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Original Article

N-Methyl-D-Aspartate Receptor-Mediated Chronic Pain: New Approaches to Fibromyalgia Syndrome Etiology and Therapy

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Pages 33-44 | Received 16 Dec 2005, Accepted 24 Feb 2006, Published online: 16 Jan 2010

REFERENCES

  • Wolfe F, Ross K, Anderson J, Russell IJ, Hebert L. The prevalence and characteristics of fibromyalgia in the general population. Arthritis Rheum 1995; 38(1)19–28
  • Goldenberg DL. Fibromyalgia syndrome a decade later: what have we learned?. Arch Intern Med 1999; 159(8)777–785
  • Wolfe F, Smythe HA, Yunus MB, Bennett RM, Bombardier C, Goldenberg DL, Tugwell P, Campbell SM, Abeles M, Clark P, Fam AG, Farber SJ, Fiechtner JJ, Franklin CM, Gatter RA, Hamaty D, Lessard J, Lichtbroun AS, Masi AT, McCain GA, Reynolds WJ, Romano TJ, Russell IJ, Sheon RP. The American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia. Arthritis Rheum 1990; 33: 160–172
  • Winfield JB. Pain in Fibromyalgia. Rheum Dis Clin North Am. 1999; 25(1)55–79
  • Arroyo JF, Cohen ML. Abnormal responses to electrocutaneous stimulation in fibromyalgia. J Rheumatol 1993; 20(11)1925–1931
  • Staud R, Vierck CJ, Cannon RL, Mauderli AP, Price DD. Abnormal sensitization and temporal summation of second pain [wind-up] in patients with fibro-myalgia syndrome. Pain 2001; 91(1–2)165–175
  • Boissevain MD, McCain GA. Toward an integrated understanding of fibromyalgia syndrome. II. Psychological and phenomenological aspects. Pain 1991; 45(3)239–248
  • Simms RW. Fibromyalgia is not a muscle disorder. Am J Med Sci 1998; 315(6)346–350
  • Epstein SA, Kay G, Clauw D, Heaton R, Klein D, Krupp L, Kuck J, Leslie V, Masur D, Wagner M, Waid R, Zisook S. Psychiatric disorders in patients with fibromyalgia. A multicenter investigation. Psychosomatics 1999; 40(1)57–63
  • Ford CV. Somatization and fashionable diagnoses: Illness as a way of life. Scand J Work Environ Health 1997; 23(Suppl 3)7–16
  • Geenen R, Jacobs JW, Bijlsma JW. Evaluation and management of endocrine dysfunction in fibromyalgia. Rheum Dis Clin North Am 2002; 28(2)389–404
  • Crofford LJ. Neuroendocrine abnormalities in fibromyalgia and related disorders. Am J Med Sci 1998; 315(6)359–366
  • Dessein PH, Shipton EA, Stanwix AE, Joffe BI. Neuroendocrine deficiency-mediated development and persistence of pain in fibromyalgia: a promising paradigm?. Pain 2000; 86(3)213–215
  • Russell IJ, Orr MD, Littman B, Vipraio GA, Alboukrek D, Michalek JE, Lopez Y, MacKillip F. Elevated cerebrospinal fluid levels of substance P in patients with the fibromyalgia syndrome. Arthritis Rheum 1994; 37(11)1593–1601
  • Yunus MB, Dailey JW, Aldag JC, Masi AT, Jobe PC. Plasma and urinary catecholamines in primary fibro-myalgia: a controlled study. J Rheumatol. 1994; 19(1)95–97
  • Sorensen J, Graven-Nielsen T, Henriksson KG, Bengtsson M, Arendt-Nielsen L. Hyperexcitability in fibromyalgia. J Rheumatol 1998; 25(1)152–155
  • Bendtsen L, Norregaard J, Jensen R, Olesen J. Evidence of qualitatively altered nociception in patients with fibromyalgia. Arthritis Rheum 1997; 40(1)98–102
  • Gibson SJ, Littlejohn GO, Gorman MM, Helme RD, Granges G. Altered heat pain thresholds and cerebral event-related potentials following painful CO2 laser stimulation in subjects with fibromyalgia syndrome. Pain 1994; 58(2)185–193
  • Gracely RH, Petzke F, Wolf JM, Clauw DJ. Functional magnetic resonance imaging evidence of augmented pain processing in fibromyalgia. Arthritis Rheum 2002; 46(5)1333–1343
  • Mountz JM, Bradley LA, Modell JG, Alexander RW, Triana-Alexander M, Aaron LA, Stewart KE, Alarcon GS, Mountz JD. Fibromyalgia in women. Abnormalities of regional cerebral blood flow in the thalamus and the caudate nucleus are associated with low pain threshold levels. Arthritis Rheum 1995; 38(7)926–938
  • Desmeules JA, Cedraschi C, Rapiti E, Baumgartner E, Finckh A, Cohen P, Dayer P, Vischer TL. Neurophysiologic evidence for a central sensitization in patients with fibromyalgia. Arthritis Rheum 2003; 48(5)1420–1429
  • Hassett AL, Cone JD, Patella SJ, Sigal LH. The role of catastrophizing in the pain and depression of women with fibromyalgia syndrome. Arthritis Rheum 2000; 43(11)2493–2500
  • McEwen BS, Wingfield JC. The concept of allostasis in biology and biomedicine. Horm Behav 2003; 43(1)2–15
  • Fisher K, Coderre TJ, Hagen NA. Targeting the N-methyl-D-aspartate receptor for chronic pain management. Preclinical animal studies, recent clinical experience and future research directions. J Pain Symptom Manage 2003; 20(5)358–373
  • Clauw DJ, Chrousos GP. Chronic pain and fatigue syndromes: overlapping clinical and neuroendocrine features and potential pathogenic mechanisms. Neuroimmunomodulation 1997; 4(3)134–153
  • Bennett RM. Emerging concepts in the neurobiology of chronic pain: evidence of abnormal sensory processing in fibromyalgia. Mayo Clin Proc 1999; 74(4)385–398
  • Woolf CJ, Salter MW. Neuronal plasticity: increasing the gain in pain. Science 2000; 288(5472)1765–1769
  • Kandel ER. Genes, synapses, and long-term memory. J Cell Physiol 1997; 173(2)124–125
  • Lewin MR, Walters ET. Cyclic GMP pathway is critical for inducing long-term sensitization of nociceptive sensory neurons. Nat Neurosci 1999; 2(1)18–23
  • Ressler KJ, Paschall G, Zhou XL, Davis M. Regulation of synaptic plasticity genes during consolidation of fear conditioning. J Neurosci 2002; 22: 7892–7902
  • Thomas RJ. Excitatory amino acids in health and disease. J Am Geriatr Soc 1995; 43(11)1279–1289
  • MacDermott AB, Mayer ML, Westbrook GL, Smith SJ, Barker JL. NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones. Nature 1986; 321(6069)519–522
  • Aarts M, Liu Y, Liu L, Besshoh S, Arundine M, Gurd JW, Wang YT, Salter MW, Tymianski M. Treatment of ischemic brain damage by perturbing NMDA receptor-PSD-95 protein interactions. Science 2002; 298(5594)846–850
  • Mayer ML, Westbrook GL, Guthrie PB. Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones. Nature 1984; 309(5965)261–263
  • Leeson PD, Iversen LL. The glycine site on the NMDA receptor: structure-activity relationships and therapeutic potential. J Med Chem 1994; 37(24)4053–4067
  • Rock DM, Macdonald RL. Polyamine regulation of N-methyl-D-aspartate receptor channels. Annu Rev Pharmacol Toxicol 1995; 35: 463–482
  • Jansen KL, Faull RL, Dragunow M, Waldvogel H. Autoradiographic localisation of NMDA, quisqualate and kainic acid receptors in human spinal cord. Neurosci Lett 1990; 108(1–2)53–57
  • South SM, Kohno T, Kaspar BK, Hegarty D, Vissel B, Drake CT, Ohata M, Jenab S, Sailer AW, Malkmus S, Masuyama T, Horner P, Bogulavsky J, Gage FH, Yaksh TL, Woolf CJ, Heinemann SF, Inturrisi CE. A conditional deletion of the NR1 subunit of the NMDA receptor in adult spinal cord dorsal horn reduces NMDA currents and injury-induced pain. J Neurosci 2003; 23(12)5031–5040
  • Larson AA, Giovengo SL, Russell IJ, Michalek JE. Changes in the concentrations of amino acids in the cerebrospinal fluid that correlate with pain in patients with fibromyalgia: implications for nitric oxide pathways. Pain 2000; 87(2)201–211
  • Dougherty PM, Palecek J, Paleckova V, Sorkin LS, Willis WD. The role of NMDA and non-NMDA excitatory amino acid receptors in the excitation of primate spinothalamic tract neurons by mechanical, chemical, thermal, and electrical stimuli. J Neurosci 1992; 12(8)3025–3041
  • Clark SR, Bennett RM. Supplemental dextromethorphan in the treatment of fibromyalgia: a double-blind, placebo-controlled study of efficacy and side-effects. Arth Rheum 2000; 43: S333
  • Graven-Nielsen T, Aspegren Kendall S, Henriksson KG, Bengtsson M, Sorensen J, Johnson A, Gerdle B, Arendt-Nielsen L. Ketamine reduces muscle pain, temporal summation, and referred pain in fibromyalgia patients. Pain 2000; 85(3)483–491
  • Moochhala SM, Sawynok J. Hyperalgesia produced by intrathecal substance P and related peptides: desensitization and cross desensitization. Br J Pharmacol 1984; 82: 381–388
  • Ohtori S, Takahashi K, Ino H, Chiba T, Yamagata M, Sameda H, Moriya H. Up-regulation of substance P and NMDA receptor mRNA in dorsal horn and preganglionic sympathetic neurons during adjuvant-induced noxious stimulation in rats. Ann Anat 2002; 184(1)71–76
  • Vaeroy H, Helle R, Forre O, Kass E, Terenius L. Elevated cerebrospinal fluid levels of substance P and high incidence of Raynaud phenomenon in patients with fibromyalgia: new features for diagnosis. Pain 1998; 32(1)21–26
  • Strittmatter M, Grauer M, Isenberg E, Hamann G, Fischer C, Hoffmann KH, Blaes F, Schimrigk K. Cerebrospinal fluid neuropeptides and monoaminergic transmitters in patients with trigeminal neuralgia. Headache 1997; 37(4)211–216
  • Gallai V, Alberti A, Gallai B, Coppola F, Floridi A, Sarchielli P. Glutamate and nitric oxide pathway in chronic daily headache: evidence from cerebrospinal fluid. Cephalalgia 2003; 23(3)166–174
  • Garthwaite J, Boulton CL. Nitric oxide signaling in the central nervous system. Annu Rev Physiol 1995; 57: 683–706
  • Takano Y, Kuno Y, Sato E, Takano M, Sato I. Hyperalgesia induced by intrathecal administration of nitroglycerin involves NMDA receptor activation in the spinal cord. Masui 1997; 46(10)1354–1361
  • Petrenko AB, Yamakura T, Baba H, Shimoji K. The role of N-methyl-D-aspartate [NMDA] receptors in pain: A review. Anesthesia & Analgesia 2003; 97(4)1108–1116
  • Walker EA, Keegan D, Gardner G, Sullivan M, Katon WJ, Bernstein D. Psychosocial factors in fibro-myalgia compared with rheumatoid arthritis: I. Psychiatric diagnoses and functional disability. Psychosomatic Medicine 1997; 59(6)565–571
  • Malt EA, Berle JE, Olafsson S, Lund A, Ursin H. Fibromyalgia is associated with panic disorder and functional dyspepsia with mood disorders. A study of women with random sample population controls. J Psychosom Res 2000; 49(5)285–289
  • Alexander RW, Bradley LA, Alarcon GS, Triana-Alexander M, Aaron LA, Alberts KR, Martin MY, Stewart KE. Sexual and physical abuse in women with fibromyalgia: association with outpatient health care utilization and pain medication usage. Arthritis Care Res 1998; 11(2)102–115
  • Anderberg UM, Marteinsdottir I, Theorell T, von Knorring L. The impact of life events in female patients with fibromyalgia and in female healthy controls. Eur Psychiatry 2000; 15(5)295–301
  • Sherman JJ, Turk DC, Okifuji A. Prevalence and impact of posttraumatic stress disorder-like symptoms on patients with fibromyalgia syndrome. Clin J Pain 2000; 16: 127–134
  • Whitehead WE, Palsson O, Jones KR. Systematic review of the comorbidity of irritable bowel syndrome with other disorders: what are the causes and implications?. Gastroenterology 2002; 122(4)1140–1156
  • Johnson M, Paananen ML, Rahinantti P, Hannonen P. Depressed fibromyalgia patients are equipped with an emphatic competence dependent self-esteem. Clinical Rheumatology 1997; 16(6)578–584
  • Gaston-Johansson F, Gustafsson M, Felldin R, Sanne H. A comparative study of feelings, attitudes and behaviors of patients with fibromyalgia and rheumatoid arthritis. Social Science & Medicine 1990; 31(8)941–947
  • Callahan LF, Smith WJ, Pincus T. Self-report questionnaires in five rheumatic diseases: comparisons of health status constructs and associations with formal education level. Arthritis Care Res 1998; 2(4)122–131
  • Ruda MA, Ling QD, Hohmann AG, Peng YB, Tachibana T. Altered nociceptive neuronal circuits after neonatal peripheral inflammation. Science 2000; 289(5479)628–631
  • Teicher MH, Andersen SL, Polcari A, Anderson CM, Navalta CP. Developmental neurobiology of childhood stress and trauma. Psychiatr Clin North Am 2002; 25(2)397–426, vii-viii
  • Kaufman J, Birmaher B, Perel J, Dahl RE, Moreci P, Nelson B, Wells W, Ryan ND. The corticotropin-releasing hormone challenge in depressed abused, depressed nonabused, and normal control children. Biol Psychiatry 1997; 42: 669–679
  • Levine S. Influence of psychological variable on the activity of the hypothalamic-pituitary-adrenal axis. Eur J Pharmacol 2000; 29: 149–160
  • Chrousos GP. Stress, chronic inflammation, and emotional and physical well-being: concurrent effects and chronic sequelae. J Allergy Clin Immunol 2000; 106(5 Suppl)S275–291
  • Takahashi T, Kimoto T, Tanabe N, Hattori TA, Yasumatsu N, Kawato S. Corticosterone acutely prolonged N-methyl-d-aspartate receptor-mediated Ca2+ elevation in cultured rat hippocampal neurons. J Neurochem 2002; 83(6)1441–1451
  • Weiland NG, Orchinik M, Tanapat P. Chronic corticosterone treatment induces parallel changes in N-methyl-D-aspartate receptor subunit messenger RNA levels and antagonist binding sites in the hippocampus. Neuroscience 1997; 78: 653–662
  • Drummond PD. The effect of noradrenaline, angiotensin II and vasopressin on blood flow and sensitivity to heat in capsaicin-treated skin. Clin Auton Res 1998; 8(2)87–93
  • Calis M, Gokce C, Ates F, Ulker S, Izgi HB, Demir H, Kirnap M, Sofuoglu S, Durak AC, Tutus A, Kelestimur F. Investigation of the hypothalamo-pituitary-adrenal axis [HPA] by 1 microg ACTH test and metyrapone test in patients with primary fibromyalgia syndrome. J Endocrinol Invest 2004; 27(1)42–46
  • Magiakou MA, Chrousos GP. Corticosteroid therapy, nonendocrine disease, and corticosteroids withdrawal. Curr Ther Endocrinol Metab 1994; 5: 120–124
  • LeDoux J. The emotional brain, fear, and the amygdala. Cell Mol Neurobiol 2003; 23(4–5)727–738
  • McEwen BS. The neurobiology and neuroendo-crinology of stress. Implications for post-traumatic stress disorder from a basic science perspective. Psychiatr Clin North Am 2002; 25(2)469–494
  • Yang B, Wang Y, Cynader MS. Synergistic interactions between noradrenaline and glutamate in cytosolic calcium influx in cultured visual cortical neurons. Brain Res 1996; 721(1–2)181–190
  • Raj S, Brouillard D, Simpson CS, Hopman WM, Abdollah H. Dysautonomia among patients with fibro-myalgia: a noninvasive assessment. J Rheumatol 2000; 27: 2660–2665
  • Cohen H, Neumann L, Haiman Y, Matar MA, Press J, Buskila D. Prevalence of post-traumatic stress disorder in fibromyalgia patients: overlapping syndromes or post-traumatic fibromyalgia syndrome. Semin Arthritis Rheum 2002; 32: 38–50
  • Dentino AN, Pieper CF, Rao MK, Currie MS, Harris T, Blazer DG, Cohen HJ. Association of inter-leukin-6 and other biologic variables with depression in older people living in the community. J Am Geriatr Soc 1999; 47(1)6–11
  • Elenkov IJ, Wilder RL, Chrousos GP, Vizi ES. The sympathetic nerve-an integrative interface between two supersystems: the brain and the immune system. Pharmacol Rev 2000; 52(4)595–638
  • Wallace DJ, Linker-Israeli M, Hallegua D, Silverman S, Silver D, Weisman MH. Cytokines play an aetiopathogenetic role in fibromyalgia: a hypothesis and pilot study. Rheumatology 2001; 40(7)743–749
  • Papanicolaou DA, Vgontzas AN. Interleukin-6: the endocrine cytokine. J Clin Endocrinol Metab 2001; 85(3)1331–1333
  • Mastorakos G, Chrousos GP, Weber JS. Recombinant interleukin-6 activates the hypothalamic-pituitary-adrenal axis in humans. J Clin Endocrinol Metab 1993; 77: 1690–1694
  • De Jongh RF, Vissers KC, Meert TF, Booij LH, De Deyne CS, Heylen RJ. The role of interleukin-6 in nociception and pain. Anesth Analg 2003; 96(4)1096–1103
  • Ploj K, Roman E, Bergstrom L, Nylander I. Effects of neonatal handling on nociceptin/orphanin FQ and opioid peptide levels in female rats. Pharmacol Biochem Behav 2001; 69(1–2)173–179
  • Millan MJ, Morris BJ, Colpaert FC, Herz A. A model of chronic pain in the rat: high-resolution neuro-anatomical approach identifies alterations in multiple opioid systems in the periaqueductal grey. Brain Res 1997; 416(2)349–353
  • Mao J, Mayer DJ. Spinal cord neuroplasticity following repeated opioid exposure and its relation to pathological pain. Ann N Y Acad Sci 2001; 933: 175–184
  • Trujillo KA. The neurobiology of opiate tolerance, dependence and sensitization: mechanisms of NMDA receptor-dependent synaptic plasticity. Neurotox Res 2002; 4(4)373–391
  • Li X, Clark JD. Hyperalgesia during opioid abstinence: mediation by glutamate and substance P. Anesth Analg 2002; 95(4)979–984
  • Panerai AE, Vecchiet J, Panzeri P, Meroni P, Scarone S, Pizzigallo E, Giamberardino MA, Sacerdote P. Peripheral blood mononuclear cell beta-endorphin concentration is decreased in chronic fatigue syndrome and fibromyalgia but not in depression: preliminary report. Clin J Pain 2002; 18(4)270–273
  • Welin M, Bragee B, Nyberg F, Kristiansson M. Elevated substance P levels are contrasted by a decrease in met-enkephalin-arg-phe levels in cerebrospinal program from fibromyalgia patients. J Musculoske Pain 1995; 3(Suppl 1)4
  • Millea PJ, Holloway RL. Treating fibromyalgia. Am Fam Physician 2000; 62(7)1575–1587
  • Rao SG, Clauw DJ. The management of fibro-myalgia. Drugs Today 2004; 40(6)539–554
  • Goldenberg DL, Burckhardt C, Crofford L. Management of fibromyalgia syndrome. JAMA 2004; 292(19)2388–2395
  • Carette S, Bell MJ, Reynolds WJ, Haraoui B, McCain GA, Bykerk VP, Edworthy SM, Baron M, Koehler BE, Fam AG, Bellamy N, Guimont C. Comparison of amitriptyline, cyclobenzaprine, and placebo in the treatment of fibromyalgia. A randomized, double blind clinical trial. Arthritis Rheum; 1994; 37(1)32–40
  • Lawson K. Tricyclic antidepressants and fibro-myalgia: what is the mechanism of action?. Expert Opin Investig Drugs 2002; 11(10)1437–1445
  • McCain GA, Bell DA, Mai FM, Halliday PD. A controlled study of the effects of a supervised cardiovascular fitness training program on the manifestations of primary fibromyalgia. Arthritis Rheum 1988; 31(9)1135–1141
  • Burckhardt CS. Nonpharmacologic management strategies in fibromyalgia. Rheum Dis Clin North Am 2002; 28(2)291–304
  • Greenberg PE, Leong SA, Birnbaum HG, Robinson RL. The economic burden of depression with painful symptoms. J Clin Psychiatry 2003; 64(Suppl 7)17–23
  • Henriksson KG, Sorensen J. The promise of N-methyl-D-aspartate receptor antagonists in fibromyalgia. Rheum Dis Clin North Am 2002; 28(2)343–351
  • Bell R, Eccleston C, Kalso E. Ketamine as an adjuvant to opioids for cancer pain. Cochrane Pain, Palliative Care and Supportive Care Group Cochrane Database of Systematic Reviews 2004; 4
  • Kristensen JD, Svensson B, Gordh T, Jr. The NMDA-receptor antagonist CPP abolishes neurogenic 'wind-up pain' after intrathecal administration in humans. Pain 1992; 51(2)249–253
  • Nikolajsen L, Hansen CL, Nielsen J, Keller J, Arendt-Nielsen L, Jensen TS. The effect of ketamine on phantom pain: a central neuropathic disorder maintained by peripheral input. Pain 1996; 67(1)69–77
  • Weinbroum AA, Gorodetzky A, Nirkin A, Kollender Y, Bickels J, Marouani N, Rudick V, Meller I. Dextromethorphan for the reduction of immediate and late postoperative pain and morphine consumption in orthopedic oncology patients: a randomized, placebo-controlled, double-blind study. Cancer 2002; 95(5)1164–1170
  • Hoffmann V, Coppejans H, Vercauteren M, Adriaensen H. Successful treatment of postherpetic neuralgia with oral ketamine. Clin J Pain 1994; 10(3)240–242
  • Broadley KE, Kurowska A, Tookman A. Ketamine injection used orally. Palliat Med 1996; 10(3)247–250
  • Church J, Lodge D, Berry SC. Differential effects of dextromethorphan and levorphanol on the excitation of rat spinal neurons by amino acids. Eur J Pharmacol 1985; 111(2)185–190
  • Weinbroum AA, Gorodezky A, Niv D, Ben-Abraham R, Rudick V, Szold A. Dextromethorphan attenuation of postoperative pain and primary and secondary thermal hyperalgesia. Can J Anaesth 2001; 48(2)167–174
  • Weinbroum AA, Rudick V, Paret G, Ben-Abraham R. the role of dextromethorphan in pain control. Can J Anaesth. 2000; 47(6)585–596
  • Freye E, Levy J. Acute abstinence syndrome following abrupt cessation of long-term use of tramadol [Ultram]: A case study. Eur J Pain 2000; 4(3)307–311
  • Bennett GJ. Update on the neurophysiology of pain transmission and modulation: focus on the NMDA-receptor. J Pain Symptom Manage 2000; 19(Suppl 1)S2–6
  • Baker AK, Hoffmann VL, Meert TF. Interactions of NMDA antagonists and an alpha 2 agonist with mu, delta and kappa opioids in an acute nociception assay. Acta Anaesthesiol Belg 2002; 53(3)203–212
  • Wiesenfeld-Hallin Z. Combined opioid-NMDA antagonist therapies. What advantages do they offer for the control of pain syndromes? Drugs 1998; 55(1)1–4
  • Tao F, Tao YX, Mao P, Johns RA. Role of postsynaptic density protein-95 in the maintenance of peripheral nerve injury-induced neuropathic pain in rats. Neuroscience 2003; 117(3)731–739
  • Claiborne CF, McCauley JA, Libby BE, Curtis NR, Diggle HJ, Kulagowski JJ, Michelson SR, Anderson KD, Claremon DA, Freidinger RM, Bednar RA, Mosser SD, Gaul SL, Connolly TM, Condra CL, Bednar B, Stump GL, Lynch JJ, Macaulay A, Wafford KA, Koblan KS, Liverton NJ. Orally Efficacious NR2B-Se-lective NMDA Receptor Antagonists. Bioorg Med Chem Lett 2003; 13(4)697–700
  • Tao YX, Huang YZ, Mei L, Johns RA. Expression of PSD-95/SAP90 is critical for N-methyl-D-aspartate receptor-mediated thermal hyperalgesia in the spinal cord. Neuroscience 2000; 98(2)201–206
  • Tao YX, Johns RA. Effect of the deficiency of spinal PSD-95/SAP90 on the minimum alveolar anesthetic concentration of isoflurane in rats. Anesthesiology 2001; 94(6)1010–1015
  • Garry EM, Moss A, Delaney A, O'Neill F, Blakemore J, Bowen J, Husi H, Mitchell R, Grant SG, Fleetwood-Walker SM. Neuropathic sensitization of behavioral reflexes and spinal NMDA receptor/CaM kinase II interactions are disrupted in PSD-95 mutant mice. Curr Biol 2003; 13(4)321–328
  • Tao F, Tao YX, Gonzalez JA, Fang M, Mao P, Johns RA. Knockdown of PSD-95/SAP90 delays the development of neuropathic pain in rats. Neuroreport 2001; 12(15)3251–3255
  • Chizh BA, Reissmuller E, Schlutz H, Scheede M, Haase G, Englberger W. Supraspinal versus spinal sites of the antinociceptive action of the subtype-selective NMDA antagonist ifenprodil. Neuropharmacology 2001; 40(2)212–220
  • Tan-No K, Esashi A, Nakagawasai O, Niijima F, Sakurada C, Sakurada T, Bakalkin G, Terenius Tadano T. Nociceptive behavior induced by poly-L-lysine and other basic compounds involves the spinal NMDA receptors. Brain Res 2004; 1008(1)49–53
  • Zhang GH, Min SS, Lee KS, Back SK, Yoon SJ, Yoon YW, Kim YI, Na HS, Hong SK, Han HC. Intra-articular pretreatment with ketamine and memantine could prevent arthritic pain: relevance to the decrease of spinal c-fos expression in rats. Anesthesia & Analgesia 2004; 99(1)152–158
  • Medvedev IO, Malyshkin AA, Belozertseva IV, Sukhotina IA, Sevostianova NY, Aliev K, Zvartau EE, Parsons CG, Danysz W, Bespalov AY. Effects of low-affinity NMDA receptor channel blockers in two rat models of chronic pain. Neuropharmacology 2004; 47(2)175–183
  • Suzuki R, Matthews EA, Dickenson AH. Comparison of the effects of MK-801, ketamine and memantine on responses of spinal dorsal horn neurones in a rat model of mononeuropathy. Pain 2001; 91(1–2)101–109
  • Sang CN, Booher S, Gilron I, Parada S, Max MB. Dextromethorphan and memantine in painful diabetic neuropathy and postherpetic neuralgia: efficacy and dose-response trials. Anesthesiology 2002; 96(5)1053–1061
  • Marchettini P, Teloni L, Formaglio F, Lacerenza M. Pain in diabetic neuropathy case study: whole patient management. Euro J Neuro 2004; 11(Suppl 1)12–21
  • Wiech K, Kiefer RT, Topfner S, Preissl H, Braun C, Unertl K, Flor H, Birbaumer N. A placebo-controlled randomized crossover trial of the N-methyl-D-aspartic acid receptor antagonist, memantine, in patients with chronic phantom limb pain. Anesthesia & Analgesia 2004; 98(2)408–413
  • Raphael KG, Janal MN, Nayak S, Schwartz JE, Gallagher RM. Familial aggregation of depression in fibromyalgia: a community-based test of alternate hypotheses. Pain 2004; 110(1–2)449–460
  • Offenbaecher M, Bondy B, De Jonge S, Glat-zeder K, Kruger M, Schoeps P, Ackenheil M. Possible association of fibromyalgia with a polymorphism in the serotonin transporter gene regulatory region. Arthritis Rheum 1999; 42(11)2482–2488
  • Bondy B, Spaeth M, Offenbaecher M, Glatzeder K, Stratz T, Schwarz M, De Jonge S, Kruger M, Engel RR, Farber L, Pongratz DE, Ackenheil M. The T102C polymorphism of the 5-HT2A-receptor gene in fibro-myalgia. Neurobiol Dis 1999; 6(5)433–439
  • Cull-candy S, Brickley S, Farrant M. NMDA receptor subunits: diversity, development and disease. Curr Opin Neurobiol 2001; 11(3)327–335

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