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Expert Opinion on Therapeutic Patents Volume 17, 2007 - Issue 4
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Patent Evaluation

A H3 antagonist for treating allergic rhinitis: a development candidate?

Glaxo Group Ltd: WO2006090142

Dr Peter Norman Norman Consulting, 18 Pink Lane, Burnham, Buckinghamshire, SL1 8JW, UK. [email protected]
Pages 449-452 | Published online: 19 Apr 2007

Bibliography

  • ARRANG JM, GARBARG M, SCHWARTZ JC: Autoregulation of histamine release in brain by presynaptic H3 receptors. Neuroscience (1985) 15:553-562.
  • WITKIN JM, NELSON DL: Selective histamine H3 receptor antagonists for treatment of cognitive deficiencies and other disorders of the CNS. Pharmacol. Ther. (2004) 103:1-20.
  • MCLEOD RL, MINGO GG, HERCZKU C et al.: Combined histamine H1 and H3 receptor blockade produces nasal decongestion in an experimental model of nasal congestion. Am. J. Rhinol. (1999) 13:391-399.
  • TAYLOR-CLARK T, SODHA R, WARNER B, FOREMAN J: Histamine receptors that influence blockage of the normal human nasal airway. Br. J. Pharmacol. (2005) 144:867-874.
  • COWART M, ALTENBACH R, BLACK L: Medicinal chemistry and biological properties of non-imidazole histamine H3 antagonists. Mini Rev. Med. Chem. (2004) 4:979-992.
  • HANCOCK AA, FOX GB: Perspectives on cognitive domains, H3 receptor ligands and neurological disease. Expert Opin. Investig. Drugs (2004) 13:1237-1248.
  • HANCOCK AA, BRUNE ME: Assessment of pharmacology and potential anti-obesity properties of H3 receptor antagonists/inverse agonists. Expert Opin. Investig. Drugs (2005) 14:223-241.

Patents

Websites

  • http://clinicaltrials.gov/ct/show/ NCT00404586 US clinical trials website.

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