Advanced search
Publication Cover
Progress in Palliative Care
Science and the Art of Caring
Volume 12, 2004 - Issue 4
Submit an article Journal homepage
10
Views
0
CrossRef citations to date
0
Altmetric
Review Article

HAART in AIDS dementia complex and palliative care

Bruce J. Brew
Pages 171-177 | Published online: 19 Jul 2013

  • McArthur JC, Hoover DR, Bacellar H, Cohen BA, Becker JT et al. Dementia in AIDS patients: incidence and risk factors. Neurology 1993;43:2245–52.
  • Dore GJ, McDonald A, Li Y, Kaldor JM, Brew BJ. Marked improvement in survival following AIDS dementia complex in the era of highly active antiretroviral therapy. AIDS 2003;17:1539–45.
  • Dore GJ, Correll PK, Li Y, Kaldor JM, Cooper DA, Brew BJ. Changes to AIDS dementia complex in the era of highly active antiretroviral therapy. AIDS 1999;13:1249–53.
  • Gonzalez E, Rovin BH, Sen L et al. HIV-1 infection and AIDS dementia are influenced by a mutant MCP-1 allele linked to increased monocyte infiltration of tissues and MCP-1 levels. Proc Natl Acad Sci USA 2002;99:13795–800.
  • Power C, McArthur JC, Nath A, Wehrly K, Mayne M, Nishio J et al. Neuronal death induced by brain-derived human immunodeficiency virus type 1 envelope genes differs between demented and nondemented AIDS patients. J Virol 1998;72):9045–53.
  • Navia BA, Jordan BD, Price RW. The AIDS dementia complex: I. Clinical features. Ann Neurol 1986;19:517–24.
  • Brew BJ. AIDS dementia complex. In: HIV Neurology. Oxford: Oxford University Press, 2001; 53–90.
  • Cysique LA, Bain M, Wright E, Maruff P, Brew BJ. Neuropsychological profile of AIDS dementia complex across pre-HAART and HAART eras. 16Th Annual Conference Australasian Society for HIV Medicine, September 2–4, Canberra, 2004.
  • McArthur JC, McDermott MP, McClernon D, St Hilliare C, Conant K, Marder K et al. Attenuated CNS infection in advanced HIV/AIDS with combination antiretroviral therapy. Arch Neurol 2004; In press.
  • Tozzi V. HIV dementia and minor cognitive motor disorders in the late HAART era. J Neurovirol 2004;10(Suppl 3):11.
  • Tozzi V, Balestra P, Galgani S, Narciso P, Sampaolesi A, Antinori A et al. Changes in neurocognitive performance in a cohort of patients treated with HAART for 3 years. J Acquir Immune Defic Syndr 2001;28:19–27.
  • Brew BJ. Evidence for a change in AIDS dementia complex in the era of highly active antiretroviral therapy and the possibility of new forms of AIDS dementia complex. AIDS 2004;18(Suppl 1):S75–8.
  • Cysique L, Brew BJ, Halman M, Catalan J, Sacktor N, Price RW et al. Undetectable CSF HIV RNA and b-2 Microglobulin do not indicate inactive AIDS dementia complex. J AIDS 2004; In press.
  • Esiri MM, Biddolph SC, Morris CS. Prevalence of Alzheimer plaques in AIDS. J Neurol Neurosurg Psychiatry 1998;65:29–33.
  • Achim CL, Green DA, Avramut M, Schindelar J, Knight D, Masliah E. Axonal degeneration in the HIV brain. J Neurovirol 2004;10(Suppl 3):60.
  • Brew BJ, Pemberton L. Relationship between Alzheimer’s disease and AIDS dementia complex. 11th Conference on Retroviruses and Opportunistic Infections (CROI), San Francisco, February 8–11, 2004.
  • Friis-Moller N, Weber R, Reiss P, Yhiebaut R, Kirk O, d’Arminio Monforte T et al. Combination antiretroviral therapy and the risk of myocardial infarction. N Engl J Med 2003;349:1993–2003.
  • Gonzalez RG. Imaging NeuroAIDS. AJNR Am J Neuroradiol 2004;25:167–8.
  • Ernst T, Chang L, Leonido-Yee M, Speck O. Cerebral metabolites correlate with clinical severity of HIV cognitive-motor complex. Neurology 1999;52:100–8.
  • Brew BJ, Pemberton L, Cunningham P, Law M. Levels of HIV-1 RNA correlate with AIDS dementia. J Infect Dis 1997;175:963–6.
  • Brew BJ, Dunbar N, Pemberton L, Kaldor J. Cerebrospinal fluid concentrations of beta2 microglobulin and neopterin predict the development of AIDS dementia Complex. J Infect Dis 1996;174:294–8.
  • Ellis RJ, Moore DJ, Childers ME, Letendre S, McCutchan JA, Wolfson T et al. Progression to neuropsychological impairment in human immunodeficiency virus infection predicted by elevated cerebrospinal fluid levels of human immunodeficiency virus RNA. Arch Neurol 2002;59:923–8.
  • Christensson B, Ljungberg B, Ryding E, Svenson G, Rosen I. SPECT with 99mTc-HMPAO in subjects with HIV infection: cognitive dysfunction correlates with high uptake. Scand J Infect Dis 1999;31:349–54.
  • Hinkin CH, van Gorp WG, Mandelkern MA, Gee M, Satz P, Holston S et al. Cerebral metabolic change in patients with AIDS: report of a six-month follow up using positron-emission tomography. Neuropsychiatry Clin Neurosci 1995;7:180–7.
  • Bencherif B, Rottenberg DA. Neuroimaging of the AIDS dementia complex. AIDS 1998;12:233–44.
  • Brew BJ, Halman M, Catalan J, Sacktor N, Price RW, Brown S et al. Abacavir in AIDS dementia complex: efficacy and lessons for future trials. Neurology 2004; Under review.
  • Navia II Navia BA, Cho ES, Petito CK, Price RW. The AIDS dementia complex: II. Neuropathology. Ann Neurol 1986;19:525–35.
  • Brew BJ, Rosenblum M, Cronin K, Price RW. AIDS dementia complex and HIV-1 brain infection: clinical- virological correlations. Ann Neurol 1995;38:563–70.
  • Anthony IC, Ramage S, Brannan FW, Bell JE. Premature neurodegeneration, inflammation and opiate misuse in HIV/AIDS before and after HAART. J Neurovirol 2004;10(Suppl 3):52.
  • Clements JE, Babas T, Mankowski JL, Suryanarayana K, Platak M Jr. Tarwater PM et al. The central nervous system as a reservoir for simian immunodeficiency virus (SIV): steady-state levels of SIV DNA in brain from acute through asymptomatic infection. J Infect Dis 2002;186:905–13.
  • Raivich G, Jones LL, Kloss CU, Werner A, Neumann H, Kreutzberg GW. Immune surveillance in the injured nervous system: T-lymphocytes invade the axotomized mouse facial motor nucleus and aggregate around sites of neuronal degeneration. Neuroscience 1998;18:5804–16.
  • Gartner S, Liu Y. Insights into the role of immune activation in HIV neuropathogenesis. J Neurovirol 2002;8):69–75.
  • Petito CK. Human immunodeficiency virus type 1 compartmentalization in the central nervous system. J Neurovirol 2004;10(Suppl 1):21–4.
  • Glass JD, Fedor H, Wesselingh SL, McArthur JC. Immunocytochemical quantitation of human immunodeficiency virus in the brain: correlations with dementia. Ann Neurol 1995;385:755–62.
  • Cysique LAJ, Maruff P, Brew BJ. Antiretroviral therapy in HIV-infection: are neurologically active drugs important? Arch Neurol 2004; In press.
  • Letendre SL, McCutchan JA, Childers ME, Woods SP, Lazzaretto D, Heaton RK et al. Enhancing antiretroviral therapy for human immunodeficiency virus cognitive disorders. Ann Neurol 2004;56:416–23.
  • Yilmaz A, Stahle L, Hagberg L, Svennerholm B, Fuchs D, Gisslen M. Cerebrospinal fluid HIV-1 RNA levels and drug concentrations following antiretroviral regimen with loponavir/ritonavir. J Neurovirol 2004;10(Suppl 3):89.
  • Cunningham P, Smith D, Satchell C, Cooper DA, Brew BJ. Evidence for independent development of reverse transcriptase inhibitor resistance patterns in the cerebrospinal fluid. AIDS 2000;14:1949–54.
  • Sacktor N, Schifitto G, McDermott MP, Marder K, McArthur JC, Kieburtz K. Transdermal selegiline in HIV-associated cognitive impairment: pilot, placebocontrolled study. Neurology 2000;54:233–5.
  • Si Q, Cosenza M, Kim MO, Zhao ML, Brownlee M, Goldstein H et al. A novel action of minocycline: inhibition of human immunodeficiency virus type 1 infection in microglia. J Neurovirol 2004;10:284–92.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.