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Current Medical Research and Opinion Volume 25, 2009 - Issue 10
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Original Article

Effect of saxagliptin monotherapy in treatment-naïve patients with type 2 diabetes

J. Rosenstocka Dallas Diabetes and Endocrine Center at Medical City, Dallas, TX, USACorrespondence[email protected]
,
C. Aguilar-Salinasb Instituto Nacional de Ciencias Médicas y Nutrición, Mexico City, Mexico
,
E. Kleinc Capital Clinical Research Center, Olympia, WA, USA
,
S. Nepald Bristol-Myers Squibb, Princeton, NJ, USA
,
J. Listd Bristol-Myers Squibb, Princeton, NJ, USA
,
R. Chend Bristol-Myers Squibb, Princeton, NJ, USA
& for the CV181-011 Study Investigators show all
Pages 2401-2411 | Accepted 13 Jul 2009, Published online: 04 Aug 2009

References

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  • Rosenstock J, Zinman B. Dipeptidyl peptidase-4 inhibitors and the management of type 2 diabetes mellitus. Curr Opin Endocrinol Diabetes Obes 2007;14:98-107
  • Augeri DJ, Robl JA, Betebenner DA, et al. Discovery and preclinical profile of Saxagliptin (BMS-477118): a highly potent, long-acting, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. J Med Chem 2005;48:5025-37
  • Baggio LL, Drucker DJ. Biology of incretins: GLP-1 and GIP. Gastroenterology 2007;132:2131-57
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  • Drucker DJ. The biology of incretin hormones. Cell Metab 2006;3:153-65
  • Levetan C. Oral antidiabetic agents in type 2 diabetes. Curr Med Res Opin 2007;23:945-52
  • Rosenstock J, Sankoh S, List JF. Glucose-lowering activity of the dipeptidyl peptidase-4 inhibitor saxagliptin in drug-naive patients with type 2 diabetes. Diabetes Obes Metab 2008;10:376-86
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  • Xu L, Man CD, Charbonnel B, et al. Effect of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on beta-cell function in patients with type 2 diabetes: a model-based approach. Diabetes Obes Metab 2008;10:1212-20
  • Pratley RE, Schweizer A, Rosenstock J, et al. Robust improvements in fasting and prandial measures of β-cell function with vildagliptin in drug-naïve patients: analysis of pooled vildagliptin monotherapy database. Diabetes Obes Metab 2008;10:931-8

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