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Original Article

Costs, quality of life, treatment satisfaction and compliance in patients with β-thalassemia major undergoing iron chelation therapy: the ITHACA study

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Pages 1905-1917 | Accepted 25 Apr 2008, Published online: 27 May 2008

References

  • Wolman IJ. Transfusion therapy in Cooley's anemia: growth and health as related to long-range hemoglobin levels, a progress report. Ann NY Acad Sci 1964; 119:736–52
  • Piomelli S, Danoff SJ, Becker MH, . Prevention of bone malformations and cardiomegaly in Cooley's anemia by early hypertransfusion regimen. Ann NY Acad Sci 1969; 165:427–36
  • Barry M, Flynn DN, Letsky EA, . Long-term chelation therapy in thalassemia major: effect on liver iron concentration, liver histology and clinical progress. Br Med J 1974; 2:16–20
  • Hussain MA, Green N, Flynn DM, . Subcutaneous infusion and intramuscular injection of desferrioxamine in patients with transfusional iron overload. Lancet 1976; 2:1278–80
  • Modell CB, Beck J. Long-term desferrioxamine therapy in thalassemia. Ann NY Acad Sci 1974; 232:201–10
  • Zurlo MG, De Stefano P, Borgna-Pignatti C, . Survival and causes of death in thalassaemia major. Lancet 1989; 8653:27–30
  • Borgna-Pignatti C, Rugolotto S, De Stefano P, . Survival and complications in patients with thalassemia major treated with transfusion and deferoxamine. Haematologica 2004; 89:1187–93
  • Borgna-Pignatti C, Rugolotto S, De Stefano P, . Survival and disease complications in thalassemia major. Ann NY Acad Sci 1998; 850:227–31
  • Olivieri NF, Nathan DG, MacMillan JH, . Survival in medically treated patients with homozygous β-thalassemia. New Engl J Med 1994; 331:574–8
  • Cohen AR, Galanello R, Piga V, . Safety and effectiveness of long-term therapy with the oral iron chelator deferiprone. Blood 2003; 102:1583–7
  • Piga A, Gaglioti C, Fogliacco E, . Comparative effects of deferiprone and deferoxamine on survival and cardiac disease in patients with thalassemia major: a retrospective analysis. Haematologica 2003; 88:489–96
  • Pennell DJ, Berdoukas V, Karagiorga M, . Randomized controlled trial of deferiprone or deferoxamine in β-thalassemia major patients with asymptomatic myocardial siderosis. Blood 2006; 107:3738–44
  • Tanner MA, Galanello R, Dessi C, . A randomized, placebo-controlled, double-blind trial of the effect of combined therapy with deferoxamine and deferiprone on myocardial iron in thalassemia major using cardiovascular magnetic resonance. Circulation 2007; 115:1876–84
  • Cappellini MD, Cohen A, Piga A, . A phase 3 study of deferasirox (ICL670), a once-daily oral iron chelator, in patients with beta-thalassemia. Blood 2006; 107:3455–62
  • Woods K, Karrison T, Koshy M, . Hospital utilization patterns and costs for adult sickle cell patients in Illinois. Public Health Rep 1997; 112:44–51
  • Ginsberg G, Tulchinsky T, Filon D, . Cost benefit analysis of a national thalassaemia prevention programme in Israel. J Med Screen 1998; 5:120–6
  • Nietert PJ, Abboud MR, Zoller JS, . Costs, charges, and reimbursements for persons with sickle cell disease. J Pediatr Hematol Oncol 1999; 21:389–96
  • Karnon J, Zeuner D, Brown J, . Lifetime treatment costs of beta-thalassaemia major. Clin Lab Haematol 1999; 21:377–85
  • Wayne AS, Schoenike SE, Pegelow CH. Financial analysis of chronic transfusion for stroke prevention in sickle cell disease. Blood 2000; 96:2369–72
  • Mayer ML, Konrad TR, Dvorak CC. Hospital resource utilization among patients with sickle cell disease. J Health Care Poor Underserved 2003; 14:122–35
  • Desrosiers MP, Payne K, Proskorovsky I, . Estimated total annual costs of infused iron chelation therapy in the United Kingdom. Poster presented at the 11th Congress of the European Hematology Association (EHA). Abstract 0810 published in Haematologica/The Hematology Journal 2006;91(s1), (EHA)Amsterdam, The Netherlands17th June, 2006
  • Brun-Strang C, Bachir D, De Montalembert M, . Socio-economic impact of infused iron chelation therapy in France: ISOSFER study results. Poster presented at the American Society of Hematology (ASH) Congress in 2006, Abstract 3354 published in Blood| 2006;108, 48th Annual CongressOrlando, Florida, US9-11 December, 2006
  • Drummond MF, O'Brien B, Stoddart GL, . Methods for the economic evaluation of health care programmesOxford, (UK): Oxford University Press, 1997
  • Van Roijen L, Essink-Bot ML, Koopmanschap MA, . Labor and health status in economic evaluation of health care. The Health and Labor Questionnaire. Int J Technol Assess Health Care 1996; 12:405–15
  • Ware J Jr, Kosinski M, Keller SD. SF-36 physical and mental health summary scales: a user's manualBoston (MA): The Health Institute, 1994
  • Ware J Jr, Gandek B, Kosinski M, . The equivalence of SF-36 summary health scores estimated using standard and country-specific algorithms in 10 countries: results from the IQOLA project [International Quality of Life Assessment]. J Clin Epidemiol 1998; 51:1167–70
  • Brooks R. Euroqol: the current state of play. Health Policy 1996; 37:53–72
  • Apolone G, Mosconi P, Ware JE Jr. Questionario sullo Stato di Salute SF-36. Manuale d'uso e guida all'interpretazione dei risultatiMilano, (Italy): Guerini e Associati, 1997
  • Gringeri A, Mantovani LG, Scalone L, . Cost of care and quality of life for patients with haemophilia complicated by inhibitors: the COCIS Study Group. Blood 2003; 102:2358–63
  • Mantovani LG, Scalone L, Mannucci PM, . The cost of care of hemophilic patients without inhibitors: the COCHE study, Poster presented at the World Federation of Hemophilia (WFH) Congress in 2006. Abstract 28 PO 880. published in Haemophilia 2006; 12:(S2) 133–5
  • Abetz L, Baladi JF, Jones P, . The development of a treatment satisfaction questionnaire for iron overload (IO) patients on chelation therapy (CT). International Society for Pharmacoeconomics and Outcomes Research 8th Annual European CongressFlorence, ItalyNovember 6–8, 2005. Abstract n. PMC27 published in Value in Health 2005;8;A72
  • Cronbach LJ. Coefficient alpha and the internal structure of tests. Psychometrika 1951; 16:297–334
  • Delea TE, Edelsberg J, Sofrygin O, . Consequences and costs of non-compliance with iron chelation therapy in patients with transfusion-dependent thalassemia: a literature review. Transfusion 2007; 47:1919–29
  • Angelucci E, Barosi G, Camaschella C, . Italian Society of Hematology practice guidelines for the management of iron overload in thalassemia major and related disorders. Haematologica 2008; 93:1–12
  • Cappellini MD, Bejaoui M, Agaoglu L, . Prospective evaluation of patient-reported outcomes during treatment with deferasirox or deferoxamine for iron overload in patients with beta-thalassemia. Clin Ther 2007; 29:909–17

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