53
Views
127
CrossRef citations to date
0
Altmetric
Mammalian Genetic Models with Minimal or Complex Phenotypes

Idiopathic Weight Reduction in Mice Deficient in the High-Mobility-Group Transcription Factor Sox8

, , , &
Pages 6951-6959 | Received 13 Apr 2001, Accepted 10 Jul 2001, Published online: 27 Mar 2023

REFERENCES

  • Bell, D. M., K. K. H. Leung, S. C. Wheatley, L. J. Ng, S. Zhou, K. W. Ling, M. H. Sham, P. Koopman, P. P. L. Tam, and K. S. E. Cheah. 1997. Sox9 directly regulates the type-II collagen gene. Nat. Genet. 16:174–178.
  • Bell, K. M., P. S. Western, and A. H. Sinclair. 2000. Sox8 expression during chick embryogenesis. Mech. Dev. 94:257–260.
  • Beranger, F., C. Mejean, B. Moniot, P. Berta, and M. Vandromme. 2000. Muscle differentiation is antagonized by SOX15, a new member of the SOX protein family. J. Biol. Chem. 275:16103–16109.
  • Bi, W., J. M. Deng, Z. Zhang, R. R. Behringer, and B. de Crombrugghe. 1999. Sox9 is required for cartilage formation. Nat. Genet. 22:85–89.
  • Bowles, J., G. Schepers, and P. Koopman. 2000. Phylogeny of the SOX family of developmental transcription factors based on sequence and structural indicators. Dev. Biol. 227:239–255.
  • Britsch, S., D. E. Goerich, D. Riethmacher, R. I. Peirano, M. Rossner, K. A. Nave, C. Birchmeier, and M. Wegner. 2001. The transcription factor Sox10 is a key regulator of peripheral glial development. Genes Dev. 15:66–78.
  • Foster, J. W., M. A. Dominguez-Steglich, S. Guioli, C. Kwok, P. A. Weller, M. Stevanovic, J. Weissenbach, S. Mansour, I. D. Young, P. N. Goodfellow, J. D. Brook, and A. J. Schafer. 1994. Campomelic dysplasia and autosomal sex reversal caused by mutations in an SRY-related gene. Nature 372:525–530.
  • Foster, J. W., and J. A. Graves. 1994. An SRY-related sequence on the marsupial X chromosome: implications for the evolution of the mammalian testis-determining gene. Proc. Natl. Acad. Sci. USA 91:1927–1931.
  • Herbarth, B., V. Pingault, N. Bondurand, K. Kuhlbrodt, I. Hermans-Borgmeyer, A. Puliti, N. Lemort, M. Goossens, and M. Wegner. 1998. Mutation of the Sry-related Sox10 gene in Dominant megacolon, a mouse model for human Hirschsprung disease. Proc. Natl. Acad. Sci. USA 95:5161–5165.
  • Hogan, B., R. Beddington, F. Costantini, and E. Lacy. 1994. Manipulating the mouse embryo: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y
  • Inoue, K., Y. Tanabe, and J. R. Lupski. 1999. Myelin deficiencies in both the central and peripheral nervous system associated with a SOX10 mutation. Ann. Neurol. 46:313–318.
  • Kapur, R. P.. 1999. Early death of neural crest cells is responsible for total enteric aganglionosis in Sox10(Dom)/Sox10(Dom) mouse embryos. Pediatr. Dev. Pathol. 2:559–569.
  • Kent, J., S. C. Wheatley, J. E. Andrews, A. H. Sinclair, and P. Koopman. 1996. A male-specific role for SOX9 in vertebrate sex determination. Development 122:2813–2822.
  • Kuhlbrodt, K., B. Herbarth, E. Sock, I. Hermans-Borgmeyer, and M. Wegner. 1998. Sox10, a novel transcriptional modulator in glial cells. J. Neurosci. 18:237–250.
  • Lefebvre, V., W. Huang, V. R. Harley, P. N. Goodfellow, and B. DeCrombrugghe. 1997. Sox9 is a potent activator of the chondrocyte-specific enhancer of the proα1(II) collagen gene. Mol. Cell. Biol. 17:2336–2346.
  • Liu, Y., H. Li, K. Tanaka, N. Tsumaki, and Y. Yamada. 2000. Identification of an enhancer sequence within the first intron required for cartilage-specific transcription of the alpha2(XI) collagen gene. J. Biol. Chem. 275:12712–12718.
  • Ng, L.-J., S. Wheatley, G. E. O. Muscat, J. Conway-Campbell, J. Bowles, E. Wright, D. M. Bell, P. P. L. Tam, K. S. E. Cheah, and P. Koopman. 1997. SOX9 binds DNA, activates transcription, and coexpresses with type II collagen during chondrogenesis in the mouse. Dev. Biol. 183:108–121.
  • Nishiguchi, S., H. Wood, H. Kondoh, R. Lovell-Badge, and V. Episkopou. 1998. Sox1 directly regulates the γ-crystallin genes and is essential for lens development in mice. Genes Dev. 12:776–781.
  • Pattyn, A., X. Morin, H. Cremer, C. Goridis, and J. F. Brunet. 1997. Expression and interactions of the two closely related homeobox genes Phox2a and Phox2b during neurogenesis. Development 124:4065–4075.
  • Pattyn, A., X. Morin, H. Cremer, C. Goridis, and J. F. Brunet. 1999. The homeobox gene Phox2b is essential for the development of autonomic neural crest derivatives. Nature 399:366–370.
  • Peirano, R. I., D. E. Goerich, D. Riethmacher, and M. Wegner. 2000. Protein zero expression is regulated by the glial transcription factor Sox10. Mol. Cell. Biol. 20:3198–3209.
  • Pevny, L. H., and R. Lovell-Badge. 1997. Sox genes find their feet. Curr. Opin. Genet. Dev. 7:338–344.
  • Pfeifer, D., F. Poulat, E. Holinski-Feder, F. Kooy, and G. Scherer. 2000. The SOX8 gene is located within 700 kb of the tip of chromosome 16p and is deleted in a patient with ATR-16 syndrome. Genomics 63:108–116.
  • Pingault, V., N. Bondurand, K. Kuhlbrodt, D. E. Goerich, M.-O. Prehu, A. Puliti, B. Herbarth, I. Hermans-Borgmeyer, E. Legius, G. Matthijs, J. Amiel, S. Lyonnet, I. Ceccherini, G. Romeo, J. C. Smith, A. P. Read, M. Wegner, and M. Goossens. 1998. Sox10 mutations in patients with Waardenburg-Hirschsprung disease. Nat. Genet. 18:171–173.
  • Schepers, G. E., M. Bullejos, B. M. Hosking, and P. Koopman. 2000. Cloning and characterisation of the sry-related transcription factor gene sox8. Nucleic Acids Res. 28:1473–1480.
  • Sekiya, I., K. Tsuji, P. Koopman, H. Watanabe, Y. Yamada, K. Shinomiya, A. Nifuji, and M. Noda. 2000. SOX9 enhances aggrecan gene promoter/enhancer activity and is up-regulated by retinoic acid in a cartilage-derived cell line, TC6. J. Biol. Chem. 275:10738–10744.
  • Southard-Smith, E. M., M. Angrist, J. S. Ellison, R. Agarwala, A. D. Baxevanis, A. Chakravarti, and W. J. Pavan. 1999. The Sox10(Dom) mouse: modeling the genetic variation of Waardenburg-Shah (WS4) syndrome. Genome Res. 9:215–225.
  • Southard-Smith, E. M., L. Kos, and W. J. Pavan. 1998. Sox10 mutation disrupts neural crest development in Dom Hirschsprung mouse model. Nat. Genet. 18:60–64.
  • Touraine, R. L., T. Attie-Bitach, E. Manceau, E. Korsch, P. Sarda, V. Pingault, F. Encha-Razavi, A. Pelet, J. Auge, A. Nivelon-Chevallier, A. M. Holschneider, M. Munnes, W. Doerfler, M. Goossens, A. Munnich, M. Vekemans, and S. Lyonnet. 2000. Neurological phenotype in Waardenburg syndrome type 4 correlates with novel SOX10 truncating mutations and expression in developing brain. Am. J. Hum. Genet. 66:1496–1503.
  • Tybulewicz, V. L., C. E. Crawford, P. K. Jackson, R. T. Bronson, and R. C. Mulligan. 1991. Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene. Cell 65:1153–1163.
  • Wagner, T., J. Wirth, J. Meyer, B. Zabel, M. Held, J. Zimmer, J. Pasantes, F. D. Bricarelli, J. Keutel, E. Hustert, U. Wolf, N. Tommerup, W. Schempp, and G. Scherer. 1994. Autosomal sex reversal and campomelic dysplasia are caused by mutations in and around the SRY-related gene Sox9. Cell 79:1111–1120.
  • Wegner, M.. 1999. From head to toes: the multiple facets of Sox proteins. Nucleic Acids Res. 27:1409–1420.
  • Wright, E., M. R. Hargrave, J. Christiansen, L. Cooper, J. Kun, T. Evans, U. Gangadharan, A. Greenfield, and P. Koopman. 1995. The Sry-related gene Sox9 is expressed during chondrogenesis in mouse embryos. Nat. Genet. 9:15–20.
  • Xie, W. F., X. Zhang, S. Sakano, V. Lefebvre, and L. J. Sandell. 1999. Trans-activation of the mouse cartilage-derived retinoic acid-sensitive protein gene by Sox9. J. Bone Miner. Res. 14:757–763.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.