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Review

Molecular basis of the potential of vitamin D to prevent cancer

, &
Pages 139-149 | Accepted 23 Oct 2007, Published online: 22 Nov 2007

References

  • Jemal A, Murray T, Ward E, et al. Cancer statistics, 2005. CA Cancer J Clin 2005;55:10–30
  • Lichtenstein P, Holm NV, Verkasalo PK, et al. Environmental and heritable factors in the causation of cancer – analyses of cohorts of twins from Sweden, Denmark, and Finland. N Engl J Med 2000;343:78–85
  • Giovannucci E. The epidemiology of vitamin D and cancer incidence and mortality: a review (United States). Cancer Causes Control 2005;16:83–95
  • Giovannucci E. The epidemiology of calcitriol and colorectal cancer: recent findings. Curr Opin Gastroenterol 2006;22:24–9
  • Garland CF, Gorham M, Newmark H, et al. An epidemiologic basis for estimating optimal vitamin D3 intake for colon cancer prevention and a public health recommendation for greater vitamin D intake. Ann Epidemiol 2005;15:6630–8
  • Bagel J, Garland WT, Breneman D, et al. Administration of DAB389IL-2 to patients with recalcitrant psoriasis: a double-blind, phase II multicenter trial. J Am Acad Dermatol 1998;38:938–44
  • Garland CF, Gorham ED, Mohr SB, et al. Vitamin D and prevention of breast cancer: pooled analysis. J Steroid Biochem Mol Biol 2007;103:708–11
  • Grant WB. Geographic variation of prostate cancer mortality rates in the United States: implications for prostate cancer risk related to vitamin D. Int J Cancer. Sep 1 2004;111:470–1; author reply 472
  • Grant WB, Holick MF. Benefits and requirements of vitamin D for optimal health: a review. Altern Med Rev 2005;10:94–111
  • Shin MH, Holmes MD, Hankinson SE, et al. Intake of dairy products, calcium, and vitamin D and risk of breast cancer. J Natl Cancer Inst 2002;94:1301–11
  • Park SY, Murphy SP, Wilkens LR, et al. Calcium and vitamin D intake and risk of colorectal cancer: the Multiethnic Cohort Study. Am J Epidemiol 2007;165:784–93
  • Lin J, Manson JE, Lee IM, et al. Intakes of calcium and vitamin D and breast cancer risk in women. Arch Intern Med 2007;167:1050–9
  • Berube S, Diorio C, Masse B, et al. Vitamin D and calcium intakes from food or supplements and mammographic breast density. Cancer Epidemiol Biomarkers Prev 2005;14:1653–9
  • Bertone-Johnson ER, Chen WY, Holick MF, et al. Plasma 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D and risk of breast cancer. Cancer Epidemiol Biomarkers Prev 2005;14: 1991–7
  • Cross HS. Commentary: from epidemiology to molecular biology – vitamin D and colorectal cancer prevention. Int J Epidemiol 2006;35:225–7
  • Feskanich D, Ma J, Fuchs CS, et al. Plasma vitamin D metabolites and risk of colorectal cancer in women. Cancer Epidemiol Biomarkers Prev 2004;13:1502–8
  • Garland FC, Garland CF, Gorham ED, Young JF. Geographic variation in breast cancer mortality in the United States: a hypothesis involving exposure to solar radiation. Prevent Med 1990;19:614–22
  • Garland FC, White MR, Garland CF, et al. Occupational sunlight exposure and melanoma in the US Navy. Arch Environ Health 1990;45:261–7
  • Grant WB. An estimate of premature cancer mortality in the US due to inadequate doses of solar ultraviolet-B radiation. Cancer 2002;94:1867–75
  • Grant WB, Garland CF. A critical review of studies on vitamin D in relation to colorectal cancer. Nutr Cancer 2004;48:115–23
  • Schwartz GG. Vitamin D and the epidemiology of prostate cancer. Semin Dial 2005;18:276–89
  • Hanchette CL, Schwartz GG. Geographic patterns of prostate cancer mortality. Evidence for a protective effect of ultraviolet radiation. Cancer1992;70:2861–9
  • Porojnicu AC, Lagunova Z, Robsahm TE, et al. Changes in risk of death from breast cancer with season and latitude: sun exposure and breast cancer survival in Norway. Breast Cancer Res Treat 2007;102:323–8
  • Berwick M, Kesler D. Ultraviolet radiation exposure, vitamin D, and cancer. Photochem Photobiol 2005;81:1261–6
  • Mizoue T. Ecological study of solar radiation and cancer mortality in Japan. Health Phys 2004;87:532–8
  • Grant WB. An ecologic study of cancer mortality rates in Spain with respect to indices of solar UVB irradiance and smoking. Int J Cancer 2007;120:1123–8
  • Gorham ED, Garland FC, Garland CF. Sunlight and breast cancer incidence in the USSR. Int J Epidemiol 1990;19:820–4
  • Skinner HG, Michaud DS, Giovannucci E, et al. Vitamin D intake and the risk for pancreatic cancer in two cohort studies. Cancer Epidemiol Biomarkers Prev2006;15:1688–95
  • DeLuca HF. Overview of general physiologic features and functions of vitamin D. Am J Clin Nutr 2004;74:494–500
  • Holick MF. The photobiology of vitamin D and its consequences for humans. Ann NY Acad Sc 1985;453:1–13
  • Holick MF. Noncalcemic actions of 1,25-dihydroxyvitamin D3 and clinical applications. Bone 1995;17:107–11S
  • Bouillon R, Carmeliet G, Daci E, et al. A. Vitamin D metabolism and action. Osteoporos Int 1998;8 Suppl 2:S13–19
  • Omdahl J, Holick M, Suda T, et al. Biological activity of 1,25-dihydroxycholecalciferol. Biochemistry 1971;10:2935–40
  • Beer TM, Myrthue A. Calcitriol in cancer treatment: from the lab to the clinic. Mol Cancer Ther 2004;3:373–81
  • Chung I, Yu W-D, Karpf AR, et al. Anti-proliferative effects of calcitriol on endothelial cells derived from two different micro-environments. J Steroid Biochem Mol Biol 2007;103:768–70
  • Flynn G, Chung I, Yu WD, et al. Calcitriol (1,25-dihydroxycholecalciferol) selectively inhibits proliferation of freshly isolated tumor-derived endothelial cells and induces apoptosis. Oncology 2006;70:447–57
  • Banerjee P, Chatterjee M. Antiproliferative role of vitamin D and its analogs – a brief overview. Mol Cell Biochem 2003;253:247–54
  • Krishnan AV, Moreno J, Nonn L, et al. Novel pathways that contribute to the anti-proliferative and chemopreventive activities of calcitriol in prostate cancer. J Steroid Biochem Mol Biol 2007;103:694–702
  • Bernardi RJ, Johnson CS, Modzelewski RA, Trump DL. Antiproliferative effects of 1-alpha,25-dihydroxyvitamin D(3) and vitamin D analogs on tumor-derived endothelial cells. Endocrinology 2002;143:2508–14
  • Campbell MJ, Gombart AF, Kwok SH, et al. The anti-proliferative effects of 1-alpha-25(OH)2D3 on breast and cancer cells are associated with induction of BRCA1 gene expression. Oncogene 2000;19:5091–7
  • Moreno J, Krishnan AV, Feldman D. Molecular mechanisms mediating the anti-proliferative effects of vitamin D in prostate cancer. J Steroid Biochem Mol Biol 2005;97:31–6
  • Colston KW, Hansen CM. Mechanisms implicated in the growth regulatory effects of vitamin D in breast cancer. Endocr Relat Cancer 2002;9:45–59
  • Bikle DD. Vitamin D regulated keratinocyte differentiation. J Cell Biochem 2004;92:436–44
  • Palmer HG, Gonzalez-Sancho JM, Espada J, et al. Vitamin D(3) promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of beta-catenin signaling. J Cell Biol 2001;154:369–87
  • Mehta RR, Bratescu L, Graves JM, et al. Differentiation of human breast carcinoma cells by a novel vitamin D analog: 1-alpha-hydroxyvitamin D5. Int J Oncol 2000;16:65–73
  • Chen TC, Holick MF. Vitamin D and prostate cancer prevention and treatment. Trends Endocrinol Metab 2003;14:423–30
  • Fernandez-Garcia NI, Palmer HG, Garcia M, et al. 1-alpha,25Dihydroxyvitamin D3 regulates the expression of Id1 and Id2 genes and the angiogenic phenotype of human colon carcinoma cells. Oncogene 2005;24: 6533–44
  • Zhang Y, Zhang J, Studzinski GP. AKT pathway is activated by 1,25-dihydroxyvitamin D3 and participates in its anti-apoptotic effect and cell cycle control in differentiating HL60 cells. Cell Cycle 2006;5: 447–51
  • Jiang F, Li P, Fornace AJ, et al. G2/M arrest by 1,25-dihydroxyvitamin D3 in ovarian cancer cells mediated through the induction of GADD45 via an exonic enhancer. J Biol Chem 2003;278:48030–40
  • Weitsman GE, Koren R, Zuck E, et al. Vitamin D sensitizes breast cancer cells to the action of H2O2: mitochondria as a convergence point in the death pathway. Free Radic Biol Med 2005;39:266–78
  • Sundaram S, Chaudhry M, Reardon D, et al. The vitamin D3 analog EB 1089 enhances the antiproliferative and apoptotic effects of adriamycin in MCF-7 breast tumor cells. Breast Cancer Res Treat 2000;63:1–10
  • Welsh J, Wietzke JA, Zinser GM, et al. Vitamin D-3 receptor as a target for breast cancer prevention. J Nutr 2003;133:2425–33S
  • Amento EP, Bhalla AK, Kurnick JT, et al. 1 alpha,25-dihydroxyvitamin D3 induces maturation of the human monocyte cell line U937, and, in association with a factor from human T lymphocytes, augments production of the monokine, mononuclear cell factor. J Clin Invest 1984;73:731–9
  • Bhalla AK, Amento EP, Clemens TL, et al. Specific high-affinity receptors for 1,25-dihydroxyvitamin D3 in human peripheral blood mononuclear cells: presence in monocytes and induction in T lymphocytes following activation. J Clin Endocrinol Metab 1983;57:1308–10
  • Deeb KK, Trump DL, Johnson CS. Vitamin D signalling pathways in cancer: potential for anticancer therapeutics. Nat Rev Cancer 2007;7:684–700
  • Flynn G, Chung I, Yu W-D, et al. Calcitriol (1,25-dihydroxycholecalciferol) selectively inhibits proliferation of freshly isolated tumor-derived endothelial cells and induces apoptosis. Oncology 2006;70: 447–57
  • Peterlik M, Cross HS. Vitamin D and calcium deficits predispose for multiple chronic diseases. Eur J Clin Invest 2005;35:290–304
  • Raiten DJ, Picciano MF. Vitamin D and health in the 21st century: bone and beyond. Executive summary. Am J Clin Nutr 2004;80:1673–7S
  • Awada A, Piccart MJ. New biological approaches to the treatment of cancer, with a focus on breast cancer. Medscape 2001 2000;www.medscape.com/Medscape/oncology/TreatmentUpdate/2000/tu01/public/toc-tu01.html
  • Holick MF. Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis. [erratum appears in Am J Clin Nutr 2004 May;79(5):890]. Am J Clin Nutr 2004;79: 362–71
  • Demay MB. Mechanism of vitamin D receptor action. Ann NY Acad Sci2006;1068:204–13
  • Holick MF. Evolutionary biology and pathology of vitamin D. J Nutr Sci Vitaminol (Tokyo) 1992;Spec No:79–83
  • Sabbagh Y, Carpenter TO, Demay MB. Hypophosphatemia leads to rickets by impairing caspase-mediated apoptosis of hypertrophic chondrocytes. Proc Natl Acad Sci U S A 2005;102:9637–42
  • Fawcett DW, Raviola E. Bone. In Bloom W, Fawcett DW, eds. Textbook of Histology, Chapter 8. 1994:194
  • Liu PT, Stenger S, Li H, et al. Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science 2006;311:1770–3
  • Dai X, Yamasaki K, Yang L, et al. Keratinocyte G2/M growth arrest by 1,25-dihydroxyvitamin D3 is caused by Cdc2 phosphorylation through Wee1 and Myt1 regulation. J Invest Dermatol 2004;122:1356–64
  • Li P, Li C, Zhao X, et al. p27(Kip1) stabilization and G(1) arrest by 1,25-dihydroxyvitamin D(3) in ovarian cancer cells mediated through down-regulation of cyclin E/cyclin-dependent kinase 2 and Skp1-Cullin-F-box protein/Skp2 ubiquitin ligase. J Biol Chem 2004;279:25260–7
  • Han SH, Jeon JH, Ju HR, et al. VDUP1 upregulated by TGFbeta1 and 1,25-dihydorxyvitamin D3 inhibits tumor cell growth by blocking cell-cycle progression. Oncogene 2003;22:4035–46
  • Wu G, Fan RS, Li W, et al. Modulation of cell cycle control by vitamin D3 and its analog, EB1089, in human breast cancer cells. Oncogene 1997;15:1555–63
  • Kawa S, Nikaido T, Aoki Y, et al. Vitamin D analogues up-regulate p21 and p27 during growth inhibition of pancreatic cancer cell lines. Br J Cancer 1997;76:884–9
  • Johnson CS, Muindi JR, Hershberger PA, Trump DL. The antitumor efficacy of calcitriol: preclinical studies. Anticancer Res 2006;26:2543–9
  • Galbiati F, Polastri L, Thorens B, et al. Molecular pathways involved in the antineoplastic effects of calcitriol on insulinoma cells. Endocrinology 2003;144:1832–41
  • Hershberger PA, Yu WD, Modzelewski RA, et al. Calcitriol (1,25-dihydroxycholecalciferol) enhances paclitaxel antitumor activity in vitro and in vivo and accelerates paclitaxel-induced apoptosis. Clin Cancer Res 2001;7:1043–51
  • Johnson DG, Walker CL. Cyclins and cell cycle checkpoints. Annu Rev Pharmacol Toxicol 1999;39:295–312
  • Stewart ZA, Pietenpol JA. Cell cycle checkpoints as therapeutic targets. J Mammary Gland Biol Neoplasia 1999;4:389–400
  • Nojima H. Cell cycle checkpoints, chromosome stability and the progression of cancer. Hum Cell 1997;10:221–30
  • Hartwell L. 1994 forbeck cancer forum on cell cycle checkpoints. Clin Cancer Res 1995;1:1067
  • Liu M, Lee MH, Cohen M, et al. Transcriptional activation of the Cdk inhibitor p21 by vitamin D3 leads to the induced differentiation of the myelomonocytic cell line U937. Genes Dev 1996;10:142–53
  • Guyton KZ, Kensler TW, Posner GH. Vitamin D and vitamin D analogs as cancer chemopreventive agents. Nutr Rev 2003;61:227–38
  • Huang Y-C, Chen J-Y, Hung W-C. Vitamin D3 receptor/Sp1 complex is required for the induction of p27kip1 expression by vitamin D3. Oncogene 2004;23: 4856–61
  • Maruyama R, Aoki F, Toyota M, et al. Comparative genome analysis identifies the vitamin D receptor gene as a direct target of p53-mediated transcriptional activation. Cancer Res 2006;66:4574–83
  • Demasters G, Di X, Newsham I, et al. Potentiation of radiation sensitivity in breast tumor cells by the vitamin D3 analogue, EB 1089, through promotion of autophagy and interference with proliferative recovery. Mol Cancer Ther 2006;5:2786–97
  • Audo I, Darjatmoko SR, Schlamp CL, et al. Vitamin D analogues increase p53, p21, and apoptosis in a xenograft model of human retinoblastoma. Invest Ophthalmol Vis Sci 2003;44:4192–9
  • James SY, Mackay AG, Colston KW. Effects of 1,25 dihydroxyvitamin D3 and its analogues on induction of apoptosis in breast cancer cells. J Steroid Biochem Mol Biol. Jul 1996;58: 395–401
  • Sebag M, Gulliver W, Kremer R. Effect of 1,25 dihydroxyvitamin D3 and calcium on growth and differentiation and on c-fos and p53 gene expression in normal human keratinocytes. J Invest Dermatol 1994;103: 323–9
  • Matsumoto T, Sowa Y, Ohtani-Fujita N, et al. p53-independent induction of WAF1/Cip1 is correlated with osteoblastic differentiation by vitamin D3. Cancer Lett 1998;129: 61–8
  • Guzey M, Luo J, Getzenberg RH. Vitamin D3 modulated gene expression patterns in human primary normal and cancer cells. J Cell Biochem 2004;93: 271–85
  • Muehlemann M, Miller KD, Dauphinee M, Mizejewski GJ. Review of Growth Inhibitory Peptide as a biotherapeutic agent for tumor growth, adhesion, and metastasis. Cancer Metastasis Rev 2005;24:441–67
  • Schlaepfer DD, Mitra SK, Ilic D. Control of motile and invasive cell phenotypes by focal adhesion kinase. Biochim Biophys Acta 2004;1692:77–102
  • Rosenau W. The nature and mechanism of metastasis. Oncology 1970;24:21–5
  • Pendas-Franco N, Gonzalez-Sancho JM, Suarez Y, et al. Vitamin D regulates the phenotype of human breast cancer cells. Differentiation 2007;75:193–207
  • Gniadecki R, Gajkowska B, Hansen M. 1,25-dihydroxyvitaminD3 stimulates the assembly of adherens junctions in keratinocytes: involvement of protein kinase C. Endocrinology 1997;138: 2241–8
  • Hathcock JN, Shao A, Vieth R, Heaney R. Risk assessment for vitamin D. Am J Clin Nutr 2007;85:6–18
  • Lappe JM, Travers-Gustafson D, Davies KM, et al. Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial. Am J Clin Nutr 2007;85:1586–91
  • Vieth R, Bischoff-Ferrari H, Boucher BJ, et al. The urgent need to recommend an intake of vitamin D that is effective. Am J Clin Nutr 2007;85:649–50
  • Holick MF. Vitamin D: important for prevention of osteoporosis, cardiovascular heart disease, type 1 diabetes, autoimmune diseases, and some cancers. South Med J 2005;98:1024–7
  • Tseng M, Breslow RA, Graubard BI, Ziegler RG. Dairy, calcium, and vitamin D intakes and prostate cancer risk in the National Health and Nutrition Examination Epidemiologic Follow-up Study cohort. Am J Clin Nutr 2005;81:1147–54
  • Tangpricha V, Colon NA, Kaul H, et al. Prevalence of vitamin D deficiency in patients attending an outpatient cancer care clinic in Boston. Endocr Pract 2004;10:292–3
  • Nesby-O’Dell S, Scanlon KS, Cogswell ME, et al. Hypovitaminosis D prevalence and determinants among African American and white women of reproductive age: Third National Health and Nutrition Survey, 1988–1994. Am J Clin Nutr 2002;76: 187–92
  • Du X, Greenfield H, Fraser DR, et al. Vitamin D deficiency and associated factors in adolescent girls in Beijing. Am J Clin Nutr 2001;80:1689–96S
  • Reginster J-Y. The high prevalence of inadequate serum vitamin D levels and implications for bone health. Curr Med Res Opin 2005;21:579–85
  • Dawson-Hughes B, Heaney RP, Holick MF, et al. Estimates of optimal vitamin D status. Osteoporos Int 2005;16:713–16
  • Malabanan AO, Holick MF. Vitamin D and bone health in postmenopausal women. J Women’s Health 2003;12:151–6
  • Suitor CWLDM. Dietary Reference Intakes Research Synthesis: Workshop Summary. Washington, DC: National Academies Press, 2006:1–33
  • Weaver CM, Fleet JC. Vitamin D requirements: current and future. Am J Clin Nutr 2004;80:1735–9S
  • Gilchrest BA. Sun protection and vitamin D: three dimensions of obfuscation. J Steroid Biochem Mol Biol 2007;103:655–63
  • Schwartz GG, Skinner HG. Vitamin D status and cancer: new insights. Curr Opin Clin Nutr Metab Care 2007;10:6–11
  • Armstrong BK, Kricker A. Sun exposure and non-Hodgkin lymphoma. Cancer Epidemiol Biomarkers Prev 2007;16:396–400
  • olpowitz D, Gilchrest BA. The vitamin D questions: how much do you need and how should you get it? J Am Acad Dermatol 2006;54:301–17
  • Reichrath J. The challenge resulting from positive and negative effects of sunlight: how much solar UV exposure is appropriate to balance between risks of vitamin D deficiency and skin cancer? Prog Biophys Mol Biol 2006;92:9–16
  • Holick MF. Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Am J Clinical Nutr 2004;80:1678–88S
  • Egan KM, Sosman JA, Blot WJ. Sunlight and reduced risk of cancer: is the real story vitamin D? J Natl Cancer Inst 2005;97:161–3
  • Egan KM. Commentary: sunlight, vitamin D, and the cancer connection revisited. Int J Epidemiol 2006;35:227–30
  • Dixon KM, Deo SS, Wong G, et al. Skin cancer prevention: a possible role of 1,25 dihydroxyvitamin D3 and its analogs. J Steroid Biochem Mol Biol 2005;97:137–43
  • Hiom S. Public awareness regarding UV risks and vitamin D – the challenges for UK skin cancer prevention campaigns. Prog Biophys Mol Biol 2006;92:161–6

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