Systematic review and meta-analysis of budesonide/formoterol in a single inhaler

References

• BTS, SIGN (British Thoracic Society/Scottish Intercollegiate Guideline Network/British Thoracic Society). British guideline on the management of asthma, revised ed. April 2004. Available at: http://www.enterpriseportal2.co.uk/filestore/bts/asthmafull.pdf [last downloaded September 2006]
   Google Scholar
• Rodrigo GJ, Rodrigoi C, Hall JB. Acute asthma in adults: a review. Chest 2004;125;1081–102
   Google Scholar
• Hoskins G, McCowan C, Neville RG, et al. Risk factors and costs associated with an asthma attack. Thorax 2000;55:19–24
   PubMed Web of Science ®Google Scholar
• Canonica GW, Vignola AM. Adjustable maintenance dosing: suitability of budesonide/formoterol in a single inhaler and overview of a clinical study programme. Int J Clin Pract 2004;58 (Suppl. 141):9–17
   Google Scholar
• Jadad A, Moore RA, Carroll D, et al. Assessing the quality of reports of randomised controlled trials: is blinding necessary? Control Clin Trials 1996;17:1–12
   PubMedGoogle Scholar
• Dahl R, Chuchalin A, Gor D, et al. EXCEL: a randomised trial comparing salmeterol/fluticasone propionate and formoterol/ budesonide combinations in adults with persistent asthma. Respir Med 2006;100:1152–62
   PubMed Web of Science ®Google Scholar
• International conference on harmonisation of technical requirements for registration of pharmaceuticals for human use (ICH). E9: statistical principles for clinical trials, February 1998. Available at: http://www.ich.org/cache/compo/475–272–1.html [last downloaded September 2006].
   Google Scholar
• Review Manager (RevMan) [Computer program]. Version 4.1 for Windows. Oxford, England: The Cochrane Collaboration; 2000 [CD-ROM and Internet]
   Google Scholar
• Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 1959;22:719–48
   PubMed Web of Science ®Google Scholar
• Petitti DB. Meta-analysis, decision analysis, and cost-effectiveness analysis: methods for quantitative synthesis in medicine, 2nd ed. Oxford University Press: Oxford; 2000
   Google Scholar
• DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials 1986;7:177–88
   PubMed Web of Science ®Google Scholar
• Pauwels RA, Lofdahl C-G, Postma DS, et al. Effect of inhaled formoterol and budesonide on exacerbations of asthma. New Eng J Med 1997;337:1405–11
   Google Scholar
• Price D, Dutchman D, Mawson A, et al. Early asthma control and maintenance with eformoterol following inhaled corticosteroid dose reduction. Thorax 2002;57:791–8
   PubMed Web of Science ®Google Scholar
• Aalbers R, Backer V, Kava TTK, et al. Adjustable maintenance dosing with budesonide/formoterol compared with fixed-dose salmeterol/fluticasone in moderate to severe asthma. Curr Med Res Opin 2004;20:225–40
   PubMed Web of Science ®Google Scholar
• Kuna P, Peters MJ, Manjira AI, et al. Effect of budesonide/ formoterol maintenance and reliever therapy on asthma exacerbations. Int J Clin Pract 2007;61:725–36
   PubMed Web of Science ®Google Scholar
• FitzGerald JM, Sears MR, Boulet L-P, et al. Adjustable maintenance dosing with budesonide/formoterol reduces asthma exacerbations compared with traditional fixed dosing: a five-month multicentre Canadian study. Can Respir J 2003;10:427–34
   Google Scholar
• Leuppi JD, Salzberg M, Meyer L, et al. An individualized, adjustable maintenance regimen of budesonide/formoterol provides effective asthma symptom control at a lower overall dose than fixed dosing. Swiss Med Wkly 2003;133:302–9
   PubMed Web of Science ®Google Scholar
• Michilis A, Peché RVJ, Verbraecken JA, et al. SURF study: real-life effectiveness of budesonide/formoterol (B/F) adjustable maintenance dosing. Allergy Clin Immunol Int 2003;15(Suppl 1):56 [Abs P-2–39].
   Google Scholar
• Ställberg B, Olsson P, Jörgensen LA, et al. Budesonide/ formoterol adjustable maintenance dosing reduces asthma exacerbations versus fixed dosing. Int J Clin Pract 2003;57:656–61
   Google Scholar
• Buhl R, Kardos P, Richter K, et al. The effect of adjustable dosing with budesonide/formoterol on health-related quality of life and asthma control compared with fixed dosing. Curr Med Res Opin 2004;20:1209–20
   PubMed Web of Science ®Google Scholar
• Canonica GW, Castellani P, Cazzola M, et al. Adjustable maintenance dosing with budesonide/formoterol in a single inhaler provides effective asthma symptom control at a lower dose than fixed maintenance dosing. Pulm Pharmacol Ther 2004;17:239–47
   PubMed Web of Science ®Google Scholar
• Ind PW, Haughney J, Price D, et al. Adjustable and fixed dosing with budesonide/formoterol via a single inhaler in asthma patients: the ASSURE study. Respir Med 2004;98:464–75
   PubMed Web of Science ®Google Scholar
• Smozik Y, Iankova Z. Effectiveness of adjustable maintenance dosing and fixed dosing with budesonide/formoterol single inhaler in a multi-ethnic asthma population. Abstract and poster presented at the 14th annual congress of the European Respiratory Society, 4–8 September 2004, Glasgow, UK
   Google Scholar
• AstraZeneca Data on File SYM/045/MAR2007
   Google Scholar
• AstraZeneca Data on File SYM/044/MAR2007
   Google Scholar
• Gøtzsche PC. Multiple publication of reports of drug trials. Eur J Clin Pharmacol 1989;36:42932
   Google Scholar
• Gøtzsche PC. Reference bias in reports of drug trials. Br Med J 1987;295:6546
   Google Scholar
• Easterbrook PJ, Berlin JA, Gopalan R, Matthews DR. Publication bias in clinical research. Lancet 1991;337:86772
   Google Scholar
• Dickersin K, Min YI, Meinert CL. Factors influencing publication of research results: follow-up of applications submitted to two institutional review boards. J Am Med Assoc 1992;263: 3748
   Google Scholar
• Stern JM, Simes RJ. Publication bias: evidence of delayed publication in a cohort study of clinical research projects. Br Med J 1997;315:6405
   Google Scholar
• Angus R, Reagon R, Cheesbrough A. Short-acting beta 2-agonist and oral corticosteroid use in asthma patients prescribed either concurrent beclomethasone and long-acting beta 2-agonist or salmeterol/fluticasone propionate combination. Int J Clin Pract 2005;59: 156–62
   Google Scholar
• Mann M, Chowdhury B, Sullivan E, et al. Serious asthma exacerbations in asthmatics treated with high-dose formoterol. Chest 2003;124:70–4
   PubMed Web of Science ®Google Scholar
• Nelson HS, Weiss ST, Bleecker ER, et al. The salmeterol multicenter asthma research trial: a comparison of usual pharmacotherapy for asthma or usual pharmacotherapy plus salmeterol. Chest 2006;129:15–26
   PubMed Web of Science ®Google Scholar
• Sin DD, Man J, Sharpe H, et al. Pharmacological management to reduce exacerbations in adults with asthma: a systematic review and meta-analysis. J Am Med Assoc 2004;292:367–76
   PubMed Web of Science ®Google Scholar
• Gibson PG, Powell H, Ducharme FM. Differential effects of maintenance long-acting beta-agonist and inhaled corticosteroid on asthma control and asthma exacerbations. J Allergy Clin Immunol 2007;119:344–50
   Google Scholar
• Ernst P, McIvor A, Ducharme FM, et al. Safety and effectiveness of long-acting inhaled beta-agonist bronchodilators when taken with inhaled corticosteroids. Ann Intern Med 2006;145:692–4
   PubMed Web of Science ®Google Scholar
• Day SJ, Altman DG. Blinding in clinical trials and other studies. Br Med J 2000;321:504
   PubMed Web of Science ®Google Scholar
• Zetterström O, Buhl R, Mellem H, et al. Improved asthma control with budesonide/formoterol in a single inhaler, compared with budesonide alone. Eur Respir J 2001;18:262–8
   Google Scholar
• Bateman ED, Bantje TA, Joao Gomes M, et al. Combination therapy with single inhaler budesonide/formoterol compared with high dose of fluticasone propionate alone in patients with moderate persistent asthma. Am J Respir Med 2003;2:275–81
   PubMedGoogle Scholar
• Rosenhall L, Heinig JH, Lindqvist A, et al. Budesonide/ formoterol (Symbicort) is well tolerated and effective in patients with moderate persistent asthma. Int J Clin Pract 2002;56:427–33
   PubMed Web of Science ®Google Scholar
• Scicchitano R, Aalbers R, Ukena D, et al. Efficacy and safety of budesonide/formoterol single inhaler therapy versus a higher dose of budesonide in moderate to severe asthma. Curr Med Res Opin 2004;20:1403–18
   PubMed Web of Science ®Google Scholar
• O’Byrne PM, Bisgaard H, Godard PP, et al. Budesonide/ formoterol combination therapy as both maintenance and reliever medication in asthma. Am J Respir Crit Care Med 2005;171:129–36
   Google Scholar
• Vogelmeier C, D’Urzo A, Pauwels R, et al. Budesonide/ formoterol maintenance and reliever therapy: an effective asthma treatment option? Eur Respir J 2005;26:819–28
   PubMed Web of Science ®Google Scholar
• Rabe KF, Atienza T, Magyar P, et al. Effect of budesonide in combination with formoterol for reliever in asthma exacerbations: a randomised controlled, double-blind study. Lancet 2006;368:744–53
   PubMed Web of Science ®Google Scholar
• Rabe KF, Pizzichini E, Ställberg B, et al. Budesonide/formoterol in a single inhaler for maintenance and relief in mild-to-moderate asthma. Chest 2006;129:246–56
   Google Scholar