch. Pharm. Chemi, Sci. Ed. 1978; 6: 1–13

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.