Versatile Role for hnRNP D Isoforms in the Differential Regulation of Cytoplasmic mRNA Turnover

REFERENCES

• Bhattacharya, S., T. Giordano, G. Brewer, and J. S. Malter. 1999. Identification of AUF-1 ligands reveals vast diversity of early response gene mRNAs. Nucleic Acids Res. 27:1464–1472.
   PubMedGoogle Scholar
• Caput, D., B. Beutler, K. Hartog, R. Thayer, S. Brown-Shimer, and A. Cerami. 1986. Identification of a common nucleotide sequence in the 3′-untranslated region of mRNA molecules specifying inflammatory mediators. Proc. Natl. Acad. Sci. USA 83:1670–1674.
   PubMed Web of Science ®Google Scholar
• Chen, A. C.-Y., and A.-B. Shyu. 1995. AU-rich elements: characterization and importance in mRNA degradation. Trends Biochem. Sci. 20:465–470.
   PubMed Web of Science ®Google Scholar
• Chen, C. Y., T. M. Chen, and A. B. Shyu. 1994. Interplay of two functionally and structurally distinct domains of the c-fos AU-rich element specifies its mRNA-destabilizing function. Mol. Cell. Biol. 14:416–426.
   PubMed Web of Science ®Google Scholar
• Chen, C. Y., and A. B. Shyu. 1994. Selective degradation of early-response-gene mRNAs: functional analyses of sequence features of the AU-rich elements. Mol. Cell. Biol. 14:8471–8482.
   PubMed Web of Science ®Google Scholar
• Chen, C. Y., N. Xu, and A. B. Shyu. 1995. mRNA decay mediated by two distinct AU-rich elements from c-fos and granulocyte-macrophage colony-stimulating factor transcripts: different deadenylation kinetics and uncoupling from translation. Mol. Cell. Biol. 15:5777–5788.
   PubMed Web of Science ®Google Scholar
• Chen, C. Y., Y. You, and A. B. Shyu. 1992. Two cellular proteins bind specifically to a purine-rich sequence necessary for the destabilization function of a c-fos protein-coding region determinant of mRNA instability. Mol. Cell. Biol. 12:5748–5757.
   PubMedGoogle Scholar
• Cravchik, A., and A. Matus. 1993. A novel strategy for the immunological tagging of cDNA constructs. Gene 137:139–143.
   PubMedGoogle Scholar
• Dehlin, E., M. Wormington, C. G. Korner, and E. Wahle. 2000. Cap-dependent deadenylation of mRNA. EMBO J. 19:1079–1086.
   PubMedGoogle Scholar
• DeMaria, C. T., and G. Brewer. 1996. AUF1 binding affinity to A+U-rich elements correlates with rapid mRNA degradation. J. Biol. Chem. 271:12179–12184.
   PubMed Web of Science ®Google Scholar
• DeMaria, C. T., Y. Sun, L. Long, B. J. Wagner, and G. Brewer. 1997. Structural determinants in AUF1 required for high affinity binding to A + U-rich elements. J. Biol. Chem. 272:27635–27643.
   PubMed Web of Science ®Google Scholar
• Dempsey, L. A., M. J. Li, A. DePace, P. Bray-Ward, and N. Maizels. 1998. The human HNRPD locus maps to 4q21 and encodes a highly conserved protein. Genomics 49:378–384.
   PubMedGoogle Scholar
• Dreyfuss, G., M. J. Matunis, S. Pinol-Roma, and C. G. Burd. 1993. hnRNP proteins and the biogenesis of mRNA. Annu. Rev. Biochem. 62:289–321.
   PubMed Web of Science ®Google Scholar
• Greenberg, M. E., and J. G. Belasco. 1993. Control of the decay of labile protooncogene and cytokine mRNAs. Control of messenger RNA stability.. J. G. Belasco, and G. Brawerman. 199–218. Academic Press, San Diego, Calif
   Google Scholar
• Grosset, C., C.-Y. A. Chen, N. Xu, N. Sonenberg, H. Jacquemin-Sablon, and A.-B. Shyu. 2000. A mechanism for translationally coupled mRNA turnover: interaction between the poly(A) tail and a c-fos RNA coding determinant via a protein complex. Cell 103:29–40.
   PubMed Web of Science ®Google Scholar
• Gueydan, C., L. Droogmans, P. Chalon, G. Huez, D. Caput, and V. Kruys. 1999. Identification of TIAR as a protein binding to the translational regulatory AU-rich element of tumor necrosis factor alpha mRNA. J. Biol. Chem. 274:2322–2326.
   PubMedGoogle Scholar
• Jacobson, A., and S. W. Peltz. 1996. Interrelationships of the pathways of mRNA decay and translation in eukaryotic cells. Annu. Rev. Biochem. 65:693–739.
   PubMed Web of Science ®Google Scholar
• Kajita, Y., J. Nakayama, M. Aizawa, and F. Ishikawa. 1995. The UUAG-specific RNA binding protein, heterogeneous nuclear ribonucleoprotein D0. Common modular structure and binding properties of the 2xRBD-Gly family. J. Biol. Chem. 270:22167–22175.
   PubMed Web of Science ®Google Scholar
• Kiledjian, M., C. T. DeMaria, G. Brewer, and K. Novick. 1997. Identification of AUF1 (heterogeneous nuclear ribonucleoprotein D) as a component of the alpha-globin mRNA stability complex. Mol. Cell. Biol. 17:4870–4876.
   PubMedGoogle Scholar
• Körner, C. G., and E. Wahle. 1997. Poly(A) tail shortening by a mammalian poly(A)-specific 3′-exoribonuclease. J. Biol. Chem. 272:10448–10456.
   PubMedGoogle Scholar
• Lai, W. S., E. Carballo, J. R. Strum, E. A. Kennington, R. S. Phillips, and P. J. Blackshear. 1999. Evidence that tristetraprolin binds to AU-rich elements and promotes the deadenylation and destabilization of tumor necrosis factor alpha mRNA. Mol. Cell. Biol. 19:4311–4323.
   PubMed Web of Science ®Google Scholar
• Larola, G., R. Guesta, G. Brewer, and R. J. Schneider. 1999. Control of mRNA decay by heat shock-ubiquitin-proteasome pathway. Science 284:499–502.
   PubMedGoogle Scholar
• Lin, S., W. Wang, G. M. Wilson, X. Yang, G. Brewer, N. J. Holbrook, and M. Gorospe. 2000. Down-regulation of cyclin D1 expression by prostaglandin A(2) is mediated by enhanced cyclin D1 mRNA turnover. Mol. Cell. Biol. 20:7903–7913.
   PubMedGoogle Scholar
• Lindsten, T. C., C. H. June, J. A. Ledbetter, G. Stella, and C. B. Thompson. 1989. Regulation of lymphokine messenger RNA stability by a surface-mediated T cell activation pathway. Science 244:339–343.
   PubMed Web of Science ®Google Scholar
• Loflin, P. A., C.-Y. A. Chen, and A.-B. Shyu. 1999. Unraveling a cytoplasmic role for hnRNP D in the in vivo mRNA destabilization directed by the AU-rich element. Genes Dev. 13:1884–1897.
   PubMedGoogle Scholar
• Loflin, T. L., C.-Y. A. Chen, N. Xu, and A.-B. Shyu. 1999. Transcriptional pulsing approaches for analysis of mRNA turnover in mammalian cells. Methods Enzymol. 17:11–20.
   Google Scholar
• Ma, W. J., S. Cheng, C. Campbell, A. Wright, and H. Furneaux. 1996. Cloning and characterization of HuR, a ubiquitously expressed Elav-like protein. J. Biol. Chem. 271:8144–8151.
   PubMed Web of Science ®Google Scholar
• Ming, X. F., M. Kaiser, and C. Moroni. 1998. c-jun N-terminal kinase is involved in AUUUA-mediated interleukin-3 mRNA turnover in mast cells. EMBO J. 17:6039–6048.
   PubMed Web of Science ®Google Scholar
• Mitchell, P., and D. Tollervey. 2000. mRNA stability in eukaryotes. Curr. Opin. Gene Dev. 10:193–198.
   PubMed Web of Science ®Google Scholar
• Nair, A. P., S. Hahn, R. Banholzer, H. H. Hirsch, and C. Moroni. 1994. Cyclosporin A inhibits growth of autocrine tumour cell lines by destabilizing interleukin-3 mRNA. Nature 369:239–242.
   PubMed Web of Science ®Google Scholar
• Peng, S.-P., C.-Y. Chen, N. Xu, and A.-B. Shyu. 1998. RNA stabilization by the AU-rich element binding protein, HuR, an ELAV protein. EMBO J. 17:3461–3470.
   PubMed Web of Science ®Google Scholar
• Peng, S. S., C. Y. Chen, and A. B. Shyu. 1996. Functional characterization of a non-AUUUA AU-rich element from the c-jun proto-oncogene mRNA: evidence for a novel class of AU-rich elements. Mol. Cell. Biol. 16:1490–1499.
   PubMed Web of Science ®Google Scholar
• Piecyk, M., S. Wax, A. R. Beck, N. Kedersha, M. Gupta, B. Maritim, S. Chen, C. Gueydan, V. Kruys, M. Streuli, and P. Anderson. 2000. TIA-1 is a translational silencer that selectively regulates the expression of TNF-alpha. EMBO J. 19:4154–4163.
   PubMed Web of Science ®Google Scholar
• Ross, J.. 1995. mRNA stability in mammalian cells. Microbiol. Rev. 59:423–450.
   PubMedGoogle Scholar
• Schiavi, S. C., C. L. Wellington, A. B. Shyu, C. Y. Chen, M. E. Greenberg, and J. G. Belasco. 1994. Multiple elements in the c-fos protein-coding region facilitate mRNA deadenylation and decay by a mechanism coupled to translation. J. Biol. Chem. 269:3441–3448.
   PubMed Web of Science ®Google Scholar
• Schuler, G. D., and M. D. Cole. 1988. GM-CSF and oncogene mRNA stabilities are independently regulated in trans in a mouse monocytic tumor. Cell 55:1115–1122.
   PubMed Web of Science ®Google Scholar
• Shaw, G., and R. Kamen. 1986. A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation. Cell 46:659–667.
   PubMed Web of Science ®Google Scholar
• Shyu, A.-B., J. G. Belasco, and M. G. Greenberg. 1991. Two distinct destabilizing elements in the c-fos message trigger deadenylation as a first step in rapid mRNA decay. Genes Dev. 5:221–232.
   PubMed Web of Science ®Google Scholar
• Shyu, A.-B., J. A. Garcia-Sanz, and E. Mullner. 1996. Analysis of mRNA decay in mammalian cells. Academic Press, London, United Kingdom
   Google Scholar
• Shyu, A.-B., M. E. Greenberg, and J. G. Belasco. 1989. The c-fos mRNA is targeted for rapid decay by two distinct mRNA degradation pathways. Genes Dev. 3:60–72.
   PubMed Web of Science ®Google Scholar
• Sirenko, O. I., A. K. Lofquist, C. T. DeMaria, J. S. Morris, G. Brewer, and J. S. Haskill. 1997. Adhesion-dependent regulation of an A+U-rich element-binding activity associated with AUF1. Mol. Cell. Biol. 17:3898–3906.
   PubMed Web of Science ®Google Scholar
• Wagner, B. J., C. T. DeMaria, Y. Sun, G. M. Wilson, and G. Brewer. 1998. Structure and genomic organization of the human AUF1 gene: alternative pre-mRNA splicing generates four protein isoforms. Genomics 48:195–202.
   PubMed Web of Science ®Google Scholar
• Wilson, G. M., and G. Brewer. 1999. Identification and characterization of proteins binding A+U-rich elements. Methods 17:74–83.
   PubMedGoogle Scholar
• Wilson, G. M., Y. Sun, H. Lu, and G. Brewer. 1999. Assembly of AUF1 oligomers on U-rich RNA targets by sequential dimer association. J. Biol. Chem. 274:33374–33381.
   PubMedGoogle Scholar
• Winzen, R., M. Kracht, B. Ritter, A. Wilhelm, C.-Y. A. Chen, A.-B. Shyu, M. Muller, M. Gaestel, K. Resch, and H. Holtmann. 1999. The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinase-activated protein kinase 2 and an AU-rich region-targeted mechanism. EMBO J. 18:4969–4980.
   PubMed Web of Science ®Google Scholar
• Xu, N., C.-Y. A. Chen, and A.-B. Shyu. 1997. Modulation of the fate of cytoplasmic mRNA by AU-rich elements: key sequence features controlling mRNA deadenylation and decay. Mol. Cell. Biol. 17:4611–4621.
   PubMed Web of Science ®Google Scholar
• Xu, N., P. Loflin, C.-Y. A. Chen, and A.-B. Shyu. 1998. A broader role for AU-rich element-mediated mRNA turnover revealed by a new transcriptional pulse strategy. Nucleic Acids Res. 26:558–565.
   PubMed Web of Science ®Google Scholar
• You, Y., C. Y. Chen, and A. B. Shyu. 1992. U-rich sequence-binding proteins (URBPs) interacting with a 20-nucleotide U-rich sequence in the 3′ untranslated region of c-fos mRNA may be involved in the first step of c-fos mRNA degradation. Mol. Cell. Biol. 12:2931–2940.
   PubMedGoogle Scholar
• Zhang, W., B. J. Wagner, K. Ehrenman, A. W. Schaefer, C. T. DeMaria, D. Crater, K. DeHaven, L. Long, and G. Brewer. 1993. Purification, characterization, and cDNA cloning of an AU-rich element RNA-binding protein, AUF1. Mol. Cell. Biol. 13:7652–7665.
   PubMed Web of Science ®Google Scholar