Antisense and small-molecule modulation of diacylglycerol acyltransferase

Bibliography

• MCGARRY J: Dysregulation of fatty acid metabolism in the etiology of Type 2 diabetes. Diabetes (2002) 51:7-18.
   PubMed Web of Science ®Google Scholar
• KAHN SE, HULL RL, UTZSCHNEIDER KM: Mechanisms linking obesity to insulin resistance and Type 2 diabetes. Nature (2006) 444:840-846.
   PubMed Web of Science ®Google Scholar
• CHEN H, FARESE R: DGAT and triglyceride synthesis: a new target for obesity treatment? Trends Cardiovasc. Med. (2000) 10:188-192.
   PubMed Web of Science ®Google Scholar
• TURKISH A, STURLEY SL: Regulation of triglyceride metabolism. I. Eukaryotic neutral lipid synthesis: ‘many ways to skin acat or a dgat.’ Am. J. Physiol. Gastrointest. Liver Physiol. (2007) 292:G953-G957.
   Web of Science ®Google Scholar
• SUBAUSTE A, BURANT C: DGAT: Novel therapeutic target for obesity and Type 2 diabetes mellitus. Curr. Drug Targets Immun. Endocrine Metabol. Disord. (2003) 3:263-270.
   PubMedGoogle Scholar
• YU Y, GINSBERG H: The role of acyl CoA:diacylglycerol acyltransferase (DGAT) in energy metabolism. Ann. Med. (2004) 36:252-261.
   PubMed Web of Science ®Google Scholar
• CHEN H, FARESE R: Inhibition of triglyceride synthesis as a treatment strategy for obesity: lessons from DGAT1-deficient mice. Arterioscler. Thromb. Vasc. Biol. (2005) 25:482-486.
   PubMed Web of Science ®Google Scholar
• CASES S, SMITH S, ZHENG Y et al.: Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis. Proc. Natl. Acad. Sci. USA (1998) 95:13018-13023.
   PubMed Web of Science ®Google Scholar
• LIN S, LU X, CHANG CC et al.: Human acyl-coenzyme A:cholesterol acyltransferase expressed in Chinese hamster ovary cells: membrane topology and active site location. Mol. Biol. Cell (2003) 14:2447-2460.
   PubMed Web of Science ®Google Scholar
• CHEN H, SMITH S, LADHA Z et al.: Increased insulin and leptin sensitivity in mice lacking acyl CoA: diacylglycerol acyltransferase 1. J. Clin. Invest. (2002) 109:1049-1055.
   PubMed Web of Science ®Google Scholar
• SMITH S, CASES S, JENSEN D et al.: Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking DGAT. Nat. Genet. (2000) 25:87-90.
   PubMed Web of Science ®Google Scholar
• STONE S, MYERS H, WATKINS S et al.: Lipopenia and skin barrier abnormalities in DGAT2-deficient mice. J. Biol. Chem. (2004) 279:11767-11776.
   PubMed Web of Science ®Google Scholar
• YU X, MURRAY S, PANDEY S et al.: Antisense oligonucleotide reduction of DGAT2 expression improves hepatic steatosis and hyperlipidemia in obese mice. Hepatology (2005) 42:362-371.
   PubMed Web of Science ®Google Scholar
• CHOI C, SAVAGE D, KULKARNI A et al.: Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverse diet-induced hepatic steatosis and insulin resistance. J. Biol. Chem. (2007) 282:22678-22688.
   PubMed Web of Science ®Google Scholar
• YAMAGUCHI K, YANG L, MCCALL S et al.: Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatosis. Hepatology (2007) 45:1366-1374.
   PubMed Web of Science ®Google Scholar
• CASES S, ZHOU P, SHILLINGFORD J et al.: Development of the mammary gland requires dgat1 expression in stromal and epithelial tissues. Development (2004) 131:3047-3055.
   PubMed Web of Science ®Google Scholar
• LIU L, ZHANG Y, CHEN N et al.: Upregulation of myocellular DGAT1 augments triglyceride synthesis in skeletal muscle and protects against fat-induced insulin resistance. J. Clin. Invest. (2007) 117:1679-1689.
   PubMed Web of Science ®Google Scholar
• TOMODO H, TABATA N, ITO M et al.: Amidepsines, inhibitors of diacylglycerol acyltransferase produced by humicola sp. FO-2942. J. Antibiotic. (1995) 48:942-947.
   PubMed Web of Science ®Google Scholar
• TABATA N, ITO M, TOMADA H et al.: Xanthohumols, diacylglycerol acyltransferase inhibitors, from humulus lupulus. Phytochemistry (1997) 46:683-687.
   PubMed Web of Science ®Google Scholar
• CASACHI A, RUBIO BK, MAIYOH GK et al.: Inhibitory activity of diacylglycerol acyltransferase (DGAT) and microsomal triglyceride transfer protein (MTP) by the flavonoid, taxifolin, in HepG2 cells: potential role in the regulation of apolipoprotein B secretion. Atherosclerosis (2004) 176:247-253.
   PubMed Web of Science ®Google Scholar
• YEN C, MONETTI M, BURRI B et al.: Acyl CoA:diacylglycerol acyltransferase 1, an enzyme that catalyzes triacylglycerol biosynthesis, also catalyzes the synthesis of diacylglycerols, wax esters, and retinyl esters. J. Lipid Res. (2005) 46:1502-1511.
   PubMed Web of Science ®Google Scholar
• GOODPASTER B, HE J, WATKINS S et al.: Skeletal muscle lipid content and insulin resistance: evidence for a paradox in endurance-trained athletes. J. Clin. Endocrin. Metab. (2001) 86:5755-5761.
   PubMed Web of Science ®Google Scholar
• CHEN H, STONE S, ZHOU P et al.: Dissociation of obesity and impaired glucose disposal in mice overexpressing acyl coenzyme A:diacylglycerol acyl transferase 1 in white adipose tissue. Diabetes (2002) 51:3189-3195.
   PubMed Web of Science ®Google Scholar
• MONETTI M, LEVIN M, WATT M et al.: Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver. Cell Metabol. (2007) 6:69-78.
   PubMed Web of Science ®Google Scholar
• STONE S, LEVIN M, FARESE R: Membrane topology and identification of key functional amino acid residues of murine acyl-CoA:diacylglycerol acyltransferase-2. J. Biol. Chem. (2006) 281:40273-40282.
   PubMed Web of Science ®Google Scholar